Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25800
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 39 member 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC39A6
Synonyms (NCBI Gene) Gene synonyms aliases
LIV-1, LIV1, ZIP6
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18q12.2
Summary Summary of gene provided in NCBI Entrez Gene.
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily o
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028339 hsa-miR-32-5p Sequencing 20371350
MIRT029131 hsa-miR-26b-5p Microarray 19088304
MIRT545425 hsa-miR-7849-3p PAR-CLIP 21572407
MIRT545416 hsa-miR-101-3p PAR-CLIP 21572407
MIRT545424 hsa-miR-144-3p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005385 Function Zinc ion transmembrane transporter activity IBA 21873635
GO:0005385 Function Zinc ion transmembrane transporter activity IDA 15642354
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005886 Component Plasma membrane IDA 12839489
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608731 18607 ENSG00000141424
Protein
UniProt ID Q13433
Protein name Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)
Protein function Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02535 Zip 322 528 ZIP Zinc transporter Family
PF02535 Zip 516 743 ZIP Zinc transporter Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum (PubMed:12839489). Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung
Sequence
MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQL
FYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEH
EHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKD
SVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKT
NESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDA
RSCLIHTSEKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSF
LVALAVGTLSGDAFLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDS
TWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTN
EEKVDTDDRTEGYLRADSQEPSHFDSQQPAVLEEE
EVMIAHAHPQEVYNEYVPRGCKNKC
HSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGVATLAWMVI
MGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLY
NALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCS
RWGYFFLQNAGMLLGFGIMLLIS
IFEHKIVFRINF
Sequence length 755
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Alzheimer disease
Parkinson disease
  Zinc influx into cells by the SLC39 gene family
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
12839489
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
12839489
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 23644492
Esophagus neoplasm Esophageal Neoplasms, Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 23644492
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 21079769, 23819905, 28833062, 32744318, 33782032, 34453638, 39300389
Death Associate 31703635
Esophageal Neoplasms Associate 26444413
Esophageal Squamous Cell Carcinoma Stimulate 26444413
Esophageal Squamous Cell Carcinoma Associate 31703635
Hypoxia Associate 28833062
Leukemia Associate 19066393
Lymphatic Metastasis Stimulate 26444413
Neoplasms Associate 31703635, 34453638
Stomach Diseases Associate 31703635