QPCT (glutaminyl-peptide cyclotransferase)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
25797
Gene name Gene Name - the full gene name approved by the HGNC.
Glutaminyl-peptide cyclotransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
QPCT
Synonyms (NCBI Gene) Gene synonyms aliases
GCT, QC, sQC
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided b
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(14)
miRTarBase ID miRNA Experiments Reference
MIRT569640 hsa-miR-7854-3p PAR-CLIP 20371350
MIRT569639 hsa-miR-3689d PAR-CLIP 20371350
MIRT569638 hsa-miR-6851-5p PAR-CLIP 20371350
MIRT569637 hsa-miR-363-5p PAR-CLIP 20371350
MIRT569636 hsa-miR-6745 PAR-CLIP 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region TAS
GO:0006464 Process Cellular protein modification process TAS 7999256
GO:0008270 Function Zinc ion binding IBA 21873635
GO:0008270 Function Zinc ion binding IDA 21288892
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
607065 9753 ENSG00000115828
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q16769
Protein name Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)
Protein function Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-termin
PDB 2AFM , 2AFO , 2AFS , 2AFU , 2AFW , 2AFX , 2AFZ , 2ZED , 2ZEE , 2ZEF , 2ZEG , 2ZEH , 2ZEL , 2ZEM , 2ZEN , 2ZEO , 2ZEP , 3PBB , 3PBE , 3SI0 , 4YU9 , 4YWY , 6GBX , 6YI1 , 6YJY , 7CM0 , 7COZ , 7CP0 , 7D8E , 8HY3 , 8XGB , 8XGT , 8XGY , 9ISD , 9IVV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04389 Peptidase_M28 122 → 355 Peptidase family M28 Family
Sequence
Sequence length 361
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Dermatitis Dermatitis, Allergic Contact rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 16033404
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)		 17145863
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 23974872
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Lymphocytic Leukemia Lymphocytic Leukemia GWAS
Show/Hide Text Mining Associations (17)
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 33863396
Alzheimer Disease Associate 22970285, 23977104, 26249687, 28587659, 32614980
Arthritis Rheumatoid Associate 30399509, 34177888
Bone Diseases Associate 15231017
Cognition Disorders Associate 24164736
COVID 19 Associate 38538269
Heart Failure Associate 35945262
Hypertension Associate 39596173
Leukemia Myeloid Acute Associate 37381175
Lupus Erythematosus Systemic Associate 39290707