PGLS (6-phosphogluconolactonase)

Gene

• Entrez ID: 25796
• Gene name: 6-phosphogluconolactonase
• Gene symbol: PGLS
• Synonyms (NCBI Gene): 6PGL, HEL-S-304
• Chromosome: 19
• Chromosome location: 19p13.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT450535	hsa-miR-5002-5p	PAR-CLIP	22100165
MIRT450534	hsa-miR-143-3p	PAR-CLIP	22100165
MIRT450533	hsa-miR-4770	PAR-CLIP	22100165
MIRT450532	hsa-miR-6088	PAR-CLIP	22100165
MIRT450531	hsa-miR-4708-5p	PAR-CLIP	22100165
MIRT450530	hsa-miR-1273f	PAR-CLIP	22100165
MIRT450529	hsa-miR-579-3p	PAR-CLIP	22100165
MIRT450528	hsa-miR-664b-3p	PAR-CLIP	22100165
MIRT450527	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450535	hsa-miR-5002-5p	PAR-CLIP	22100165
MIRT450534	hsa-miR-143-3p	PAR-CLIP	22100165
MIRT450533	hsa-miR-4770	PAR-CLIP	22100165
MIRT450532	hsa-miR-6088	PAR-CLIP	22100165
MIRT450531	hsa-miR-4708-5p	PAR-CLIP	22100165
MIRT450530	hsa-miR-1273f	PAR-CLIP	22100165
MIRT450529	hsa-miR-579-3p	PAR-CLIP	22100165
MIRT450528	hsa-miR-664b-3p	PAR-CLIP	22100165
MIRT450527	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT2066636	hsa-miR-15a	CLIP-seq
MIRT2066637	hsa-miR-15b	CLIP-seq
MIRT2066638	hsa-miR-16	CLIP-seq
MIRT2066639	hsa-miR-195	CLIP-seq
MIRT2066640	hsa-miR-2115	CLIP-seq
MIRT2066641	hsa-miR-338-3p	CLIP-seq
MIRT2066642	hsa-miR-424	CLIP-seq
MIRT2066643	hsa-miR-4530	CLIP-seq
MIRT2066644	hsa-miR-497	CLIP-seq
MIRT2294171	hsa-miR-198	CLIP-seq
MIRT2294172	hsa-miR-2964a-5p	CLIP-seq
MIRT2294173	hsa-miR-520a-5p	CLIP-seq
MIRT2294174	hsa-miR-525-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21044950, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006098	Process	Pentose-phosphate shunt	IDA	10518023
GO:0006098	Process	Pentose-phosphate shunt	IEA
GO:0006098	Process	Pentose-phosphate shunt	TAS
GO:0009051	Process	Pentose-phosphate shunt, oxidative branch	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017057	Function	6-phosphogluconolactonase activity	EXP	10518023
GO:0017057	Function	6-phosphogluconolactonase activity	IBA
GO:0017057	Function	6-phosphogluconolactonase activity	IDA	10518023, 11457850
GO:0017057	Function	6-phosphogluconolactonase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

Other IDs

• MIM: 604951
• HGNC: 8903
• e!Ensembl: ENSG00000130313

Protein

• UniProt ID: O95336
• Protein name: 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)
• Protein function: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01182	Glucosamine_iso	13 → 238	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	Domain

• Sequence:

  MAAPAPGLISVFSSSQELGAALAQLVAQRAACCLAGARARFALGLSGGSLVSMLARELPA
  AVAPAGPASLARWTLGFCDERLVPFDHAESTYGLYRTHLLSRLPIPESQVITINPELPVE
  EAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKIVAPISDSPK
  PPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFL
  DEAAARLLTVPFEKHSTL

• Sequence length: 258

Pathways

KEGG:

Pentose phosphate pathway
Metabolic pathways
Carbon metabolism

Reactome:

Pentose phosphate pathway