Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25796
Gene name Gene Name - the full gene name approved by the HGNC.	6-phosphogluconolactonase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PGLS
Synonyms (NCBI Gene) Gene synonyms aliases	6PGL, HEL-S-304
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.11

Show/Hide all(31)

miRTarBase ID	miRNA	Experiments	Reference
MIRT450535	hsa-miR-5002-5p	PAR-CLIP	22100165
MIRT450534	hsa-miR-143-3p	PAR-CLIP	22100165
MIRT450533	hsa-miR-4770	PAR-CLIP	22100165
MIRT450532	hsa-miR-6088	PAR-CLIP	22100165
MIRT450531	hsa-miR-4708-5p	PAR-CLIP	22100165
MIRT450530	hsa-miR-1273f	PAR-CLIP	22100165
MIRT450529	hsa-miR-579-3p	PAR-CLIP	22100165
MIRT450528	hsa-miR-664b-3p	PAR-CLIP	22100165
MIRT450527	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT450535	hsa-miR-5002-5p	PAR-CLIP	22100165
MIRT450534	hsa-miR-143-3p	PAR-CLIP	22100165
MIRT450533	hsa-miR-4770	PAR-CLIP	22100165
MIRT450532	hsa-miR-6088	PAR-CLIP	22100165
MIRT450531	hsa-miR-4708-5p	PAR-CLIP	22100165
MIRT450530	hsa-miR-1273f	PAR-CLIP	22100165
MIRT450529	hsa-miR-579-3p	PAR-CLIP	22100165
MIRT450528	hsa-miR-664b-3p	PAR-CLIP	22100165
MIRT450527	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT2066636	hsa-miR-15a	CLIP-seq
MIRT2066637	hsa-miR-15b	CLIP-seq
MIRT2066638	hsa-miR-16	CLIP-seq
MIRT2066639	hsa-miR-195	CLIP-seq
MIRT2066640	hsa-miR-2115	CLIP-seq
MIRT2066641	hsa-miR-338-3p	CLIP-seq
MIRT2066642	hsa-miR-424	CLIP-seq
MIRT2066643	hsa-miR-4530	CLIP-seq
MIRT2066644	hsa-miR-497	CLIP-seq
MIRT2294171	hsa-miR-198	CLIP-seq
MIRT2294172	hsa-miR-2964a-5p	CLIP-seq
MIRT2294173	hsa-miR-520a-5p	CLIP-seq
MIRT2294174	hsa-miR-525-5p	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21044950, 32296183
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0006098	Process	Pentose-phosphate shunt	IDA	10518023
GO:0006098	Process	Pentose-phosphate shunt	TAS
GO:0009051	Process	Pentose-phosphate shunt, oxidative branch	IBA	21873635
GO:0017057	Function	6-phosphogluconolactonase activity	EXP	10518023
GO:0017057	Function	6-phosphogluconolactonase activity	IBA	21873635
GO:0017057	Function	6-phosphogluconolactonase activity	IDA	10518023
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
604951	8903	ENSG00000130313

Protein

UniProt ID

O95336

Protein name

6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)

Protein function

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01182	Glucosamine_iso	13 → 238	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	Domain

Sequence

MAAPAPGLISVFSSSQELGAALAQLVAQRAACCLAGARARFALGLSGGSLVSMLARELPA
AVAPAGPASLARWTLGFCDERLVPFDHAESTYGLYRTHLLSRLPIPESQVITINPELPVE
EAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPDHPLLQEREKIVAPISDSPK
PPPQRVTLTLPVLNAARTVIFVATGEGKAAVLKRILEDQEENPLPAALVQPHTGKLCWFL
DEAAARLLTVPFEKHSTL

Sequence length

258

Interactions

View interactions

	KEGG		Reactome
	Pentose phosphate pathway Metabolic pathways Carbon metabolism		Pentose phosphate pathway

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Osteoporosis	Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	18924182

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	28260828, 29682102
Genetic Diseases Inborn	Associate	3858849
Lymphatic Metastasis	Stimulate	34953081
Neoplasm Metastasis	Associate	28260828
Stomach Neoplasms	Stimulate	34953081

PGLS (6-phosphogluconolactonase)