Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	25792
Gene name	CDKN1A interacting zinc finger protein 1
Gene symbol	CIZ1
Synonyms (NCBI Gene)	LSFR1NP94ZNF356
Chromosome	9
Chromosome location	9q34.11
Summary	The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms ha

Show/Hide all (16)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052245	hsa-let-7b-5p	CLASH	23622248
MIRT051724	hsa-let-7d-5p	CLASH	23622248
MIRT050670	hsa-miR-18a-5p	CLASH	23622248
MIRT043659	hsa-miR-326	CLASH	23622248
MIRT043659	hsa-miR-326	CLASH	23622248
MIRT042923	hsa-miR-324-3p	CLASH	23622248
MIRT040834	hsa-miR-18a-3p	CLASH	23622248
MIRT040834	hsa-miR-18a-3p	CLASH	23622248
MIRT040439	hsa-miR-615-3p	CLASH	23622248
MIRT1965049	hsa-miR-548ac	CLIP-seq
MIRT1965050	hsa-miR-548ae	CLIP-seq
MIRT1965051	hsa-miR-548aj	CLIP-seq
MIRT1965052	hsa-miR-548am	CLIP-seq
MIRT1965053	hsa-miR-548d-3p	CLIP-seq
MIRT1965054	hsa-miR-548x	CLIP-seq
MIRT1965055	hsa-miR-548z	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005515	Function	Protein binding	IPI	18654987
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	23145069
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	10529385
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	TAS	10529385
GO:0030332	Function	Cyclin binding	IEA
GO:0032298	Process	Positive regulation of DNA-templated DNA replication initiation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051457	Process	Maintenance of protein location in nucleus	IEA
GO:0060816	Process	Random inactivation of X chromosome	IEA

MIM	HGNC	e!Ensembl
611420	16744	ENSG00000148337

Q9ULV3

Protein name

Cip1-interacting zinc finger protein (CDKN1A-interacting zinc finger protein 1) (Nuclear protein NP94) (Zinc finger protein 356)

Protein function

May regulate the subcellular localization of CIP/WAF1.

PDB

7X39

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12171	zf-C2H2_jaz	684 → 710	Zinc-finger double-stranded RNA-binding	Family

Sequence

MFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQLLQLQQLLQQSPPQAPLPMAVSRGLP
PQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLG
NLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRN
PQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAK
EKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLP
EALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQ
VQPQLQQEAEPQKQVQPQVQPQAHSQGPRQVQLQQEAEPLKQVQPQVQPQAHSQPPRQVQ
LQLQKQVQTQTYPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTP
VVVHVCGLEMPPDAVEAGGGMEKTLPEPVGTQVSMEEIQNESACGLDVGECENRAREMPG
VWGAGGSLKVTILQSSDSRAFSTVPLTPVPRPSDSVSSTPAATSTPSKQALQFFCYICKA
SCSSQQEFQDHMSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQ
LYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFVEHVKSQGHKDKAKELKSLE
KEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSE
TYSPNTAYGVDFLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPT
TRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVTARPSQPPLPRRSTRLKT

Sequence length

898

Interactions

View interactions

312

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs45467292	RCV005923190
Cervical cancer	Benign	rs45467292	RCV005923191
Cholangiocarcinoma	Benign	rs45467292	RCV005923194
CIZ1-related disorder	Benign; Likely benign	rs11549266, rs144814370, rs184547222, rs200014240, rs61740197, rs747930059, rs1426201227, rs45536439, rs45559035, rs11549264, rs139585516, rs1407130246	RCV003980525 RCV003956214 RCV003951074 RCV003958582 RCV003929983 RCV004731564 RCV003914771 RCV003915287 RCV003902668 RCV003975371 RCV003955572 RCV003965682
Dystonia 23	Uncertain significance	rs769352644	RCV003447718
Dystonia, primary cervical	not provided	rs759174857	RCV000709866
Dystonic disorder	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity; Benign	rs1831181227, rs200687531, rs531041620, rs1831494504, rs373247353, rs971527949, rs749765483, rs138297392, rs200010931, rs2130888991, rs146779077, rs1022815988, rs148927894, rs184638839, rs200387684 View all (265 more)	RCV001324970 RCV001316077 RCV001349241 RCV001339770 RCV001364287 RCV001373468 RCV001366267 RCV001368259 RCV001371952 RCV001415853 RCV001400051 RCV001405420 RCV001419708 RCV001433993 RCV001434439 RCV001435328 RCV001442905 RCV001460315 RCV001474613 RCV001473167 RCV001472282 RCV001497918 RCV001493839 RCV001514464 RCV002073186 RCV002073319 RCV002073330 RCV002074250 RCV001900871 RCV001913668 RCV001989401 RCV001924196 RCV001934459 RCV001950729 RCV001985497 RCV001981695 RCV001951919 RCV002045457 RCV001889873 RCV001899033 RCV001903454 RCV002015515 RCV001940712 RCV001993091 RCV001990057 RCV001908057 RCV001885734 RCV001943949 RCV001934855 RCV001934008 RCV001983540 RCV002135188 RCV002087507 RCV002080431 RCV002129742 RCV002156478 RCV002194791 RCV002072691 RCV002218958 RCV002130316 RCV002101604 RCV002139440 RCV002122818 RCV002119630 RCV002103658 RCV002109733 RCV002215029 RCV002149251 RCV003068715 RCV003052603 RCV003056854 RCV003073796 RCV003068364 RCV003077276 RCV003073694 RCV003053228 RCV003077176 RCV003071761 RCV003093548 RCV003084189 RCV003081752 RCV003070461 RCV003082662 RCV002602286 RCV003087034 RCV003088812 RCV002598833 RCV002616671 RCV002623389 RCV002643631 RCV002606713 RCV002599075 RCV002599110 RCV002600044 RCV002637982 RCV002644254 RCV002664167 RCV002647902 RCV002647912 RCV002632703 RCV002612661 RCV003121339 RCV002570919 RCV002569628 RCV002576831 RCV002604210 RCV002622909 RCV002658201 RCV002667922 RCV002685564 RCV002736591 RCV002726515 RCV002730733 RCV002776340 RCV002775205 RCV002775837 RCV002796395 RCV002819643 RCV002838704 RCV002862127 RCV002839259 RCV002861474 RCV002857371 RCV002900047 RCV002867786 RCV002903866 RCV002885488 RCV002886381 RCV002942125 RCV002966444 RCV002961984 RCV002961985 RCV002962064 RCV002971174 RCV002952978 RCV002958341 RCV002929044 RCV002943641 RCV002944103 RCV002948342 RCV002954291 RCV002938927 RCV002953474 RCV002967261 RCV002995030 RCV002983084 RCV002983117 RCV002982303 RCV003013671 RCV003024765 RCV003054886 RCV003047223 RCV003586382 RCV003746654 RCV003586384 RCV000225904 RCV000232078 RCV005101235 RCV005100315 RCV003586446 RCV003586631 RCV003586923 RCV003586961 RCV003586966 RCV003587001 RCV003586916 RCV003586949 RCV003586951 RCV003586997 RCV003586821 RCV003586860 RCV003586911 RCV003587122 RCV003587124 RCV003587160 RCV003587260 RCV003587019 RCV003587246 RCV003587247 RCV003587058 RCV003587085 RCV003587370 RCV003587436 RCV003587827 RCV003587839 RCV003587887 RCV003587866 RCV003746725 RCV003746759 RCV003746767 RCV003746806 RCV003746807 RCV003746928 RCV003747194 RCV003747055 RCV003747146 RCV003747173 RCV003747245 RCV003747291 RCV003747431 RCV003746019 RCV003746031 RCV003746032 RCV003746157 RCV003746184 RCV003746251 RCV003746257 RCV003746362 RCV003746363 RCV003746386 RCV003746418 RCV003746443 RCV003746454 RCV003747517 RCV003747451 RCV003747491 RCV003747524 RCV003747557 RCV003747626 RCV003810679 RCV003836454 RCV003859272 RCV003859273 RCV003879036 RCV003878373 RCV003881023 RCV003880659 RCV005104606 RCV000461114 RCV000475007 RCV000467279 RCV000475715 RCV000474995 RCV000473525 RCV000474174 RCV000468340 RCV000460456 RCV000462075 RCV000468857 RCV000458874 RCV000463729 RCV000524791 RCV000536794 RCV000550892 RCV000551687 RCV001852662 RCV001510861 RCV000630717 RCV000694758 RCV000705560 RCV000694598 RCV000704623 RCV000685572 RCV000823087 RCV000794866 RCV000823727 RCV000805036 RCV000820817 RCV000799297 RCV000802090 RCV000802511 RCV000805738 RCV000861280 RCV000862759 RCV000861442 RCV001438029 RCV001464360 RCV001511865 RCV000868276 RCV001456341 RCV000866469 RCV001425538 RCV001501319 RCV000928153 RCV001441359 RCV001070264 RCV001037857 RCV001041185 RCV001068316 RCV001219892 RCV001219074 RCV001204671 RCV001211677 RCV001227243 RCV001246184 RCV001307941
Ovarian serous cystadenocarcinoma	Benign	rs45467292	RCV005923192
Uterine carcinosarcoma	Benign	rs45467292	RCV005923193
Variant of unknown significance	Uncertain significance	rs397514566	RCV000032913

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	40067149
Carcinogenesis	Associate	25427641
Carcinoma Hepatocellular	Associate	26906552
Carcinoma Non Small Cell Lung	Associate	32196604
Dystonia	Associate	35041927
Dystonia musculorum deformans type 1	Associate	23222958
Dystonic Disorders	Associate	23449625
Gallbladder Neoplasms	Stimulate	25427641
Hemangioma	Stimulate	30456533
Lung Neoplasms	Associate	20831784, 30107825
Neoplasms	Associate	20831784, 26906552, 30107825, 30280956, 30456533, 40067149
Neurodegenerative Diseases	Associate	23849371
Uveal melanoma	Associate	30107825

CIZ1 (CDKN1A interacting zinc finger protein 1)