TMEM59L (transmembrane protein 59 like)

Gene

• Entrez ID: 25789
• Gene name: Transmembrane protein 59 like
• Gene symbol: TMEM59L
• Synonyms (NCBI Gene): BSMAP, C19orf4
• Chromosome: 19
• Chromosome location: 19p13.11
• Summary: This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1438220	hsa-miR-10a	CLIP-seq
MIRT1438221	hsa-miR-10b	CLIP-seq
MIRT1438222	hsa-miR-320e	CLIP-seq
MIRT1438223	hsa-miR-339-5p	CLIP-seq
MIRT1438224	hsa-miR-3620	CLIP-seq
MIRT1438225	hsa-miR-4330	CLIP-seq
MIRT1438226	hsa-miR-4421	CLIP-seq
MIRT1438227	hsa-miR-593	CLIP-seq
MIRT1438220	hsa-miR-10a	CLIP-seq
MIRT1438221	hsa-miR-10b	CLIP-seq
MIRT2131286	hsa-miR-1270	CLIP-seq
MIRT1438224	hsa-miR-3620	CLIP-seq
MIRT2131287	hsa-miR-3622b-5p	CLIP-seq
MIRT2131288	hsa-miR-4253	CLIP-seq
MIRT2131289	hsa-miR-4683	CLIP-seq
MIRT2131290	hsa-miR-4708-5p	CLIP-seq
MIRT2131291	hsa-miR-620	CLIP-seq
MIRT2352578	hsa-miR-1266	CLIP-seq
MIRT2352579	hsa-miR-1269	CLIP-seq
MIRT2352580	hsa-miR-1269b	CLIP-seq
MIRT2352581	hsa-miR-1343	CLIP-seq
MIRT2352582	hsa-miR-24	CLIP-seq
MIRT2352583	hsa-miR-3127-5p	CLIP-seq
MIRT2352584	hsa-miR-378g	CLIP-seq
MIRT2352585	hsa-miR-3918	CLIP-seq
MIRT2352586	hsa-miR-4437	CLIP-seq
MIRT2352587	hsa-miR-4518	CLIP-seq
MIRT2352588	hsa-miR-4529-3p	CLIP-seq
MIRT2352589	hsa-miR-4674	CLIP-seq
MIRT2646325	hsa-miR-1825	CLIP-seq
MIRT2646326	hsa-miR-3169	CLIP-seq
MIRT2646327	hsa-miR-3170	CLIP-seq
MIRT2646328	hsa-miR-3173-3p	CLIP-seq
MIRT2646329	hsa-miR-3671	CLIP-seq
MIRT2646330	hsa-miR-371b-3p	CLIP-seq
MIRT2646331	hsa-miR-3914	CLIP-seq
MIRT2646332	hsa-miR-3928	CLIP-seq
MIRT2646333	hsa-miR-3943	CLIP-seq
MIRT2646334	hsa-miR-4258	CLIP-seq
MIRT2646335	hsa-miR-4515	CLIP-seq
MIRT2646336	hsa-miR-451b	CLIP-seq
MIRT2646337	hsa-miR-4700-3p	CLIP-seq
MIRT2646338	hsa-miR-4706	CLIP-seq
MIRT2646339	hsa-miR-4749-5p	CLIP-seq
MIRT2646340	hsa-miR-4781-5p	CLIP-seq
MIRT2646341	hsa-miR-510	CLIP-seq
MIRT2646342	hsa-miR-512-5p	CLIP-seq
MIRT2646343	hsa-miR-548n	CLIP-seq
MIRT2646344	hsa-miR-562	CLIP-seq
MIRT2646345	hsa-miR-607	CLIP-seq
MIRT2646346	hsa-miR-642b	CLIP-seq
MIRT2693564	hsa-miR-1207-3p	CLIP-seq
MIRT2693565	hsa-miR-1236	CLIP-seq
MIRT2646325	hsa-miR-1825	CLIP-seq
MIRT2646326	hsa-miR-3169	CLIP-seq
MIRT2646327	hsa-miR-3170	CLIP-seq
MIRT2646328	hsa-miR-3173-3p	CLIP-seq
MIRT2646329	hsa-miR-3671	CLIP-seq
MIRT2646330	hsa-miR-371b-3p	CLIP-seq
MIRT2646331	hsa-miR-3914	CLIP-seq
MIRT2646332	hsa-miR-3928	CLIP-seq
MIRT2646333	hsa-miR-3943	CLIP-seq
MIRT2646334	hsa-miR-4258	CLIP-seq
MIRT2646335	hsa-miR-4515	CLIP-seq
MIRT2646336	hsa-miR-451b	CLIP-seq
MIRT2646337	hsa-miR-4700-3p	CLIP-seq
MIRT2646338	hsa-miR-4706	CLIP-seq
MIRT2693566	hsa-miR-4731-5p	CLIP-seq
MIRT2646339	hsa-miR-4749-5p	CLIP-seq
MIRT2646340	hsa-miR-4781-5p	CLIP-seq
MIRT2693567	hsa-miR-486-3p	CLIP-seq
MIRT2646341	hsa-miR-510	CLIP-seq
MIRT2646342	hsa-miR-512-5p	CLIP-seq
MIRT2646343	hsa-miR-548n	CLIP-seq
MIRT2646344	hsa-miR-562	CLIP-seq
MIRT2646345	hsa-miR-607	CLIP-seq
MIRT2646346	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0001658	Process	Branching involved in ureteric bud morphogenesis	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005794	Component	Golgi apparatus	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10527841

Other IDs

• MIM: 617096
• HGNC: 13237
• e!Ensembl: ENSG00000105696

Protein

• UniProt ID: Q9UK28
• Protein name: Transmembrane protein 59-like (Brain-specific membrane-anchored protein)
• Protein function: Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12280	BSMAP	79 → 284	Brain specific membrane anchored protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed preferentially at high level in the brain.
• Sequence:

  MAAVALMPPPLLLLLLLASPPAASAPSARDPFAPQLGDTQNCQLRCRDRDLGPQPSQAGL
  EGASESPYDRAVLISACERGCRLFSICRFVARSSKPNATQTECEAACVEAYVKEAEQQAC
  SHGCWSQPAEPEPEQKRKVLEAPSGALSLLDLFSTLCNDLVNSAQGFVSSTWTYYLQTDN
  GKVVVFQTQPIVESLGFQGGRLQRVEVTWRGSHPEALEVHVDPVGPLDKVRKAKIRVKTS
  SKAKVESEEPQDNDFLSCMSRRSGLPRWILACCLFLSVLVMLWLSCSTLVTAPGQHLKFQ
  PLTLEQHKGFMMEPDWPLYPPPSHACEDSLPPYKLKLDLTKL

• Sequence length: 342