Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25789
Gene name Gene Name - the full gene name approved by the HGNC.	Transmembrane protein 59 like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TMEM59L
Synonyms (NCBI Gene) Gene synonyms aliases	BSMAP, C19orf4
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.11
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

Show/Hide all(77)

miRTarBase ID	miRNA	Experiments
MIRT1438220	hsa-miR-10a	CLIP-seq
MIRT1438221	hsa-miR-10b	CLIP-seq
MIRT1438222	hsa-miR-320e	CLIP-seq
MIRT1438223	hsa-miR-339-5p	CLIP-seq
MIRT1438224	hsa-miR-3620	CLIP-seq
MIRT1438225	hsa-miR-4330	CLIP-seq
MIRT1438226	hsa-miR-4421	CLIP-seq
MIRT1438227	hsa-miR-593	CLIP-seq
MIRT1438220	hsa-miR-10a	CLIP-seq
MIRT1438221	hsa-miR-10b	CLIP-seq
MIRT2131286	hsa-miR-1270	CLIP-seq
MIRT1438224	hsa-miR-3620	CLIP-seq
MIRT2131287	hsa-miR-3622b-5p	CLIP-seq
MIRT2131288	hsa-miR-4253	CLIP-seq
MIRT2131289	hsa-miR-4683	CLIP-seq
MIRT2131290	hsa-miR-4708-5p	CLIP-seq
MIRT2131291	hsa-miR-620	CLIP-seq
MIRT2352578	hsa-miR-1266	CLIP-seq
MIRT2352579	hsa-miR-1269	CLIP-seq
MIRT2352580	hsa-miR-1269b	CLIP-seq
MIRT2352581	hsa-miR-1343	CLIP-seq
MIRT2352582	hsa-miR-24	CLIP-seq
MIRT2352583	hsa-miR-3127-5p	CLIP-seq
MIRT2352584	hsa-miR-378g	CLIP-seq
MIRT2352585	hsa-miR-3918	CLIP-seq
MIRT2352586	hsa-miR-4437	CLIP-seq
MIRT2352587	hsa-miR-4518	CLIP-seq
MIRT2352588	hsa-miR-4529-3p	CLIP-seq
MIRT2352589	hsa-miR-4674	CLIP-seq
MIRT2646325	hsa-miR-1825	CLIP-seq
MIRT2646326	hsa-miR-3169	CLIP-seq
MIRT2646327	hsa-miR-3170	CLIP-seq
MIRT2646328	hsa-miR-3173-3p	CLIP-seq
MIRT2646329	hsa-miR-3671	CLIP-seq
MIRT2646330	hsa-miR-371b-3p	CLIP-seq
MIRT2646331	hsa-miR-3914	CLIP-seq
MIRT2646332	hsa-miR-3928	CLIP-seq
MIRT2646333	hsa-miR-3943	CLIP-seq
MIRT2646334	hsa-miR-4258	CLIP-seq
MIRT2646335	hsa-miR-4515	CLIP-seq
MIRT2646336	hsa-miR-451b	CLIP-seq
MIRT2646337	hsa-miR-4700-3p	CLIP-seq
MIRT2646338	hsa-miR-4706	CLIP-seq
MIRT2646339	hsa-miR-4749-5p	CLIP-seq
MIRT2646340	hsa-miR-4781-5p	CLIP-seq
MIRT2646341	hsa-miR-510	CLIP-seq
MIRT2646342	hsa-miR-512-5p	CLIP-seq
MIRT2646343	hsa-miR-548n	CLIP-seq
MIRT2646344	hsa-miR-562	CLIP-seq
MIRT2646345	hsa-miR-607	CLIP-seq
MIRT2646346	hsa-miR-642b	CLIP-seq
MIRT2693564	hsa-miR-1207-3p	CLIP-seq
MIRT2693565	hsa-miR-1236	CLIP-seq
MIRT2646325	hsa-miR-1825	CLIP-seq
MIRT2646326	hsa-miR-3169	CLIP-seq
MIRT2646327	hsa-miR-3170	CLIP-seq
MIRT2646328	hsa-miR-3173-3p	CLIP-seq
MIRT2646329	hsa-miR-3671	CLIP-seq
MIRT2646330	hsa-miR-371b-3p	CLIP-seq
MIRT2646331	hsa-miR-3914	CLIP-seq
MIRT2646332	hsa-miR-3928	CLIP-seq
MIRT2646333	hsa-miR-3943	CLIP-seq
MIRT2646334	hsa-miR-4258	CLIP-seq
MIRT2646335	hsa-miR-4515	CLIP-seq
MIRT2646336	hsa-miR-451b	CLIP-seq
MIRT2646337	hsa-miR-4700-3p	CLIP-seq
MIRT2646338	hsa-miR-4706	CLIP-seq
MIRT2693566	hsa-miR-4731-5p	CLIP-seq
MIRT2646339	hsa-miR-4749-5p	CLIP-seq
MIRT2646340	hsa-miR-4781-5p	CLIP-seq
MIRT2693567	hsa-miR-486-3p	CLIP-seq
MIRT2646341	hsa-miR-510	CLIP-seq
MIRT2646342	hsa-miR-512-5p	CLIP-seq
MIRT2646343	hsa-miR-548n	CLIP-seq
MIRT2646344	hsa-miR-562	CLIP-seq
MIRT2646345	hsa-miR-607	CLIP-seq
MIRT2646346	hsa-miR-642b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0001658	Process	Branching involved in ureteric bud morphogenesis	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005794	Component	Golgi apparatus	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10527841

MIM	HGNC	e!Ensembl
617096	13237	ENSG00000105696

Protein

UniProt ID

Q9UK28

Protein name

Transmembrane protein 59-like (Brain-specific membrane-anchored protein)

Protein function

Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12280	BSMAP	79 → 284	Brain specific membrane anchored protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed preferentially at high level in the brain.

Sequence

MAAVALMPPPLLLLLLLASPPAASAPSARDPFAPQLGDTQNCQLRCRDRDLGPQPSQAGL
EGASESPYDRAVLISACERGCRLFSICRFVARSSKPNATQTECEAACVEAYVKEAEQQAC
SHGCWSQPAEPEPEQKRKVLEAPSGALSLLDLFSTLCNDLVNSAQGFVSSTWTYYLQTDN
GKVVVFQTQPIVESLGFQGGRLQRVEVTWRGSHPEALEVHVDPVGPLDKVRKAKIRVKTS
SKAKVESEEPQDNDFLSCMSRRSGLPRWILACCLFLSVLVMLWLSCSTLVTAPGQHLKFQ
PLTLEQHKGFMMEPDWPLYPPPSHACEDSLPPYKLKLDLTKL

Sequence length

342

Interactions

View interactions

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Dental caries	Dental caries	N/A	N/A	GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Carcinoma Renal Cell	Associate	36618425
Colonic Neoplasms	Stimulate	36618425
Colorectal Neoplasms	Associate	38466182
Glioblastoma	Stimulate	37439405
Glioma	Associate	37439405
Neoplasms	Associate	35361846, 36618425
Recombinant chromosome 8 syndrome	Inhibit	36618425
Urinary Bladder Neoplasms	Stimulate	36618425

TMEM59L (transmembrane protein 59 like)