Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	25777
Gene name Gene Name - the full gene name approved by the HGNC.	Sad1 and UNC84 domain containing 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SUN2
Synonyms (NCBI Gene) Gene synonyms aliases	UNC84B, rab5IP
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a `bridge` across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KAS

Show/Hide all(169)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020123	hsa-miR-130b-3p	Sequencing	20371350
MIRT027033	hsa-miR-103a-3p	Sequencing	20371350
MIRT050037	hsa-miR-27a-3p	CLASH	23622248
MIRT047952	hsa-miR-30c-5p	CLASH	23622248
MIRT046749	hsa-miR-222-3p	CLASH	23622248
MIRT036434	hsa-miR-1226-3p	CLASH	23622248
MIRT652978	hsa-miR-335-5p	HITS-CLIP	23824327
MIRT652977	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT652976	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT652975	hsa-miR-665	HITS-CLIP	23824327
MIRT652974	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT652973	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT652972	hsa-miR-4286	HITS-CLIP	23824327
MIRT652971	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT652970	hsa-miR-7106-3p	HITS-CLIP	23824327
MIRT652969	hsa-miR-5581-3p	HITS-CLIP	23824327
MIRT553904	hsa-miR-542-3p	PAR-CLIP	20371350
MIRT553903	hsa-miR-758-3p	PAR-CLIP	20371350
MIRT553902	hsa-miR-107	PAR-CLIP	20371350
MIRT027033	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT553901	hsa-miR-548b-3p	PAR-CLIP	20371350
MIRT553900	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT020123	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT553899	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT553898	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT553896	hsa-miR-3666	PAR-CLIP	20371350
MIRT553897	hsa-miR-4295	PAR-CLIP	20371350
MIRT553895	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT553893	hsa-miR-4310	PAR-CLIP	20371350
MIRT553894	hsa-miR-7157-5p	PAR-CLIP	20371350
MIRT553891	hsa-miR-4504	PAR-CLIP	20371350
MIRT553890	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT553889	hsa-miR-4671-3p	PAR-CLIP	20371350
MIRT553888	hsa-miR-6808-3p	PAR-CLIP	20371350
MIRT553887	hsa-miR-3660	PAR-CLIP	20371350
MIRT553904	hsa-miR-542-3p	PAR-CLIP	21572407
MIRT553903	hsa-miR-758-3p	PAR-CLIP	21572407
MIRT553902	hsa-miR-107	PAR-CLIP	21572407
MIRT027033	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT553901	hsa-miR-548b-3p	PAR-CLIP	21572407
MIRT553900	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT020123	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT553899	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT553898	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT553896	hsa-miR-3666	PAR-CLIP	21572407
MIRT553897	hsa-miR-4295	PAR-CLIP	21572407
MIRT553895	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT553893	hsa-miR-4310	PAR-CLIP	21572407
MIRT553894	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT553892	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT553891	hsa-miR-4504	PAR-CLIP	21572407
MIRT553890	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT553889	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT553888	hsa-miR-6808-3p	PAR-CLIP	21572407
MIRT553887	hsa-miR-3660	PAR-CLIP	21572407
MIRT652978	hsa-miR-335-5p	HITS-CLIP	23824327
MIRT652977	hsa-miR-4433a-3p	HITS-CLIP	23824327
MIRT652976	hsa-miR-6777-3p	HITS-CLIP	23824327
MIRT652975	hsa-miR-665	HITS-CLIP	23824327
MIRT652974	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT652973	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT652972	hsa-miR-4286	HITS-CLIP	23824327
MIRT652971	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT652970	hsa-miR-7106-3p	HITS-CLIP	23824327
MIRT652969	hsa-miR-5581-3p	HITS-CLIP	23824327
MIRT553904	hsa-miR-542-3p	PAR-CLIP	20371350
MIRT553903	hsa-miR-758-3p	PAR-CLIP	20371350
MIRT553902	hsa-miR-107	PAR-CLIP	20371350
MIRT027033	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT553901	hsa-miR-548b-3p	PAR-CLIP	20371350
MIRT553900	hsa-miR-130a-3p	PAR-CLIP	20371350
MIRT020123	hsa-miR-130b-3p	PAR-CLIP	20371350
MIRT553899	hsa-miR-301a-3p	PAR-CLIP	20371350
MIRT553898	hsa-miR-301b-3p	PAR-CLIP	20371350
MIRT553896	hsa-miR-3666	PAR-CLIP	20371350
MIRT553897	hsa-miR-4295	PAR-CLIP	20371350
MIRT553895	hsa-miR-454-3p	PAR-CLIP	20371350
MIRT553893	hsa-miR-4310	PAR-CLIP	20371350
MIRT553894	hsa-miR-7157-5p	PAR-CLIP	20371350
MIRT553891	hsa-miR-4504	PAR-CLIP	20371350
MIRT553890	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT553889	hsa-miR-4671-3p	PAR-CLIP	20371350
MIRT553888	hsa-miR-6808-3p	PAR-CLIP	20371350
MIRT553887	hsa-miR-3660	PAR-CLIP	20371350
MIRT553904	hsa-miR-542-3p	PAR-CLIP	21572407
MIRT553903	hsa-miR-758-3p	PAR-CLIP	21572407
MIRT553902	hsa-miR-107	PAR-CLIP	21572407
MIRT027033	hsa-miR-103a-3p	PAR-CLIP	21572407
MIRT553901	hsa-miR-548b-3p	PAR-CLIP	21572407
MIRT553900	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT020123	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT553899	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT553898	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT553896	hsa-miR-3666	PAR-CLIP	21572407
MIRT553897	hsa-miR-4295	PAR-CLIP	21572407
MIRT553895	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT553893	hsa-miR-4310	PAR-CLIP	21572407
MIRT553894	hsa-miR-7157-5p	PAR-CLIP	21572407
MIRT553892	hsa-miR-4768-3p	PAR-CLIP	21572407
MIRT553891	hsa-miR-4504	PAR-CLIP	21572407
MIRT553890	hsa-miR-3944-5p	PAR-CLIP	21572407
MIRT553889	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT553888	hsa-miR-6808-3p	PAR-CLIP	21572407
MIRT553887	hsa-miR-3660	PAR-CLIP	21572407
MIRT1403446	hsa-miR-1252	CLIP-seq
MIRT1403447	hsa-miR-1825	CLIP-seq
MIRT1403448	hsa-miR-3154	CLIP-seq
MIRT1403449	hsa-miR-3185	CLIP-seq
MIRT1403450	hsa-miR-3189-5p	CLIP-seq
MIRT1403451	hsa-miR-371b-3p	CLIP-seq
MIRT1403452	hsa-miR-4293	CLIP-seq
MIRT1403453	hsa-miR-4300	CLIP-seq
MIRT1403454	hsa-miR-4533	CLIP-seq
MIRT1403455	hsa-miR-4747-5p	CLIP-seq
MIRT1403456	hsa-miR-4749-3p	CLIP-seq
MIRT1403457	hsa-miR-4758-3p	CLIP-seq
MIRT1403458	hsa-miR-486-3p	CLIP-seq
MIRT1403459	hsa-miR-499-3p	CLIP-seq
MIRT1403460	hsa-miR-499a-3p	CLIP-seq
MIRT1403461	hsa-miR-558	CLIP-seq
MIRT1403462	hsa-miR-920	CLIP-seq
MIRT1403463	hsa-miR-10a	CLIP-seq
MIRT1403464	hsa-miR-10b	CLIP-seq
MIRT1403465	hsa-miR-1248	CLIP-seq
MIRT1403466	hsa-miR-1913	CLIP-seq
MIRT1403467	hsa-miR-3127-3p	CLIP-seq
MIRT1403450	hsa-miR-3189-5p	CLIP-seq
MIRT1403468	hsa-miR-3190	CLIP-seq
MIRT1403469	hsa-miR-3192	CLIP-seq
MIRT1403470	hsa-miR-324-3p	CLIP-seq
MIRT1403471	hsa-miR-3919	CLIP-seq
MIRT1403472	hsa-miR-3925-5p	CLIP-seq
MIRT1403473	hsa-miR-3978	CLIP-seq
MIRT1403474	hsa-miR-4292	CLIP-seq
MIRT1403475	hsa-miR-4491	CLIP-seq
MIRT1403476	hsa-miR-4493	CLIP-seq
MIRT1403477	hsa-miR-4657	CLIP-seq
MIRT1403478	hsa-miR-4707-3p	CLIP-seq
MIRT1403456	hsa-miR-4749-3p	CLIP-seq
MIRT1403457	hsa-miR-4758-3p	CLIP-seq
MIRT1403479	hsa-miR-4763-5p	CLIP-seq
MIRT1403480	hsa-miR-495	CLIP-seq
MIRT1403447	hsa-miR-1825	CLIP-seq
MIRT1403451	hsa-miR-371b-3p	CLIP-seq
MIRT2342900	hsa-miR-1291	CLIP-seq
MIRT1403447	hsa-miR-1825	CLIP-seq
MIRT2342901	hsa-miR-2467-3p	CLIP-seq
MIRT2342902	hsa-miR-296-5p	CLIP-seq
MIRT2342903	hsa-miR-3130-5p	CLIP-seq
MIRT1403450	hsa-miR-3189-5p	CLIP-seq
MIRT2342904	hsa-miR-328	CLIP-seq
MIRT2342905	hsa-miR-3664-3p	CLIP-seq
MIRT2342906	hsa-miR-370	CLIP-seq
MIRT1403451	hsa-miR-371b-3p	CLIP-seq
MIRT1403474	hsa-miR-4292	CLIP-seq
MIRT2342907	hsa-miR-4482	CLIP-seq
MIRT2342908	hsa-miR-4738-3p	CLIP-seq
MIRT1403457	hsa-miR-4758-3p	CLIP-seq
MIRT2342909	hsa-miR-496	CLIP-seq
MIRT2342910	hsa-miR-767-3p	CLIP-seq
MIRT2395436	hsa-miR-2861	CLIP-seq
MIRT2440880	hsa-miR-335	CLIP-seq
MIRT2460818	hsa-miR-1247	CLIP-seq
MIRT2342905	hsa-miR-3664-3p	CLIP-seq
MIRT2460819	hsa-miR-4433	CLIP-seq
MIRT2460820	hsa-miR-4459	CLIP-seq
MIRT2460821	hsa-miR-4725-5p	CLIP-seq
MIRT2460822	hsa-miR-504	CLIP-seq
MIRT2342910	hsa-miR-767-3p	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0000794	Component	Condensed nuclear chromosome	IEA
GO:0005515	Function	Protein binding	IPI	18396275, 19933576, 20551905, 21391237, 21988832, 22555292, 22632968, 25416956, 26496610, 28514442, 30833792, 31980649
GO:0005521	Function	Lamin binding	IDA	19933576
GO:0005635	Component	Nuclear envelope	IBA	21873635
GO:0005635	Component	Nuclear envelope	IDA	16380439, 19933576
GO:0005635	Component	Nuclear envelope	IDA	21610090
GO:0005635	Component	Nuclear envelope	TAS	10375507
GO:0005639	Component	Integral component of nuclear inner membrane	IEA
GO:0006998	Process	Nuclear envelope organization	IBA	21873635
GO:0006998	Process	Nuclear envelope organization	IGI	16380439
GO:0007052	Process	Mitotic spindle organization	TAS	10375507
GO:0007097	Process	Nuclear migration	TAS	10508607
GO:0008017	Function	Microtubule binding	TAS	10375507
GO:0010008	Component	Endosome membrane	IEA
GO:0021817	Process	Nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration	IEA
GO:0030335	Process	Positive regulation of cell migration	ISS
GO:0031022	Process	Nuclear migration along microfilament	ISS
GO:0031965	Component	Nuclear membrane	IDA
GO:0034993	Component	Meiotic nuclear membrane microtubule tethering complex	IBA	21873635
GO:0034993	Component	Meiotic nuclear membrane microtubule tethering complex	IDA	18396275
GO:0042802	Function	Identical protein binding	IPI	22632968
GO:0043495	Function	Protein-membrane adaptor activity	IBA	21873635
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0051642	Process	Centrosome localization	ISS
GO:0090292	Process	Nuclear matrix anchoring at nuclear membrane	IDA	19933576
GO:0140444	Function	Cytoskeleton-nuclear membrane anchor activity	IDA	18396275

MIM	HGNC	e!Ensembl
613569	14210	ENSG00000100242

Protein

UniProt ID

Q9UH99

Protein name

SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)

Protein function

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role

PDB

3UNP , 4DXR , 4DXS , 4DXT , 4FI9 , 6WMD , 6WME , 6WMF , 6WMG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18580	HTH_SUN2	481 → 538	SUN2 helix-turn-helix domain	Domain
PF07738	Sad1_UNC	581 → 715	Sad1 / UNC-like C-terminal	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects. {ECO:0000269|PubMed:10818110, ECO:0000269|PubMed:1

Sequence

MSRRSQRLTRYSQGDDDGSSSSGGSSVAGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLG
PSSDAHTSYYSESLVHESWFPPRSSLEELHGDANWGEDLRVRRRRGTGGSESSRASGLVG
RKATEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRSAVSRAGSLLWMVATSPGRLFRLL
YWWAGTTWYRLTTAASLLDVFVLTRRFSSLKTFLWFLLPLLLLTCLTYGAWYFYPYGLQT
FHPALVSWWAAKDSRRPDEGWEARDSSPHFQAEQRVMSRVHSLERRLEALAAEFSSNWQK
EAMRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELS
ALRAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAG
LQQELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWISQFLARGGGGRVGLLQREE
MQAQLRELESKILTHVAEMQGKSAREAAASLSLTLQKEGVIGVTEEQVHHIVKQALQRYS
EDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGN
CWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGT
LLGKFTYDQDGEPIQTFHFQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH

Sequence length

717

Interactions

View interactions

	KEGG
	Cytoskeleton in muscle cells

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733 View all (171 more)	23587638
Mirror movements	MIRROR MOVEMENTS 3	rs199925463, rs34091239, rs606231254, rs1555429623, rs1567750186, rs1567749982, rs1567750187
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	31562322

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Inhibit	26175118
Charcot Marie Tooth Disease	Associate	22555292
Charcot Marie Tooth disease Type 2B	Associate	22555292
HIV Infections	Associate	26865710
HIV Infections	Inhibit	28077629, 34592156
HTLV I Infections	Associate	28747499
Infections	Associate	28077629
Leukemia Lymphoma Adult T Cell	Associate	26865710
Lung Neoplasms	Inhibit	26658802
Lymphoma Non Hodgkin	Stimulate	17827388
Lymphoma Non Hodgkin	Associate	17827388
Mandibuloacral dysplasia with type A lipodystrophy	Associate	22706480
Muscular Dystrophy Emery Dreifuss	Associate	22555292
Neoplasms	Inhibit	26658802
Progeria	Associate	26865710
Prostatic Neoplasms	Associate	31562322

SUN2 (Sad1 and UNC84 domain containing 2)