Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	25769
Gene name	Solute carrier family 24 member 2
Gene symbol	SLC24A2
Synonyms (NCBI Gene)	NCKX2
Chromosome	9
Chromosome location	9p22.1-p21.3
Summary	This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. Thi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT723106	hsa-miR-1245b-5p	HITS-CLIP	19536157
MIRT723105	hsa-miR-3142	HITS-CLIP	19536157
MIRT723104	hsa-miR-3922-5p	HITS-CLIP	19536157
MIRT723103	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT723102	hsa-miR-5695	HITS-CLIP	19536157
MIRT723101	hsa-miR-4474-5p	HITS-CLIP	19536157
MIRT723100	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT723099	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT504387	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504386	hsa-miR-3924	HITS-CLIP	21572407
MIRT521092	hsa-miR-142-5p	HITS-CLIP	21572407
MIRT521093	hsa-miR-5590-3p	HITS-CLIP	21572407
MIRT504388	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT521091	hsa-miR-340-5p	HITS-CLIP	21572407
MIRT504387	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504386	hsa-miR-3924	HITS-CLIP	21572407
MIRT504385	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT521093	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT521092	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT521091	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504386	hsa-miR-3924	PAR-CLIP	20371350
MIRT510761	hsa-miR-6083	PAR-CLIP	20371350
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504386	hsa-miR-3924	PAR-CLIP	20371350
MIRT510761	hsa-miR-6083	PAR-CLIP	20371350
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT554226	hsa-miR-6768-5p	PAR-CLIP	21572407
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT554225	hsa-miR-4672	PAR-CLIP	21572407
MIRT521088	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504386	hsa-miR-3924	PAR-CLIP	21572407
MIRT510761	hsa-miR-6083	PAR-CLIP	21572407
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504386	hsa-miR-3924	PAR-CLIP	21572407
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521097	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT521096	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521095	hsa-miR-29a-5p	PAR-CLIP	23446348
MIRT521094	hsa-miR-4775	PAR-CLIP	23446348
MIRT510761	hsa-miR-6083	PAR-CLIP	23446348
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT521093	hsa-miR-5590-3p	PAR-CLIP	23446348
MIRT521092	hsa-miR-142-5p	PAR-CLIP	23446348
MIRT521091	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT521090	hsa-miR-4490	PAR-CLIP	23446348
MIRT521089	hsa-miR-4774-5p	PAR-CLIP	23446348
MIRT521088	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504386	hsa-miR-3924	PAR-CLIP	23446348
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504386	hsa-miR-3924	PAR-CLIP	23446348
MIRT510761	hsa-miR-6083	PAR-CLIP	23446348
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504386	hsa-miR-3924	PAR-CLIP	23446348
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT733692	hsa-miR-223-5p	Luciferase reporter assayqRT-PCRWestern blotting	31791013
MIRT733692	hsa-miR-223-5p	Luciferase reporter assayqRT-PCRWestern blotting	31791013
MIRT723106	hsa-miR-1245b-5p	HITS-CLIP	19536157
MIRT723105	hsa-miR-3142	HITS-CLIP	19536157
MIRT723104	hsa-miR-3922-5p	HITS-CLIP	19536157
MIRT723103	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT723102	hsa-miR-5695	HITS-CLIP	19536157
MIRT723101	hsa-miR-4474-5p	HITS-CLIP	19536157
MIRT723100	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT723099	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT504387	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504386	hsa-miR-3924	HITS-CLIP	21572407
MIRT521092	hsa-miR-142-5p	HITS-CLIP	21572407
MIRT521093	hsa-miR-5590-3p	HITS-CLIP	21572407
MIRT504388	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT521091	hsa-miR-340-5p	HITS-CLIP	21572407
MIRT504387	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504386	hsa-miR-3924	HITS-CLIP	21572407
MIRT504385	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT521093	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT521092	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT521091	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504386	hsa-miR-3924	PAR-CLIP	20371350
MIRT510761	hsa-miR-6083	PAR-CLIP	20371350
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT504386	hsa-miR-3924	PAR-CLIP	20371350
MIRT510761	hsa-miR-6083	PAR-CLIP	20371350
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT554226	hsa-miR-6768-5p	PAR-CLIP	21572407
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT554225	hsa-miR-4672	PAR-CLIP	21572407
MIRT521088	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504386	hsa-miR-3924	PAR-CLIP	21572407
MIRT510761	hsa-miR-6083	PAR-CLIP	21572407
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT504386	hsa-miR-3924	PAR-CLIP	21572407
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT521097	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT521096	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT521095	hsa-miR-29a-5p	PAR-CLIP	23446348
MIRT521094	hsa-miR-4775	PAR-CLIP	23446348
MIRT510761	hsa-miR-6083	PAR-CLIP	23446348
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT521093	hsa-miR-5590-3p	PAR-CLIP	23446348
MIRT521092	hsa-miR-142-5p	PAR-CLIP	23446348
MIRT521091	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT521090	hsa-miR-4490	PAR-CLIP	23446348
MIRT521089	hsa-miR-4774-5p	PAR-CLIP	23446348
MIRT521088	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504386	hsa-miR-3924	PAR-CLIP	23446348
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504386	hsa-miR-3924	PAR-CLIP	23446348
MIRT510761	hsa-miR-6083	PAR-CLIP	23446348
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504388	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504387	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504386	hsa-miR-3924	PAR-CLIP	23446348
MIRT504385	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1354791	hsa-miR-1225-3p	CLIP-seq
MIRT1354792	hsa-miR-1233	CLIP-seq
MIRT1354793	hsa-miR-1302	CLIP-seq
MIRT1354794	hsa-miR-135a	CLIP-seq
MIRT1354795	hsa-miR-135b	CLIP-seq
MIRT1354796	hsa-miR-138	CLIP-seq
MIRT1354797	hsa-miR-140-3p	CLIP-seq
MIRT1354798	hsa-miR-197	CLIP-seq
MIRT1354799	hsa-miR-24	CLIP-seq
MIRT1354800	hsa-miR-3074-5p	CLIP-seq
MIRT1354801	hsa-miR-3119	CLIP-seq
MIRT1354802	hsa-miR-3126-5p	CLIP-seq
MIRT1354803	hsa-miR-3173-3p	CLIP-seq
MIRT1354804	hsa-miR-3194-3p	CLIP-seq
MIRT1354805	hsa-miR-3591-3p	CLIP-seq
MIRT1354806	hsa-miR-3672	CLIP-seq
MIRT1354807	hsa-miR-4284	CLIP-seq
MIRT1354808	hsa-miR-4298	CLIP-seq
MIRT1354809	hsa-miR-4312	CLIP-seq
MIRT1354810	hsa-miR-4433	CLIP-seq
MIRT1354811	hsa-miR-4446-3p	CLIP-seq
MIRT1354812	hsa-miR-4492	CLIP-seq
MIRT1354813	hsa-miR-4498	CLIP-seq
MIRT1354814	hsa-miR-4505	CLIP-seq
MIRT1354815	hsa-miR-4696	CLIP-seq
MIRT1354816	hsa-miR-4714-3p	CLIP-seq
MIRT1354817	hsa-miR-4731-5p	CLIP-seq
MIRT1354818	hsa-miR-4779	CLIP-seq
MIRT1354819	hsa-miR-4786-5p	CLIP-seq
MIRT1354820	hsa-miR-4803	CLIP-seq
MIRT1354821	hsa-miR-548q	CLIP-seq
MIRT1354822	hsa-miR-555	CLIP-seq
MIRT1354823	hsa-miR-661	CLIP-seq
MIRT1354824	hsa-miR-665	CLIP-seq
MIRT1354825	hsa-miR-762	CLIP-seq
MIRT1354826	hsa-miR-769-5p	CLIP-seq
MIRT1354827	hsa-miR-1305	CLIP-seq
MIRT1354828	hsa-miR-145	CLIP-seq
MIRT1354829	hsa-miR-198	CLIP-seq
MIRT1354830	hsa-miR-31	CLIP-seq
MIRT1354831	hsa-miR-3180-5p	CLIP-seq
MIRT1354832	hsa-miR-3667-3p	CLIP-seq
MIRT1354833	hsa-miR-3911	CLIP-seq
MIRT1354834	hsa-miR-4283	CLIP-seq
MIRT1354835	hsa-miR-4489	CLIP-seq
MIRT1354836	hsa-miR-4667-5p	CLIP-seq
MIRT1354837	hsa-miR-4670-3p	CLIP-seq
MIRT1354838	hsa-miR-4675	CLIP-seq
MIRT1354839	hsa-miR-4694-3p	CLIP-seq
MIRT1354840	hsa-miR-4700-5p	CLIP-seq
MIRT1354841	hsa-miR-4716-5p	CLIP-seq
MIRT1354842	hsa-miR-4741	CLIP-seq
MIRT1354843	hsa-miR-520a-5p	CLIP-seq
MIRT1354844	hsa-miR-522	CLIP-seq
MIRT1354845	hsa-miR-525-5p	CLIP-seq
MIRT1354846	hsa-miR-561	CLIP-seq
MIRT1354847	hsa-miR-570	CLIP-seq
MIRT1354848	hsa-miR-574-5p	CLIP-seq
MIRT1354849	hsa-miR-607	CLIP-seq
MIRT1354850	hsa-miR-637	CLIP-seq
MIRT1354851	hsa-miR-660	CLIP-seq
MIRT1354852	hsa-miR-759	CLIP-seq
MIRT1354853	hsa-miR-885-3p	CLIP-seq
MIRT1354804	hsa-miR-3194-3p	CLIP-seq
MIRT1354809	hsa-miR-4312	CLIP-seq
MIRT2105083	hsa-miR-1208	CLIP-seq
MIRT1354791	hsa-miR-1225-3p	CLIP-seq
MIRT1354792	hsa-miR-1233	CLIP-seq
MIRT2105084	hsa-miR-1236	CLIP-seq
MIRT2105085	hsa-miR-1251	CLIP-seq
MIRT2105086	hsa-miR-1262	CLIP-seq
MIRT2105087	hsa-miR-129-3p	CLIP-seq
MIRT2105088	hsa-miR-1303	CLIP-seq
MIRT1354827	hsa-miR-1305	CLIP-seq
MIRT2105089	hsa-miR-1324	CLIP-seq
MIRT1354794	hsa-miR-135a	CLIP-seq
MIRT1354795	hsa-miR-135b	CLIP-seq
MIRT2105090	hsa-miR-3117-5p	CLIP-seq
MIRT2105091	hsa-miR-3123	CLIP-seq
MIRT1354831	hsa-miR-3180-5p	CLIP-seq
MIRT2105092	hsa-miR-3185	CLIP-seq
MIRT1354804	hsa-miR-3194-3p	CLIP-seq
MIRT2105093	hsa-miR-3200-5p	CLIP-seq
MIRT2105094	hsa-miR-330-3p	CLIP-seq
MIRT2105095	hsa-miR-335	CLIP-seq
MIRT2105096	hsa-miR-345	CLIP-seq
MIRT2105097	hsa-miR-3925-5p	CLIP-seq
MIRT2105098	hsa-miR-410	CLIP-seq
MIRT2105099	hsa-miR-4282	CLIP-seq
MIRT2105100	hsa-miR-4293	CLIP-seq
MIRT1354809	hsa-miR-4312	CLIP-seq
MIRT1354810	hsa-miR-4433	CLIP-seq
MIRT2105101	hsa-miR-4459	CLIP-seq
MIRT2105102	hsa-miR-4473	CLIP-seq
MIRT2105103	hsa-miR-4477b	CLIP-seq
MIRT2105104	hsa-miR-451	CLIP-seq
MIRT1354837	hsa-miR-4670-3p	CLIP-seq
MIRT2105105	hsa-miR-4671-3p	CLIP-seq
MIRT2105106	hsa-miR-4701-3p	CLIP-seq
MIRT2105107	hsa-miR-4722-5p	CLIP-seq
MIRT2105108	hsa-miR-4768-5p	CLIP-seq
MIRT2105109	hsa-miR-4793-3p	CLIP-seq
MIRT2105110	hsa-miR-494	CLIP-seq
MIRT2105111	hsa-miR-511	CLIP-seq
MIRT2105112	hsa-miR-512-3p	CLIP-seq
MIRT1354843	hsa-miR-520a-5p	CLIP-seq
MIRT1354845	hsa-miR-525-5p	CLIP-seq
MIRT2105113	hsa-miR-526b	CLIP-seq
MIRT2105114	hsa-miR-542-3p	CLIP-seq
MIRT2105115	hsa-miR-548c-3p	CLIP-seq
MIRT2105116	hsa-miR-548l	CLIP-seq
MIRT2105117	hsa-miR-548n	CLIP-seq
MIRT2105118	hsa-miR-578	CLIP-seq
MIRT2105119	hsa-miR-596	CLIP-seq
MIRT1354849	hsa-miR-607	CLIP-seq
MIRT1354823	hsa-miR-661	CLIP-seq
MIRT1354824	hsa-miR-665	CLIP-seq
MIRT2105120	hsa-miR-668	CLIP-seq
MIRT2105121	hsa-miR-758	CLIP-seq
MIRT2105122	hsa-miR-942	CLIP-seq
MIRT2105086	hsa-miR-1262	CLIP-seq
MIRT2329673	hsa-miR-133a	CLIP-seq
MIRT2329674	hsa-miR-133b	CLIP-seq
MIRT2329675	hsa-miR-199a-3p	CLIP-seq
MIRT2329676	hsa-miR-199b-3p	CLIP-seq
MIRT2329677	hsa-miR-3129-5p	CLIP-seq
MIRT2329678	hsa-miR-3667-5p	CLIP-seq
MIRT2105099	hsa-miR-4282	CLIP-seq
MIRT2329679	hsa-miR-4666-5p	CLIP-seq
MIRT1354837	hsa-miR-4670-3p	CLIP-seq
MIRT2105106	hsa-miR-4701-3p	CLIP-seq
MIRT2105110	hsa-miR-494	CLIP-seq
MIRT2329680	hsa-miR-550a	CLIP-seq
MIRT2105118	hsa-miR-578	CLIP-seq
MIRT2105121	hsa-miR-758	CLIP-seq
MIRT2329681	hsa-miR-9	CLIP-seq
MIRT2329682	hsa-miR-936	CLIP-seq
MIRT2329683	hsa-miR-22	CLIP-seq
MIRT2329684	hsa-miR-4705	CLIP-seq
MIRT2394651	hsa-miR-129-5p	CLIP-seq
MIRT2394652	hsa-miR-219-2-3p	CLIP-seq
MIRT2394653	hsa-miR-4251	CLIP-seq
MIRT2394654	hsa-miR-587	CLIP-seq
MIRT2394655	hsa-miR-627	CLIP-seq
MIRT2466044	hsa-miR-3174	CLIP-seq
MIRT2105093	hsa-miR-3200-5p	CLIP-seq
MIRT1354806	hsa-miR-3672	CLIP-seq
MIRT2466045	hsa-miR-3920	CLIP-seq
MIRT1354819	hsa-miR-4786-5p	CLIP-seq
MIRT1354820	hsa-miR-4803	CLIP-seq
MIRT1354822	hsa-miR-555	CLIP-seq
MIRT1354823	hsa-miR-661	CLIP-seq
MIRT1354826	hsa-miR-769-5p	CLIP-seq
MIRT2466046	hsa-miR-921	CLIP-seq
MIRT1354791	hsa-miR-1225-3p	CLIP-seq
MIRT1354792	hsa-miR-1233	CLIP-seq
MIRT2105093	hsa-miR-3200-5p	CLIP-seq
MIRT2105094	hsa-miR-330-3p	CLIP-seq
MIRT1354806	hsa-miR-3672	CLIP-seq
MIRT2466045	hsa-miR-3920	CLIP-seq
MIRT1354810	hsa-miR-4433	CLIP-seq
MIRT2105101	hsa-miR-4459	CLIP-seq
MIRT2105107	hsa-miR-4722-5p	CLIP-seq
MIRT1354819	hsa-miR-4786-5p	CLIP-seq
MIRT2105113	hsa-miR-526b	CLIP-seq
MIRT1354822	hsa-miR-555	CLIP-seq
MIRT1354823	hsa-miR-661	CLIP-seq
MIRT1354824	hsa-miR-665	CLIP-seq
MIRT1354826	hsa-miR-769-5p	CLIP-seq
MIRT2105085	hsa-miR-1251	CLIP-seq
MIRT2105086	hsa-miR-1262	CLIP-seq
MIRT2105093	hsa-miR-3200-5p	CLIP-seq
MIRT2329678	hsa-miR-3667-5p	CLIP-seq
MIRT2466045	hsa-miR-3920	CLIP-seq
MIRT2105100	hsa-miR-4293	CLIP-seq
MIRT2690970	hsa-miR-451b	CLIP-seq
MIRT1354815	hsa-miR-4696	CLIP-seq
MIRT2105106	hsa-miR-4701-3p	CLIP-seq
MIRT1354819	hsa-miR-4786-5p	CLIP-seq
MIRT2105109	hsa-miR-4793-3p	CLIP-seq
MIRT2105114	hsa-miR-542-3p	CLIP-seq
MIRT2105119	hsa-miR-596	CLIP-seq
MIRT1354823	hsa-miR-661	CLIP-seq
MIRT1354826	hsa-miR-769-5p	CLIP-seq

Show/Hide all (48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001917	Component	Photoreceptor inner segment	ISS	10662833
GO:0005262	Function	Calcium channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	26631410
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	RCA	26631410
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006811	Process	Monoatomic ion transport	TAS
GO:0006813	Process	Potassium ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IBA
GO:0006874	Process	Intracellular calcium ion homeostasis	IDA	26631410
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0007602	Process	Phototransduction	IEA
GO:0007602	Process	Phototransduction	ISS
GO:0007612	Process	Learning	IEA
GO:0007613	Process	Memory	IEA
GO:0008273	Function	Calcium, potassium:sodium antiporter activity	IBA
GO:0008273	Function	Calcium, potassium:sodium antiporter activity	IDA	10662833, 18166528, 26631410, 27093457
GO:0008273	Function	Calcium, potassium:sodium antiporter activity	IEA
GO:0008273	Function	Calcium, potassium:sodium antiporter activity	TAS
GO:0015293	Function	Symporter activity	IEA
GO:0015297	Function	Antiporter activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IDA	18166528
GO:0035725	Process	Sodium ion transmembrane transport	IDA	26631410
GO:0036368	Process	Cone photoresponse recovery	IEA
GO:0036368	Process	Cone photoresponse recovery	ISS
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0060291	Process	Long-term synaptic potentiation	IBA
GO:0060291	Process	Long-term synaptic potentiation	IEA
GO:0060292	Process	Long-term synaptic depression	IBA
GO:0060292	Process	Long-term synaptic depression	IEA
GO:0070050	Process	Neuron cellular homeostasis	IEA
GO:0070509	Process	Calcium ion import	IDA	27093457
GO:0070588	Process	Calcium ion transmembrane transport	IBA
GO:0070588	Process	Calcium ion transmembrane transport	IDA	26631410
GO:0071486	Process	Cellular response to high light intensity	IEA
GO:0071486	Process	Cellular response to high light intensity	ISS
GO:0071805	Process	Potassium ion transmembrane transport	IDA	26631410
GO:0098703	Process	Calcium ion import across plasma membrane	IDA	10662833
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA

MIM	HGNC	e!Ensembl
609838	10976	ENSG00000155886

Q9UI40

Protein name

Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2)

Protein function

Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:10662833, PubMed:26631410). Required for learming and memory by regulating neuronal Ca(2+), which is essential for the development of synapt

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01699	Na_Ca_ex	138 → 282	Sodium/calcium exchanger protein	Family
PF01699	Na_Ca_ex	498 → 649	Sodium/calcium exchanger protein	Family

Sequence

MDLQQSTTITSLEKWCLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFS
ETDTQSTGEASVVSGPRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGDY
PKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFM
AAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFR
DVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVV
KVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEE
LGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTST
DVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIV
FPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTIL
AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS
NGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRILTCPVS
I

Sequence length

661

Interactions

View interactions

	Reactome
			Sodium/Calcium exchangers

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Abnormal retinal morphology	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL TREMOR	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Brain Ischemia	Stimulate	35806133	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Associate	28413183	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	35601016	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Associate	37939667	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infarction	Associate	35806133	★★★★★ ★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Associate	34646884	★★★★★ ★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Associate	28683437	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Associate	35806133	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35601016	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pigmentation Disorders	Associate	27129268	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	29518100	★★★★★ ★☆☆☆☆ Found in Text Mining only
Scrub Typhus	Associate	37939667	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Associate	35806133	★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC24A2 (solute carrier family 24 member 2)