Gene Gene information from NCBI Gene database.
Entrez ID 257194
Gene name Neuronal growth regulator 1
Gene symbol NEGR1
Synonyms (NCBI Gene)
DMML2433IGLON4KILONNtra
Chromosome 1
Chromosome location 1p31.1
miRNA miRNA information provided by mirtarbase database.
595
miRTarBase ID miRNA Experiments Reference
MIRT722855 hsa-miR-6819-3p HITS-CLIP 19536157
MIRT722854 hsa-miR-6877-3p HITS-CLIP 19536157
MIRT722853 hsa-miR-4528 HITS-CLIP 19536157
MIRT722852 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT722851 hsa-miR-2114-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21982860, 27940359, 37207277
GO:0005576 Component Extracellular region TAS
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
GO:0007155 Process Cell adhesion IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613173 17302 ENSG00000172260
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z3B1
Protein name Neuronal growth regulator 1 (IgLON family member 4)
Protein function May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity).
PDB 6DLD , 6U6T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07679 I-set 43 135 Immunoglobulin I-set domain Domain
PF13927 Ig_3 138 207 Domain
PF13927 Ig_3 224 301 Domain
Sequence
Sequence length 354
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules   Post-translational modification: synthesis of GPI-anchored proteins
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
NEGR1-related disorder Likely benign rs138963902 RCV003922922
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Anorexia Nervosa Associate 35703085
Asthma Associate 20816195
Breast Neoplasms Associate 24648515, 26544852
Cell Transformation Neoplastic Associate 24648515
Cerebral Infarction Associate 33000228
Delayed Emergence from Anesthesia Associate 22179955
Depressive Disorder Associate 36634823
Diabetes Mellitus Associate 25370040
Diabetes Mellitus Type 2 Associate 34391409, 40141237
Diabetes Mellitus Type 2 Inhibit 37935012