ARHGAP30 (Rho GTPase activating protein 30)

Gene

• Entrez ID: 257106
• Gene name: Rho GTPase activating protein 30
• Gene symbol: ARHGAP30
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT794428	hsa-miR-147	CLIP-seq
MIRT794429	hsa-miR-202	CLIP-seq
MIRT794430	hsa-miR-3190	CLIP-seq
MIRT794431	hsa-miR-3202	CLIP-seq
MIRT794432	hsa-miR-3911	CLIP-seq
MIRT794433	hsa-miR-4459	CLIP-seq
MIRT794434	hsa-miR-4475	CLIP-seq
MIRT794435	hsa-miR-4493	CLIP-seq
MIRT794436	hsa-miR-4533	CLIP-seq
MIRT794437	hsa-miR-490-3p	CLIP-seq
MIRT794438	hsa-miR-644	CLIP-seq
MIRT794439	hsa-miR-649	CLIP-seq
MIRT794440	hsa-miR-188-3p	CLIP-seq
MIRT794441	hsa-miR-2682	CLIP-seq
MIRT794442	hsa-miR-34a	CLIP-seq
MIRT794443	hsa-miR-34c-5p	CLIP-seq
MIRT794444	hsa-miR-3714	CLIP-seq
MIRT794445	hsa-miR-449a	CLIP-seq
MIRT794446	hsa-miR-449b	CLIP-seq
MIRT794447	hsa-miR-449c	CLIP-seq
MIRT794448	hsa-miR-515-3p	CLIP-seq
MIRT794449	hsa-miR-519e	CLIP-seq
MIRT794450	hsa-miR-532-3p	CLIP-seq
MIRT738045	hsa-miR-27a	CLIP-seq
MIRT738046	hsa-miR-27b	CLIP-seq
MIRT738042	hsa-miR-3125	CLIP-seq
MIRT738041	hsa-miR-3916	CLIP-seq
MIRT738043	hsa-miR-4257	CLIP-seq
MIRT738047	hsa-miR-4709-3p	CLIP-seq
MIRT738044	hsa-miR-513a-5p	CLIP-seq
MIRT1934462	hsa-miR-1270	CLIP-seq
MIRT1934463	hsa-miR-3914	CLIP-seq
MIRT1934464	hsa-miR-4254	CLIP-seq
MIRT1934465	hsa-miR-4308	CLIP-seq
MIRT1934466	hsa-miR-4683	CLIP-seq
MIRT1934467	hsa-miR-620	CLIP-seq
MIRT1934468	hsa-miR-873	CLIP-seq
MIRT2174290	hsa-miR-3135b	CLIP-seq
MIRT2174291	hsa-miR-3652	CLIP-seq
MIRT2174292	hsa-miR-4274	CLIP-seq
MIRT2174293	hsa-miR-4430	CLIP-seq
MIRT2174294	hsa-miR-4434	CLIP-seq
MIRT2174295	hsa-miR-4516	CLIP-seq
MIRT2174296	hsa-miR-4531	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	21565175
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	21565175
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IDA	21565175
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 614264
• HGNC: 27414
• e!Ensembl: ENSG00000186517

Protein

• UniProt ID: Q7Z6I6
• Protein name: Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)
• Protein function: GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	34 → 186	RhoGAP domain	Domain

• Sequence:

  MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
  SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
  QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
  KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
  PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
  ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
  ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
  PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
  PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
  FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
  EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
  KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
  KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
  EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
  GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
  EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
  PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
  CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
  SSQRRSYAFETQANPGKGEGL

• Sequence length: 1101

Pathways

Reactome:

Rho GTPase cycle

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