ARHGAP30 (Rho GTPase activating protein 30)

Gene

• Entrez ID: 257106
• Gene name: Rho GTPase activating protein 30
• Gene symbol: ARHGAP30
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT794428	hsa-miR-147	CLIP-seq
MIRT794429	hsa-miR-202	CLIP-seq
MIRT794430	hsa-miR-3190	CLIP-seq
MIRT794431	hsa-miR-3202	CLIP-seq
MIRT794432	hsa-miR-3911	CLIP-seq
MIRT794433	hsa-miR-4459	CLIP-seq
MIRT794434	hsa-miR-4475	CLIP-seq
MIRT794435	hsa-miR-4493	CLIP-seq
MIRT794436	hsa-miR-4533	CLIP-seq
MIRT794437	hsa-miR-490-3p	CLIP-seq
MIRT794438	hsa-miR-644	CLIP-seq
MIRT794439	hsa-miR-649	CLIP-seq
MIRT794440	hsa-miR-188-3p	CLIP-seq
MIRT794441	hsa-miR-2682	CLIP-seq
MIRT794442	hsa-miR-34a	CLIP-seq
MIRT794443	hsa-miR-34c-5p	CLIP-seq
MIRT794444	hsa-miR-3714	CLIP-seq
MIRT794445	hsa-miR-449a	CLIP-seq
MIRT794446	hsa-miR-449b	CLIP-seq
MIRT794447	hsa-miR-449c	CLIP-seq
MIRT794448	hsa-miR-515-3p	CLIP-seq
MIRT794449	hsa-miR-519e	CLIP-seq
MIRT794450	hsa-miR-532-3p	CLIP-seq
MIRT738045	hsa-miR-27a	CLIP-seq
MIRT738046	hsa-miR-27b	CLIP-seq
MIRT738042	hsa-miR-3125	CLIP-seq
MIRT738041	hsa-miR-3916	CLIP-seq
MIRT738043	hsa-miR-4257	CLIP-seq
MIRT738047	hsa-miR-4709-3p	CLIP-seq
MIRT738044	hsa-miR-513a-5p	CLIP-seq
MIRT1934462	hsa-miR-1270	CLIP-seq
MIRT1934463	hsa-miR-3914	CLIP-seq
MIRT1934464	hsa-miR-4254	CLIP-seq
MIRT1934465	hsa-miR-4308	CLIP-seq
MIRT1934466	hsa-miR-4683	CLIP-seq
MIRT1934467	hsa-miR-620	CLIP-seq
MIRT1934468	hsa-miR-873	CLIP-seq
MIRT2174290	hsa-miR-3135b	CLIP-seq
MIRT2174291	hsa-miR-3652	CLIP-seq
MIRT2174292	hsa-miR-4274	CLIP-seq
MIRT2174293	hsa-miR-4430	CLIP-seq
MIRT2174294	hsa-miR-4434	CLIP-seq
MIRT2174295	hsa-miR-4516	CLIP-seq
MIRT2174296	hsa-miR-4531	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	21565175
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	21565175
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IBA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0035024	Process	Negative regulation of Rho protein signal transduction	IDA	21565175
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 614264
• HGNC: 27414
• e!Ensembl: ENSG00000186517

Protein

• UniProt ID: Q7Z6I6
• Protein name: Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)
• Protein function: GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	34 → 186	RhoGAP domain	Domain

• Sequence:

  MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLSGVS
  SNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGV
  QLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
  KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGS
  PEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGH
  ETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPESL
  ENDSIEAAEGEQEPEAEALGGTNSEPGTPRAGRSAIRAGGSSRAERCAGVHISDPYNVNL
  PLHITSILSVPPNIISNVSLARLTRGLECPALQHRPSPASGPGPGPGLGPGPPDEKLEAS
  PASSPLADSGPDDLAPALEDSLSQEVQDSFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAA
  FSPGEDDPGMGYLEELLGVGPQVEEFSVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEV
  EEENGEEVFLSAYDDLSPLLGPKPPIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGED
  KQAEPGGRLDIREEAEGSPETKVEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKS
  KGQKKADSMEAKGVEEPGGDEYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAE
  EKWEVVQKQEAEGVREDEDKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERES
  GDGEAEGDQRAGGYYLEEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEP
  EGQPSPDGCLCPCSLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVA
  PANPCPRPGRLDGTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQT
  CTEGGDYCLIPRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLL
  SSQRRSYAFETQANPGKGEGL

• Sequence length: 1101

Pathways

Reactome:

Rho GTPase cycle

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Ovarian serous cystadenocarcinoma	Uncertain significance	rs761510561	RCV005926869

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	30587197, 34910688
Endometrial Neoplasms	Associate	34763648
Glioblastoma	Associate	35185876
Lung Neoplasms	Associate	32045668
Neoplasm Metastasis	Inhibit	37170915
Neoplasm Metastasis	Stimulate	37254890
Neoplasms	Associate	34910688, 35185876
Ovarian Neoplasms	Associate	37170915
Ovarian Neoplasms	Stimulate	37254890