Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	257019
Gene name	FERM domain containing 3
Gene symbol	FRMD3
Synonyms (NCBI Gene)	4.1OEPB41L4OEPB41LOP410
Chromosome	9
Chromosome location	9q21.32
Summary	The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some e

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Show/Hide all (214)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022494	hsa-miR-124-3p	Microarray	18668037
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT658068	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT658068	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT541344	hsa-miR-8485	PAR-CLIP	21572407
MIRT541343	hsa-miR-7110-3p	PAR-CLIP	21572407
MIRT542956	hsa-miR-6817-3p	PAR-CLIP	21572407
MIRT541342	hsa-miR-8064	PAR-CLIP	21572407
MIRT541341	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT542955	hsa-miR-6873-3p	PAR-CLIP	21572407
MIRT541345	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT541344	hsa-miR-8485	PAR-CLIP	21572407
MIRT541343	hsa-miR-7110-3p	PAR-CLIP	21572407
MIRT541342	hsa-miR-8064	PAR-CLIP	21572407
MIRT541341	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT541345	hsa-miR-342-3p	HITS-CLIP	27418678
MIRT541345	hsa-miR-342-3p	HITS-CLIP	27418678
MIRT541341	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT541341	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT541341	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	27418678
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	27418678
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	27418678
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	27418678
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	27418678
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	27418678
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	27418678
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	27418678
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	27418678
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	27418678
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	27418678
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	27418678
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	27418678
MIRT541344	hsa-miR-8485	HITS-CLIP	27418678
MIRT541344	hsa-miR-8485	HITS-CLIP	27418678
MIRT541344	hsa-miR-8485	HITS-CLIP	27418678
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT658068	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT658068	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT623894	hsa-miR-1279	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT623893	hsa-miR-5007-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541342	hsa-miR-8064	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541344	hsa-miR-8485	HITS-CLIP	23824327
MIRT541343	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT542956	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT541341	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT542955	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT613029	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT613028	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT541345	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT541344	hsa-miR-8485	PAR-CLIP	21572407
MIRT541343	hsa-miR-7110-3p	PAR-CLIP	21572407
MIRT542956	hsa-miR-6817-3p	PAR-CLIP	21572407
MIRT541342	hsa-miR-8064	PAR-CLIP	21572407
MIRT541341	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT542955	hsa-miR-6873-3p	PAR-CLIP	21572407
MIRT541345	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT541344	hsa-miR-8485	PAR-CLIP	21572407
MIRT541343	hsa-miR-7110-3p	PAR-CLIP	21572407
MIRT541342	hsa-miR-8064	PAR-CLIP	21572407
MIRT541341	hsa-miR-377-3p	PAR-CLIP	21572407

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005856	Component	Cytoskeleton	IBA
GO:0008092	Function	Cytoskeletal protein binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0031032	Process	Actomyosin structure organization	IBA

MIM	HGNC	e!Ensembl
607619	24125	ENSG00000172159

A2A2Y4

Protein name

FERM domain-containing protein 3 (Band 4.1-like protein 4O) (Ovary type protein 4.1) (4.1O)

Protein function

Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09379	FERM_N	36 → 99	FERM N-terminal domain	Domain
PF00373	FERM_M	115 → 225	FERM central domain	Domain
PF09380	FERM_C	229 → 316	FERM C-terminal PH-like domain	Domain
PF08736	FA	323 → 366	FERM adjacent (FA)	Family

Tissue specificity

TISSUE SPECIFICITY: Ovary-specific. {ECO:0000269|PubMed:12601556}.

Sequence

MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDH
ICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIK
EELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFP
KQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFT
AAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKC
GVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANI
TQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKA
AREYEDPPSEEEDKIKEEPLTISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDT
DSFEDLEADENAFLIAEEEELKEARRALSWSYDILTGHIRVNPLVKSFSRLLVVGLGLLL
FVFPLLLLLLESGIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS

Sequence length

597

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEWY BODY DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SARCOIDOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	34865205	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Inhibit	36631457	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Associate	19252134	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	21698141, 24551085	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Associate	19252134, 23434934	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Associate	21698141, 24551085	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Inhibit	36631457	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pelvic Organ Prolapse	Associate	26347886	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tissue Adhesions	Inhibit	36631457	★★★★★ ★☆☆☆☆ Found in Text Mining only

FRMD3 (FERM domain containing 3)