Gene Gene information from NCBI Gene database.
Entrez ID 256987
Gene name Serine incorporator 5
Gene symbol SERINC5
Synonyms (NCBI Gene)
C5orf12TPO1
Chromosome 5
Chromosome location 5q14.1
miRNA miRNA information provided by mirtarbase database.
766
miRTarBase ID miRNA Experiments Reference
MIRT021507 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT051076 hsa-miR-16-5p CLASH 23622248
MIRT442743 hsa-miR-9-5p PAR-CLIP 22100165
MIRT442742 hsa-miR-548an PAR-CLIP 22100165
MIRT442741 hsa-miR-6768-3p PAR-CLIP 22100165
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0005737 Component Cytoplasm IEA
GO:0005794 Component Golgi apparatus IEA
GO:0005813 Component Centrosome IDA
GO:0005829 Component Cytosol IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614551 18825 ENSG00000164300
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86VE9
Protein name Serine incorporator 5
Protein function Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03348 Serinc 12 421 Serine incorporator (Serinc) Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain. {ECO:0000269|PubMed:12688535}.
Sequence
Sequence length 423
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Viral life cycle - HIV-1   Serine biosynthesis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONNECTIVE TISSUE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL SQUAMOUS CELL CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
HIV Infections Associate 26416733, 33173092
★☆☆☆☆
Found in Text Mining only
Viremia Associate 33173092
★☆☆☆☆
Found in Text Mining only