Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	256435
Gene name	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Gene symbol	ST6GALNAC3
Synonyms (NCBI Gene)	PRO7177SIAT7CST6GALNACIIISTY
Chromosome	1
Chromosome location	1p31.1
Summary	ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]

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Show/Hide all (144)

miRTarBase ID	miRNA	Experiments	Reference
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620031	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT653077	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620031	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT534061	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT534060	hsa-miR-4286	PAR-CLIP	22012620
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	22012620
MIRT534058	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT534057	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT534061	hsa-miR-1224-3p	PAR-CLIP	26701625
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	26701625
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	26701625
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	26701625
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	26701625
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	26701625
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	26701625
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	26701625
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	26701625
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620031	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT653077	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT620038	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT620037	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT620036	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT620035	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT620034	hsa-miR-3123	HITS-CLIP	23824327
MIRT620033	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT620032	hsa-miR-6832-5p	HITS-CLIP	23824327
MIRT620031	hsa-miR-4732-5p	HITS-CLIP	23824327
MIRT534062	hsa-miR-3121-3p	PAR-CLIP	22012620
MIRT534061	hsa-miR-1224-3p	PAR-CLIP	22012620
MIRT534060	hsa-miR-4286	PAR-CLIP	22012620
MIRT534059	hsa-miR-5009-3p	PAR-CLIP	22012620
MIRT534058	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT534057	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT1393733	hsa-miR-1273g	CLIP-seq
MIRT1393734	hsa-miR-297	CLIP-seq
MIRT1393735	hsa-miR-299-3p	CLIP-seq
MIRT1393736	hsa-miR-323-5p	CLIP-seq
MIRT1393737	hsa-miR-4491	CLIP-seq
MIRT1393738	hsa-miR-4657	CLIP-seq
MIRT1393739	hsa-miR-567	CLIP-seq
MIRT1393740	hsa-miR-876-3p	CLIP-seq
MIRT1393741	hsa-miR-1	CLIP-seq
MIRT1393742	hsa-miR-1208	CLIP-seq
MIRT1393743	hsa-miR-1267	CLIP-seq
MIRT1393744	hsa-miR-128	CLIP-seq
MIRT1393745	hsa-miR-1299	CLIP-seq
MIRT1393746	hsa-miR-144	CLIP-seq
MIRT1393747	hsa-miR-203	CLIP-seq
MIRT1393748	hsa-miR-206	CLIP-seq
MIRT1393749	hsa-miR-27a	CLIP-seq
MIRT1393750	hsa-miR-27b	CLIP-seq
MIRT1393751	hsa-miR-3616-5p	CLIP-seq
MIRT1393752	hsa-miR-3647-5p	CLIP-seq
MIRT1393753	hsa-miR-3680	CLIP-seq
MIRT1393754	hsa-miR-4307	CLIP-seq
MIRT1393755	hsa-miR-4670-3p	CLIP-seq
MIRT1393756	hsa-miR-4717-3p	CLIP-seq
MIRT1393757	hsa-miR-4761-3p	CLIP-seq
MIRT1393758	hsa-miR-4782-5p	CLIP-seq
MIRT1393759	hsa-miR-4795-5p	CLIP-seq
MIRT1393760	hsa-miR-4798-3p	CLIP-seq
MIRT1393761	hsa-miR-5096	CLIP-seq
MIRT1393762	hsa-miR-513a-5p	CLIP-seq
MIRT1393763	hsa-miR-516b	CLIP-seq
MIRT1393764	hsa-miR-573	CLIP-seq
MIRT1393765	hsa-miR-613	CLIP-seq
MIRT1393766	hsa-miR-653	CLIP-seq
MIRT1393767	hsa-miR-875-3p	CLIP-seq
MIRT1393742	hsa-miR-1208	CLIP-seq
MIRT1393743	hsa-miR-1267	CLIP-seq
MIRT1393745	hsa-miR-1299	CLIP-seq
MIRT1393753	hsa-miR-3680	CLIP-seq
MIRT1393755	hsa-miR-4670-3p	CLIP-seq
MIRT1393758	hsa-miR-4782-5p	CLIP-seq
MIRT1393760	hsa-miR-4798-3p	CLIP-seq
MIRT1393763	hsa-miR-516b	CLIP-seq
MIRT1393767	hsa-miR-875-3p	CLIP-seq
MIRT1393745	hsa-miR-1299	CLIP-seq
MIRT2118183	hsa-miR-183	CLIP-seq
MIRT2118184	hsa-miR-3121-5p	CLIP-seq
MIRT2118185	hsa-miR-3689a-5p	CLIP-seq
MIRT2118186	hsa-miR-3689b	CLIP-seq
MIRT2118187	hsa-miR-3689e	CLIP-seq
MIRT2118188	hsa-miR-3689f	CLIP-seq
MIRT2118189	hsa-miR-3926	CLIP-seq
MIRT2118190	hsa-miR-4496	CLIP-seq
MIRT2118191	hsa-miR-4742-3p	CLIP-seq
MIRT1393758	hsa-miR-4782-5p	CLIP-seq
MIRT1393763	hsa-miR-516b	CLIP-seq
MIRT2118192	hsa-miR-548s	CLIP-seq
MIRT2118193	hsa-miR-579	CLIP-seq
MIRT2118194	hsa-miR-622	CLIP-seq
MIRT2118195	hsa-miR-758	CLIP-seq
MIRT1393767	hsa-miR-875-3p	CLIP-seq
MIRT1393744	hsa-miR-128	CLIP-seq
MIRT2340197	hsa-miR-182	CLIP-seq
MIRT1393749	hsa-miR-27a	CLIP-seq
MIRT1393750	hsa-miR-27b	CLIP-seq
MIRT2118184	hsa-miR-3121-5p	CLIP-seq
MIRT2340198	hsa-miR-3614-5p	CLIP-seq
MIRT2118185	hsa-miR-3689a-5p	CLIP-seq
MIRT2118186	hsa-miR-3689b	CLIP-seq
MIRT2118187	hsa-miR-3689e	CLIP-seq
MIRT2118188	hsa-miR-3689f	CLIP-seq
MIRT2118189	hsa-miR-3926	CLIP-seq
MIRT2118192	hsa-miR-548s	CLIP-seq
MIRT2340199	hsa-miR-580	CLIP-seq
MIRT2118195	hsa-miR-758	CLIP-seq

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001574	Process	Ganglioside biosynthetic process	IBA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0006486	Process	Protein glycosylation	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006664	Process	Glycolipid metabolic process	IEA
GO:0006677	Process	Glycosylceramide metabolic process	IDA	17123352
GO:0006687	Process	Glycosphingolipid metabolic process	IDA	17123352
GO:0008373	Function	Sialyltransferase activity	IDA	17123352
GO:0008373	Function	Sialyltransferase activity	IEA
GO:0008373	Function	Sialyltransferase activity	TAS
GO:0009100	Process	Glycoprotein metabolic process	IDA	17123352
GO:0009311	Process	Oligosaccharide metabolic process	IBA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0019082	Process	Viral protein processing	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:0047290	Function	Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity	IEA

MIM	HGNC	e!Ensembl
610133	19343	ENSG00000184005

Q8NDV1

Protein name

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.3.7) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (ST6GalNAcIII) (STY) (Sialyltransferase 7C) (SIAT7-C)

Protein function

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disial

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00777	Glyco_transf_29	55 → 299	Glycosyltransferase family 29 (sialyltransferase)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain and kidney (PubMed:16169874, PubMed:17123352). Observed in the epithelium of the proximal tubules, marginal expression was also found in the distal tubules and collecting tubules (PubMed:17123352). {ECO:0000269|PubMe

Sequence

MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRT
HYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVG
RMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIY
PNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGMIND
TYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHP
NWTLS

Sequence length

305

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series Metabolic pathways		Sialic acid metabolism Termination of O-glycan biosynthesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPORADIC AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	29291743	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	29465788	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	29465788	★★★★★ ★☆☆☆☆ Found in Text Mining only

ST6GALNAC3 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3)