TMCO4 (transmembrane and coiled-coil domains 4)

Gene

• Entrez ID: 255104
• Gene name: Transmembrane and coiled-coil domains 4
• Gene symbol: TMCO4
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p36.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT040301	hsa-miR-615-3p	CLASH	23622248
MIRT1428455	hsa-miR-1184	CLIP-seq
MIRT1428456	hsa-miR-1205	CLIP-seq
MIRT1428457	hsa-miR-1248	CLIP-seq
MIRT1428458	hsa-miR-134	CLIP-seq
MIRT1428459	hsa-miR-1343	CLIP-seq
MIRT1428460	hsa-miR-22	CLIP-seq
MIRT1428461	hsa-miR-2278	CLIP-seq
MIRT1428462	hsa-miR-3118	CLIP-seq
MIRT1428463	hsa-miR-3158-5p	CLIP-seq
MIRT1428464	hsa-miR-3160-3p	CLIP-seq
MIRT1428465	hsa-miR-3164	CLIP-seq
MIRT1428466	hsa-miR-3184	CLIP-seq
MIRT1428467	hsa-miR-3192	CLIP-seq
MIRT1428468	hsa-miR-3665	CLIP-seq
MIRT1428469	hsa-miR-3689a-3p	CLIP-seq
MIRT1428470	hsa-miR-3689c	CLIP-seq
MIRT1428471	hsa-miR-3914	CLIP-seq
MIRT1428472	hsa-miR-3921	CLIP-seq
MIRT1428473	hsa-miR-3928	CLIP-seq
MIRT1428474	hsa-miR-423-5p	CLIP-seq
MIRT1428475	hsa-miR-4292	CLIP-seq
MIRT1428476	hsa-miR-4297	CLIP-seq
MIRT1428477	hsa-miR-4308	CLIP-seq
MIRT1428478	hsa-miR-4433	CLIP-seq
MIRT1428479	hsa-miR-4487	CLIP-seq
MIRT1428480	hsa-miR-4502	CLIP-seq
MIRT1428481	hsa-miR-4653-5p	CLIP-seq
MIRT1428482	hsa-miR-4711-3p	CLIP-seq
MIRT1428483	hsa-miR-4722-5p	CLIP-seq
MIRT1428484	hsa-miR-4728-5p	CLIP-seq
MIRT1428485	hsa-miR-486-3p	CLIP-seq
MIRT1428486	hsa-miR-558	CLIP-seq
MIRT1428487	hsa-miR-592	CLIP-seq
MIRT1428488	hsa-miR-593	CLIP-seq
MIRT1428489	hsa-miR-599	CLIP-seq
MIRT1428490	hsa-miR-657	CLIP-seq
MIRT2128341	hsa-miR-1253	CLIP-seq
MIRT2128342	hsa-miR-1298	CLIP-seq
MIRT2128343	hsa-miR-27a	CLIP-seq
MIRT2128344	hsa-miR-27b	CLIP-seq
MIRT2128345	hsa-miR-3124-3p	CLIP-seq
MIRT2128346	hsa-miR-4282	CLIP-seq
MIRT2128347	hsa-miR-4495	CLIP-seq
MIRT2128348	hsa-miR-4514	CLIP-seq
MIRT2128349	hsa-miR-4692	CLIP-seq
MIRT2128350	hsa-miR-4712-3p	CLIP-seq
MIRT2128351	hsa-miR-4716-5p	CLIP-seq
MIRT2128352	hsa-miR-4760-3p	CLIP-seq
MIRT2128353	hsa-miR-513a-5p	CLIP-seq
MIRT2128354	hsa-miR-587	CLIP-seq
MIRT2128355	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5TGY1
• Protein name: Transmembrane and coiled-coil domain-containing protein 4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05277	DUF726	185 → 521	Protein of unknown function (DUF726)	Family

• Sequence:

  MAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAALCGISLSQLFPEPEHS
  SFCTEFMAGLVQWLELSEAVLPTMTAFASGLGGEGADVFVQILLKDPILKDDPTVITQDL
  LSFSLKDGHYDARARVLVCHMTSLLQVPLEELDVLEEMFLESLKEIKEEESEMAEASRKK
  KENRRKWKRYLLIGLATVGGGTVIGVTGGLAAPLVAAGAATIIGSAGAAALGSAAGIAIM
  TSLFGAAGAGLTGYKMKKRVGAIEEFTFLPLTEGRQLHITIAVTGWLASGKYRTFSAPWA
  ALAHSREQYCLAWEAKYLMELGNALETILSGLANMVAQEALKYTVLSGIVAALTWPASLL
  SVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQE
  KDCQGIIEDVILLGAPVEGEAKHWEPFRKVVSGRIINGYCRGDWLLSFVYRTSSVQLRVA
  GLQPVLLQDRRVENVDLTSVVSGHLDYAKQMDAILKAVGIRTKPGWDEKGLLLAPGCLPS
  EEPRQAAAAASSGETPHQVGQTQGPISGDTSKLAMSTDPSQAQVPVGLDQSEGASLPAAA
  SPERPPICSHGMDPNPLGCPDCACKTQGPSTGLD

• Sequence length: 634

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations