GABPA (GA binding protein transcription factor subunit alpha)

Gene

• Entrez ID: 2551
• Gene name: GA binding protein transcription factor subunit alpha
• Gene symbol: GABPA
• Synonyms (NCBI Gene): E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07
• Chromosome: 21
• Chromosome location: 21q21.3
• Summary: This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031329	hsa-miR-18a-5p	Sequencing	20371350
MIRT048948	hsa-miR-92a-3p	CLASH	23622248
MIRT297783	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT297779	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT297781	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT297778	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT297787	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT297782	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT297780	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT557712	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT557713	hsa-miR-4422	PAR-CLIP	20371350
MIRT297785	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT297788	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT297786	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT297784	hsa-miR-922	PAR-CLIP	20371350
MIRT557711	hsa-miR-4744	PAR-CLIP	20371350
MIRT557710	hsa-miR-4509	PAR-CLIP	20371350
MIRT557709	hsa-miR-4261	PAR-CLIP	20371350
MIRT297783	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT297779	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT297781	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT297778	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT297787	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT297782	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT297780	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT557712	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT557713	hsa-miR-4422	PAR-CLIP	21572407
MIRT297785	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT297788	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT297786	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT297784	hsa-miR-922	PAR-CLIP	21572407
MIRT557711	hsa-miR-4744	PAR-CLIP	21572407
MIRT557710	hsa-miR-4509	PAR-CLIP	21572407
MIRT557709	hsa-miR-4261	PAR-CLIP	21572407
MIRT548138	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT548137	hsa-miR-6731-3p	PAR-CLIP	21572407
MIRT548136	hsa-miR-378a-5p	PAR-CLIP	21572407
MIRT548135	hsa-miR-1200	PAR-CLIP	21572407
MIRT548134	hsa-miR-943	PAR-CLIP	21572407
MIRT548133	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT737374	hsa-miR-146a-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR	32303750
MIRT297783	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT297779	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT297781	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT297778	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT297787	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT297782	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT297780	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT557712	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT557713	hsa-miR-4422	PAR-CLIP	20371350
MIRT297785	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT297788	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT297786	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT297784	hsa-miR-922	PAR-CLIP	20371350
MIRT557711	hsa-miR-4744	PAR-CLIP	20371350
MIRT557710	hsa-miR-4509	PAR-CLIP	20371350
MIRT557709	hsa-miR-4261	PAR-CLIP	20371350
MIRT297783	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT297779	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT297781	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT297778	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT297787	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT297782	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT297780	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT557712	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT557713	hsa-miR-4422	PAR-CLIP	21572407
MIRT297785	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT297788	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT297786	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT297784	hsa-miR-922	PAR-CLIP	21572407
MIRT557711	hsa-miR-4744	PAR-CLIP	21572407
MIRT557710	hsa-miR-4509	PAR-CLIP	21572407
MIRT557709	hsa-miR-4261	PAR-CLIP	21572407
MIRT548138	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT548137	hsa-miR-6731-3p	PAR-CLIP	21572407
MIRT548136	hsa-miR-378a-5p	PAR-CLIP	21572407
MIRT548135	hsa-miR-1200	PAR-CLIP	21572407
MIRT548134	hsa-miR-943	PAR-CLIP	21572407
MIRT548133	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT1009525	hsa-miR-1236	CLIP-seq
MIRT1009526	hsa-miR-2054	CLIP-seq
MIRT1009527	hsa-miR-3159	CLIP-seq
MIRT1009528	hsa-miR-3182	CLIP-seq
MIRT1009529	hsa-miR-3183	CLIP-seq
MIRT1009530	hsa-miR-329	CLIP-seq
MIRT1009531	hsa-miR-3613-3p	CLIP-seq
MIRT1009532	hsa-miR-3617	CLIP-seq
MIRT1009533	hsa-miR-362-3p	CLIP-seq
MIRT1009534	hsa-miR-3671	CLIP-seq
MIRT1009535	hsa-miR-369-3p	CLIP-seq
MIRT1009536	hsa-miR-374a	CLIP-seq
MIRT1009537	hsa-miR-374b	CLIP-seq
MIRT1009538	hsa-miR-380	CLIP-seq
MIRT1009539	hsa-miR-3924	CLIP-seq
MIRT1009540	hsa-miR-3941	CLIP-seq
MIRT1009541	hsa-miR-410	CLIP-seq
MIRT1009542	hsa-miR-4461	CLIP-seq
MIRT1009543	hsa-miR-4469	CLIP-seq
MIRT1009544	hsa-miR-4643	CLIP-seq
MIRT1009545	hsa-miR-4652-3p	CLIP-seq
MIRT1009546	hsa-miR-466	CLIP-seq
MIRT1009547	hsa-miR-4686	CLIP-seq
MIRT1009548	hsa-miR-4712-3p	CLIP-seq
MIRT1009549	hsa-miR-4723-3p	CLIP-seq
MIRT1009550	hsa-miR-4727-5p	CLIP-seq
MIRT1009551	hsa-miR-4753-3p	CLIP-seq
MIRT1009552	hsa-miR-4769-3p	CLIP-seq
MIRT1009553	hsa-miR-4775	CLIP-seq
MIRT1009554	hsa-miR-4789-3p	CLIP-seq
MIRT1009555	hsa-miR-4795-3p	CLIP-seq
MIRT1009556	hsa-miR-502-5p	CLIP-seq
MIRT1009557	hsa-miR-548a-5p	CLIP-seq
MIRT1009558	hsa-miR-548ab	CLIP-seq
MIRT1009559	hsa-miR-548ak	CLIP-seq
MIRT1009560	hsa-miR-548b-5p	CLIP-seq
MIRT1009561	hsa-miR-548c-5p	CLIP-seq
MIRT1009562	hsa-miR-548d-5p	CLIP-seq
MIRT1009563	hsa-miR-548g	CLIP-seq
MIRT1009564	hsa-miR-548h	CLIP-seq
MIRT1009565	hsa-miR-548i	CLIP-seq
MIRT1009566	hsa-miR-548j	CLIP-seq
MIRT1009567	hsa-miR-548n	CLIP-seq
MIRT1009568	hsa-miR-548w	CLIP-seq
MIRT1009569	hsa-miR-548y	CLIP-seq
MIRT1009570	hsa-miR-559	CLIP-seq
MIRT1009571	hsa-miR-590-3p	CLIP-seq
MIRT1009572	hsa-miR-593	CLIP-seq
MIRT1009573	hsa-miR-603	CLIP-seq
MIRT1009574	hsa-miR-607	CLIP-seq
MIRT1009575	hsa-miR-633	CLIP-seq
MIRT1009576	hsa-miR-641	CLIP-seq
MIRT1009577	hsa-miR-642a	CLIP-seq
MIRT1009578	hsa-miR-942	CLIP-seq
MIRT1009579	hsa-miR-1305	CLIP-seq
MIRT1009580	hsa-miR-15a	CLIP-seq
MIRT1009581	hsa-miR-15b	CLIP-seq
MIRT1009582	hsa-miR-16	CLIP-seq
MIRT1009583	hsa-miR-195	CLIP-seq
MIRT1009584	hsa-miR-23a	CLIP-seq
MIRT1009585	hsa-miR-23b	CLIP-seq
MIRT1009586	hsa-miR-23c	CLIP-seq
MIRT1009587	hsa-miR-3148	CLIP-seq
MIRT1009588	hsa-miR-320e	CLIP-seq
MIRT1009531	hsa-miR-3613-3p	CLIP-seq
MIRT1009589	hsa-miR-361-5p	CLIP-seq
MIRT1009590	hsa-miR-365	CLIP-seq
MIRT1009591	hsa-miR-3688-3p	CLIP-seq
MIRT1009538	hsa-miR-380	CLIP-seq
MIRT1009592	hsa-miR-409-3p	CLIP-seq
MIRT1009593	hsa-miR-424	CLIP-seq
MIRT1009594	hsa-miR-4307	CLIP-seq
MIRT1009595	hsa-miR-4312	CLIP-seq
MIRT1009596	hsa-miR-4434	CLIP-seq
MIRT1009597	hsa-miR-4495	CLIP-seq
MIRT1009598	hsa-miR-4516	CLIP-seq
MIRT1009599	hsa-miR-4531	CLIP-seq
MIRT1009600	hsa-miR-4635	CLIP-seq
MIRT1009601	hsa-miR-4699-3p	CLIP-seq
MIRT1009602	hsa-miR-4717-3p	CLIP-seq
MIRT1009603	hsa-miR-4802-3p	CLIP-seq
MIRT1009604	hsa-miR-488	CLIP-seq
MIRT1009605	hsa-miR-497	CLIP-seq
MIRT1009606	hsa-miR-526b	CLIP-seq
MIRT1009607	hsa-miR-532-5p	CLIP-seq
MIRT1009608	hsa-miR-539	CLIP-seq
MIRT1009557	hsa-miR-548a-5p	CLIP-seq
MIRT1009558	hsa-miR-548ab	CLIP-seq
MIRT1009559	hsa-miR-548ak	CLIP-seq
MIRT1009560	hsa-miR-548b-5p	CLIP-seq
MIRT1009561	hsa-miR-548c-5p	CLIP-seq
MIRT1009562	hsa-miR-548d-5p	CLIP-seq
MIRT1009564	hsa-miR-548h	CLIP-seq
MIRT1009565	hsa-miR-548i	CLIP-seq
MIRT1009566	hsa-miR-548j	CLIP-seq
MIRT1009567	hsa-miR-548n	CLIP-seq
MIRT1009609	hsa-miR-548t	CLIP-seq
MIRT1009568	hsa-miR-548w	CLIP-seq
MIRT1009569	hsa-miR-548y	CLIP-seq
MIRT1009570	hsa-miR-559	CLIP-seq
MIRT1009610	hsa-miR-570	CLIP-seq
MIRT1009571	hsa-miR-590-3p	CLIP-seq
MIRT1009574	hsa-miR-607	CLIP-seq
MIRT1999125	hsa-miR-1273e	CLIP-seq
MIRT1999126	hsa-miR-1276	CLIP-seq
MIRT1009587	hsa-miR-3148	CLIP-seq
MIRT1009534	hsa-miR-3671	CLIP-seq
MIRT1009535	hsa-miR-369-3p	CLIP-seq
MIRT1009536	hsa-miR-374a	CLIP-seq
MIRT1009537	hsa-miR-374b	CLIP-seq
MIRT1999127	hsa-miR-4311	CLIP-seq
MIRT1009597	hsa-miR-4495	CLIP-seq
MIRT1999128	hsa-miR-583	CLIP-seq
MIRT1999129	hsa-miR-595	CLIP-seq
MIRT1009574	hsa-miR-607	CLIP-seq
MIRT1009587	hsa-miR-3148	CLIP-seq
MIRT1009610	hsa-miR-570	CLIP-seq
MIRT1009584	hsa-miR-23a	CLIP-seq
MIRT1009585	hsa-miR-23b	CLIP-seq
MIRT1009586	hsa-miR-23c	CLIP-seq
MIRT2232827	hsa-miR-3158-3p	CLIP-seq
MIRT2232828	hsa-miR-3614-3p	CLIP-seq
MIRT2232829	hsa-miR-3667-3p	CLIP-seq
MIRT2232830	hsa-miR-3685	CLIP-seq
MIRT2232831	hsa-miR-3692	CLIP-seq
MIRT2232832	hsa-miR-374c	CLIP-seq
MIRT2232833	hsa-miR-377	CLIP-seq
MIRT2232834	hsa-miR-384	CLIP-seq
MIRT2232835	hsa-miR-4297	CLIP-seq
MIRT2232836	hsa-miR-4446-3p	CLIP-seq
MIRT2232837	hsa-miR-4494	CLIP-seq
MIRT2232838	hsa-miR-452	CLIP-seq
MIRT1009544	hsa-miR-4643	CLIP-seq
MIRT1009546	hsa-miR-466	CLIP-seq
MIRT2232839	hsa-miR-4676-3p	CLIP-seq
MIRT2232840	hsa-miR-4719	CLIP-seq
MIRT1009554	hsa-miR-4789-3p	CLIP-seq
MIRT2232841	hsa-miR-579	CLIP-seq
MIRT2232842	hsa-miR-655	CLIP-seq
MIRT2429180	hsa-miR-4729	CLIP-seq
MIRT2232841	hsa-miR-579	CLIP-seq
MIRT1009536	hsa-miR-374a	CLIP-seq
MIRT1009537	hsa-miR-374b	CLIP-seq
MIRT2536436	hsa-miR-3200-5p	CLIP-seq
MIRT2536437	hsa-miR-383	CLIP-seq
MIRT2536438	hsa-miR-3908	CLIP-seq
MIRT2536439	hsa-miR-3942-5p	CLIP-seq
MIRT2536440	hsa-miR-4679	CLIP-seq
MIRT2536441	hsa-miR-4699-5p	CLIP-seq
MIRT2536442	hsa-miR-4703-5p	CLIP-seq
MIRT2536443	hsa-miR-4704-3p	CLIP-seq
MIRT1009550	hsa-miR-4727-5p	CLIP-seq
MIRT2536444	hsa-miR-4766-3p	CLIP-seq
MIRT2536445	hsa-miR-4772-5p	CLIP-seq
MIRT1009554	hsa-miR-4789-3p	CLIP-seq
MIRT2681307	hsa-miR-3154	CLIP-seq
MIRT2536436	hsa-miR-3200-5p	CLIP-seq
MIRT2681308	hsa-miR-3682-3p	CLIP-seq
MIRT2536437	hsa-miR-383	CLIP-seq
MIRT2536438	hsa-miR-3908	CLIP-seq
MIRT2536439	hsa-miR-3942-5p	CLIP-seq
MIRT2681309	hsa-miR-4282	CLIP-seq
MIRT2681310	hsa-miR-4517	CLIP-seq
MIRT2536440	hsa-miR-4679	CLIP-seq
MIRT2536441	hsa-miR-4699-5p	CLIP-seq
MIRT2536442	hsa-miR-4703-5p	CLIP-seq
MIRT2536443	hsa-miR-4704-3p	CLIP-seq
MIRT2536444	hsa-miR-4766-3p	CLIP-seq
MIRT2536445	hsa-miR-4772-5p	CLIP-seq
MIRT1009554	hsa-miR-4789-3p	CLIP-seq
MIRT2681311	hsa-miR-4796-5p	CLIP-seq
MIRT1009571	hsa-miR-590-3p	CLIP-seq
MIRT2681312	hsa-miR-654-3p	CLIP-seq
MIRT2681313	hsa-miR-889	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ATF1	Unknown	10585419
CREB1	Unknown	10585419

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	IDA	22306510
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription cis-regulatory region binding	IDA	9857059
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12750007, 22306510
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12750007, 22306510
GO:0001701	Process	In utero embryonic development	IEA
GO:0001825	Process	Blastocyst formation	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	7590737
GO:0005515	Function	Protein binding	IPI	10675337, 16624878, 24501276, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	9857059
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9016666
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0030154	Process	Cell differentiation	IBA
GO:0043565	Function	Sequence-specific DNA binding	IEA
GO:0045653	Process	Negative regulation of megakaryocyte differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9857059
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12750007, 22306510, 24501276
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

Other IDs

• MIM: 600609
• HGNC: 4071
• e!Ensembl: ENSG00000154727

Protein

• UniProt ID: Q06546
• Protein name: GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60)
• Protein function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). ; (Microbial infection) Nec
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11620	GABP-alpha	36 → 119	GA-binding protein alpha chain	Family
  PF02198	SAM_PNT	170 → 251	Sterile alpha motif (SAM)/Pointed domain	Domain
  PF00178	Ets	321 → 400	Ets-domain	Domain

• Sequence:

  MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQ
  CSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTV
  EVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERL
  GIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEIL
  WSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSATPTTIKVINSSAKAAKVQRAP
  RISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKW
  GQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTE
  CEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN

• Sequence length: 454

Pathways

Reactome:

Transcriptional activation of mitochondrial biogenesis