Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2551
Gene name Gene Name - the full gene name approved by the HGNC.	GA binding protein transcription factor subunit alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GABPA
Synonyms (NCBI Gene) Gene synonyms aliases	E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07
Chromosome Chromosome number	21
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	21q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation

Show/Hide all(253)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031329	hsa-miR-18a-5p	Sequencing	20371350
MIRT048948	hsa-miR-92a-3p	CLASH	23622248
MIRT297783	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT297779	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT297781	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT297778	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT297787	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT297782	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT297780	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT557712	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT557713	hsa-miR-4422	PAR-CLIP	20371350
MIRT297785	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT297788	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT297786	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT297784	hsa-miR-922	PAR-CLIP	20371350
MIRT557711	hsa-miR-4744	PAR-CLIP	20371350
MIRT557710	hsa-miR-4509	PAR-CLIP	20371350
MIRT557709	hsa-miR-4261	PAR-CLIP	20371350
MIRT297783	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT297779	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT297781	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT297778	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT297787	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT297782	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT297780	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT557712	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT557713	hsa-miR-4422	PAR-CLIP	21572407
MIRT297785	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT297788	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT297786	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT297784	hsa-miR-922	PAR-CLIP	21572407
MIRT557711	hsa-miR-4744	PAR-CLIP	21572407
MIRT557710	hsa-miR-4509	PAR-CLIP	21572407
MIRT557709	hsa-miR-4261	PAR-CLIP	21572407
MIRT548138	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT548137	hsa-miR-6731-3p	PAR-CLIP	21572407
MIRT548136	hsa-miR-378a-5p	PAR-CLIP	21572407
MIRT548135	hsa-miR-1200	PAR-CLIP	21572407
MIRT548134	hsa-miR-943	PAR-CLIP	21572407
MIRT548133	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT737374	hsa-miR-146a-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR	32303750
MIRT297783	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT297779	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT297781	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT297778	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT297787	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT297782	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT297780	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT557712	hsa-miR-6835-3p	PAR-CLIP	20371350
MIRT557713	hsa-miR-4422	PAR-CLIP	20371350
MIRT297785	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT297788	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT297786	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT297784	hsa-miR-922	PAR-CLIP	20371350
MIRT557711	hsa-miR-4744	PAR-CLIP	20371350
MIRT557710	hsa-miR-4509	PAR-CLIP	20371350
MIRT557709	hsa-miR-4261	PAR-CLIP	20371350
MIRT297783	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT297779	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT297781	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT297778	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT297787	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT297782	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT297780	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT557712	hsa-miR-6835-3p	PAR-CLIP	21572407
MIRT557713	hsa-miR-4422	PAR-CLIP	21572407
MIRT297785	hsa-miR-6758-5p	PAR-CLIP	21572407
MIRT297788	hsa-miR-6856-5p	PAR-CLIP	21572407
MIRT297786	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT297784	hsa-miR-922	PAR-CLIP	21572407
MIRT557711	hsa-miR-4744	PAR-CLIP	21572407
MIRT557710	hsa-miR-4509	PAR-CLIP	21572407
MIRT557709	hsa-miR-4261	PAR-CLIP	21572407
MIRT548138	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT548137	hsa-miR-6731-3p	PAR-CLIP	21572407
MIRT548136	hsa-miR-378a-5p	PAR-CLIP	21572407
MIRT548135	hsa-miR-1200	PAR-CLIP	21572407
MIRT548134	hsa-miR-943	PAR-CLIP	21572407
MIRT548133	hsa-miR-3692-3p	PAR-CLIP	21572407
MIRT1009525	hsa-miR-1236	CLIP-seq
MIRT1009526	hsa-miR-2054	CLIP-seq
MIRT1009527	hsa-miR-3159	CLIP-seq
MIRT1009528	hsa-miR-3182	CLIP-seq
MIRT1009529	hsa-miR-3183	CLIP-seq
MIRT1009530	hsa-miR-329	CLIP-seq
MIRT1009531	hsa-miR-3613-3p	CLIP-seq
MIRT1009532	hsa-miR-3617	CLIP-seq
MIRT1009533	hsa-miR-362-3p	CLIP-seq
MIRT1009534	hsa-miR-3671	CLIP-seq
MIRT1009535	hsa-miR-369-3p	CLIP-seq
MIRT1009536	hsa-miR-374a	CLIP-seq
MIRT1009537	hsa-miR-374b	CLIP-seq
MIRT1009538	hsa-miR-380	CLIP-seq
MIRT1009539	hsa-miR-3924	CLIP-seq
MIRT1009540	hsa-miR-3941	CLIP-seq
MIRT1009541	hsa-miR-410	CLIP-seq
MIRT1009542	hsa-miR-4461	CLIP-seq
MIRT1009543	hsa-miR-4469	CLIP-seq
MIRT1009544	hsa-miR-4643	CLIP-seq
MIRT1009545	hsa-miR-4652-3p	CLIP-seq
MIRT1009546	hsa-miR-466	CLIP-seq
MIRT1009547	hsa-miR-4686	CLIP-seq
MIRT1009548	hsa-miR-4712-3p	CLIP-seq
MIRT1009549	hsa-miR-4723-3p	CLIP-seq
MIRT1009550	hsa-miR-4727-5p	CLIP-seq
MIRT1009551	hsa-miR-4753-3p	CLIP-seq
MIRT1009552	hsa-miR-4769-3p	CLIP-seq
MIRT1009553	hsa-miR-4775	CLIP-seq
MIRT1009554	hsa-miR-4789-3p	CLIP-seq
MIRT1009555	hsa-miR-4795-3p	CLIP-seq
MIRT1009556	hsa-miR-502-5p	CLIP-seq
MIRT1009557	hsa-miR-548a-5p	CLIP-seq
MIRT1009558	hsa-miR-548ab	CLIP-seq
MIRT1009559	hsa-miR-548ak	CLIP-seq
MIRT1009560	hsa-miR-548b-5p	CLIP-seq
MIRT1009561	hsa-miR-548c-5p	CLIP-seq
MIRT1009562	hsa-miR-548d-5p	CLIP-seq
MIRT1009563	hsa-miR-548g	CLIP-seq
MIRT1009564	hsa-miR-548h	CLIP-seq
MIRT1009565	hsa-miR-548i	CLIP-seq
MIRT1009566	hsa-miR-548j	CLIP-seq
MIRT1009567	hsa-miR-548n	CLIP-seq
MIRT1009568	hsa-miR-548w	CLIP-seq
MIRT1009569	hsa-miR-548y	CLIP-seq
MIRT1009570	hsa-miR-559	CLIP-seq
MIRT1009571	hsa-miR-590-3p	CLIP-seq
MIRT1009572	hsa-miR-593	CLIP-seq
MIRT1009573	hsa-miR-603	CLIP-seq
MIRT1009574	hsa-miR-607	CLIP-seq
MIRT1009575	hsa-miR-633	CLIP-seq
MIRT1009576	hsa-miR-641	CLIP-seq
MIRT1009577	hsa-miR-642a	CLIP-seq
MIRT1009578	hsa-miR-942	CLIP-seq
MIRT1009579	hsa-miR-1305	CLIP-seq
MIRT1009580	hsa-miR-15a	CLIP-seq
MIRT1009581	hsa-miR-15b	CLIP-seq
MIRT1009582	hsa-miR-16	CLIP-seq
MIRT1009583	hsa-miR-195	CLIP-seq
MIRT1009584	hsa-miR-23a	CLIP-seq
MIRT1009585	hsa-miR-23b	CLIP-seq
MIRT1009586	hsa-miR-23c	CLIP-seq
MIRT1009587	hsa-miR-3148	CLIP-seq
MIRT1009588	hsa-miR-320e	CLIP-seq
MIRT1009531	hsa-miR-3613-3p	CLIP-seq
MIRT1009589	hsa-miR-361-5p	CLIP-seq
MIRT1009590	hsa-miR-365	CLIP-seq
MIRT1009591	hsa-miR-3688-3p	CLIP-seq
MIRT1009538	hsa-miR-380	CLIP-seq
MIRT1009592	hsa-miR-409-3p	CLIP-seq
MIRT1009593	hsa-miR-424	CLIP-seq
MIRT1009594	hsa-miR-4307	CLIP-seq
MIRT1009595	hsa-miR-4312	CLIP-seq
MIRT1009596	hsa-miR-4434	CLIP-seq
MIRT1009597	hsa-miR-4495	CLIP-seq
MIRT1009598	hsa-miR-4516	CLIP-seq
MIRT1009599	hsa-miR-4531	CLIP-seq
MIRT1009600	hsa-miR-4635	CLIP-seq
MIRT1009601	hsa-miR-4699-3p	CLIP-seq
MIRT1009602	hsa-miR-4717-3p	CLIP-seq
MIRT1009603	hsa-miR-4802-3p	CLIP-seq
MIRT1009604	hsa-miR-488	CLIP-seq
MIRT1009605	hsa-miR-497	CLIP-seq
MIRT1009606	hsa-miR-526b	CLIP-seq
MIRT1009607	hsa-miR-532-5p	CLIP-seq
MIRT1009608	hsa-miR-539	CLIP-seq
MIRT1009557	hsa-miR-548a-5p	CLIP-seq
MIRT1009558	hsa-miR-548ab	CLIP-seq
MIRT1009559	hsa-miR-548ak	CLIP-seq
MIRT1009560	hsa-miR-548b-5p	CLIP-seq
MIRT1009561	hsa-miR-548c-5p	CLIP-seq
MIRT1009562	hsa-miR-548d-5p	CLIP-seq
MIRT1009564	hsa-miR-548h	CLIP-seq
MIRT1009565	hsa-miR-548i	CLIP-seq
MIRT1009566	hsa-miR-548j	CLIP-seq
MIRT1009567	hsa-miR-548n	CLIP-seq
MIRT1009609	hsa-miR-548t	CLIP-seq
MIRT1009568	hsa-miR-548w	CLIP-seq
MIRT1009569	hsa-miR-548y	CLIP-seq
MIRT1009570	hsa-miR-559	CLIP-seq
MIRT1009610	hsa-miR-570	CLIP-seq
MIRT1009571	hsa-miR-590-3p	CLIP-seq
MIRT1009574	hsa-miR-607	CLIP-seq
MIRT1999125	hsa-miR-1273e	CLIP-seq
MIRT1999126	hsa-miR-1276	CLIP-seq
MIRT1009587	hsa-miR-3148	CLIP-seq
MIRT1009534	hsa-miR-3671	CLIP-seq
MIRT1009535	hsa-miR-369-3p	CLIP-seq
MIRT1009536	hsa-miR-374a	CLIP-seq
MIRT1009537	hsa-miR-374b	CLIP-seq
MIRT1999127	hsa-miR-4311	CLIP-seq
MIRT1009597	hsa-miR-4495	CLIP-seq
MIRT1999128	hsa-miR-583	CLIP-seq
MIRT1999129	hsa-miR-595	CLIP-seq
MIRT1009574	hsa-miR-607	CLIP-seq
MIRT1009587	hsa-miR-3148	CLIP-seq
MIRT1009610	hsa-miR-570	CLIP-seq
MIRT1009584	hsa-miR-23a	CLIP-seq
MIRT1009585	hsa-miR-23b	CLIP-seq
MIRT1009586	hsa-miR-23c	CLIP-seq
MIRT2232827	hsa-miR-3158-3p	CLIP-seq
MIRT2232828	hsa-miR-3614-3p	CLIP-seq
MIRT2232829	hsa-miR-3667-3p	CLIP-seq
MIRT2232830	hsa-miR-3685	CLIP-seq
MIRT2232831	hsa-miR-3692	CLIP-seq
MIRT2232832	hsa-miR-374c	CLIP-seq
MIRT2232833	hsa-miR-377	CLIP-seq
MIRT2232834	hsa-miR-384	CLIP-seq
MIRT2232835	hsa-miR-4297	CLIP-seq
MIRT2232836	hsa-miR-4446-3p	CLIP-seq
MIRT2232837	hsa-miR-4494	CLIP-seq
MIRT2232838	hsa-miR-452	CLIP-seq
MIRT1009544	hsa-miR-4643	CLIP-seq
MIRT1009546	hsa-miR-466	CLIP-seq
MIRT2232839	hsa-miR-4676-3p	CLIP-seq
MIRT2232840	hsa-miR-4719	CLIP-seq
MIRT1009554	hsa-miR-4789-3p	CLIP-seq
MIRT2232841	hsa-miR-579	CLIP-seq
MIRT2232842	hsa-miR-655	CLIP-seq
MIRT2429180	hsa-miR-4729	CLIP-seq
MIRT2232841	hsa-miR-579	CLIP-seq
MIRT1009536	hsa-miR-374a	CLIP-seq
MIRT1009537	hsa-miR-374b	CLIP-seq
MIRT2536436	hsa-miR-3200-5p	CLIP-seq
MIRT2536437	hsa-miR-383	CLIP-seq
MIRT2536438	hsa-miR-3908	CLIP-seq
MIRT2536439	hsa-miR-3942-5p	CLIP-seq
MIRT2536440	hsa-miR-4679	CLIP-seq
MIRT2536441	hsa-miR-4699-5p	CLIP-seq
MIRT2536442	hsa-miR-4703-5p	CLIP-seq
MIRT2536443	hsa-miR-4704-3p	CLIP-seq
MIRT1009550	hsa-miR-4727-5p	CLIP-seq
MIRT2536444	hsa-miR-4766-3p	CLIP-seq
MIRT2536445	hsa-miR-4772-5p	CLIP-seq
MIRT1009554	hsa-miR-4789-3p	CLIP-seq
MIRT2681307	hsa-miR-3154	CLIP-seq
MIRT2536436	hsa-miR-3200-5p	CLIP-seq
MIRT2681308	hsa-miR-3682-3p	CLIP-seq
MIRT2536437	hsa-miR-383	CLIP-seq
MIRT2536438	hsa-miR-3908	CLIP-seq
MIRT2536439	hsa-miR-3942-5p	CLIP-seq
MIRT2681309	hsa-miR-4282	CLIP-seq
MIRT2681310	hsa-miR-4517	CLIP-seq
MIRT2536440	hsa-miR-4679	CLIP-seq
MIRT2536441	hsa-miR-4699-5p	CLIP-seq
MIRT2536442	hsa-miR-4703-5p	CLIP-seq
MIRT2536443	hsa-miR-4704-3p	CLIP-seq
MIRT2536444	hsa-miR-4766-3p	CLIP-seq
MIRT2536445	hsa-miR-4772-5p	CLIP-seq
MIRT1009554	hsa-miR-4789-3p	CLIP-seq
MIRT2681311	hsa-miR-4796-5p	CLIP-seq
MIRT1009571	hsa-miR-590-3p	CLIP-seq
MIRT2681312	hsa-miR-654-3p	CLIP-seq
MIRT2681313	hsa-miR-889	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
ATF1	Unknown	10585419
CREB1	Unknown	10585419

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	IDA	22306510
GO:0000785	Component	Chromatin	ISA
GO:0000976	Function	Transcription regulatory region sequence-specific DNA binding	IDA	9857059
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	12750007, 22306510
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12750007, 22306510
GO:0001825	Process	Blastocyst formation	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	TAS	7590737
GO:0005515	Function	Protein binding	IPI	10675337, 28514442, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	9857059
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007005	Process	Mitochondrion organization	TAS
GO:0010628	Process	Positive regulation of gene expression	IMP	24136195
GO:0030154	Process	Cell differentiation	IBA	21873635
GO:0033613	Function	Activating transcription factor binding	IPI	24501276
GO:0045653	Process	Negative regulation of megakaryocyte differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	9857059, 12750007, 22306510, 24501276
GO:1903351	Process	Cellular response to dopamine	IMP	24136195
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
600609	4071	ENSG00000154727

Protein

UniProt ID

Q06546

Protein name

GA-binding protein alpha chain (GABP subunit alpha) (Nuclear respiratory factor 2 subunit alpha) (Transcription factor E4TF1-60)

Protein function

Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510). ; (Microbial infection) Nec

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11620	GABP-alpha	36 → 119	GA-binding protein alpha chain	Family
PF02198	SAM_PNT	170 → 251	Sterile alpha motif (SAM)/Pointed domain	Domain
PF00178	Ets	321 → 400	Ets-domain	Domain

Sequence

MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQ
CSLDAHEICLQDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTV
EVVIDPDAHHAESEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERL
GIPYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEIL
WSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSATPTTIKVINSSAKAAKVQRAP
RISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKW
GQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTE
CEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN

Sequence length

454

Interactions

View interactions

	Reactome
			Transcriptional activation of mitochondrial biogenesis

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Depressive disorder		23623252	ClinVar

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma Follicular	Associate	32163919
Breast Neoplasms	Associate	26517092, 7914192
Carcinoma Hepatocellular	Associate	35958019
COVID 19	Associate	37373377
Dyspnea	Inhibit	37373377
Endometrial Neoplasms	Inhibit	34306255
Hyperlipidemia Familial Combined	Associate	18230803
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	26072332
Melanoma	Associate	28108517
Metabolic Diseases	Associate	18230803
Mitochondrial Diseases	Associate	18332166
Neoplasms	Inhibit	19324871
Neoplasms	Associate	35440061
Post Acute COVID 19 Syndrome	Associate	37373377
Stomach Neoplasms	Associate	32468960
Thyroid cancer follicular	Associate	32163919
Thyroid Neoplasms	Associate	30664813

GABPA (GA binding protein transcription factor subunit alpha)