TMEM86B (transmembrane protein 86B)

Gene

• Entrez ID: 255043
• Gene name: Transmembrane protein 86B
• Gene symbol: TMEM86B
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.42

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017820	hsa-miR-335-5p	Microarray	18185580
MIRT1439233	hsa-miR-15a	CLIP-seq
MIRT1439234	hsa-miR-15b	CLIP-seq
MIRT1439235	hsa-miR-16	CLIP-seq
MIRT1439236	hsa-miR-1909	CLIP-seq
MIRT1439237	hsa-miR-195	CLIP-seq
MIRT1439238	hsa-miR-214	CLIP-seq
MIRT1439239	hsa-miR-2278	CLIP-seq
MIRT1439240	hsa-miR-299-5p	CLIP-seq
MIRT1439241	hsa-miR-3180	CLIP-seq
MIRT1439242	hsa-miR-3180-3p	CLIP-seq
MIRT1439243	hsa-miR-3196	CLIP-seq
MIRT1439244	hsa-miR-3619-5p	CLIP-seq
MIRT1439245	hsa-miR-3692	CLIP-seq
MIRT1439246	hsa-miR-424	CLIP-seq
MIRT1439247	hsa-miR-4488	CLIP-seq
MIRT1439248	hsa-miR-4668-5p	CLIP-seq
MIRT1439249	hsa-miR-4697-5p	CLIP-seq
MIRT1439250	hsa-miR-4725-5p	CLIP-seq
MIRT1439251	hsa-miR-497	CLIP-seq
MIRT1439252	hsa-miR-504	CLIP-seq
MIRT1439253	hsa-miR-761	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IDA	21515882
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	ISS
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	21515882
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016803	Function	Ether hydrolase activity	TAS
GO:0036151	Process	Phosphatidylcholine acyl-chain remodeling	TAS
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0046485	Process	Ether lipid metabolic process	IBA
GO:0046485	Process	Ether lipid metabolic process	IDA	21515882
GO:0047408	Function	Alkenylglycerophosphocholine hydrolase activity	IBA
GO:0047408	Function	Alkenylglycerophosphocholine hydrolase activity	IDA	21515882
GO:0047408	Function	Alkenylglycerophosphocholine hydrolase activity	IEA
GO:0047826	Function	D-lysine 5,6-aminomutase activity	IBA
GO:0047826	Function	D-lysine 5,6-aminomutase activity	IDA	21515882

Other IDs

• MIM: 617806
• HGNC: 28448
• e!Ensembl: ENSG00000180089

Protein

• UniProt ID: Q8N661
• Protein name: Lysoplasmalogenase TMEM86B (EC 3.3.2.2) (Transmembrane protein 86B)
• Protein function: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of pla
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07947	YhhN	48 → 217	YhhN family	Family

• Sequence:

  MDAGKAGQTLKTHCSAQRPDVCRWLSPFILSCCVYFCLWIPEDQLSWFAALVKCLPVLCL
  AGFLWVMSPSGGYTQLLQGALVCSAVGDACLIWPAAFVPGMAAFATAHLLYVWAFGFSPL
  QPGLLLLIILAPGPYLSLVLQHLEPDMVLPVAAYGLILMAMLWRGLAQGGSAGWGALLFT
  LSDGVLAWDTFAQPLPHAHLVIMTTYYAAQLLITLSALRSPVPKTD

• Sequence length: 226

Pathways

KEGG:

Ether lipid metabolism
Metabolic pathways

Reactome:

Acyl chain remodelling of PC

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
HYPOTHYROIDISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations