Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	255022
Gene name Gene Name - the full gene name approved by the HGNC.	Calcium homeostasis modulator 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CALHM1
Synonyms (NCBI Gene) Gene synonyms aliases	FAM26C
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q24.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer`s disease in some populations, but the patho

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SNP ID	Visualize variation	Clinical significance	Consequence
rs371900329	C>T	Likely-pathogenic	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments
MIRT859025	hsa-miR-1236	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT859028	hsa-miR-1262	CLIP-seq
MIRT859029	hsa-miR-138	CLIP-seq
MIRT859030	hsa-miR-150	CLIP-seq
MIRT859031	hsa-miR-185	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT859033	hsa-miR-2467-5p	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT859039	hsa-miR-3065-5p	CLIP-seq
MIRT859040	hsa-miR-3150b-3p	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859042	hsa-miR-3182	CLIP-seq
MIRT859043	hsa-miR-3188	CLIP-seq
MIRT859044	hsa-miR-3189-3p	CLIP-seq
MIRT859045	hsa-miR-3192	CLIP-seq
MIRT859046	hsa-miR-323-3p	CLIP-seq
MIRT859047	hsa-miR-3545-3p	CLIP-seq
MIRT859048	hsa-miR-3652	CLIP-seq
MIRT859049	hsa-miR-3689a-3p	CLIP-seq
MIRT859050	hsa-miR-3689c	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT859053	hsa-miR-3926	CLIP-seq
MIRT859054	hsa-miR-3975	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT859056	hsa-miR-4306	CLIP-seq
MIRT859057	hsa-miR-4430	CLIP-seq
MIRT859058	hsa-miR-4438	CLIP-seq
MIRT859059	hsa-miR-4505	CLIP-seq
MIRT859060	hsa-miR-4644	CLIP-seq
MIRT859061	hsa-miR-4646-5p	CLIP-seq
MIRT859062	hsa-miR-4649-3p	CLIP-seq
MIRT859063	hsa-miR-4662a-5p	CLIP-seq
MIRT859064	hsa-miR-4691-3p	CLIP-seq
MIRT859065	hsa-miR-4701-3p	CLIP-seq
MIRT859066	hsa-miR-4711-3p	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT859068	hsa-miR-4725-5p	CLIP-seq
MIRT859069	hsa-miR-4728-5p	CLIP-seq
MIRT859070	hsa-miR-4731-5p	CLIP-seq
MIRT859071	hsa-miR-4747-5p	CLIP-seq
MIRT859072	hsa-miR-4757-5p	CLIP-seq
MIRT859073	hsa-miR-4774-5p	CLIP-seq
MIRT859074	hsa-miR-4784	CLIP-seq
MIRT859075	hsa-miR-4800-5p	CLIP-seq
MIRT859076	hsa-miR-485-5p	CLIP-seq
MIRT859077	hsa-miR-490-3p	CLIP-seq
MIRT859078	hsa-miR-504	CLIP-seq
MIRT859079	hsa-miR-5095	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT859086	hsa-miR-548s	CLIP-seq
MIRT859087	hsa-miR-576-5p	CLIP-seq
MIRT859088	hsa-miR-661	CLIP-seq
MIRT859089	hsa-miR-711	CLIP-seq
MIRT859090	hsa-miR-765	CLIP-seq
MIRT859091	hsa-miR-889	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT1954994	hsa-miR-1238	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT859030	hsa-miR-150	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT1954995	hsa-miR-1915	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT1954996	hsa-miR-3155	CLIP-seq
MIRT1954997	hsa-miR-3155b	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859044	hsa-miR-3189-3p	CLIP-seq
MIRT1954998	hsa-miR-3663-5p	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT859058	hsa-miR-4438	CLIP-seq
MIRT859061	hsa-miR-4646-5p	CLIP-seq
MIRT1954999	hsa-miR-4691-5p	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT1955000	hsa-miR-4726-3p	CLIP-seq
MIRT859070	hsa-miR-4731-5p	CLIP-seq
MIRT859071	hsa-miR-4747-5p	CLIP-seq
MIRT859072	hsa-miR-4757-5p	CLIP-seq
MIRT1955001	hsa-miR-484	CLIP-seq
MIRT859079	hsa-miR-5095	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT1955002	hsa-miR-515-5p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT859088	hsa-miR-661	CLIP-seq
MIRT859090	hsa-miR-765	CLIP-seq
MIRT2192721	hsa-miR-1245	CLIP-seq
MIRT859026	hsa-miR-1260	CLIP-seq
MIRT859027	hsa-miR-1260b	CLIP-seq
MIRT2192722	hsa-miR-1470	CLIP-seq
MIRT859030	hsa-miR-150	CLIP-seq
MIRT859032	hsa-miR-188-3p	CLIP-seq
MIRT1954995	hsa-miR-1915	CLIP-seq
MIRT859034	hsa-miR-302a	CLIP-seq
MIRT859035	hsa-miR-302b	CLIP-seq
MIRT859036	hsa-miR-302c	CLIP-seq
MIRT859037	hsa-miR-302d	CLIP-seq
MIRT859038	hsa-miR-302e	CLIP-seq
MIRT2192723	hsa-miR-3127-5p	CLIP-seq
MIRT1954996	hsa-miR-3155	CLIP-seq
MIRT1954997	hsa-miR-3155b	CLIP-seq
MIRT859041	hsa-miR-3156-3p	CLIP-seq
MIRT859044	hsa-miR-3189-3p	CLIP-seq
MIRT1954998	hsa-miR-3663-5p	CLIP-seq
MIRT859051	hsa-miR-372	CLIP-seq
MIRT859052	hsa-miR-373	CLIP-seq
MIRT2192724	hsa-miR-3918	CLIP-seq
MIRT859055	hsa-miR-4301	CLIP-seq
MIRT2192725	hsa-miR-4423-5p	CLIP-seq
MIRT859058	hsa-miR-4438	CLIP-seq
MIRT2192726	hsa-miR-4469	CLIP-seq
MIRT859061	hsa-miR-4646-5p	CLIP-seq
MIRT2192727	hsa-miR-4667-3p	CLIP-seq
MIRT859067	hsa-miR-4715-3p	CLIP-seq
MIRT1955000	hsa-miR-4726-3p	CLIP-seq
MIRT859070	hsa-miR-4731-5p	CLIP-seq
MIRT859071	hsa-miR-4747-5p	CLIP-seq
MIRT859072	hsa-miR-4757-5p	CLIP-seq
MIRT2192728	hsa-miR-4781-3p	CLIP-seq
MIRT1955001	hsa-miR-484	CLIP-seq
MIRT859079	hsa-miR-5095	CLIP-seq
MIRT859080	hsa-miR-512-3p	CLIP-seq
MIRT1955002	hsa-miR-515-5p	CLIP-seq
MIRT859081	hsa-miR-520a-3p	CLIP-seq
MIRT859082	hsa-miR-520b	CLIP-seq
MIRT859083	hsa-miR-520c-3p	CLIP-seq
MIRT859084	hsa-miR-520d-3p	CLIP-seq
MIRT859085	hsa-miR-520e	CLIP-seq
MIRT2192729	hsa-miR-617	CLIP-seq
MIRT859088	hsa-miR-661	CLIP-seq
MIRT2192721	hsa-miR-1245	CLIP-seq
MIRT2192722	hsa-miR-1470	CLIP-seq
MIRT1954995	hsa-miR-1915	CLIP-seq
MIRT1954996	hsa-miR-3155	CLIP-seq
MIRT1954997	hsa-miR-3155b	CLIP-seq
MIRT859044	hsa-miR-3189-3p	CLIP-seq
MIRT2192726	hsa-miR-4469	CLIP-seq
MIRT859061	hsa-miR-4646-5p	CLIP-seq
MIRT2192727	hsa-miR-4667-3p	CLIP-seq
MIRT1955000	hsa-miR-4726-3p	CLIP-seq
MIRT859071	hsa-miR-4747-5p	CLIP-seq
MIRT1955001	hsa-miR-484	CLIP-seq
MIRT859088	hsa-miR-661	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005227	Function	Calcium-activated cation channel activity	IDA	22711817
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	IDA	22711817, 23300080
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	IEA
GO:0005245	Function	Voltage-gated calcium channel activity	IEA
GO:0005261	Function	Monoatomic cation channel activity	IBA
GO:0005262	Function	Calcium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	22711817, 23300080
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006812	Process	Monoatomic cation transport	IDA	22711817
GO:0006816	Process	Calcium ion transport	IEA
GO:0015867	Process	ATP transport	IEA
GO:0015867	Process	ATP transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	ISS
GO:0022832	Function	Voltage-gated channel activity	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034765	Process	Regulation of monoatomic ion transmembrane transport	IDA	23300080
GO:0042802	Function	Identical protein binding	IPI	18585350
GO:0044853	Component	Plasma membrane raft	IEA
GO:0050909	Process	Sensory perception of taste	IEA
GO:0050913	Process	Sensory perception of bitter taste	IEA
GO:0050913	Process	Sensory perception of bitter taste	ISS
GO:0050916	Process	Sensory perception of sweet taste	IEA
GO:0050916	Process	Sensory perception of sweet taste	ISS
GO:0050917	Process	Sensory perception of umami taste	IEA
GO:0050917	Process	Sensory perception of umami taste	ISS
GO:0051260	Process	Protein homooligomerization	IDA	23300080
GO:0051291	Process	Protein heterooligomerization	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:1904669	Process	ATP export	IDA	32832629
GO:1904669	Process	ATP export	IEA

MIM	HGNC	e!Ensembl
612234	23494	ENSG00000185933

Protein

UniProt ID

Q8IU99

Protein name

Calcium homeostasis modulator protein 1 (Protein FAM26C)

Protein function

Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes (By similarity). With CALHM3 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP

PDB

8GMP , 8GMR , 8S8Z , 8S90

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14798	Ca_hom_mod	2 → 256	Calcium homeostasis modulator	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. {ECO:0000269|PubMed:18585350, ECO:0000269|PubMed:19997627}.

Sequence

MMDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCLPGYNAAYSAGILLAP
PLVLFLLGLVMNNNVSMLAEEWKRPLGRRAKDPAVLRYMFCSMAQRALIAPVVWVAVTLL
DGKCFLCAFCTAVPVSALGNGSLAPGLPAPELARLLARVPCPEIYDGDWLLAREVAVRYL
RCISQALGWSFVLLTTLLAFVVRSVRPCFTQAAFLKSKYWSHYIDIERKLFDETCTEHAK
AFAKVCIQQFFEAMNHDLELGHTHGTLATAPASAAAPTTPDGAEEEREKLRGITDQGTMN
RLLTSWHKCKPPLRLGQEEPPLMGNGWAGGGPRPPRKEVATYFSKV

Sequence length

346

Interactions

View interactions

	KEGG
	Taste transduction

CALHM1 (calcium homeostasis modulator 1)