Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	254827
Gene name	N-acetylated alpha-linked acidic dipeptidase like 2
Gene symbol	NAALADL2
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3q26.31

127

Show/Hide all (127)

miRTarBase ID	miRNA	Experiments
MIRT1172342	hsa-miR-1	CLIP-seq
MIRT1172343	hsa-miR-206	CLIP-seq
MIRT1172344	hsa-miR-3119	CLIP-seq
MIRT1172345	hsa-miR-3125	CLIP-seq
MIRT1172346	hsa-miR-3152-3p	CLIP-seq
MIRT1172347	hsa-miR-3161	CLIP-seq
MIRT1172348	hsa-miR-34b	CLIP-seq
MIRT1172349	hsa-miR-3653	CLIP-seq
MIRT1172350	hsa-miR-3658	CLIP-seq
MIRT1172351	hsa-miR-3673	CLIP-seq
MIRT1172352	hsa-miR-3682-3p	CLIP-seq
MIRT1172353	hsa-miR-375	CLIP-seq
MIRT1172354	hsa-miR-3916	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT1172356	hsa-miR-3936	CLIP-seq
MIRT1172357	hsa-miR-4273	CLIP-seq
MIRT1172358	hsa-miR-4477a	CLIP-seq
MIRT1172359	hsa-miR-4502	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT1172361	hsa-miR-4677-5p	CLIP-seq
MIRT1172362	hsa-miR-4695-3p	CLIP-seq
MIRT1172363	hsa-miR-4709-3p	CLIP-seq
MIRT1172364	hsa-miR-4714-3p	CLIP-seq
MIRT1172365	hsa-miR-4762-3p	CLIP-seq
MIRT1172366	hsa-miR-4799-5p	CLIP-seq
MIRT1172367	hsa-miR-582-3p	CLIP-seq
MIRT1172368	hsa-miR-613	CLIP-seq
MIRT2049825	hsa-miR-1275	CLIP-seq
MIRT2049826	hsa-miR-196a	CLIP-seq
MIRT2049827	hsa-miR-196b	CLIP-seq
MIRT2049828	hsa-miR-2909	CLIP-seq
MIRT2049829	hsa-miR-296-3p	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT2049830	hsa-miR-3927	CLIP-seq
MIRT2049831	hsa-miR-4260	CLIP-seq
MIRT2049832	hsa-miR-4525	CLIP-seq
MIRT2049833	hsa-miR-4650-3p	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT2049834	hsa-miR-4665-5p	CLIP-seq
MIRT2049835	hsa-miR-4723-5p	CLIP-seq
MIRT2049836	hsa-miR-590-3p	CLIP-seq
MIRT2049837	hsa-miR-607	CLIP-seq
MIRT2049838	hsa-miR-625	CLIP-seq
MIRT1172342	hsa-miR-1	CLIP-seq
MIRT2049825	hsa-miR-1275	CLIP-seq
MIRT2278783	hsa-miR-1284	CLIP-seq
MIRT2278784	hsa-miR-1305	CLIP-seq
MIRT2278785	hsa-miR-139-5p	CLIP-seq
MIRT2278786	hsa-miR-190	CLIP-seq
MIRT2278787	hsa-miR-190b	CLIP-seq
MIRT2049826	hsa-miR-196a	CLIP-seq
MIRT2049827	hsa-miR-196b	CLIP-seq
MIRT2278788	hsa-miR-1976	CLIP-seq
MIRT1172343	hsa-miR-206	CLIP-seq
MIRT2278789	hsa-miR-2110	CLIP-seq
MIRT2278790	hsa-miR-2116	CLIP-seq
MIRT2278791	hsa-miR-2467-5p	CLIP-seq
MIRT2278792	hsa-miR-2681	CLIP-seq
MIRT2049828	hsa-miR-2909	CLIP-seq
MIRT2049829	hsa-miR-296-3p	CLIP-seq
MIRT2278793	hsa-miR-3120-3p	CLIP-seq
MIRT2278794	hsa-miR-3124-3p	CLIP-seq
MIRT2278795	hsa-miR-3150a-3p	CLIP-seq
MIRT2278796	hsa-miR-3175	CLIP-seq
MIRT2278797	hsa-miR-3188	CLIP-seq
MIRT2278798	hsa-miR-329	CLIP-seq
MIRT2278799	hsa-miR-337-3p	CLIP-seq
MIRT1172348	hsa-miR-34b	CLIP-seq
MIRT2278800	hsa-miR-3613-3p	CLIP-seq
MIRT2278801	hsa-miR-3614-3p	CLIP-seq
MIRT2278802	hsa-miR-362-3p	CLIP-seq
MIRT2278803	hsa-miR-3664-5p	CLIP-seq
MIRT2278804	hsa-miR-3671	CLIP-seq
MIRT1172351	hsa-miR-3673	CLIP-seq
MIRT2278805	hsa-miR-3684	CLIP-seq
MIRT2278806	hsa-miR-3685	CLIP-seq
MIRT2278807	hsa-miR-3690	CLIP-seq
MIRT2278808	hsa-miR-384	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT2049830	hsa-miR-3927	CLIP-seq
MIRT2278809	hsa-miR-3941	CLIP-seq
MIRT2278810	hsa-miR-3975	CLIP-seq
MIRT2278811	hsa-miR-421	CLIP-seq
MIRT2278812	hsa-miR-4254	CLIP-seq
MIRT2049831	hsa-miR-4260	CLIP-seq
MIRT2278813	hsa-miR-4264	CLIP-seq
MIRT2278814	hsa-miR-4271	CLIP-seq
MIRT2278815	hsa-miR-4279	CLIP-seq
MIRT2278816	hsa-miR-4307	CLIP-seq
MIRT2278817	hsa-miR-4328	CLIP-seq
MIRT2278818	hsa-miR-4452	CLIP-seq
MIRT2278819	hsa-miR-4470	CLIP-seq
MIRT2278820	hsa-miR-4639-3p	CLIP-seq
MIRT2278821	hsa-miR-4649-3p	CLIP-seq
MIRT2049833	hsa-miR-4650-3p	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT2049834	hsa-miR-4665-5p	CLIP-seq
MIRT2278822	hsa-miR-4668-5p	CLIP-seq
MIRT1172361	hsa-miR-4677-5p	CLIP-seq
MIRT2278823	hsa-miR-4704-3p	CLIP-seq
MIRT2278824	hsa-miR-4705	CLIP-seq
MIRT2278825	hsa-miR-4714-5p	CLIP-seq
MIRT2278826	hsa-miR-4725-3p	CLIP-seq
MIRT2278827	hsa-miR-4780	CLIP-seq
MIRT2278828	hsa-miR-4789-5p	CLIP-seq
MIRT2278829	hsa-miR-485-5p	CLIP-seq
MIRT2278830	hsa-miR-548p	CLIP-seq
MIRT2278831	hsa-miR-579	CLIP-seq
MIRT2278832	hsa-miR-582-5p	CLIP-seq
MIRT2049836	hsa-miR-590-3p	CLIP-seq
MIRT2278833	hsa-miR-603	CLIP-seq
MIRT2049837	hsa-miR-607	CLIP-seq
MIRT1172368	hsa-miR-613	CLIP-seq
MIRT2278834	hsa-miR-623	CLIP-seq
MIRT2278835	hsa-miR-668	CLIP-seq
MIRT2278836	hsa-miR-939	CLIP-seq
MIRT2278811	hsa-miR-421	CLIP-seq
MIRT2278819	hsa-miR-4470	CLIP-seq
MIRT2431465	hsa-miR-450b-5p	CLIP-seq
MIRT2431466	hsa-miR-518a-5p	CLIP-seq
MIRT2431467	hsa-miR-527	CLIP-seq
MIRT2454811	hsa-miR-1279	CLIP-seq
MIRT2454812	hsa-miR-203	CLIP-seq
MIRT2454813	hsa-miR-3612	CLIP-seq
MIRT2454814	hsa-miR-4443	CLIP-seq
MIRT2278818	hsa-miR-4452	CLIP-seq
MIRT2454815	hsa-miR-650	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005654	Component	Nucleoplasm	IDA
GO:0009617	Process	Response to bacterium	IEA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
608806	23219	ENSG00000177694

Q58DX5

Protein name

Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2)

Protein function

May be catalytically inactive.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04389	Peptidase_M28	431 → 622	Peptidase family M28	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas.

Sequence

MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESG
FDQFQLDGAENQNLGHSETIDLNLDSIQPATSPKGRFQRLQEESDYITHYTRSAPKSNRC
NFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCF
HPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQI
ALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQV
QTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSK
VKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLE
GPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQN
NLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFL
VKQAPPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASNETLQEALSEVLNSINSAQVYF
KAGLDVFKSVLDGKN

Sequence length

795

Interactions

View interactions

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Uncertain significance	rs199849033	RCV005939237
Colorectal cancer	Uncertain significance	rs199849033	RCV005939238
Developmental cataract	Likely benign	rs1553904048	RCV001376653
Lung cancer	Benign	rs80191780	RCV005908758
NAALADL2-related disorder	Likely benign; Uncertain significance	rs758498922, rs182698376, rs2529933561	RCV003894529 RCV003954713 RCV003967177
Thyroid cancer, nonmedullary, 1	Benign	rs80191780	RCV005908757

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Autism Spectrum Disorder	Associate	26398136
Behcet Syndrome	Associate	28045058
Breast Neoplasms	Associate	28145423
Inflammation	Associate	28045058
Mucocutaneous Lymph Node Syndrome	Associate	19132087
Personality Disorders	Associate	32796921
Prostate Cancer Hereditary 7	Associate	25939597, 32796921
Prostatic Neoplasms	Associate	25939597, 27409348, 32796921
Squamous Cell Carcinoma of Head and Neck	Associate	37232821
Vascular Diseases	Associate	25939597

NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2)