NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2)

Gene

• Entrez ID: 254827
• Gene name: N-acetylated alpha-linked acidic dipeptidase like 2
• Gene symbol: NAALADL2
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3q26.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1172342	hsa-miR-1	CLIP-seq
MIRT1172343	hsa-miR-206	CLIP-seq
MIRT1172344	hsa-miR-3119	CLIP-seq
MIRT1172345	hsa-miR-3125	CLIP-seq
MIRT1172346	hsa-miR-3152-3p	CLIP-seq
MIRT1172347	hsa-miR-3161	CLIP-seq
MIRT1172348	hsa-miR-34b	CLIP-seq
MIRT1172349	hsa-miR-3653	CLIP-seq
MIRT1172350	hsa-miR-3658	CLIP-seq
MIRT1172351	hsa-miR-3673	CLIP-seq
MIRT1172352	hsa-miR-3682-3p	CLIP-seq
MIRT1172353	hsa-miR-375	CLIP-seq
MIRT1172354	hsa-miR-3916	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT1172356	hsa-miR-3936	CLIP-seq
MIRT1172357	hsa-miR-4273	CLIP-seq
MIRT1172358	hsa-miR-4477a	CLIP-seq
MIRT1172359	hsa-miR-4502	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT1172361	hsa-miR-4677-5p	CLIP-seq
MIRT1172362	hsa-miR-4695-3p	CLIP-seq
MIRT1172363	hsa-miR-4709-3p	CLIP-seq
MIRT1172364	hsa-miR-4714-3p	CLIP-seq
MIRT1172365	hsa-miR-4762-3p	CLIP-seq
MIRT1172366	hsa-miR-4799-5p	CLIP-seq
MIRT1172367	hsa-miR-582-3p	CLIP-seq
MIRT1172368	hsa-miR-613	CLIP-seq
MIRT2049825	hsa-miR-1275	CLIP-seq
MIRT2049826	hsa-miR-196a	CLIP-seq
MIRT2049827	hsa-miR-196b	CLIP-seq
MIRT2049828	hsa-miR-2909	CLIP-seq
MIRT2049829	hsa-miR-296-3p	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT2049830	hsa-miR-3927	CLIP-seq
MIRT2049831	hsa-miR-4260	CLIP-seq
MIRT2049832	hsa-miR-4525	CLIP-seq
MIRT2049833	hsa-miR-4650-3p	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT2049834	hsa-miR-4665-5p	CLIP-seq
MIRT2049835	hsa-miR-4723-5p	CLIP-seq
MIRT2049836	hsa-miR-590-3p	CLIP-seq
MIRT2049837	hsa-miR-607	CLIP-seq
MIRT2049838	hsa-miR-625	CLIP-seq
MIRT1172342	hsa-miR-1	CLIP-seq
MIRT2049825	hsa-miR-1275	CLIP-seq
MIRT2278783	hsa-miR-1284	CLIP-seq
MIRT2278784	hsa-miR-1305	CLIP-seq
MIRT2278785	hsa-miR-139-5p	CLIP-seq
MIRT2278786	hsa-miR-190	CLIP-seq
MIRT2278787	hsa-miR-190b	CLIP-seq
MIRT2049826	hsa-miR-196a	CLIP-seq
MIRT2049827	hsa-miR-196b	CLIP-seq
MIRT2278788	hsa-miR-1976	CLIP-seq
MIRT1172343	hsa-miR-206	CLIP-seq
MIRT2278789	hsa-miR-2110	CLIP-seq
MIRT2278790	hsa-miR-2116	CLIP-seq
MIRT2278791	hsa-miR-2467-5p	CLIP-seq
MIRT2278792	hsa-miR-2681	CLIP-seq
MIRT2049828	hsa-miR-2909	CLIP-seq
MIRT2049829	hsa-miR-296-3p	CLIP-seq
MIRT2278793	hsa-miR-3120-3p	CLIP-seq
MIRT2278794	hsa-miR-3124-3p	CLIP-seq
MIRT2278795	hsa-miR-3150a-3p	CLIP-seq
MIRT2278796	hsa-miR-3175	CLIP-seq
MIRT2278797	hsa-miR-3188	CLIP-seq
MIRT2278798	hsa-miR-329	CLIP-seq
MIRT2278799	hsa-miR-337-3p	CLIP-seq
MIRT1172348	hsa-miR-34b	CLIP-seq
MIRT2278800	hsa-miR-3613-3p	CLIP-seq
MIRT2278801	hsa-miR-3614-3p	CLIP-seq
MIRT2278802	hsa-miR-362-3p	CLIP-seq
MIRT2278803	hsa-miR-3664-5p	CLIP-seq
MIRT2278804	hsa-miR-3671	CLIP-seq
MIRT1172351	hsa-miR-3673	CLIP-seq
MIRT2278805	hsa-miR-3684	CLIP-seq
MIRT2278806	hsa-miR-3685	CLIP-seq
MIRT2278807	hsa-miR-3690	CLIP-seq
MIRT2278808	hsa-miR-384	CLIP-seq
MIRT1172355	hsa-miR-3921	CLIP-seq
MIRT2049830	hsa-miR-3927	CLIP-seq
MIRT2278809	hsa-miR-3941	CLIP-seq
MIRT2278810	hsa-miR-3975	CLIP-seq
MIRT2278811	hsa-miR-421	CLIP-seq
MIRT2278812	hsa-miR-4254	CLIP-seq
MIRT2049831	hsa-miR-4260	CLIP-seq
MIRT2278813	hsa-miR-4264	CLIP-seq
MIRT2278814	hsa-miR-4271	CLIP-seq
MIRT2278815	hsa-miR-4279	CLIP-seq
MIRT2278816	hsa-miR-4307	CLIP-seq
MIRT2278817	hsa-miR-4328	CLIP-seq
MIRT2278818	hsa-miR-4452	CLIP-seq
MIRT2278819	hsa-miR-4470	CLIP-seq
MIRT2278820	hsa-miR-4639-3p	CLIP-seq
MIRT2278821	hsa-miR-4649-3p	CLIP-seq
MIRT2049833	hsa-miR-4650-3p	CLIP-seq
MIRT1172360	hsa-miR-4653-5p	CLIP-seq
MIRT2049834	hsa-miR-4665-5p	CLIP-seq
MIRT2278822	hsa-miR-4668-5p	CLIP-seq
MIRT1172361	hsa-miR-4677-5p	CLIP-seq
MIRT2278823	hsa-miR-4704-3p	CLIP-seq
MIRT2278824	hsa-miR-4705	CLIP-seq
MIRT2278825	hsa-miR-4714-5p	CLIP-seq
MIRT2278826	hsa-miR-4725-3p	CLIP-seq
MIRT2278827	hsa-miR-4780	CLIP-seq
MIRT2278828	hsa-miR-4789-5p	CLIP-seq
MIRT2278829	hsa-miR-485-5p	CLIP-seq
MIRT2278830	hsa-miR-548p	CLIP-seq
MIRT2278831	hsa-miR-579	CLIP-seq
MIRT2278832	hsa-miR-582-5p	CLIP-seq
MIRT2049836	hsa-miR-590-3p	CLIP-seq
MIRT2278833	hsa-miR-603	CLIP-seq
MIRT2049837	hsa-miR-607	CLIP-seq
MIRT1172368	hsa-miR-613	CLIP-seq
MIRT2278834	hsa-miR-623	CLIP-seq
MIRT2278835	hsa-miR-668	CLIP-seq
MIRT2278836	hsa-miR-939	CLIP-seq
MIRT2278811	hsa-miR-421	CLIP-seq
MIRT2278819	hsa-miR-4470	CLIP-seq
MIRT2431465	hsa-miR-450b-5p	CLIP-seq
MIRT2431466	hsa-miR-518a-5p	CLIP-seq
MIRT2431467	hsa-miR-527	CLIP-seq
MIRT2454811	hsa-miR-1279	CLIP-seq
MIRT2454812	hsa-miR-203	CLIP-seq
MIRT2454813	hsa-miR-3612	CLIP-seq
MIRT2454814	hsa-miR-4443	CLIP-seq
MIRT2278818	hsa-miR-4452	CLIP-seq
MIRT2454815	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005654	Component	Nucleoplasm	IDA
GO:0009617	Process	Response to bacterium	IEA
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: 608806
• HGNC: 23219
• e!Ensembl: ENSG00000177694

Protein

• UniProt ID: Q58DX5
• Protein name: Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2)
• Protein function: May be catalytically inactive.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04389	Peptidase_M28	431 → 622	Peptidase family M28	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas.
• Sequence:

  MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESG
  FDQFQLDGAENQNLGHSETIDLNLDSIQPATSPKGRFQRLQEESDYITHYTRSAPKSNRC
  NFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKS
  FRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCF
  HPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQI
  ALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGY
  PSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQV
  QTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSK
  VKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPV
  ASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLE
  GPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQN
  NLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFL
  VKQAPPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASNETLQEALSEVLNSINSAQVYF
  KAGLDVFKSVLDGKN

• Sequence length: 795

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	25939597

Unknown
Disease term	Disease name	Evidence	References	Source
Endometriosis	Endometriosis		28333195	ClinVar
Ischemic stroke	Ischemic stroke		30796134	ClinVar
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Uterine Fibroids	Uterine Fibroids			GWAS
Lung adenocarcinoma	Lung adenocarcinoma	Validation that loss of Tgfbr2 results in more aggressive and T cell-excluded KP lung tumors		GWAS, CBGDA
Oligodendroglioma	Oligodendroglioma			GWAS
Alzheimer disease	Alzheimer disease			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Schizophrenia	Schizophrenia			GWAS
Insomnia	Insomnia			GWAS
Eosinophilia	Eosinophilia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Autism Spectrum Disorder	Associate	26398136
Behcet Syndrome	Associate	28045058
Breast Neoplasms	Associate	28145423
Inflammation	Associate	28045058
Mucocutaneous Lymph Node Syndrome	Associate	19132087
Personality Disorders	Associate	32796921
Prostate Cancer Hereditary 7	Associate	25939597, 32796921
Prostatic Neoplasms	Associate	25939597, 27409348, 32796921
Squamous Cell Carcinoma of Head and Neck	Associate	37232821
Vascular Diseases	Associate	25939597