Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
254428
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 41 member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC41A1
Synonyms (NCBI Gene) Gene synonyms aliases
MgtE, NPHPL2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT653521 hsa-miR-224-5p HITS-CLIP 23824327
MIRT061952 hsa-miR-1250-3p HITS-CLIP 23824327
MIRT653520 hsa-miR-153-5p HITS-CLIP 23824327
MIRT653519 hsa-miR-205-5p HITS-CLIP 23824327
MIRT653518 hsa-miR-3124-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 18367447, 22031603, 23976986
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610801 19429 ENSG00000133065
Protein
UniProt ID Q8IVJ1
Protein name Solute carrier family 41 member 1
Protein function Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed:18367447, PubMed:22031603, PubMed:23661805, PubMed:23976986). Transporter activity is driven by the inwardly directed electrochemical gradi
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01769 MgtE 139 273 Divalent cation transporter Family
PF01769 MgtE 353 497 Divalent cation transporter Family
Tissue specificity TISSUE SPECIFICITY: Highest expression levels in heart and testis, slightly less in skeletal muscles, prostate, adrenal gland and thyroid, and weakest in the hematopoietic tissues bones marrow, lymph node, thymus and spleen. In the kidney, it is expressed
Sequence
MSSKPEPKDVHQLNGTGPSASPCSSDGPGREPLAGTSEFLGPDGAGVEVVIESRANAKGV
REEDALLENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQVLFPFLLAGFGTVAAGMVL
DIVQHWEVFQKVTEVFILVPALLGLKGNLEMTLASRLSTAANIGHMDTPKELWRMITGNM
ALIQVQATVVGFLASIAAVVFGWIPDGHFSIPHAFLLCASSVATAFIASLVLGMIMIGVI
IGSRKIGINPDNVATPIAASLGDLITLALLSGI
SWGLYLELNHWRYIYPLVCAFFVALLP
VWVVLARRSPATREVLYSGWEPVIIAMAISSVGGLILDKTVSDPNFAGMAVFTPVINGVG
GNLVAVQASRISTFLHMNGMPGENSEQAPRRCPSPCTTFFSPDVNSRSARVLFLLVVPGH
LVFLYTISCMQGGHTTLTLIFIIFYMTAALLQVLILLYIADWMVHWMWGRGLDPDNFSIP
YLTALGDLLGTGLLALS
FHVLWLIGDRDTDVGD
Sequence length 513
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Metal ion SLC transporters
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Allergic Sensitization Allergic sensitization N/A N/A GWAS
Nephronophthisis nephronophthisis-like nephropathy 2 N/A N/A GenCC
Prostate cancer Prostate cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 35163527
Carcinoma Hepatocellular Stimulate 39628683
Diabetes Mellitus Type 2 Associate 25733456
Hypertension Associate 22031603
Neoplasms Associate 39628683
Nerve Degeneration Associate 23976986
Neurodegenerative Diseases Associate 35163527
Parkinson Disease Associate 20683486, 23976986, 27612022, 35163527