Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	253827
Gene name	Methionine sulfoxide reductase B3
Gene symbol	MSRB3
Synonyms (NCBI Gene)	DFNB74
Chromosome	12
Chromosome location	12q14.3
Summary	The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One o

Show/Hide all (5)

SNP ID	Visualize variation	Clinical significance	Consequence
rs144038296	C>A,T	Conflicting-interpretations-of-pathogenicity	Missense variant, genic downstream transcript variant, coding sequence variant
rs149258390	C>A,T	Pathogenic	Synonymous variant, intron variant, stop gained, coding sequence variant
rs201306709	G>A	Likely-pathogenic, not-provided	Genic downstream transcript variant, splice acceptor variant
rs387907088	T>G	Pathogenic	Missense variant, coding sequence variant
rs751906778	G>A	Pathogenic	Splice acceptor variant, genic downstream transcript variant

231

Show/Hide all (231)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022224	hsa-miR-124-3p	Microarray	18668037
MIRT026193	hsa-miR-192-5p	Microarray	19074876
MIRT656117	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT656116	hsa-miR-4676-5p	HITS-CLIP	23824327
MIRT656115	hsa-miR-575	HITS-CLIP	23824327
MIRT656114	hsa-miR-2392	HITS-CLIP	23824327
MIRT656113	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT656112	hsa-miR-1193	HITS-CLIP	23824327
MIRT656111	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT656110	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT656109	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT656108	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT656107	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT656106	hsa-miR-5096	HITS-CLIP	23824327
MIRT656105	hsa-miR-1303	HITS-CLIP	23824327
MIRT733797	hsa-miR-107	MicroarrayqRT-PCR	33789319
MIRT656117	hsa-miR-6858-3p	HITS-CLIP	23824327
MIRT656116	hsa-miR-4676-5p	HITS-CLIP	23824327
MIRT656115	hsa-miR-575	HITS-CLIP	23824327
MIRT656114	hsa-miR-2392	HITS-CLIP	23824327
MIRT656113	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT656112	hsa-miR-1193	HITS-CLIP	23824327
MIRT656111	hsa-miR-193b-5p	HITS-CLIP	23824327
MIRT656110	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT656109	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT656108	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT656107	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT656106	hsa-miR-5096	HITS-CLIP	23824327
MIRT656105	hsa-miR-1303	HITS-CLIP	23824327
MIRT1161872	hsa-miR-1	CLIP-seq
MIRT1161873	hsa-miR-1200	CLIP-seq
MIRT1161874	hsa-miR-128	CLIP-seq
MIRT1161875	hsa-miR-1305	CLIP-seq
MIRT1161876	hsa-miR-136	CLIP-seq
MIRT1161877	hsa-miR-1976	CLIP-seq
MIRT1161878	hsa-miR-206	CLIP-seq
MIRT1161879	hsa-miR-2113	CLIP-seq
MIRT1161880	hsa-miR-2467-3p	CLIP-seq
MIRT1161881	hsa-miR-3138	CLIP-seq
MIRT1161882	hsa-miR-3153	CLIP-seq
MIRT1161883	hsa-miR-3199	CLIP-seq
MIRT1161884	hsa-miR-3678-3p	CLIP-seq
MIRT1161885	hsa-miR-377	CLIP-seq
MIRT1161886	hsa-miR-3941	CLIP-seq
MIRT1161887	hsa-miR-4279	CLIP-seq
MIRT1161888	hsa-miR-4297	CLIP-seq
MIRT1161889	hsa-miR-4324	CLIP-seq
MIRT1161890	hsa-miR-4491	CLIP-seq
MIRT1161891	hsa-miR-4497	CLIP-seq
MIRT1161892	hsa-miR-4657	CLIP-seq
MIRT1161893	hsa-miR-466	CLIP-seq
MIRT1161894	hsa-miR-4672	CLIP-seq
MIRT1161895	hsa-miR-4699-5p	CLIP-seq
MIRT1161896	hsa-miR-4722-3p	CLIP-seq
MIRT1161897	hsa-miR-4760-3p	CLIP-seq
MIRT1161898	hsa-miR-4781-3p	CLIP-seq
MIRT1161899	hsa-miR-4800-5p	CLIP-seq
MIRT1161900	hsa-miR-496	CLIP-seq
MIRT1161901	hsa-miR-544b	CLIP-seq
MIRT1161902	hsa-miR-548t	CLIP-seq
MIRT1161903	hsa-miR-552	CLIP-seq
MIRT1161904	hsa-miR-607	CLIP-seq
MIRT1161905	hsa-miR-613	CLIP-seq
MIRT1161906	hsa-miR-616	CLIP-seq
MIRT1161907	hsa-miR-640	CLIP-seq
MIRT1161908	hsa-miR-764	CLIP-seq
MIRT1161909	hsa-miR-938	CLIP-seq
MIRT1161876	hsa-miR-136	CLIP-seq
MIRT1161910	hsa-miR-150	CLIP-seq
MIRT1161877	hsa-miR-1976	CLIP-seq
MIRT1161887	hsa-miR-4279	CLIP-seq
MIRT1161888	hsa-miR-4297	CLIP-seq
MIRT1161891	hsa-miR-4497	CLIP-seq
MIRT1161911	hsa-miR-4757-5p	CLIP-seq
MIRT1161907	hsa-miR-640	CLIP-seq
MIRT1161912	hsa-miR-25	CLIP-seq
MIRT1161883	hsa-miR-3199	CLIP-seq
MIRT1161913	hsa-miR-32	CLIP-seq
MIRT1161914	hsa-miR-363	CLIP-seq
MIRT1161915	hsa-miR-367	CLIP-seq
MIRT1161916	hsa-miR-4277	CLIP-seq
MIRT1161917	hsa-miR-4317	CLIP-seq
MIRT1161918	hsa-miR-4325	CLIP-seq
MIRT1161903	hsa-miR-552	CLIP-seq
MIRT1161908	hsa-miR-764	CLIP-seq
MIRT1161919	hsa-miR-92a	CLIP-seq
MIRT1161920	hsa-miR-92b	CLIP-seq
MIRT1161876	hsa-miR-136	CLIP-seq
MIRT1161876	hsa-miR-136	CLIP-seq
MIRT1161877	hsa-miR-1976	CLIP-seq
MIRT1161907	hsa-miR-640	CLIP-seq
MIRT2046426	hsa-miR-4727-5p	CLIP-seq
MIRT2046427	hsa-miR-590-3p	CLIP-seq
MIRT2275505	hsa-miR-4695-3p	CLIP-seq
MIRT2275506	hsa-miR-4735-5p	CLIP-seq
MIRT2275507	hsa-miR-4775	CLIP-seq
MIRT2275508	hsa-miR-3670	CLIP-seq
MIRT2275509	hsa-miR-556-5p	CLIP-seq
MIRT1161885	hsa-miR-377	CLIP-seq
MIRT2391125	hsa-miR-587	CLIP-seq
MIRT2465671	hsa-miR-1281	CLIP-seq
MIRT1161910	hsa-miR-150	CLIP-seq
MIRT2465672	hsa-miR-498	CLIP-seq
MIRT2574514	hsa-miR-105	CLIP-seq
MIRT2574515	hsa-miR-1257	CLIP-seq
MIRT1161874	hsa-miR-128	CLIP-seq
MIRT2465671	hsa-miR-1281	CLIP-seq
MIRT2574516	hsa-miR-1298	CLIP-seq
MIRT2574517	hsa-miR-135a	CLIP-seq
MIRT2574518	hsa-miR-135b	CLIP-seq
MIRT2574519	hsa-miR-1468	CLIP-seq
MIRT1161910	hsa-miR-150	CLIP-seq
MIRT2574520	hsa-miR-1915	CLIP-seq
MIRT2574521	hsa-miR-197	CLIP-seq
MIRT2574522	hsa-miR-2116	CLIP-seq
MIRT2574523	hsa-miR-221	CLIP-seq
MIRT2574524	hsa-miR-222	CLIP-seq
MIRT2574525	hsa-miR-2355-3p	CLIP-seq
MIRT2574526	hsa-miR-3064-3p	CLIP-seq
MIRT2574527	hsa-miR-3121-5p	CLIP-seq
MIRT2574528	hsa-miR-3126-3p	CLIP-seq
MIRT2574529	hsa-miR-3128	CLIP-seq
MIRT2574530	hsa-miR-3135b	CLIP-seq
MIRT2574531	hsa-miR-3143	CLIP-seq
MIRT2574532	hsa-miR-3168	CLIP-seq
MIRT1161883	hsa-miR-3199	CLIP-seq
MIRT2574533	hsa-miR-3607-5p	CLIP-seq
MIRT2574534	hsa-miR-3611	CLIP-seq
MIRT2574535	hsa-miR-365	CLIP-seq
MIRT2574536	hsa-miR-3664-3p	CLIP-seq
MIRT2574537	hsa-miR-3925-3p	CLIP-seq
MIRT2574538	hsa-miR-3975	CLIP-seq
MIRT2574539	hsa-miR-411	CLIP-seq
MIRT2574540	hsa-miR-4257	CLIP-seq
MIRT2574541	hsa-miR-4282	CLIP-seq
MIRT2574542	hsa-miR-4433	CLIP-seq
MIRT2574543	hsa-miR-4459	CLIP-seq
MIRT2574544	hsa-miR-4487	CLIP-seq
MIRT2574545	hsa-miR-4641	CLIP-seq
MIRT2574546	hsa-miR-4720-5p	CLIP-seq
MIRT2275506	hsa-miR-4735-5p	CLIP-seq
MIRT2574547	hsa-miR-4738-3p	CLIP-seq
MIRT2574548	hsa-miR-4749-3p	CLIP-seq
MIRT2574549	hsa-miR-4768-3p	CLIP-seq
MIRT2275507	hsa-miR-4775	CLIP-seq
MIRT2574550	hsa-miR-4787-3p	CLIP-seq
MIRT2574551	hsa-miR-4794	CLIP-seq
MIRT2574552	hsa-miR-4797-3p	CLIP-seq
MIRT2574553	hsa-miR-4797-5p	CLIP-seq
MIRT2574554	hsa-miR-4799-3p	CLIP-seq
MIRT2574555	hsa-miR-4802-3p	CLIP-seq
MIRT2574556	hsa-miR-4803	CLIP-seq
MIRT2574557	hsa-miR-483-5p	CLIP-seq
MIRT2465672	hsa-miR-498	CLIP-seq
MIRT2574558	hsa-miR-499-3p	CLIP-seq
MIRT2574559	hsa-miR-499a-3p	CLIP-seq
MIRT2574560	hsa-miR-520a-5p	CLIP-seq
MIRT2574561	hsa-miR-525-5p	CLIP-seq
MIRT2574562	hsa-miR-548u	CLIP-seq
MIRT2574563	hsa-miR-570	CLIP-seq
MIRT2574564	hsa-miR-576-5p	CLIP-seq
MIRT2574565	hsa-miR-578	CLIP-seq
MIRT2391125	hsa-miR-587	CLIP-seq
MIRT2046427	hsa-miR-590-3p	CLIP-seq
MIRT2574566	hsa-miR-593	CLIP-seq
MIRT2574567	hsa-miR-676	CLIP-seq
MIRT2574568	hsa-miR-766	CLIP-seq
MIRT2685433	hsa-miR-1178	CLIP-seq
MIRT2685434	hsa-miR-1252	CLIP-seq
MIRT2465671	hsa-miR-1281	CLIP-seq
MIRT2685435	hsa-miR-1299	CLIP-seq
MIRT2574517	hsa-miR-135a	CLIP-seq
MIRT2574518	hsa-miR-135b	CLIP-seq
MIRT2685436	hsa-miR-137	CLIP-seq
MIRT1161910	hsa-miR-150	CLIP-seq
MIRT2685437	hsa-miR-1587	CLIP-seq
MIRT2574520	hsa-miR-1915	CLIP-seq
MIRT2574522	hsa-miR-2116	CLIP-seq
MIRT2574523	hsa-miR-221	CLIP-seq
MIRT2574524	hsa-miR-222	CLIP-seq
MIRT2574525	hsa-miR-2355-3p	CLIP-seq
MIRT2574526	hsa-miR-3064-3p	CLIP-seq
MIRT2574527	hsa-miR-3121-5p	CLIP-seq
MIRT2574528	hsa-miR-3126-3p	CLIP-seq
MIRT2574529	hsa-miR-3128	CLIP-seq
MIRT2574530	hsa-miR-3135b	CLIP-seq
MIRT2574532	hsa-miR-3168	CLIP-seq
MIRT1161883	hsa-miR-3199	CLIP-seq
MIRT2574534	hsa-miR-3611	CLIP-seq
MIRT2685438	hsa-miR-3652	CLIP-seq
MIRT2574536	hsa-miR-3664-3p	CLIP-seq
MIRT2685439	hsa-miR-3913-3p	CLIP-seq
MIRT2574538	hsa-miR-3975	CLIP-seq
MIRT2574539	hsa-miR-411	CLIP-seq
MIRT1161888	hsa-miR-4297	CLIP-seq
MIRT2685440	hsa-miR-4420	CLIP-seq
MIRT2685441	hsa-miR-4430	CLIP-seq
MIRT2574542	hsa-miR-4433	CLIP-seq
MIRT2574543	hsa-miR-4459	CLIP-seq
MIRT2574544	hsa-miR-4487	CLIP-seq
MIRT2685442	hsa-miR-4492	CLIP-seq
MIRT1161891	hsa-miR-4497	CLIP-seq
MIRT2685443	hsa-miR-4498	CLIP-seq
MIRT2685444	hsa-miR-4656	CLIP-seq
MIRT2685445	hsa-miR-4675	CLIP-seq
MIRT2574546	hsa-miR-4720-5p	CLIP-seq
MIRT2275506	hsa-miR-4735-5p	CLIP-seq
MIRT2685446	hsa-miR-4741	CLIP-seq
MIRT2574548	hsa-miR-4749-3p	CLIP-seq
MIRT2574549	hsa-miR-4768-3p	CLIP-seq
MIRT2275507	hsa-miR-4775	CLIP-seq
MIRT2574550	hsa-miR-4787-3p	CLIP-seq
MIRT2574551	hsa-miR-4794	CLIP-seq
MIRT2574552	hsa-miR-4797-3p	CLIP-seq
MIRT2574553	hsa-miR-4797-5p	CLIP-seq
MIRT2574554	hsa-miR-4799-3p	CLIP-seq
MIRT2574555	hsa-miR-4802-3p	CLIP-seq
MIRT2574557	hsa-miR-483-5p	CLIP-seq
MIRT2685447	hsa-miR-489	CLIP-seq
MIRT2465672	hsa-miR-498	CLIP-seq
MIRT2574558	hsa-miR-499-3p	CLIP-seq
MIRT2574559	hsa-miR-499a-3p	CLIP-seq
MIRT2685448	hsa-miR-550a	CLIP-seq
MIRT1161903	hsa-miR-552	CLIP-seq
MIRT2574563	hsa-miR-570	CLIP-seq
MIRT2046427	hsa-miR-590-3p	CLIP-seq
MIRT2574567	hsa-miR-676	CLIP-seq
MIRT2685449	hsa-miR-718	CLIP-seq
MIRT2685450	hsa-miR-762	CLIP-seq
MIRT1161908	hsa-miR-764	CLIP-seq
MIRT2685451	hsa-miR-875-3p	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005739	Component	Mitochondrion	IDA	14699060
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	14699060
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006979	Process	Response to oxidative stress	IEA
GO:0008270	Function	Zinc ion binding	IDA	14699060
GO:0008270	Function	Zinc ion binding	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016671	Function	Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IEA
GO:0030091	Process	Protein repair	IDA	14699060
GO:0030091	Process	Protein repair	IEA
GO:0030091	Process	Protein repair	TAS
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	IBA
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	IDA	14699060
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	IEA
GO:0033743	Function	Peptide-methionine (R)-S-oxide reductase activity	TAS
GO:0033745	Function	L-methionine-(R)-S-oxide reductase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
613719	27375	ENSG00000174099

Q8IXL7

Protein name

Methionine-R-sulfoxide reductase B3 (MsrB3) (EC 1.8.4.12) (EC 1.8.4.14)

Protein function

Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.

PDB

6QA0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01641	SelR	49 → 168	SelR domain	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15914630, ECO:0000269|PubMed:21185009}.

Sequence

MSPRRTLPRPLSLCLSLCLCLCLAAALGSAQSGSCRDKKNCKVVFSQQELRKRLTPLQYH
VTQEKGTESAFEGEYTHHKDPGIYKCVVCGTPLFKSETKFDSGSGWPSFHDVINSEAITF
TDDFSYGMHRVETSCSQCGAHLGHIFDDGPRPTGKRYCINSAALSFTPADSSGTAEGGSG
VASPAQADKAEL

Sequence length

192

Interactions

View interactions

	Reactome
			Protein repair

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autosomal recessive nonsyndromic hearing loss 74	Likely pathogenic; Pathogenic	rs2136722469, rs949229098, rs774879831, rs387907088, rs149258390, rs751906778	RCV001823225 RCV001782462 RCV004018020 RCV000024049 RCV000024050 RCV000681530	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Hearing loss	Likely pathogenic	rs201306709	RCV000509391	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Hearing loss, autosomal recessive	Pathogenic	rs387907088	RCV001291459	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Rare genetic deafness	Likely pathogenic	rs201306709	RCV000216815	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOSOMAL RECESSIVE ISOLATED SENSORINEURAL DEAFNESS TYPE DFNB	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 74	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING IMPAIRMENT	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MSRB3-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SMALL CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSTRUCTIVE SLEEP APNEA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Papillary renal cell carcinoma type 1	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS OF BILATERAL EARS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SLEEP APNEA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Alzheimer Disease	Associate	30775993	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Infarction	Associate	30775993	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Injuries	Associate	30775993	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Associate	37884639	★★★★★ ★☆☆☆☆ Found in Text Mining only
Deafness	Associate	24949729	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hippocampal Sclerosis	Associate	36674637	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	25176350	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	25176350	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non Muscle Invasive Bladder Neoplasms	Associate	31011911	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	31900140	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prion Diseases	Associate	25313508	★★★★★ ★☆☆☆☆ Found in Text Mining only
Snoring	Associate	32060260	★★★★★ ★☆☆☆☆ Found in Text Mining only
Weight Gain	Associate	31900140	★★★★★ ★☆☆☆☆ Found in Text Mining only

MSRB3 (methionine sulfoxide reductase B3)