Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2537
Gene name	Interferon alpha inducible protein 6
Gene symbol	IFI6
Synonyms (NCBI Gene)	6-16FAM14CG1P3IFI-6-16IFI616
Chromosome	1
Chromosome location	1p35.3
Summary	This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mam

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019676	hsa-miR-375	Microarray	20215506
MIRT054332	hsa-miR-1225-3p	MicroarrayqRT-PCR	23593351
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT1060283	hsa-miR-2054	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1060285	hsa-miR-3672	CLIP-seq
MIRT1060286	hsa-miR-3689a-3p	CLIP-seq
MIRT1060287	hsa-miR-3689c	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT1060295	hsa-miR-4693-3p	CLIP-seq
MIRT1060296	hsa-miR-4728-5p	CLIP-seq
MIRT1060297	hsa-miR-4765	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT1060299	hsa-miR-500a	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1060302	hsa-miR-890	CLIP-seq
MIRT1060303	hsa-miR-1262	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060304	hsa-miR-4652-3p	CLIP-seq
MIRT1060305	hsa-miR-4670-3p	CLIP-seq
MIRT1060306	hsa-miR-4701-3p	CLIP-seq
MIRT1060307	hsa-miR-4778-5p	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1556558	hsa-miR-1304	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT1060283	hsa-miR-2054	CLIP-seq
MIRT1556559	hsa-miR-2110	CLIP-seq
MIRT1556560	hsa-miR-2467-5p	CLIP-seq
MIRT1556561	hsa-miR-3147	CLIP-seq
MIRT1556562	hsa-miR-3150a-3p	CLIP-seq
MIRT1556563	hsa-miR-3175	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1556564	hsa-miR-3188	CLIP-seq
MIRT1556565	hsa-miR-3612	CLIP-seq
MIRT1556566	hsa-miR-3614-5p	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1556567	hsa-miR-3975	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1556568	hsa-miR-4425	CLIP-seq
MIRT1556569	hsa-miR-4443	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT1556570	hsa-miR-4677-3p	CLIP-seq
MIRT1556571	hsa-miR-4679	CLIP-seq
MIRT1060295	hsa-miR-4693-3p	CLIP-seq
MIRT1060297	hsa-miR-4765	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT1556572	hsa-miR-485-5p	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT1556573	hsa-miR-571	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1556574	hsa-miR-650	CLIP-seq
MIRT1556575	hsa-miR-939	CLIP-seq
MIRT2014102	hsa-miR-1251	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT1556559	hsa-miR-2110	CLIP-seq
MIRT2014103	hsa-miR-23a	CLIP-seq
MIRT2014104	hsa-miR-23b	CLIP-seq
MIRT2014105	hsa-miR-23c	CLIP-seq
MIRT1556561	hsa-miR-3147	CLIP-seq
MIRT1556562	hsa-miR-3150a-3p	CLIP-seq
MIRT1556563	hsa-miR-3175	CLIP-seq
MIRT2014106	hsa-miR-4252	CLIP-seq
MIRT2014107	hsa-miR-4293	CLIP-seq
MIRT1556568	hsa-miR-4425	CLIP-seq
MIRT1060304	hsa-miR-4652-3p	CLIP-seq
MIRT1060295	hsa-miR-4693-3p	CLIP-seq
MIRT1060297	hsa-miR-4765	CLIP-seq
MIRT1060307	hsa-miR-4778-5p	CLIP-seq
MIRT2014108	hsa-miR-4793-3p	CLIP-seq
MIRT2014109	hsa-miR-5096	CLIP-seq
MIRT2014110	hsa-miR-596	CLIP-seq
MIRT1556575	hsa-miR-939	CLIP-seq
MIRT2014103	hsa-miR-23a	CLIP-seq
MIRT2014104	hsa-miR-23b	CLIP-seq
MIRT2014105	hsa-miR-23c	CLIP-seq
MIRT1060304	hsa-miR-4652-3p	CLIP-seq
MIRT1060307	hsa-miR-4778-5p	CLIP-seq
MIRT2014109	hsa-miR-5096	CLIP-seq
MIRT2014102	hsa-miR-1251	CLIP-seq
MIRT2437695	hsa-miR-1254	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1556558	hsa-miR-1304	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT1556560	hsa-miR-2467-5p	CLIP-seq
MIRT2437696	hsa-miR-3116	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1556564	hsa-miR-3188	CLIP-seq
MIRT1556565	hsa-miR-3612	CLIP-seq
MIRT1556566	hsa-miR-3614-5p	CLIP-seq
MIRT2437697	hsa-miR-3690	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1556567	hsa-miR-3975	CLIP-seq
MIRT2014106	hsa-miR-4252	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT2014107	hsa-miR-4293	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1556569	hsa-miR-4443	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT2437698	hsa-miR-4638-3p	CLIP-seq
MIRT1556570	hsa-miR-4677-3p	CLIP-seq
MIRT1556571	hsa-miR-4679	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT2014108	hsa-miR-4793-3p	CLIP-seq
MIRT1556572	hsa-miR-485-5p	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT1556573	hsa-miR-571	CLIP-seq
MIRT2014110	hsa-miR-596	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1556574	hsa-miR-650	CLIP-seq
MIRT2014102	hsa-miR-1251	CLIP-seq
MIRT2549544	hsa-miR-1252	CLIP-seq
MIRT2437695	hsa-miR-1254	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT2549545	hsa-miR-1273d	CLIP-seq
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1556558	hsa-miR-1304	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT2549546	hsa-miR-146a	CLIP-seq
MIRT2549547	hsa-miR-146b-5p	CLIP-seq
MIRT1060283	hsa-miR-2054	CLIP-seq
MIRT1556560	hsa-miR-2467-5p	CLIP-seq
MIRT2437696	hsa-miR-3116	CLIP-seq
MIRT2549548	hsa-miR-3174	CLIP-seq
MIRT2549549	hsa-miR-3185	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1556564	hsa-miR-3188	CLIP-seq
MIRT2549550	hsa-miR-3192	CLIP-seq
MIRT2549551	hsa-miR-338-5p	CLIP-seq
MIRT1556565	hsa-miR-3612	CLIP-seq
MIRT2549552	hsa-miR-3613-3p	CLIP-seq
MIRT1556566	hsa-miR-3614-5p	CLIP-seq
MIRT1060285	hsa-miR-3672	CLIP-seq
MIRT1060286	hsa-miR-3689a-3p	CLIP-seq
MIRT1060287	hsa-miR-3689c	CLIP-seq
MIRT2437697	hsa-miR-3690	CLIP-seq
MIRT2549553	hsa-miR-371-5p	CLIP-seq
MIRT2549554	hsa-miR-371b-5p	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1556567	hsa-miR-3975	CLIP-seq
MIRT2014106	hsa-miR-4252	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT2014107	hsa-miR-4293	CLIP-seq
MIRT2549555	hsa-miR-4300	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1556569	hsa-miR-4443	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT2437698	hsa-miR-4638-3p	CLIP-seq
MIRT2549556	hsa-miR-4646-5p	CLIP-seq
MIRT1556570	hsa-miR-4677-3p	CLIP-seq
MIRT1556571	hsa-miR-4679	CLIP-seq
MIRT1060296	hsa-miR-4728-5p	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT2014108	hsa-miR-4793-3p	CLIP-seq
MIRT1556572	hsa-miR-485-5p	CLIP-seq
MIRT1060299	hsa-miR-500a	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT2549557	hsa-miR-558	CLIP-seq
MIRT1556573	hsa-miR-571	CLIP-seq
MIRT2549558	hsa-miR-589	CLIP-seq
MIRT2014110	hsa-miR-596	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1556574	hsa-miR-650	CLIP-seq
MIRT1060302	hsa-miR-890	CLIP-seq
MIRT2549559	hsa-miR-920	CLIP-seq
MIRT2549560	hsa-miR-921	CLIP-seq
MIRT2014102	hsa-miR-1251	CLIP-seq
MIRT2437695	hsa-miR-1254	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT2549545	hsa-miR-1273d	CLIP-seq
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1556558	hsa-miR-1304	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT2549546	hsa-miR-146a	CLIP-seq
MIRT2549547	hsa-miR-146b-5p	CLIP-seq
MIRT1060283	hsa-miR-2054	CLIP-seq
MIRT1556560	hsa-miR-2467-5p	CLIP-seq
MIRT2437696	hsa-miR-3116	CLIP-seq
MIRT2549548	hsa-miR-3174	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1556564	hsa-miR-3188	CLIP-seq
MIRT2549551	hsa-miR-338-5p	CLIP-seq
MIRT1556565	hsa-miR-3612	CLIP-seq
MIRT2549552	hsa-miR-3613-3p	CLIP-seq
MIRT1556566	hsa-miR-3614-5p	CLIP-seq
MIRT1060285	hsa-miR-3672	CLIP-seq
MIRT1060286	hsa-miR-3689a-3p	CLIP-seq
MIRT1060287	hsa-miR-3689c	CLIP-seq
MIRT2437697	hsa-miR-3690	CLIP-seq
MIRT2549553	hsa-miR-371-5p	CLIP-seq
MIRT2549554	hsa-miR-371b-5p	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1556567	hsa-miR-3975	CLIP-seq
MIRT2014106	hsa-miR-4252	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT2014107	hsa-miR-4293	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1556569	hsa-miR-4443	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT2437698	hsa-miR-4638-3p	CLIP-seq
MIRT1556570	hsa-miR-4677-3p	CLIP-seq
MIRT1556571	hsa-miR-4679	CLIP-seq
MIRT1060296	hsa-miR-4728-5p	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT2014108	hsa-miR-4793-3p	CLIP-seq
MIRT1556572	hsa-miR-485-5p	CLIP-seq
MIRT1060299	hsa-miR-500a	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT1556573	hsa-miR-571	CLIP-seq
MIRT2549558	hsa-miR-589	CLIP-seq
MIRT2014110	hsa-miR-596	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1556574	hsa-miR-650	CLIP-seq
MIRT1060302	hsa-miR-890	CLIP-seq
MIRT2549560	hsa-miR-921	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	15685448
GO:0005739	Component	Mitochondrion	IDA	15685448, 25757571
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005743	Component	Mitochondrial inner membrane	IDA	29899394
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	IMP	27673746
GO:0006955	Process	Immune response	TAS	3017706
GO:0016020	Component	Membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IBA
GO:0031966	Component	Mitochondrial membrane	IDA	17823654
GO:0042058	Process	Regulation of epidermal growth factor receptor signaling pathway	IMP	25757571
GO:0043066	Process	Negative regulation of apoptotic process	IMP	17823654
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IMP	25757571
GO:0051607	Process	Defense response to virus	IEA
GO:0051607	Process	Defense response to virus	IMP	25757571
GO:0051902	Process	Negative regulation of mitochondrial depolarization	IMP	15685448
GO:0060090	Function	Molecular adaptor activity	IBA
GO:0072593	Process	Reactive oxygen species metabolic process	IMP	29899394
GO:0090201	Process	Negative regulation of release of cytochrome c from mitochondria	IMP	15685448
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IBA
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IMP	26244642
GO:0098586	Process	Cellular response to virus	IMP	26244642
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP	15685448

MIM	HGNC	e!Ensembl
147572	4054	ENSG00000126709

P09912

Protein name

Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16)

Protein function

Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06140	Ifi-6-16	41 → 119	Interferon-induced 6-16 family	Family

Sequence

MRQKAVSLFLCYLLLFTCSGVEAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPALG
FTGAGIAANSVAASLMSWSAILNGGGVPAGGLVATLQSLGAGGSSVVIGNIGALMGYATH
KYLDSEEDEE

Sequence length

130

Interactions

View interactions

	Reactome
			Interferon alpha/beta signaling

IFI6 (interferon alpha inducible protein 6)