Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2537
Gene name Gene Name - the full gene name approved by the HGNC.	Interferon alpha inducible protein 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IFI6
Synonyms (NCBI Gene) Gene synonyms aliases	6-16, FAM14C, G1P3, IFI-6-16, IFI616
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p35.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mam

Show/Hide all(242)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019676	hsa-miR-375	Microarray	20215506
MIRT054332	hsa-miR-1225-3p	Microarray, qRT-PCR	23593351
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT1060283	hsa-miR-2054	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1060285	hsa-miR-3672	CLIP-seq
MIRT1060286	hsa-miR-3689a-3p	CLIP-seq
MIRT1060287	hsa-miR-3689c	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT1060295	hsa-miR-4693-3p	CLIP-seq
MIRT1060296	hsa-miR-4728-5p	CLIP-seq
MIRT1060297	hsa-miR-4765	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT1060299	hsa-miR-500a	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1060302	hsa-miR-890	CLIP-seq
MIRT1060303	hsa-miR-1262	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060304	hsa-miR-4652-3p	CLIP-seq
MIRT1060305	hsa-miR-4670-3p	CLIP-seq
MIRT1060306	hsa-miR-4701-3p	CLIP-seq
MIRT1060307	hsa-miR-4778-5p	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1556558	hsa-miR-1304	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT1060283	hsa-miR-2054	CLIP-seq
MIRT1556559	hsa-miR-2110	CLIP-seq
MIRT1556560	hsa-miR-2467-5p	CLIP-seq
MIRT1556561	hsa-miR-3147	CLIP-seq
MIRT1556562	hsa-miR-3150a-3p	CLIP-seq
MIRT1556563	hsa-miR-3175	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1556564	hsa-miR-3188	CLIP-seq
MIRT1556565	hsa-miR-3612	CLIP-seq
MIRT1556566	hsa-miR-3614-5p	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1556567	hsa-miR-3975	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1556568	hsa-miR-4425	CLIP-seq
MIRT1556569	hsa-miR-4443	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT1556570	hsa-miR-4677-3p	CLIP-seq
MIRT1556571	hsa-miR-4679	CLIP-seq
MIRT1060295	hsa-miR-4693-3p	CLIP-seq
MIRT1060297	hsa-miR-4765	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT1556572	hsa-miR-485-5p	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT1556573	hsa-miR-571	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1556574	hsa-miR-650	CLIP-seq
MIRT1556575	hsa-miR-939	CLIP-seq
MIRT2014102	hsa-miR-1251	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT1556559	hsa-miR-2110	CLIP-seq
MIRT2014103	hsa-miR-23a	CLIP-seq
MIRT2014104	hsa-miR-23b	CLIP-seq
MIRT2014105	hsa-miR-23c	CLIP-seq
MIRT1556561	hsa-miR-3147	CLIP-seq
MIRT1556562	hsa-miR-3150a-3p	CLIP-seq
MIRT1556563	hsa-miR-3175	CLIP-seq
MIRT2014106	hsa-miR-4252	CLIP-seq
MIRT2014107	hsa-miR-4293	CLIP-seq
MIRT1556568	hsa-miR-4425	CLIP-seq
MIRT1060304	hsa-miR-4652-3p	CLIP-seq
MIRT1060295	hsa-miR-4693-3p	CLIP-seq
MIRT1060297	hsa-miR-4765	CLIP-seq
MIRT1060307	hsa-miR-4778-5p	CLIP-seq
MIRT2014108	hsa-miR-4793-3p	CLIP-seq
MIRT2014109	hsa-miR-5096	CLIP-seq
MIRT2014110	hsa-miR-596	CLIP-seq
MIRT1556575	hsa-miR-939	CLIP-seq
MIRT2014103	hsa-miR-23a	CLIP-seq
MIRT2014104	hsa-miR-23b	CLIP-seq
MIRT2014105	hsa-miR-23c	CLIP-seq
MIRT1060304	hsa-miR-4652-3p	CLIP-seq
MIRT1060307	hsa-miR-4778-5p	CLIP-seq
MIRT2014109	hsa-miR-5096	CLIP-seq
MIRT2014102	hsa-miR-1251	CLIP-seq
MIRT2437695	hsa-miR-1254	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1556558	hsa-miR-1304	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT1556560	hsa-miR-2467-5p	CLIP-seq
MIRT2437696	hsa-miR-3116	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1556564	hsa-miR-3188	CLIP-seq
MIRT1556565	hsa-miR-3612	CLIP-seq
MIRT1556566	hsa-miR-3614-5p	CLIP-seq
MIRT2437697	hsa-miR-3690	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1556567	hsa-miR-3975	CLIP-seq
MIRT2014106	hsa-miR-4252	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT2014107	hsa-miR-4293	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1556569	hsa-miR-4443	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT2437698	hsa-miR-4638-3p	CLIP-seq
MIRT1556570	hsa-miR-4677-3p	CLIP-seq
MIRT1556571	hsa-miR-4679	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT2014108	hsa-miR-4793-3p	CLIP-seq
MIRT1556572	hsa-miR-485-5p	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT1556573	hsa-miR-571	CLIP-seq
MIRT2014110	hsa-miR-596	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1556574	hsa-miR-650	CLIP-seq
MIRT2014102	hsa-miR-1251	CLIP-seq
MIRT2549544	hsa-miR-1252	CLIP-seq
MIRT2437695	hsa-miR-1254	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT2549545	hsa-miR-1273d	CLIP-seq
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1556558	hsa-miR-1304	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT2549546	hsa-miR-146a	CLIP-seq
MIRT2549547	hsa-miR-146b-5p	CLIP-seq
MIRT1060283	hsa-miR-2054	CLIP-seq
MIRT1556560	hsa-miR-2467-5p	CLIP-seq
MIRT2437696	hsa-miR-3116	CLIP-seq
MIRT2549548	hsa-miR-3174	CLIP-seq
MIRT2549549	hsa-miR-3185	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1556564	hsa-miR-3188	CLIP-seq
MIRT2549550	hsa-miR-3192	CLIP-seq
MIRT2549551	hsa-miR-338-5p	CLIP-seq
MIRT1556565	hsa-miR-3612	CLIP-seq
MIRT2549552	hsa-miR-3613-3p	CLIP-seq
MIRT1556566	hsa-miR-3614-5p	CLIP-seq
MIRT1060285	hsa-miR-3672	CLIP-seq
MIRT1060286	hsa-miR-3689a-3p	CLIP-seq
MIRT1060287	hsa-miR-3689c	CLIP-seq
MIRT2437697	hsa-miR-3690	CLIP-seq
MIRT2549553	hsa-miR-371-5p	CLIP-seq
MIRT2549554	hsa-miR-371b-5p	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1556567	hsa-miR-3975	CLIP-seq
MIRT2014106	hsa-miR-4252	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT2014107	hsa-miR-4293	CLIP-seq
MIRT2549555	hsa-miR-4300	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1556569	hsa-miR-4443	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT2437698	hsa-miR-4638-3p	CLIP-seq
MIRT2549556	hsa-miR-4646-5p	CLIP-seq
MIRT1556570	hsa-miR-4677-3p	CLIP-seq
MIRT1556571	hsa-miR-4679	CLIP-seq
MIRT1060296	hsa-miR-4728-5p	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT2014108	hsa-miR-4793-3p	CLIP-seq
MIRT1556572	hsa-miR-485-5p	CLIP-seq
MIRT1060299	hsa-miR-500a	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT2549557	hsa-miR-558	CLIP-seq
MIRT1556573	hsa-miR-571	CLIP-seq
MIRT2549558	hsa-miR-589	CLIP-seq
MIRT2014110	hsa-miR-596	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1556574	hsa-miR-650	CLIP-seq
MIRT1060302	hsa-miR-890	CLIP-seq
MIRT2549559	hsa-miR-920	CLIP-seq
MIRT2549560	hsa-miR-921	CLIP-seq
MIRT2014102	hsa-miR-1251	CLIP-seq
MIRT2437695	hsa-miR-1254	CLIP-seq
MIRT1556557	hsa-miR-1257	CLIP-seq
MIRT2549545	hsa-miR-1273d	CLIP-seq
MIRT1060280	hsa-miR-1285	CLIP-seq
MIRT1060281	hsa-miR-1299	CLIP-seq
MIRT1556558	hsa-miR-1304	CLIP-seq
MIRT1060282	hsa-miR-1469	CLIP-seq
MIRT2549546	hsa-miR-146a	CLIP-seq
MIRT2549547	hsa-miR-146b-5p	CLIP-seq
MIRT1060283	hsa-miR-2054	CLIP-seq
MIRT1556560	hsa-miR-2467-5p	CLIP-seq
MIRT2437696	hsa-miR-3116	CLIP-seq
MIRT2549548	hsa-miR-3174	CLIP-seq
MIRT1060284	hsa-miR-3187-5p	CLIP-seq
MIRT1556564	hsa-miR-3188	CLIP-seq
MIRT2549551	hsa-miR-338-5p	CLIP-seq
MIRT1556565	hsa-miR-3612	CLIP-seq
MIRT2549552	hsa-miR-3613-3p	CLIP-seq
MIRT1556566	hsa-miR-3614-5p	CLIP-seq
MIRT1060285	hsa-miR-3672	CLIP-seq
MIRT1060286	hsa-miR-3689a-3p	CLIP-seq
MIRT1060287	hsa-miR-3689c	CLIP-seq
MIRT2437697	hsa-miR-3690	CLIP-seq
MIRT2549553	hsa-miR-371-5p	CLIP-seq
MIRT2549554	hsa-miR-371b-5p	CLIP-seq
MIRT1060288	hsa-miR-378g	CLIP-seq
MIRT1060289	hsa-miR-3945	CLIP-seq
MIRT1556567	hsa-miR-3975	CLIP-seq
MIRT2014106	hsa-miR-4252	CLIP-seq
MIRT1060290	hsa-miR-4253	CLIP-seq
MIRT2014107	hsa-miR-4293	CLIP-seq
MIRT1060291	hsa-miR-4314	CLIP-seq
MIRT1060292	hsa-miR-4320	CLIP-seq
MIRT1556569	hsa-miR-4443	CLIP-seq
MIRT1060293	hsa-miR-4459	CLIP-seq
MIRT1060294	hsa-miR-4486	CLIP-seq
MIRT2437698	hsa-miR-4638-3p	CLIP-seq
MIRT1556570	hsa-miR-4677-3p	CLIP-seq
MIRT1556571	hsa-miR-4679	CLIP-seq
MIRT1060296	hsa-miR-4728-5p	CLIP-seq
MIRT1060298	hsa-miR-4782-5p	CLIP-seq
MIRT2014108	hsa-miR-4793-3p	CLIP-seq
MIRT1556572	hsa-miR-485-5p	CLIP-seq
MIRT1060299	hsa-miR-500a	CLIP-seq
MIRT1060300	hsa-miR-516b	CLIP-seq
MIRT1556573	hsa-miR-571	CLIP-seq
MIRT2549558	hsa-miR-589	CLIP-seq
MIRT2014110	hsa-miR-596	CLIP-seq
MIRT1060301	hsa-miR-612	CLIP-seq
MIRT1556574	hsa-miR-650	CLIP-seq
MIRT1060302	hsa-miR-890	CLIP-seq
MIRT2549560	hsa-miR-921	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001836	Process	Release of cytochrome c from mitochondria	IMP	15685448
GO:0005515	Function	Protein binding	IPI	15685448
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA	15685448, 25757571
GO:0005743	Component	Mitochondrial inner membrane	IDA	29899394
GO:0005886	Component	Plasma membrane	TAS
GO:0006915	Process	Apoptotic process	IMP	27673746
GO:0006955	Process	Immune response	TAS	3017706
GO:0016021	Component	Integral component of membrane	IEA
GO:0031966	Component	Mitochondrial membrane	IDA	17823654
GO:0042058	Process	Regulation of epidermal growth factor receptor signaling pathway	IMP	25757571
GO:0043066	Process	Negative regulation of apoptotic process	IMP	17823654
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA	21873635
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	15685448
GO:0045087	Process	Innate immune response	IMP	25757571
GO:0051607	Process	Defense response to virus	IMP	25757571
GO:0051902	Process	Negative regulation of mitochondrial depolarization	IBA	21873635
GO:0051902	Process	Negative regulation of mitochondrial depolarization	IMP	15685448
GO:0060337	Process	Type I interferon signaling pathway	TAS
GO:0072593	Process	Reactive oxygen species metabolic process	IMP	29899394
GO:0097190	Process	Apoptotic signaling pathway	IBA	21873635
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IMP	26244642
GO:0098586	Process	Cellular response to virus	IMP	26244642
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IBA	21873635
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP	15685448

MIM	HGNC	e!Ensembl
147572	4054	ENSG00000126709

Protein

UniProt ID

P09912

Protein name

Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16)

Protein function

Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06140	Ifi-6-16	41 → 119	Interferon-induced 6-16 family	Family

Sequence

MRQKAVSLFLCYLLLFTCSGVEAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPALG
FTGAGIAANSVAASLMSWSAILNGGGVPAGGLVATLQSLGAGGSSVVIGNIGALMGYATH
KYLDSEEDEE

Sequence length

130

Interactions

View interactions

	Reactome
			Interferon alpha/beta signaling

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		29175309	ClinVar

Show/Hide Text Mining Associations (39)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	15685448
Asthma	Associate	23148572
Breast Neoplasms	Associate	12841681, 29899394, 34055036, 35075167, 36766731
Breast Neoplasms	Inhibit	35301803
Carcinogenesis	Associate	24098334
Colorectal Neoplasms	Associate	36596524
COVID 19	Associate	33138195, 34730223, 36072597, 36333264, 36507688, 36911695, 38162574
Dermatitis Allergic Contact	Associate	35028126
Dermatomyositis	Associate	35609018, 35711463, 37353938
Desmoid disease hereditary	Associate	33444924
Fatty Liver	Inhibit	39490745
Gaucher Disease	Associate	30988500
Hepatitis B	Inhibit	35301803
Hepatitis C	Inhibit	25757571
Hepatitis C	Associate	30199576
Histiocytic Necrotizing Lymphadenitis	Associate	34952944
Inflammation	Associate	32308549
Inflammation	Stimulate	36793726
Influenza Human	Associate	34367124, 36911695
Lupus Erythematosus Systemic	Stimulate	27257790
Lupus Erythematosus Systemic	Associate	33468161
Mastocytosis Systemic	Associate	36333264
Moyamoya Disease	Associate	37400835
Multiple Myeloma	Associate	17823654
Multiple Sclerosis	Associate	16504146
Muscular Diseases	Associate	35609018
Muscular Dystrophy Duchenne	Associate	25338682
Neoplasm Metastasis	Associate	29899394
Neoplasms	Associate	17823654, 30008265, 35301803
Polymyositis	Associate	35609018
Post Acute COVID 19 Syndrome	Associate	39339845
Psoriasis	Associate	38115636
Respiratory Syncytial Virus Infections	Associate	18838000
Scleroderma Systemic	Associate	33253099
Squamous Cell Carcinoma of Head and Neck	Associate	18254958, 28176846
Stomach Neoplasms	Associate	15685448
Syphilis	Associate	34781038
Syphilis secondary	Stimulate	34781038
Virus Diseases	Associate	36793726

IFI6 (interferon alpha inducible protein 6)