Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
253461
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger and BTB domain containing 38
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZBTB38
Synonyms (NCBI Gene) Gene synonyms aliases
CIBZ, PPP1R171, ZNF921
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q23
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with a
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023427 hsa-miR-30b-5p Sequencing 20371350
MIRT030256 hsa-miR-26b-5p Microarray 19088304
MIRT031057 hsa-miR-21-5p Microarray 18591254
MIRT037337 hsa-miR-877-5p CLASH 23622248
MIRT037337 hsa-miR-877-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003700 Function DNA-binding transcription factor activity ISS
GO:0005515 Function Protein binding IPI 16354688, 23251453, 24726359, 32814053
GO:0005634 Component Nucleus IDA 16354688
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612218 26636 ENSG00000177311
Protein
UniProt ID Q8NAP3
Protein name Zinc finger and BTB domain-containing protein 38
Protein function Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a
PDB 6E93 , 6E94
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 23 131 BTB/POZ domain Domain
PF00096 zf-C2H2 460 482 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1038 1060 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 1066 1088 Zinc finger, C2H2 type Domain
Sequence
MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKFKAHSNVLAASSLYFKN
IFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQETVTDLAAAGKKLGISFLE
DLTDRNFSNSP
GPYVFCITEKGVVKEEKNEKRHEEPAITNGPRITNAFSIIETENSNNMF
SPLDLRASFKKVSDSMRTASLCLERTDVCHEAEPVRTLAEHSYAVSSVAEAYRSQPVREH
DGSSPGNTGKENCEALAAKPKTCRKPKTFSIPQDSDSATENIPPPPVSNLEVNQERSPQP
AAVLTRSKSPNNEGDVHFSREDENQSSDVPGPPAAEVPPLVYNCSCCSKAFDSSTLLSAH
MQLHKPTQEPLVCKYCNKQFTTLNRLDRHEQICMRSSHMPIPGGNQRFLENYPTIGQNGG
SFTGPEPLLSENRIGEFSSTGSTLPDTDHMVKFVNGQMLYSCVVCKRSYVTLSSLRRHAN
VH
SWRRTYPCHYCNKVFALAEYRTRHEIWHTGERRYQCIFCLETFMTYYILKNHQKSFHA
IDHRLSISKKTANGGLKPSVYPYKLYRLLPMKCKRAPYKSYRNSSYENARENSQMNESAP
GTYVVQNPHSSELPTLNFQDTVNTLTNSPAIPLETSACQDIPTSANVQNAEGTKWGEEAL
KMDLDNNFYSTEVSVSSTENAVSSDLRAGDVPVLSLSNSSENAASVISYSGSAPSVIVHS
SQFSSVIMHSNAIAAMTSSNHRAFSDPAVSQSLKDDSKPEPDKVGRFASRPKSIKEKKKT
TSHTRGEIPEESNYVADPGGSLSKTTNIAEETSKIETYIAKPALPGTSTNSNVAPLCQIT
VKIGNEAIVKRHILGSKLFYKRGRRPKYQMQEEPLPQGNDPEPSGDSPLGLCQSECMEMS
EVFDDASDQDSTDKPWRPYYNYKPKKKSRQLKKMRKVNWRKEHGNRSPSHKCKYPAELDC
AVGKAPQDKPFEEEETKEMPKLQCELCDGDKAVGAGNQGRPHRHLTSRPYACELCAKQFQ
SPSTLKMHMRCHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGLKEFVCQYCNKAFTLNET
LKIHERIH
TGEKRYHCQFCFQRFLYLSTKRNHEQRHIREHNGKGYACFQCPKICKTAAAL
GMHQKKHLFKSPSQQEKIGDVCHENSNPLENQHFIGSEDNDQKDNIQTGVENVVL
Sequence length 1195
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059683
Multiple sclerosis Multiple Sclerosis rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039
View all (4 more)
24076602
Myopia Myopia rs387907109, rs146936371, rs587776903, rs786205127, rs398122836, rs199624584, rs587777625, rs786205216, rs758872875, rs764211125, rs1135402746, rs765658563, rs1555941129, rs1555941116, rs199923805
View all (6 more)
27182965
Prostate cancer Malignant neoplasm of prostate, Prostate carcinoma rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 21743467, 29892016
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma, Childhood asthma 30929738 ClinVar, GWAS
Chronic obstructive pulmonary disease Chronic Obstructive Airway Disease 30804561 ClinVar
Crohn disease Crohn Disease 28067908 ClinVar
Eczema Eczema GWAS
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 40296166
Breast Neoplasms Associate 39614330
Carcinoma Hepatocellular Associate 38302914
Creutzfeldt Jakob Syndrome Associate 29216791
Diabetes Mellitus Type 2 Associate 26915486, 33290408
Endometrial Neoplasms Associate 36047377
Fibrosis Associate 38302914
Growth Disorders Associate 28744006
Insomnia Fatal Familial Associate 29216791
Lung Diseases Associate 40296166