Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
253430
Gene name Gene Name - the full gene name approved by the HGNC.
Inositol polyphosphate multikinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IPMK
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017660 hsa-miR-335-5p Microarray 18185580
MIRT042775 hsa-miR-339-5p CLASH 23622248
MIRT544115 hsa-miR-519a-3p PAR-CLIP 21572407
MIRT544114 hsa-miR-519b-3p PAR-CLIP 21572407
MIRT544113 hsa-miR-519c-3p PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000823 Function Inositol-1,4,5-trisphosphate 6-kinase activity IEA
GO:0000824 Function Inositol tetrakisphosphate 3-kinase activity TAS
GO:0000825 Function Inositol tetrakisphosphate 6-kinase activity IMP 29883610
GO:0000825 Function Inositol tetrakisphosphate 6-kinase activity TAS
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609851 20739 ENSG00000151151
Protein
UniProt ID Q8NFU5
Protein name Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)
Protein function Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphos
PDB 5W2G , 5W2H , 5W2I , 6E7F , 6M88 , 6M89 , 6M8A , 6M8B , 6M8C , 6M8D , 6M8E , 8V6W , 8V6X , 8V6Y , 8V6Z , 8V70 , 8V71 , 8V72 , 8V73 , 8V74 , 8V75 , 8V76 , 8V77 , 8V78 , 8V79
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03770 IPK 127 411 Inositol polyphosphate kinase Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon. {ECO:0000269|PubMed:12223481}.
Sequence
Sequence length 416
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of IPs in the nucleus
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Inflammatory bowel disease Inflammatory Bowel Diseases rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 23128233, 26192919
Unknown
Disease term Disease name Evidence References Source
Hereditary Neuroendocrine Tumor Of Small Intestine hereditary neuroendocrine tumor of small intestine GenCC
Crohn Disease Crohn Disease GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Autoimmune Diseases Associate 34143178
Breast Neoplasms Associate 35864548
Carcinogenesis Associate 25865046
Carcinoid Tumor Associate 25865046
Carcinoid Tumors Intestinal Associate 25865046
CD59 Deficiency Associate 27088644
Colonic Neoplasms Associate 39333335
Gaucher Disease Associate 34143178
Graves Disease Associate 34143178
Hashimoto Disease Associate 34143178