Gene Gene information from NCBI Gene database.
Entrez ID 253430
Gene name Inositol polyphosphate multikinase
Gene symbol IPMK
Synonyms (NCBI Gene)
-
Chromosome 10
Chromosome location 10q21.1
Summary This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,
miRNA miRNA information provided by mirtarbase database.
596
miRTarBase ID miRNA Experiments Reference
MIRT017660 hsa-miR-335-5p Microarray 18185580
MIRT042775 hsa-miR-339-5p CLASH 23622248
MIRT544115 hsa-miR-519a-3p PAR-CLIP 21572407
MIRT544114 hsa-miR-519b-3p PAR-CLIP 21572407
MIRT544113 hsa-miR-519c-3p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000823 Function Inositol-1,4,5-trisphosphate 6-kinase activity ISS
GO:0000824 Function Inositol-1,4,5,6-tetrakisphosphate 3-kinase activity IEA
GO:0000824 Function Inositol-1,4,5,6-tetrakisphosphate 3-kinase activity ISS
GO:0000824 Function Inositol-1,4,5,6-tetrakisphosphate 3-kinase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609851 20739 ENSG00000151151
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NFU5
Protein name Inositol polyphosphate multikinase (EC 2.7.1.140) (EC 2.7.1.151) (EC 2.7.1.153) (Inositol 1,3,4,6-tetrakisphosphate 5-kinase)
Protein function Inositol phosphate kinase with a broad substrate specificity (PubMed:12027805, PubMed:12223481, PubMed:28882892, PubMed:30420721, PubMed:30624931). Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphos
PDB 5W2G , 5W2H , 5W2I , 6E7F , 6M88 , 6M89 , 6M8A , 6M8B , 6M8C , 6M8D , 6M8E , 8V6W , 8V6X , 8V6Y , 8V6Z , 8V70 , 8V71 , 8V72 , 8V73 , 8V74 , 8V75 , 8V76 , 8V77 , 8V78 , 8V79
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03770 IPK 127 411 Inositol polyphosphate kinase Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon. {ECO:0000269|PubMed:12223481}.
Sequence
Sequence length 416
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
  Synthesis of IPs in the nucleus
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Thyroid cancer, nonmedullary, 1 Uncertain significance rs2493282661 RCV005932719
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Autoimmune Diseases Associate 34143178
Breast Neoplasms Associate 35864548
Carcinogenesis Associate 25865046
Carcinoid Tumor Associate 25865046
Carcinoid Tumors Intestinal Associate 25865046
CD59 Deficiency Associate 27088644
Colonic Neoplasms Associate 39333335
Gaucher Disease Associate 34143178
Graves Disease Associate 34143178
Hashimoto Disease Associate 34143178