Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2534
Gene name Gene Name - the full gene name approved by the HGNC.
FYN proto-oncogene, Src family tyrosine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FYN
Synonyms (NCBI Gene) Gene synonyms aliases
SLK, SYN, p59-FYN
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022048 hsa-miR-128-3p Microarray 17612493
MIRT038910 hsa-miR-93-3p CLASH 23622248
MIRT437821 hsa-miR-125a-3p Luciferase reporter assay 23606749
MIRT437821 hsa-miR-125a-3p Luciferase reporter assay 23606749
MIRT699208 hsa-miR-5580-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade TAS
GO:0000304 Process Response to singlet oxygen ISS 27525436
GO:0001764 Process Neuron migration IEA
GO:0002223 Process Stimulatory C-type lectin receptor signaling pathway TAS
GO:0002250 Process Adaptive immune response IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
137025 4037 ENSG00000010810
Protein
UniProt ID P06241
Protein name Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Protein function Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon gu
PDB 1A0N , 1AOT , 1AOU , 1AVZ , 1AZG , 1EFN , 1FYN , 1G83 , 1M27 , 1NYF , 1NYG , 1SHF , 1ZBJ , 2DQ7 , 2MQI , 2MRJ , 2MRK , 3H0F , 3H0H , 3H0I , 3UA6 , 3UA7 , 4D8D , 4EIK , 4U17 , 4U1P , 4ZNX , 5ZAU , 6EDF , 6IPY , 6IPZ , 7A2J , 7A2K , 7A2L , 7A2M , 7A2N , 7A2O , 7A2P , 7A2Q , 7A2R , 7A2S , 7A2T , 7A2U , 7A2V , 7A2W , 7A2X , 7A2Y , 7A2Z , 7UD6 , 8KDX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00018 SH3_1 88 135 SH3 domain Domain
PF00017 SH2 149 231 SH2 domain Domain
PF07714 PK_Tyr_Ser-Thr 271 520 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. {ECO:0000269|PubMed:10196263}.
Sequence
Sequence length 537
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Sphingolipid signaling pathway
Phospholipase D signaling pathway
Axon guidance
Osteoclast differentiation
Focal adhesion
Adherens junction
Platelet activation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Cholinergic synapse
Prion disease
Pathogenic Escherichia coli infection
Viral myocarditis
  GPVI-mediated activation cascade
Signaling by ERBB2
PIP3 activates AKT signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Nef and signal transduction
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Nephrin family interactions
NCAM signaling for neurite out-growth
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
Dectin-2 family
CD209 (DC-SIGN) signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Platelet Adhesion to exposed collagen
Reelin signalling pathway
NTRK2 activates RAC1
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
16367923
Hypothyroidism Hypothyroidism rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912
View all (22 more)
30595370
Lung carcinoma Squamous cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
Pulmonary fibrosis Pulmonary Fibrosis rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899
View all (1 more)
30658076
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Psoriasis vulgaris Psoriasis vulgaris GWAS
Psoriasis Psoriasis GWAS
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Inhibit 8823293
Adenocarcinoma of Lung Associate 29266838
Alzheimer Disease Associate 22927204, 28033507, 32751526, 35563596, 36258016
Aneuploidy Associate 19404734
Arthritis Rheumatoid Associate 33430905
Ataxia Telangiectasia Associate 11315256
Autistic Disorder Associate 36039581
Bone Resorption Associate 9844106
Breast Neoplasms Associate 19404734, 21480388, 37958964
Calcinosis Cutis Associate 26493492