UniProt ID |
P06241
|
Protein name |
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn) |
Protein function |
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon gu |
PDB |
1A0N
,
1AOT
,
1AOU
,
1AVZ
,
1AZG
,
1EFN
,
1FYN
,
1G83
,
1M27
,
1NYF
,
1NYG
,
1SHF
,
1ZBJ
,
2DQ7
,
2MQI
,
2MRJ
,
2MRK
,
3H0F
,
3H0H
,
3H0I
,
3UA6
,
3UA7
,
4D8D
,
4EIK
,
4U17
,
4U1P
,
4ZNX
,
5ZAU
,
6EDF
,
6IPY
,
6IPZ
,
7A2J
,
7A2K
,
7A2L
,
7A2M
,
7A2N
,
7A2O
,
7A2P
,
7A2Q
,
7A2R
,
7A2S
,
7A2T
,
7A2U
,
7A2V
,
7A2W
,
7A2X
,
7A2Y
,
7A2Z
,
7UD6
,
8KDX
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00018
|
SH3_1 |
88 → 135 |
SH3 domain |
Domain |
PF00017
|
SH2 |
149 → 231 |
SH2 domain |
Domain |
PF07714
|
PK_Tyr_Ser-Thr |
271 → 520 |
Protein tyrosine and serine/threonine kinase |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes. {ECO:0000269|PubMed:10196263}. |
Sequence |
|
Sequence length |
537 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Gastric cancer |
Hereditary Diffuse Gastric Cancer |
rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208 View all (244 more) |
16367923 |
Hypothyroidism |
Hypothyroidism |
rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605 View all (22 more) |
30595370 |
Lung carcinoma |
Squamous cell carcinoma of lung |
rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 View all (44 more) |
|
Pulmonary fibrosis |
Pulmonary Fibrosis |
rs121918666, rs199422300, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578 View all (1 more) |
30658076 |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
28991256, 19102774, 19501919, 30285260 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Bipolar Disorder |
Bipolar Disorder |
|
|
GWAS |
Psoriasis vulgaris |
Psoriasis vulgaris |
|
|
GWAS |
Psoriasis |
Psoriasis |
|
|
GWAS |
Insomnia |
Insomnia |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Acquired Immunodeficiency Syndrome |
Inhibit
|
8823293 |
Adenocarcinoma of Lung |
Associate
|
29266838 |
Alzheimer Disease |
Associate
|
22927204, 28033507, 32751526, 35563596, 36258016 |
Aneuploidy |
Associate
|
19404734 |
Arthritis Rheumatoid |
Associate
|
33430905 |
Ataxia Telangiectasia |
Associate
|
11315256 |
Autistic Disorder |
Associate
|
36039581 |
Bone Resorption |
Associate
|
9844106 |
Breast Neoplasms |
Associate
|
19404734, 21480388, 37958964 |
Calcinosis Cutis |
Associate
|
26493492 |
Carcinogenesis |
Stimulate
|
29453318 |
Carcinogenesis |
Associate
|
33987980 |
Carcinoma Hepatocellular |
Associate
|
39795978 |
Carcinoma Ovarian Epithelial |
Associate
|
36708583 |
Carcinoma Pancreatic Ductal |
Associate
|
36905103 |
Carcinoma Renal Cell |
Associate
|
36708583 |
Cerebral Hemorrhage |
Associate
|
30836997 |
Cholangiocarcinoma |
Associate
|
25526346 |
Chondrosarcoma |
Associate
|
23922104 |
Chromosome Disorders |
Associate
|
19404734 |
Cleft Lip |
Associate
|
30127215 |
Colorectal Neoplasms |
Associate
|
18805444, 29693170, 32811808, 33987980, 36510452 |
Dementia |
Associate
|
35327643, 36258016 |
Diabetes Gestational |
Associate
|
33890634 |
Diabetes Mellitus Type 1 |
Associate
|
24098138 |
Diabetic Nephropathies |
Associate
|
28990106 |
Diabetic Retinopathy |
Associate
|
38194422 |
Diffuse Neurofibrillary Tangles with Calcification |
Associate
|
28033507 |
Frontotemporal Lobar Degeneration |
Associate
|
36258016 |
Genetic Diseases Inborn |
Associate
|
24413734 |
Glioblastoma |
Associate
|
22323579, 26136341, 39946771 |
Glioma |
Associate
|
21480388 |
HIV Infections |
Inhibit
|
8823293 |
Hodgkin Disease |
Associate
|
12881301 |
Hyperplasia |
Stimulate
|
11477536 |
Idiopathic Pulmonary Fibrosis |
Inhibit
|
33325804 |
Inflammation |
Associate
|
29693170, 38194422 |
Ischemic Stroke |
Associate
|
32945445 |
Keratoconus |
Associate
|
37965330 |
Leukemia |
Associate
|
27566560, 28978570 |
Leukemia Large Granular Lymphocytic |
Associate
|
27566560 |
Leukemia Lymphocytic Chronic B Cell |
Inhibit
|
32986360 |
Leukemia Lymphoma Adult T Cell |
Associate
|
28978570 |
Leukemia Myelogenous Chronic BCR ABL Positive |
Associate
|
19131339, 21480388, 26136341 |
Leukemia T Cell |
Stimulate
|
9045636 |
Lymphoma T Cell Peripheral |
Inhibit
|
23716562 |
Metabolic Diseases |
Associate
|
35240786 |
Multiple Myeloma |
Associate
|
14717778, 9217182 |
Multiple Sclerosis |
Associate
|
23469041 |
Myotonia with Skeletal Abnormalities and Mental Retardation |
Associate
|
33242826 |
Nasopharyngeal Carcinoma |
Associate
|
37274867 |
Neoplasm Invasiveness |
Associate
|
26549256 |
Neoplasm Metastasis |
Associate
|
24597767, 26493492, 28944885 |
Neoplasms |
Inhibit
|
12450793 |
Neoplasms |
Associate
|
12881301, 18990162, 20233874, 21480388, 24597767, 26001218, 26136341, 27566560, 29307797, 31189776, 39241280, 7829390, 9490199, 9531350 |
Neoplasms |
Stimulate
|
26549256 |
Neoplasms Cystic Mucinous and Serous |
Associate
|
36708583 |
Neuroblastoma |
Associate
|
12450793 |
Neuroinflammatory Diseases |
Associate
|
30836997 |
Neurotoxicity Syndromes |
Associate
|
16864581 |
Obesity |
Associate
|
26646899, 34964707 |
Osteoarthritis |
Associate
|
37140355 |
Osteoblastoma |
Associate
|
31467230 |
Pancreatic Neoplasms |
Associate
|
33213062 |
Pancreatitis |
Associate
|
21480388 |
Prostatic Neoplasms |
Stimulate
|
18990162 |
Prostatic Neoplasms |
Associate
|
37771187 |
Prostatic Neoplasms Castration Resistant |
Stimulate
|
26493492 |
Prostatitis |
Associate
|
21480388 |
Psoriasis |
Associate
|
24303025 |
Pulmonary Fibrosis |
Associate
|
33325804 |
Radiation Injuries |
Associate
|
36530656 |
Sarcoma |
Associate
|
35839307 |
Squamous Cell Carcinoma of Head and Neck |
Associate
|
12771142, 24192080 |
Stomach Neoplasms |
Associate
|
16367923, 26811494 |
Subarachnoid Hemorrhage |
Associate
|
36214715 |
Tauopathies |
Associate
|
28033507 |
Thyroiditis Autoimmune |
Associate
|
37197658 |
Urinary Bladder Neoplasms |
Associate
|
26786295, 36530656 |
Uveal melanoma |
Associate
|
24597767 |
Virus Diseases |
Associate
|
23405030 |
|