Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2530
Gene name Gene Name - the full gene name approved by the HGNC.	Fucosyltransferase 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FUT8
Synonyms (NCBI Gene) Gene synonyms aliases	CDGF, CDGF1
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CDGF1
Chromosome Chromosome number	14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	14q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which cata

Show/Hide all(4)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1297536872	C>G,T	Pathogenic	Missense variant, intron variant, coding sequence variant
rs1334593208	C>T	Pathogenic	Stop gained, coding sequence variant, intron variant
rs1460811017	C>T	Pathogenic	Non coding transcript variant, coding sequence variant, stop gained
rs1555388034	G>T	Pathogenic	Intron variant

Show/Hide all(215)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029006	hsa-miR-26b-5p	Microarray	19088304
MIRT438734	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR, Western blot	24130780
MIRT438733	hsa-miR-34a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24130780
MIRT438734	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR, Western blot	24130780
MIRT438733	hsa-miR-34a-5p	Luciferase reporter assay, qRT-PCR, Western blot	24130780
MIRT438733	hsa-miR-34a-5p	Flow, Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27533464
MIRT438733	hsa-miR-34a-5p	Flow, Immunofluorescence, Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27533464
MIRT735586	hsa-miR-570-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC)	32072011
MIRT1006783	hsa-miR-1264	CLIP-seq
MIRT1006784	hsa-miR-1272	CLIP-seq
MIRT1006785	hsa-miR-133a	CLIP-seq
MIRT1006786	hsa-miR-133b	CLIP-seq
MIRT1006787	hsa-miR-139-5p	CLIP-seq
MIRT1006788	hsa-miR-142-5p	CLIP-seq
MIRT1006789	hsa-miR-1827	CLIP-seq
MIRT1006790	hsa-miR-183	CLIP-seq
MIRT1006791	hsa-miR-1911	CLIP-seq
MIRT1006792	hsa-miR-198	CLIP-seq
MIRT1006793	hsa-miR-203	CLIP-seq
MIRT1006794	hsa-miR-3115	CLIP-seq
MIRT1006795	hsa-miR-3123	CLIP-seq
MIRT1006796	hsa-miR-3137	CLIP-seq
MIRT1006797	hsa-miR-3144-5p	CLIP-seq
MIRT1006798	hsa-miR-3148	CLIP-seq
MIRT1006799	hsa-miR-3171	CLIP-seq
MIRT1006800	hsa-miR-3191	CLIP-seq
MIRT1006801	hsa-miR-323-3p	CLIP-seq
MIRT1006802	hsa-miR-338-5p	CLIP-seq
MIRT1006803	hsa-miR-340	CLIP-seq
MIRT1006804	hsa-miR-342-3p	CLIP-seq
MIRT1006805	hsa-miR-34a	CLIP-seq
MIRT1006806	hsa-miR-34c-5p	CLIP-seq
MIRT1006807	hsa-miR-3545-3p	CLIP-seq
MIRT1006808	hsa-miR-3612	CLIP-seq
MIRT1006809	hsa-miR-3622a-5p	CLIP-seq
MIRT1006810	hsa-miR-3675-5p	CLIP-seq
MIRT1006811	hsa-miR-377	CLIP-seq
MIRT1006812	hsa-miR-3941	CLIP-seq
MIRT1006813	hsa-miR-3973	CLIP-seq
MIRT1006814	hsa-miR-412	CLIP-seq
MIRT1006815	hsa-miR-4266	CLIP-seq
MIRT1006816	hsa-miR-4307	CLIP-seq
MIRT1006817	hsa-miR-4311	CLIP-seq
MIRT1006818	hsa-miR-4330	CLIP-seq
MIRT1006819	hsa-miR-4423-3p	CLIP-seq
MIRT1006820	hsa-miR-4477a	CLIP-seq
MIRT1006821	hsa-miR-449a	CLIP-seq
MIRT1006822	hsa-miR-449b	CLIP-seq
MIRT1006823	hsa-miR-4501	CLIP-seq
MIRT1006824	hsa-miR-4502	CLIP-seq
MIRT1006825	hsa-miR-4650-5p	CLIP-seq
MIRT1006826	hsa-miR-4652-5p	CLIP-seq
MIRT1006827	hsa-miR-466	CLIP-seq
MIRT1006828	hsa-miR-4672	CLIP-seq
MIRT1006829	hsa-miR-4682	CLIP-seq
MIRT1006830	hsa-miR-4688	CLIP-seq
MIRT1006831	hsa-miR-4695-5p	CLIP-seq
MIRT1006832	hsa-miR-4716-5p	CLIP-seq
MIRT1006833	hsa-miR-4724-5p	CLIP-seq
MIRT1006834	hsa-miR-4731-3p	CLIP-seq
MIRT1006835	hsa-miR-4757-5p	CLIP-seq
MIRT1006836	hsa-miR-4762-3p	CLIP-seq
MIRT1006837	hsa-miR-4766-5p	CLIP-seq
MIRT1006838	hsa-miR-4779	CLIP-seq
MIRT1006839	hsa-miR-4801	CLIP-seq
MIRT1006840	hsa-miR-488	CLIP-seq
MIRT1006841	hsa-miR-494	CLIP-seq
MIRT1006842	hsa-miR-511	CLIP-seq
MIRT1006843	hsa-miR-513c	CLIP-seq
MIRT1006844	hsa-miR-514b-5p	CLIP-seq
MIRT1006845	hsa-miR-522	CLIP-seq
MIRT1006846	hsa-miR-570	CLIP-seq
MIRT1006847	hsa-miR-582-5p	CLIP-seq
MIRT1006848	hsa-miR-597	CLIP-seq
MIRT1006849	hsa-miR-630	CLIP-seq
MIRT1006850	hsa-miR-647	CLIP-seq
MIRT1006851	hsa-miR-649	CLIP-seq
MIRT1006852	hsa-miR-650	CLIP-seq
MIRT1006853	hsa-miR-668	CLIP-seq
MIRT1006854	hsa-miR-767-5p	CLIP-seq
MIRT1006855	hsa-miR-940	CLIP-seq
MIRT1006856	hsa-miR-942	CLIP-seq
MIRT1006857	hsa-miR-185	CLIP-seq
MIRT1006858	hsa-miR-4306	CLIP-seq
MIRT1006859	hsa-miR-4644	CLIP-seq
MIRT1006860	hsa-miR-4693-3p	CLIP-seq
MIRT1006836	hsa-miR-4762-3p	CLIP-seq
MIRT1998294	hsa-miR-1183	CLIP-seq
MIRT1998295	hsa-miR-1233	CLIP-seq
MIRT1998296	hsa-miR-1256	CLIP-seq
MIRT1006784	hsa-miR-1272	CLIP-seq
MIRT1006787	hsa-miR-139-5p	CLIP-seq
MIRT1006790	hsa-miR-183	CLIP-seq
MIRT1998297	hsa-miR-186	CLIP-seq
MIRT1006793	hsa-miR-203	CLIP-seq
MIRT1998298	hsa-miR-223	CLIP-seq
MIRT1006794	hsa-miR-3115	CLIP-seq
MIRT1998299	hsa-miR-3117-5p	CLIP-seq
MIRT1998300	hsa-miR-3122	CLIP-seq
MIRT1998301	hsa-miR-3130-3p	CLIP-seq
MIRT1006797	hsa-miR-3144-5p	CLIP-seq
MIRT1006799	hsa-miR-3171	CLIP-seq
MIRT1998302	hsa-miR-3173-3p	CLIP-seq
MIRT1998303	hsa-miR-3188	CLIP-seq
MIRT1006800	hsa-miR-3191	CLIP-seq
MIRT1998304	hsa-miR-323-5p	CLIP-seq
MIRT1006802	hsa-miR-338-5p	CLIP-seq
MIRT1006805	hsa-miR-34a	CLIP-seq
MIRT1006806	hsa-miR-34c-5p	CLIP-seq
MIRT1006807	hsa-miR-3545-3p	CLIP-seq
MIRT1006810	hsa-miR-3675-5p	CLIP-seq
MIRT1998305	hsa-miR-3689a-3p	CLIP-seq
MIRT1998306	hsa-miR-3689c	CLIP-seq
MIRT1998307	hsa-miR-383	CLIP-seq
MIRT1998308	hsa-miR-3913-5p	CLIP-seq
MIRT1006812	hsa-miR-3941	CLIP-seq
MIRT1006813	hsa-miR-3973	CLIP-seq
MIRT1998309	hsa-miR-410	CLIP-seq
MIRT1006814	hsa-miR-412	CLIP-seq
MIRT1998310	hsa-miR-4277	CLIP-seq
MIRT1998311	hsa-miR-4282	CLIP-seq
MIRT1998312	hsa-miR-4428	CLIP-seq
MIRT1998313	hsa-miR-4452	CLIP-seq
MIRT1998314	hsa-miR-4476	CLIP-seq
MIRT1006820	hsa-miR-4477a	CLIP-seq
MIRT1006821	hsa-miR-449a	CLIP-seq
MIRT1006822	hsa-miR-449b	CLIP-seq
MIRT1006824	hsa-miR-4502	CLIP-seq
MIRT1006826	hsa-miR-4652-5p	CLIP-seq
MIRT1998315	hsa-miR-4653-3p	CLIP-seq
MIRT1006827	hsa-miR-466	CLIP-seq
MIRT1998316	hsa-miR-4670-3p	CLIP-seq
MIRT1006828	hsa-miR-4672	CLIP-seq
MIRT1998317	hsa-miR-4687-5p	CLIP-seq
MIRT1998318	hsa-miR-4697-3p	CLIP-seq
MIRT1998319	hsa-miR-4698	CLIP-seq
MIRT1998320	hsa-miR-4728-5p	CLIP-seq
MIRT1006834	hsa-miR-4731-3p	CLIP-seq
MIRT1006836	hsa-miR-4762-3p	CLIP-seq
MIRT1998321	hsa-miR-4775	CLIP-seq
MIRT1998322	hsa-miR-4793-3p	CLIP-seq
MIRT1006839	hsa-miR-4801	CLIP-seq
MIRT1006841	hsa-miR-494	CLIP-seq
MIRT1006842	hsa-miR-511	CLIP-seq
MIRT1006843	hsa-miR-513c	CLIP-seq
MIRT1006844	hsa-miR-514b-5p	CLIP-seq
MIRT1006845	hsa-miR-522	CLIP-seq
MIRT1998323	hsa-miR-539	CLIP-seq
MIRT1998324	hsa-miR-544	CLIP-seq
MIRT1998325	hsa-miR-548aa	CLIP-seq
MIRT1998326	hsa-miR-548ac	CLIP-seq
MIRT1998327	hsa-miR-548d-3p	CLIP-seq
MIRT1998328	hsa-miR-548z	CLIP-seq
MIRT1998329	hsa-miR-580	CLIP-seq
MIRT1006847	hsa-miR-582-5p	CLIP-seq
MIRT1998330	hsa-miR-592	CLIP-seq
MIRT1006848	hsa-miR-597	CLIP-seq
MIRT1006849	hsa-miR-630	CLIP-seq
MIRT1006850	hsa-miR-647	CLIP-seq
MIRT1998331	hsa-miR-654-3p	CLIP-seq
MIRT1006853	hsa-miR-668	CLIP-seq
MIRT1998332	hsa-miR-759	CLIP-seq
MIRT1998333	hsa-miR-876-3p	CLIP-seq
MIRT1998334	hsa-miR-9	CLIP-seq
MIRT1006856	hsa-miR-942	CLIP-seq
MIRT1006799	hsa-miR-3171	CLIP-seq
MIRT1006836	hsa-miR-4762-3p	CLIP-seq
MIRT1006849	hsa-miR-630	CLIP-seq
MIRT1006811	hsa-miR-377	CLIP-seq
MIRT1998294	hsa-miR-1183	CLIP-seq
MIRT1006789	hsa-miR-1827	CLIP-seq
MIRT2388263	hsa-miR-221	CLIP-seq
MIRT2388264	hsa-miR-222	CLIP-seq
MIRT1998299	hsa-miR-3117-5p	CLIP-seq
MIRT1998300	hsa-miR-3122	CLIP-seq
MIRT1006796	hsa-miR-3137	CLIP-seq
MIRT1998303	hsa-miR-3188	CLIP-seq
MIRT1006808	hsa-miR-3612	CLIP-seq
MIRT1998305	hsa-miR-3689a-3p	CLIP-seq
MIRT1998306	hsa-miR-3689c	CLIP-seq
MIRT1998308	hsa-miR-3913-5p	CLIP-seq
MIRT1006815	hsa-miR-4266	CLIP-seq
MIRT1998314	hsa-miR-4476	CLIP-seq
MIRT1998316	hsa-miR-4670-3p	CLIP-seq
MIRT1006831	hsa-miR-4695-5p	CLIP-seq
MIRT1998320	hsa-miR-4728-5p	CLIP-seq
MIRT1006835	hsa-miR-4757-5p	CLIP-seq
MIRT1998321	hsa-miR-4775	CLIP-seq
MIRT1006838	hsa-miR-4779	CLIP-seq
MIRT1006852	hsa-miR-650	CLIP-seq
MIRT1998334	hsa-miR-9	CLIP-seq
MIRT1006855	hsa-miR-940	CLIP-seq
MIRT1006790	hsa-miR-183	CLIP-seq
MIRT1006802	hsa-miR-338-5p	CLIP-seq
MIRT1006805	hsa-miR-34a	CLIP-seq
MIRT1006806	hsa-miR-34c-5p	CLIP-seq
MIRT1006812	hsa-miR-3941	CLIP-seq
MIRT1006813	hsa-miR-3973	CLIP-seq
MIRT1006821	hsa-miR-449a	CLIP-seq
MIRT1006822	hsa-miR-449b	CLIP-seq
MIRT1006827	hsa-miR-466	CLIP-seq
MIRT1006828	hsa-miR-4672	CLIP-seq
MIRT1006830	hsa-miR-4688	CLIP-seq
MIRT1998319	hsa-miR-4698	CLIP-seq
MIRT1006834	hsa-miR-4731-3p	CLIP-seq
MIRT1006839	hsa-miR-4801	CLIP-seq
MIRT1006840	hsa-miR-488	CLIP-seq
MIRT1006846	hsa-miR-570	CLIP-seq
MIRT1998330	hsa-miR-592	CLIP-seq
MIRT1006848	hsa-miR-597	CLIP-seq
MIRT1006851	hsa-miR-649	CLIP-seq
MIRT1998331	hsa-miR-654-3p	CLIP-seq
MIRT1006853	hsa-miR-668	CLIP-seq
MIRT1006833	hsa-miR-4724-5p	CLIP-seq
MIRT2681237	hsa-miR-4761-3p	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001701	Process	In utero embryonic development	NAS	11698403
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005794	Component	Golgi apparatus	NAS	11698403
GO:0006487	Process	Protein N-linked glycosylation	IBA	21873635
GO:0006491	Process	N-glycan processing	TAS	11698403
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0007585	Process	Respiratory gaseous exchange by respiratory system	IEA
GO:0008424	Function	Glycoprotein 6-alpha-L-fucosyltransferase activity	IDA	17172260
GO:0008424	Function	Glycoprotein 6-alpha-L-fucosyltransferase activity	TAS	11698403
GO:0009312	Process	Oligosaccharide biosynthetic process	TAS	9133635
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0016477	Process	Cell migration	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IDA	17172260
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0033578	Process	Protein glycosylation in Golgi	IEA
GO:0036071	Process	N-glycan fucosylation	IBA	21873635
GO:0042355	Process	L-fucose catabolic process	NAS	11698403
GO:0043112	Process	Receptor metabolic process	IEA
GO:0046368	Process	GDP-L-fucose metabolic process	IDA	17172260
GO:0046921	Function	Alpha-(1->6)-fucosyltransferase activity	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:1900407	Process	Regulation of cellular response to oxidative stress	IEA

MIM	HGNC	e!Ensembl
602589	4019	ENSG00000033170

Protein

UniProt ID

Q9BYC5

Protein name

Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase)

Protein function

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

PDB

2DE0 , 6VLD , 6VLE , 6X5H , 6X5R , 6X5S , 6X5T , 6X5U

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14604	SH3_9	509 → 559	Variant SH3 domain	Domain

Sequence

MRPWTGSWRWIMLILFAWGTLLFYIGGHLVRDNDHPDHSSRELSKILAKLERLKQQNEDL
RRMAESLRIPEGPIDQGPAIGRVRVLEEQLVKAKEQIENYKKQTRNGLGKDHEILRRRIE
NGAKELWFFLQSELKKLKNLEGNELQRHADEFLLDLGHHERSIMTDLYYLSQTDGAGDWR
EKEAKDLTELVQRRITYLQNPKDCSKAKKLVCNINKGCGYGCQLHHVVYCFMIAYGTQRT
LILESQNWRYATGGWETVFRPVSETCTDRSGISTGHWSGEVKDKNVQVVELPIVDSLHPR
PPYLPLAVPEDLADRLVRVHGDPAVWWVSQFVKYLIRPQPWLEKEIEEATKKLGFKHPVI
GVHVRRTDKVGTEAAFHPIEEYMVHVEEHFQLLARRMQVDKKRVYLATDDPSLLKEAKTK
YPNYEFISDNSISWSAGLHNRYTENSLRGVILDIHFLSQADFLVCTFSSQVCRVAYEIMQ
TLHPDASANFHSLDDIYYFGGQNAHNQIAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYS
KGVNRKLGRTGLYPSYKVREKIETVKYPTYPEAEK

Sequence length

575

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Various types of N-glycan biosynthesis Glycosaminoglycan biosynthesis - keratan sulfate Metabolic pathways Transcriptional misregulation in cancer		Reactions specific to the complex N-glycan synthesis pathway

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291 View all (32 more)
Mental retardation	Intellectual Disability	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)	15917429
Microcephaly	Microcephaly	rs397704721, rs267607176, rs267607177, rs397704725, rs267606717, rs267606718, rs199422202, rs121434311, rs199422203, rs199422126, rs387906274, rs121434305, rs199422125, rs199422135, rs189678019 View all (280 more)
Schizophrenia	Schizophrenia, Schizophrenia and related disorders	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	25979332, 21471224

Show/Hide Unknown Diseases (5)

Disease term	Disease name	Source
Unknown
Congenital Disorder Of Glycosylation With Defective Fucosylation	congenital disorder of glycosylation with defective fucosylation 1	GenCC
Coenzyme Q10 Deficiency	Coenzyme Q10 Deficiency	GWAS
Gout	Gout	GWAS
Ischemic Stroke	Ischemic Stroke	GWAS
Metabolic Syndrome	Metabolic Syndrome	GWAS

Show/Hide Text Mining Associations (41)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Kidney Injury	Associate	36039648
Apraxia Ideomotor	Associate	30231941
Brain Diseases Metabolic Inborn	Associate	32049367
Breast Neoplasms	Associate	23819905, 28982386, 31306109
Carcinogenesis	Associate	19302290
Carcinoma Hepatocellular	Associate	24232099, 24927126, 31022917, 35504805
Carcinoma Non Small Cell Lung	Associate	31894325
Cerebral Hemorrhage	Associate	32474671
Colorectal Neoplasms	Stimulate	19302290
Colorectal Neoplasms	Associate	22152070, 29975776, 35955598
Congenital Disorders of Glycosylation	Associate	29304374
Drug Resistant Epilepsy	Stimulate	37053181
Epilepsy	Associate	37053181
Fetal Growth Retardation	Associate	29304374, 32049367
Fibrosis	Associate	36039648
Glomerulonephritis IGA	Stimulate	36039648
Glycogen Storage Disease XIV	Associate	32049367
Growth Disorders	Associate	29304374
Inflammation	Associate	36039648, 38643887
Lung Neoplasms	Stimulate	30101373
Lymphatic Metastasis	Associate	28951630
Lymphoma B Cell	Associate	35784355
Mouth Neoplasms	Stimulate	30987719
Mouth Neoplasms	Associate	36849997
Neoplasm Metastasis	Associate	28982386
Neoplasms	Associate	21709263, 22152070, 28951630, 29975776, 35955598
Neoplasms	Stimulate	24927126
Nervous System Diseases	Associate	29304374, 32049367
Olfaction Disorders	Stimulate	38643887
Ovarian Neoplasms	Associate	35022380
Pancreatic Neoplasms	Associate	19302290
Parkinson Disease	Stimulate	38643887
Personality Disorders	Associate	24906821
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	34106877
Prostatic Neoplasms	Stimulate	24906821
Prostatic Neoplasms	Associate	32378902
Respiratory Tract Diseases	Associate	29304374, 32049367
Seizures	Associate	37053181
Stomach Neoplasms	Associate	24732908
Stress Disorders Post Traumatic	Associate	36982780
Uterine Cervical Neoplasms	Associate	34799549

FUT8 (fucosyltransferase 8)