Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
252983
Gene name Gene Name - the full gene name approved by the HGNC.
Syntaxin binding protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STXBP4
Synonyms (NCBI Gene) Gene synonyms aliases
Synip
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q22
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026794 hsa-miR-192-5p Microarray 19074876
MIRT043123 hsa-miR-324-5p CLASH 23622248
MIRT534023 hsa-miR-556-5p PAR-CLIP 22012620
MIRT534022 hsa-miR-3670 PAR-CLIP 22012620
MIRT534021 hsa-miR-4448 PAR-CLIP 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19451233
GO:0006605 Process Protein targeting IEA
GO:0006974 Process Cellular response to DNA damage stimulus IDA 19451233
GO:0008286 Process Insulin receptor signaling pathway IEA
GO:0010827 Process Regulation of glucose transmembrane transport IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610415 19694 ENSG00000166263
Protein
UniProt ID Q6ZWJ1
Protein name Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)
Protein function Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between ST
PDB 2YSG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00595 PDZ 21 99 PDZ domain Domain
PF00397 WW 498 527 WW domain Domain
Sequence
MNKNTSTVVSPSLLEKDPAFQMITIAKETGLGLKVLGGINRNEGPLVYIQEIIPGGDCYK
DGRLKPGDQLVSVNKESMIGVSFEEAKSIITGAKLRLES
AWEIAFIRQKSDNIQPENLSC
TSLIEASGEYGPQASTLSLFSSPPEILIPKTSSTPKTNNDILSSCEIKTGYNKTVQIPIT
SENSTVGLSNTDVASAWTENYGLQEKISLNPSVRFKAEKLEMALNYLGIQPTKEQHQALR
QQVQADSKGTVSFGDFVQVARNLFCLQLDEVNVGAHEISNILDSQLLPCDSSEADEMERL
KCERDDALKEVNTLKEKLLESDKQRKQLTEELQNVKQEAKAVVEETRALRSRIHLAEAAQ
RQAHGMEMDYEEVIRLLEAKITELKAQLADYSDQNKESVQDLKKRIMVLDCQLRKSEMAR
KTFEASTEKLLHFVEAIQEVFSDNSTPLSNLSERRAVLASQTSLTPLGRNGRSIPATLAL
ESKELVKSVRALLDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSVLNLSRSEEN
EEDCSRELPNQKS
Sequence length 553
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
29915430, 23535729, 19330027
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
25751625, 29915430, 19330027, 29059683, 23535729
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)
29915430
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Schizophrenia Schizophrenia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Blood Coagulation Disorders Associate 25042561
Breast Neoplasms Associate 19330027, 20699374, 21118973, 21194473, 21596841, 21791674, 21949660, 22532573, 23635555, 23893088, 26472073, 27600471, 32115800, 35772352
Breast Neoplasms Stimulate 35772352
Breast Neoplasms Male Associate 21949660
Carcinoma Squamous Cell Associate 32993587
Death Associate 23635555
Glioma Associate 40593136
Neoplasms Associate 32993587
Obesity Associate 36291149