TMEM9 (transmembrane protein 9)

Gene

• Entrez ID: 252839
• Gene name: Transmembrane protein 9
• Gene symbol: TMEM9
• Synonyms (NCBI Gene): DERM4, TMEM9A
• Chromosome: 1
• Chromosome location: 1q32.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050914	hsa-miR-17-5p	CLASH	23622248
MIRT046083	hsa-miR-125b-5p	CLASH	23622248
MIRT1439637	hsa-miR-1226	CLIP-seq
MIRT1439638	hsa-miR-136	CLIP-seq
MIRT1439639	hsa-miR-2277-3p	CLIP-seq
MIRT1439640	hsa-miR-329	CLIP-seq
MIRT1439641	hsa-miR-3591-3p	CLIP-seq
MIRT1439642	hsa-miR-3617	CLIP-seq
MIRT1439643	hsa-miR-362-3p	CLIP-seq
MIRT1439644	hsa-miR-3941	CLIP-seq
MIRT1439645	hsa-miR-4282	CLIP-seq
MIRT1439646	hsa-miR-466	CLIP-seq
MIRT1439647	hsa-miR-4672	CLIP-seq
MIRT1439648	hsa-miR-4768-5p	CLIP-seq
MIRT1439649	hsa-miR-519a	CLIP-seq
MIRT1439650	hsa-miR-519b-3p	CLIP-seq
MIRT1439651	hsa-miR-519c-3p	CLIP-seq
MIRT1439652	hsa-miR-543	CLIP-seq
MIRT1439653	hsa-miR-603	CLIP-seq
MIRT1439654	hsa-miR-618	CLIP-seq
MIRT1439655	hsa-miR-641	CLIP-seq
MIRT2131635	hsa-miR-1254	CLIP-seq
MIRT2131636	hsa-miR-198	CLIP-seq
MIRT2131637	hsa-miR-2355-3p	CLIP-seq
MIRT2131638	hsa-miR-24	CLIP-seq
MIRT2131639	hsa-miR-3116	CLIP-seq
MIRT2131640	hsa-miR-320e	CLIP-seq
MIRT2131641	hsa-miR-3943	CLIP-seq
MIRT2131642	hsa-miR-4323	CLIP-seq
MIRT2131643	hsa-miR-4646-3p	CLIP-seq
MIRT1439649	hsa-miR-519a	CLIP-seq
MIRT1439650	hsa-miR-519b-3p	CLIP-seq
MIRT1439651	hsa-miR-519c-3p	CLIP-seq
MIRT2131644	hsa-miR-671-5p	CLIP-seq
MIRT2131645	hsa-miR-885-3p	CLIP-seq
MIRT2352971	hsa-miR-1288	CLIP-seq
MIRT2352972	hsa-miR-135a	CLIP-seq
MIRT2352973	hsa-miR-135b	CLIP-seq
MIRT2352974	hsa-miR-3126-5p	CLIP-seq
MIRT2352975	hsa-miR-3175	CLIP-seq
MIRT2352976	hsa-miR-3199	CLIP-seq
MIRT2352977	hsa-miR-3667-5p	CLIP-seq
MIRT2352978	hsa-miR-4756-3p	CLIP-seq
MIRT2352979	hsa-miR-4779	CLIP-seq
MIRT2352980	hsa-miR-502-5p	CLIP-seq
MIRT2352981	hsa-miR-516a-3p	CLIP-seq
MIRT2352972	hsa-miR-135a	CLIP-seq
MIRT2352973	hsa-miR-135b	CLIP-seq
MIRT2352980	hsa-miR-502-5p	CLIP-seq
MIRT2352981	hsa-miR-516a-3p	CLIP-seq
MIRT2646487	hsa-miR-1200	CLIP-seq
MIRT1439637	hsa-miR-1226	CLIP-seq
MIRT2646488	hsa-miR-1237	CLIP-seq
MIRT2131635	hsa-miR-1254	CLIP-seq
MIRT2646489	hsa-miR-125a-3p	CLIP-seq
MIRT2646490	hsa-miR-1266	CLIP-seq
MIRT1439638	hsa-miR-136	CLIP-seq
MIRT2646491	hsa-miR-145	CLIP-seq
MIRT2646492	hsa-miR-148a	CLIP-seq
MIRT2646493	hsa-miR-148b	CLIP-seq
MIRT2646494	hsa-miR-149	CLIP-seq
MIRT2646495	hsa-miR-150	CLIP-seq
MIRT2646496	hsa-miR-152	CLIP-seq
MIRT2646497	hsa-miR-1825	CLIP-seq
MIRT2646498	hsa-miR-185	CLIP-seq
MIRT2131636	hsa-miR-198	CLIP-seq
MIRT2646499	hsa-miR-199a-5p	CLIP-seq
MIRT2646500	hsa-miR-199b-5p	CLIP-seq
MIRT2646501	hsa-miR-204	CLIP-seq
MIRT2646502	hsa-miR-211	CLIP-seq
MIRT2646503	hsa-miR-2115	CLIP-seq
MIRT1439639	hsa-miR-2277-3p	CLIP-seq
MIRT2131637	hsa-miR-2355-3p	CLIP-seq
MIRT2131638	hsa-miR-24	CLIP-seq
MIRT2646504	hsa-miR-3064-5p	CLIP-seq
MIRT2646505	hsa-miR-31	CLIP-seq
MIRT2131639	hsa-miR-3116	CLIP-seq
MIRT2646506	hsa-miR-3127-5p	CLIP-seq
MIRT2646507	hsa-miR-3130-5p	CLIP-seq
MIRT2646508	hsa-miR-3135b	CLIP-seq
MIRT2646509	hsa-miR-3144-5p	CLIP-seq
MIRT2646510	hsa-miR-3147	CLIP-seq
MIRT2646511	hsa-miR-3176	CLIP-seq
MIRT2646512	hsa-miR-3184	CLIP-seq
MIRT2646513	hsa-miR-3189-5p	CLIP-seq
MIRT2646514	hsa-miR-3197	CLIP-seq
MIRT2131640	hsa-miR-320e	CLIP-seq
MIRT1439640	hsa-miR-329	CLIP-seq
MIRT1439641	hsa-miR-3591-3p	CLIP-seq
MIRT1439642	hsa-miR-3617	CLIP-seq
MIRT2646515	hsa-miR-3620	CLIP-seq
MIRT1439643	hsa-miR-362-3p	CLIP-seq
MIRT2646516	hsa-miR-3652	CLIP-seq
MIRT2646517	hsa-miR-3665	CLIP-seq
MIRT2352977	hsa-miR-3667-5p	CLIP-seq
MIRT2646518	hsa-miR-3679-3p	CLIP-seq
MIRT2646519	hsa-miR-383	CLIP-seq
MIRT2646520	hsa-miR-3909	CLIP-seq
MIRT2646521	hsa-miR-3918	CLIP-seq
MIRT2646522	hsa-miR-3919	CLIP-seq
MIRT2646523	hsa-miR-3922-3p	CLIP-seq
MIRT2646524	hsa-miR-3938	CLIP-seq
MIRT1439644	hsa-miR-3941	CLIP-seq
MIRT2646525	hsa-miR-3942-3p	CLIP-seq
MIRT2131641	hsa-miR-3943	CLIP-seq
MIRT2646526	hsa-miR-423-5p	CLIP-seq
MIRT2646527	hsa-miR-4260	CLIP-seq
MIRT2646528	hsa-miR-4267	CLIP-seq
MIRT2646529	hsa-miR-4270	CLIP-seq
MIRT2646530	hsa-miR-4276	CLIP-seq
MIRT1439645	hsa-miR-4282	CLIP-seq
MIRT2646531	hsa-miR-4283	CLIP-seq
MIRT2646532	hsa-miR-4284	CLIP-seq
MIRT2646533	hsa-miR-4287	CLIP-seq
MIRT2646534	hsa-miR-4297	CLIP-seq
MIRT2646535	hsa-miR-4313	CLIP-seq
MIRT2131642	hsa-miR-4323	CLIP-seq
MIRT2646536	hsa-miR-4324	CLIP-seq
MIRT2646537	hsa-miR-4417	CLIP-seq
MIRT2646538	hsa-miR-4425	CLIP-seq
MIRT2646539	hsa-miR-4430	CLIP-seq
MIRT2646540	hsa-miR-4434	CLIP-seq
MIRT2646541	hsa-miR-4437	CLIP-seq
MIRT2646542	hsa-miR-4441	CLIP-seq
MIRT2646543	hsa-miR-4446-3p	CLIP-seq
MIRT2646544	hsa-miR-4482	CLIP-seq
MIRT2646545	hsa-miR-4489	CLIP-seq
MIRT2646546	hsa-miR-4492	CLIP-seq
MIRT2646547	hsa-miR-4498	CLIP-seq
MIRT2646548	hsa-miR-4505	CLIP-seq
MIRT2646549	hsa-miR-4516	CLIP-seq
MIRT2646550	hsa-miR-4518	CLIP-seq
MIRT2646551	hsa-miR-4633-3p	CLIP-seq
MIRT2131643	hsa-miR-4646-3p	CLIP-seq
MIRT2646552	hsa-miR-4649-3p	CLIP-seq
MIRT2646553	hsa-miR-4656	CLIP-seq
MIRT1439646	hsa-miR-466	CLIP-seq
MIRT1439647	hsa-miR-4672	CLIP-seq
MIRT2646554	hsa-miR-4674	CLIP-seq
MIRT2646555	hsa-miR-4675	CLIP-seq
MIRT2646556	hsa-miR-4685-3p	CLIP-seq
MIRT2646557	hsa-miR-4690-3p	CLIP-seq
MIRT2646558	hsa-miR-4694-5p	CLIP-seq
MIRT2646559	hsa-miR-4710	CLIP-seq
MIRT2646560	hsa-miR-4713-5p	CLIP-seq
MIRT2646561	hsa-miR-4731-5p	CLIP-seq
MIRT2646562	hsa-miR-4741	CLIP-seq
MIRT2646563	hsa-miR-4747-5p	CLIP-seq
MIRT2646564	hsa-miR-4755-5p	CLIP-seq
MIRT2352978	hsa-miR-4756-3p	CLIP-seq
MIRT2646565	hsa-miR-4758-3p	CLIP-seq
MIRT2646566	hsa-miR-4763-5p	CLIP-seq
MIRT1439648	hsa-miR-4768-5p	CLIP-seq
MIRT2646567	hsa-miR-4794	CLIP-seq
MIRT2646568	hsa-miR-483-3p	CLIP-seq
MIRT1439649	hsa-miR-519a	CLIP-seq
MIRT1439650	hsa-miR-519b-3p	CLIP-seq
MIRT1439651	hsa-miR-519c-3p	CLIP-seq
MIRT2646569	hsa-miR-532-3p	CLIP-seq
MIRT1439652	hsa-miR-543	CLIP-seq
MIRT2646570	hsa-miR-544b	CLIP-seq
MIRT2646571	hsa-miR-562	CLIP-seq
MIRT2646572	hsa-miR-574-3p	CLIP-seq
MIRT2646573	hsa-miR-586	CLIP-seq
MIRT1439653	hsa-miR-603	CLIP-seq
MIRT1439654	hsa-miR-618	CLIP-seq
MIRT2646574	hsa-miR-623	CLIP-seq
MIRT1439655	hsa-miR-641	CLIP-seq
MIRT2646575	hsa-miR-657	CLIP-seq
MIRT2131644	hsa-miR-671-5p	CLIP-seq
MIRT2646576	hsa-miR-762	CLIP-seq
MIRT2131645	hsa-miR-885-3p	CLIP-seq
MIRT2646577	hsa-miR-922	CLIP-seq
MIRT2646487	hsa-miR-1200	CLIP-seq
MIRT1439637	hsa-miR-1226	CLIP-seq
MIRT2646488	hsa-miR-1237	CLIP-seq
MIRT2131635	hsa-miR-1254	CLIP-seq
MIRT2646489	hsa-miR-125a-3p	CLIP-seq
MIRT2646490	hsa-miR-1266	CLIP-seq
MIRT2352971	hsa-miR-1288	CLIP-seq
MIRT1439638	hsa-miR-136	CLIP-seq
MIRT2646491	hsa-miR-145	CLIP-seq
MIRT2646492	hsa-miR-148a	CLIP-seq
MIRT2646493	hsa-miR-148b	CLIP-seq
MIRT2646494	hsa-miR-149	CLIP-seq
MIRT2646495	hsa-miR-150	CLIP-seq
MIRT2646496	hsa-miR-152	CLIP-seq
MIRT2646497	hsa-miR-1825	CLIP-seq
MIRT2131636	hsa-miR-198	CLIP-seq
MIRT2646499	hsa-miR-199a-5p	CLIP-seq
MIRT2646500	hsa-miR-199b-5p	CLIP-seq
MIRT2646501	hsa-miR-204	CLIP-seq
MIRT2646502	hsa-miR-211	CLIP-seq
MIRT2646503	hsa-miR-2115	CLIP-seq
MIRT1439639	hsa-miR-2277-3p	CLIP-seq
MIRT2131637	hsa-miR-2355-3p	CLIP-seq
MIRT2131638	hsa-miR-24	CLIP-seq
MIRT2693569	hsa-miR-3064-3p	CLIP-seq
MIRT2646504	hsa-miR-3064-5p	CLIP-seq
MIRT2131639	hsa-miR-3116	CLIP-seq
MIRT2693570	hsa-miR-3119	CLIP-seq
MIRT2352974	hsa-miR-3126-5p	CLIP-seq
MIRT2646506	hsa-miR-3127-5p	CLIP-seq
MIRT2646507	hsa-miR-3130-5p	CLIP-seq
MIRT2646509	hsa-miR-3144-5p	CLIP-seq
MIRT2646510	hsa-miR-3147	CLIP-seq
MIRT2693571	hsa-miR-3150a-3p	CLIP-seq
MIRT2352975	hsa-miR-3175	CLIP-seq
MIRT2646511	hsa-miR-3176	CLIP-seq
MIRT2646512	hsa-miR-3184	CLIP-seq
MIRT2646513	hsa-miR-3189-5p	CLIP-seq
MIRT2352976	hsa-miR-3199	CLIP-seq
MIRT2131640	hsa-miR-320e	CLIP-seq
MIRT1439640	hsa-miR-329	CLIP-seq
MIRT1439641	hsa-miR-3591-3p	CLIP-seq
MIRT1439642	hsa-miR-3617	CLIP-seq
MIRT2646515	hsa-miR-3620	CLIP-seq
MIRT1439643	hsa-miR-362-3p	CLIP-seq
MIRT2646517	hsa-miR-3665	CLIP-seq
MIRT2352977	hsa-miR-3667-5p	CLIP-seq
MIRT2646518	hsa-miR-3679-3p	CLIP-seq
MIRT2646523	hsa-miR-3922-3p	CLIP-seq
MIRT2646524	hsa-miR-3938	CLIP-seq
MIRT1439644	hsa-miR-3941	CLIP-seq
MIRT2646525	hsa-miR-3942-3p	CLIP-seq
MIRT2131641	hsa-miR-3943	CLIP-seq
MIRT2646526	hsa-miR-423-5p	CLIP-seq
MIRT2646527	hsa-miR-4260	CLIP-seq
MIRT2646528	hsa-miR-4267	CLIP-seq
MIRT2646529	hsa-miR-4270	CLIP-seq
MIRT1439645	hsa-miR-4282	CLIP-seq
MIRT2646532	hsa-miR-4284	CLIP-seq
MIRT2646533	hsa-miR-4287	CLIP-seq
MIRT2646534	hsa-miR-4297	CLIP-seq
MIRT2646535	hsa-miR-4313	CLIP-seq
MIRT2131642	hsa-miR-4323	CLIP-seq
MIRT2646536	hsa-miR-4324	CLIP-seq
MIRT2646537	hsa-miR-4417	CLIP-seq
MIRT2646538	hsa-miR-4425	CLIP-seq
MIRT2646540	hsa-miR-4434	CLIP-seq
MIRT2646541	hsa-miR-4437	CLIP-seq
MIRT2693572	hsa-miR-4438	CLIP-seq
MIRT2646542	hsa-miR-4441	CLIP-seq
MIRT2693573	hsa-miR-4463	CLIP-seq
MIRT2646544	hsa-miR-4482	CLIP-seq
MIRT2646549	hsa-miR-4516	CLIP-seq
MIRT2646550	hsa-miR-4518	CLIP-seq
MIRT2131643	hsa-miR-4646-3p	CLIP-seq
MIRT2646552	hsa-miR-4649-3p	CLIP-seq
MIRT1439646	hsa-miR-466	CLIP-seq
MIRT2693574	hsa-miR-4667-5p	CLIP-seq
MIRT1439647	hsa-miR-4672	CLIP-seq
MIRT2646554	hsa-miR-4674	CLIP-seq
MIRT2646555	hsa-miR-4675	CLIP-seq
MIRT2646556	hsa-miR-4685-3p	CLIP-seq
MIRT2646557	hsa-miR-4690-3p	CLIP-seq
MIRT2646558	hsa-miR-4694-5p	CLIP-seq
MIRT2693575	hsa-miR-4700-5p	CLIP-seq
MIRT2646559	hsa-miR-4710	CLIP-seq
MIRT2646560	hsa-miR-4713-5p	CLIP-seq
MIRT2646562	hsa-miR-4741	CLIP-seq
MIRT2646563	hsa-miR-4747-5p	CLIP-seq
MIRT2646564	hsa-miR-4755-5p	CLIP-seq
MIRT2352978	hsa-miR-4756-3p	CLIP-seq
MIRT2646565	hsa-miR-4758-3p	CLIP-seq
MIRT2646566	hsa-miR-4763-5p	CLIP-seq
MIRT1439648	hsa-miR-4768-5p	CLIP-seq
MIRT2352979	hsa-miR-4779	CLIP-seq
MIRT2646567	hsa-miR-4794	CLIP-seq
MIRT2646568	hsa-miR-483-3p	CLIP-seq
MIRT1439649	hsa-miR-519a	CLIP-seq
MIRT1439650	hsa-miR-519b-3p	CLIP-seq
MIRT1439651	hsa-miR-519c-3p	CLIP-seq
MIRT2646569	hsa-miR-532-3p	CLIP-seq
MIRT2646570	hsa-miR-544b	CLIP-seq
MIRT2646571	hsa-miR-562	CLIP-seq
MIRT2646572	hsa-miR-574-3p	CLIP-seq
MIRT2646573	hsa-miR-586	CLIP-seq
MIRT1439653	hsa-miR-603	CLIP-seq
MIRT1439654	hsa-miR-618	CLIP-seq
MIRT2646574	hsa-miR-623	CLIP-seq
MIRT1439655	hsa-miR-641	CLIP-seq
MIRT2646575	hsa-miR-657	CLIP-seq
MIRT2131644	hsa-miR-671-5p	CLIP-seq
MIRT2693576	hsa-miR-7	CLIP-seq
MIRT2131645	hsa-miR-885-3p	CLIP-seq
MIRT2646577	hsa-miR-922	CLIP-seq
MIRT2693577	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	30374053, 32296183, 33961781
GO:0005764	Component	Lysosome	IDA	12359240
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	30374053
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IDA	12359240
GO:0007042	Process	Lysosomal lumen acidification	IDA	30374053
GO:0015031	Process	Protein transport	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0032585	Component	Multivesicular body membrane	IDA	30374053
GO:0032585	Component	Multivesicular body membrane	IEA
GO:0042176	Process	Regulation of protein catabolic process	IEA
GO:0042176	Process	Regulation of protein catabolic process	ISS
GO:0045171	Component	Intercellular bridge	IDA
GO:0048388	Process	Endosomal lumen acidification	IDA	30374053
GO:0070070	Process	Proton-transporting V-type ATPase complex assembly	IDA	30374053
GO:0072686	Component	Mitotic spindle	IDA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IDA	30374053
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IEA

Other IDs

• MIM: 616877
• HGNC: 18823
• e!Ensembl: ENSG00000116857

Protein

• UniProt ID: Q9P0T7
• Protein name: Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9)
• Protein function: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053). By bringing the v-ATPase accessory prote
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05434	Tmemb_9	41 → 182	TMEM9	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate (PubMed:12359240). Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen (PubMed:12359240, PubMed:30374053). Low expression
• Sequence:

  MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVE
  PMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPD
  AYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHK
  MLS

• Sequence length: 183

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Adenomatous Polyposis Coli	Inhibit	36596527	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	36596527	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	31210410	★☆☆☆☆ Found in Text Mining only
Lung Injury	Associate	32459537	★☆☆☆☆ Found in Text Mining only
Muscular Diseases	Associate	35543701	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	36596527	★☆☆☆☆ Found in Text Mining only