Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	246330
Gene name	Pellino E3 ubiquitin protein ligase family member 3
Gene symbol	PELI3
Synonyms (NCBI Gene)	-
Chromosome	11
Chromosome location	11q13.2
Summary	The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several tr

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Show/Hide all (169)

miRTarBase ID	miRNA	Experiments	Reference
MIRT647632	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT647631	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT647630	hsa-miR-885-5p	HITS-CLIP	23824327
MIRT647628	hsa-miR-4469	HITS-CLIP	23824327
MIRT647629	hsa-miR-4786-3p	HITS-CLIP	23824327
MIRT647627	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647626	hsa-miR-7843-3p	HITS-CLIP	23824327
MIRT647625	hsa-miR-587	HITS-CLIP	23824327
MIRT647632	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT647631	hsa-miR-5003-3p	HITS-CLIP	23824327
MIRT647630	hsa-miR-885-5p	HITS-CLIP	23824327
MIRT647628	hsa-miR-4469	HITS-CLIP	23824327
MIRT647629	hsa-miR-4786-3p	HITS-CLIP	23824327
MIRT647627	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT647626	hsa-miR-7843-3p	HITS-CLIP	23824327
MIRT647625	hsa-miR-587	HITS-CLIP	23824327
MIRT1224860	hsa-miR-128	CLIP-seq
MIRT1224861	hsa-miR-3065-3p	CLIP-seq
MIRT1224862	hsa-miR-3127-5p	CLIP-seq
MIRT1224863	hsa-miR-3605-3p	CLIP-seq
MIRT1224864	hsa-miR-3945	CLIP-seq
MIRT1224865	hsa-miR-425	CLIP-seq
MIRT1224866	hsa-miR-4253	CLIP-seq
MIRT1224867	hsa-miR-4270	CLIP-seq
MIRT1224868	hsa-miR-4441	CLIP-seq
MIRT1224869	hsa-miR-4706	CLIP-seq
MIRT1224870	hsa-miR-4717-3p	CLIP-seq
MIRT1224871	hsa-miR-4749-5p	CLIP-seq
MIRT1224872	hsa-miR-541	CLIP-seq
MIRT1224873	hsa-miR-654-5p	CLIP-seq
MIRT1224874	hsa-miR-744	CLIP-seq
MIRT1224875	hsa-miR-15a	CLIP-seq
MIRT1224876	hsa-miR-15b	CLIP-seq
MIRT1224877	hsa-miR-16	CLIP-seq
MIRT1224878	hsa-miR-1909	CLIP-seq
MIRT1224879	hsa-miR-1915	CLIP-seq
MIRT1224880	hsa-miR-195	CLIP-seq
MIRT1224881	hsa-miR-214	CLIP-seq
MIRT1224882	hsa-miR-296-5p	CLIP-seq
MIRT1224883	hsa-miR-3619-5p	CLIP-seq
MIRT1224884	hsa-miR-424	CLIP-seq
MIRT1224885	hsa-miR-497	CLIP-seq
MIRT1224886	hsa-miR-761	CLIP-seq
MIRT2065581	hsa-miR-1237	CLIP-seq
MIRT1224860	hsa-miR-128	CLIP-seq
MIRT2065582	hsa-miR-132	CLIP-seq
MIRT2065583	hsa-miR-1914	CLIP-seq
MIRT2065584	hsa-miR-212	CLIP-seq
MIRT2065585	hsa-miR-2278	CLIP-seq
MIRT2065586	hsa-miR-3127-3p	CLIP-seq
MIRT2065587	hsa-miR-3138	CLIP-seq
MIRT2065588	hsa-miR-3182	CLIP-seq
MIRT2065589	hsa-miR-3622a-3p	CLIP-seq
MIRT2065590	hsa-miR-3622b-3p	CLIP-seq
MIRT2065591	hsa-miR-3686	CLIP-seq
MIRT2065592	hsa-miR-3976	CLIP-seq
MIRT2065593	hsa-miR-4287	CLIP-seq
MIRT2065594	hsa-miR-4290	CLIP-seq
MIRT2065595	hsa-miR-4663	CLIP-seq
MIRT2065596	hsa-miR-4685-3p	CLIP-seq
MIRT2065597	hsa-miR-4742-3p	CLIP-seq
MIRT2065598	hsa-miR-4752	CLIP-seq
MIRT2065599	hsa-miR-4795-3p	CLIP-seq
MIRT2065600	hsa-miR-4800-5p	CLIP-seq
MIRT2065601	hsa-miR-581	CLIP-seq
MIRT2065602	hsa-miR-622	CLIP-seq
MIRT1224862	hsa-miR-3127-5p	CLIP-seq
MIRT1224872	hsa-miR-541	CLIP-seq
MIRT1224873	hsa-miR-654-5p	CLIP-seq
MIRT2065599	hsa-miR-4795-3p	CLIP-seq
MIRT1224860	hsa-miR-128	CLIP-seq
MIRT1224861	hsa-miR-3065-3p	CLIP-seq
MIRT1224862	hsa-miR-3127-5p	CLIP-seq
MIRT1224864	hsa-miR-3945	CLIP-seq
MIRT1224866	hsa-miR-4253	CLIP-seq
MIRT1224867	hsa-miR-4270	CLIP-seq
MIRT1224868	hsa-miR-4441	CLIP-seq
MIRT1224869	hsa-miR-4706	CLIP-seq
MIRT1224870	hsa-miR-4717-3p	CLIP-seq
MIRT1224871	hsa-miR-4749-5p	CLIP-seq
MIRT1224872	hsa-miR-541	CLIP-seq
MIRT2065601	hsa-miR-581	CLIP-seq
MIRT1224873	hsa-miR-654-5p	CLIP-seq
MIRT1224874	hsa-miR-744	CLIP-seq
MIRT2392397	hsa-miR-1256	CLIP-seq
MIRT2392398	hsa-miR-1275	CLIP-seq
MIRT2392399	hsa-miR-25	CLIP-seq
MIRT2392400	hsa-miR-3135b	CLIP-seq
MIRT2392401	hsa-miR-32	CLIP-seq
MIRT2392402	hsa-miR-3612	CLIP-seq
MIRT2392403	hsa-miR-3614-5p	CLIP-seq
MIRT2392404	hsa-miR-363	CLIP-seq
MIRT2392405	hsa-miR-3652	CLIP-seq
MIRT2392406	hsa-miR-367	CLIP-seq
MIRT2392407	hsa-miR-4430	CLIP-seq
MIRT2392408	hsa-miR-4443	CLIP-seq
MIRT2392409	hsa-miR-4488	CLIP-seq
MIRT2392410	hsa-miR-4492	CLIP-seq
MIRT2392411	hsa-miR-4498	CLIP-seq
MIRT2392412	hsa-miR-4665-5p	CLIP-seq
MIRT2392413	hsa-miR-4697-5p	CLIP-seq
MIRT2065599	hsa-miR-4795-3p	CLIP-seq
MIRT2392414	hsa-miR-650	CLIP-seq
MIRT2392415	hsa-miR-762	CLIP-seq
MIRT2392416	hsa-miR-92a	CLIP-seq
MIRT2392417	hsa-miR-92b	CLIP-seq
MIRT2065581	hsa-miR-1237	CLIP-seq
MIRT2392398	hsa-miR-1275	CLIP-seq
MIRT2456241	hsa-miR-138	CLIP-seq
MIRT2065583	hsa-miR-1914	CLIP-seq
MIRT1224879	hsa-miR-1915	CLIP-seq
MIRT2065585	hsa-miR-2278	CLIP-seq
MIRT2065586	hsa-miR-3127-3p	CLIP-seq
MIRT2065588	hsa-miR-3182	CLIP-seq
MIRT2456242	hsa-miR-3189-5p	CLIP-seq
MIRT2456243	hsa-miR-361-3p	CLIP-seq
MIRT2392403	hsa-miR-3614-5p	CLIP-seq
MIRT2065589	hsa-miR-3622a-3p	CLIP-seq
MIRT2065590	hsa-miR-3622b-3p	CLIP-seq
MIRT2392405	hsa-miR-3652	CLIP-seq
MIRT2456244	hsa-miR-3680	CLIP-seq
MIRT2065591	hsa-miR-3686	CLIP-seq
MIRT2456245	hsa-miR-3907	CLIP-seq
MIRT2065592	hsa-miR-3976	CLIP-seq
MIRT2065593	hsa-miR-4287	CLIP-seq
MIRT2065594	hsa-miR-4290	CLIP-seq
MIRT2392407	hsa-miR-4430	CLIP-seq
MIRT2456246	hsa-miR-4487	CLIP-seq
MIRT2392409	hsa-miR-4488	CLIP-seq
MIRT2392410	hsa-miR-4492	CLIP-seq
MIRT2456247	hsa-miR-4493	CLIP-seq
MIRT2392411	hsa-miR-4498	CLIP-seq
MIRT2392412	hsa-miR-4665-5p	CLIP-seq
MIRT2065596	hsa-miR-4685-3p	CLIP-seq
MIRT2392413	hsa-miR-4697-5p	CLIP-seq
MIRT2456248	hsa-miR-4715-3p	CLIP-seq
MIRT2065597	hsa-miR-4742-3p	CLIP-seq
MIRT2456249	hsa-miR-483-3p	CLIP-seq
MIRT2456250	hsa-miR-548q	CLIP-seq
MIRT2392415	hsa-miR-762	CLIP-seq
MIRT2065581	hsa-miR-1237	CLIP-seq
MIRT2456241	hsa-miR-138	CLIP-seq
MIRT2065583	hsa-miR-1914	CLIP-seq
MIRT2065585	hsa-miR-2278	CLIP-seq
MIRT2065588	hsa-miR-3182	CLIP-seq
MIRT2456242	hsa-miR-3189-5p	CLIP-seq
MIRT2065589	hsa-miR-3622a-3p	CLIP-seq
MIRT2065590	hsa-miR-3622b-3p	CLIP-seq
MIRT2065591	hsa-miR-3686	CLIP-seq
MIRT2456245	hsa-miR-3907	CLIP-seq
MIRT2065592	hsa-miR-3976	CLIP-seq
MIRT2065593	hsa-miR-4287	CLIP-seq
MIRT2065594	hsa-miR-4290	CLIP-seq
MIRT2591506	hsa-miR-4310	CLIP-seq
MIRT2456247	hsa-miR-4493	CLIP-seq
MIRT2065596	hsa-miR-4685-3p	CLIP-seq
MIRT2065597	hsa-miR-4742-3p	CLIP-seq
MIRT2065598	hsa-miR-4752	CLIP-seq
MIRT2456250	hsa-miR-548q	CLIP-seq
MIRT2065601	hsa-miR-581	CLIP-seq
MIRT2456241	hsa-miR-138	CLIP-seq
MIRT2065585	hsa-miR-2278	CLIP-seq
MIRT2456242	hsa-miR-3189-5p	CLIP-seq
MIRT2456245	hsa-miR-3907	CLIP-seq
MIRT2065592	hsa-miR-3976	CLIP-seq
MIRT2591506	hsa-miR-4310	CLIP-seq
MIRT2456247	hsa-miR-4493	CLIP-seq
MIRT2456250	hsa-miR-548q	CLIP-seq
MIRT2065601	hsa-miR-581	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	12874243, 19081057, 25814554, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0008592	Process	Regulation of Toll signaling pathway	IEA
GO:0010804	Process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IMP	24113711
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IBA
GO:2001237	Process	Negative regulation of extrinsic apoptotic signaling pathway	IMP	24113711

MIM	HGNC	e!Ensembl
609827	30010	ENSG00000174516

Q8N2H9

Protein name

E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27)

Protein function

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:12874243, PubMed:17675297). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04710	Pellino	71 → 469	Pellino	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung. {ECO:0000269|PubMed:12874243}.

Sequence

MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGCCEEGGEET
EAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKAL
SNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGGGAAEGPSA
QSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLV
MHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGAT
LLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYV
RCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGH
VCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD

Sequence length

469

Interactions

View interactions

	Reactome
			Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Inflammation	Associate	32366870	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	31520466	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	31520466	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Associate	32366870	★★★★★ ★☆☆☆☆ Found in Text Mining only

PELI3 (pellino E3 ubiquitin protein ligase family member 3)