AFG1L (AFG1 like ATPase)

Gene

• Entrez ID: 246269
• Gene name: AFG1 like ATPase
• Gene symbol: AFG1L
• Synonyms (NCBI Gene): AFG1, LACE1, c222389
• Chromosome: 6
• Chromosome location: 6q21
• Summary: This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT560489	hsa-miR-3141	PAR-CLIP	20371350
MIRT560488	hsa-miR-4715-5p	PAR-CLIP	20371350
MIRT560487	hsa-miR-571	PAR-CLIP	20371350
MIRT560486	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT560485	hsa-miR-4467	PAR-CLIP	20371350
MIRT560484	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT560483	hsa-miR-663a	PAR-CLIP	20371350
MIRT560482	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT560481	hsa-miR-4730	PAR-CLIP	20371350
MIRT560480	hsa-miR-6770-3p	PAR-CLIP	20371350
MIRT560479	hsa-miR-1228-5p	PAR-CLIP	20371350

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 26759378, 27323408, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	27323408
GO:0005739	Component	Mitochondrion	IEA
GO:0007005	Process	Mitochondrion organization	IMP	26759378
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0031966	Component	Mitochondrial membrane	IDA	26759378
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0035694	Process	Mitochondrial protein catabolic process	IMP	26759378
GO:0141164	Process	Mitochondrial protein quality control	IMP	27323408

Other IDs

• MIM: 617469
• HGNC: 16411
• e!Ensembl: ENSG00000135537

Protein

• UniProt ID: Q8WV93
• Protein name: AFG1-like ATPase (Lactation elevated protein 1) (EC 3.6.-.-) (Protein AFG1 homolog)
• Protein function: Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03969	AFG1_ATPase	74 → 433	AFG1-like ATPase	Family

• Sequence:

  MAASWSLLVTLRPLAQSPLRGRCVGCGAWAAALAPLATAPGKPFWKAYTVQTSESMTPTA
  TSETYLKALAVCHGPLDHYDFLIKAHELKDDEHQRRVIQCLQKLHEDLKGYNIEAEGLFS
  KLFSRSKPPRGLYVYGDVGTGKTMVMDMFYAYVEMKRKKRVHFHGFMLDVHKRIHRLKQS
  LPKRKPGFMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFENLFKNGVVV
  VATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSGIDYRKRELPAAGKLYYLTSE
  ADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTVADCTFEELCERPLGASD
  YLELSKNFDTIFLRNIPQFTLANRTQGRRFITLIDNFYDLKVRIICSASTPISSLFLHQH
  HDSELEQSRILMDDLGLSQDSAEGLSMFTGEEEIFAFQRTISRLTEMQTEQYWNEGDRTK
  K

• Sequence length: 481