Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
246
Gene name Gene Name - the full gene name approved by the HGNC.
Arachidonate 15-lipoxygenase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ALOX15
Synonyms (NCBI Gene) Gene synonyms aliases
12-LOX, 15-LOX, 15-LOX-1, LOG15
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The e
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT437575 hsa-miR-203a-3p Microarray, qRT-PCR 22815788
MIRT541602 hsa-miR-4432 PAR-CLIP 21572407
MIRT541601 hsa-miR-451b PAR-CLIP 21572407
MIRT541599 hsa-miR-6501-3p PAR-CLIP 21572407
MIRT541600 hsa-miR-6849-3p PAR-CLIP 21572407
Transcription factors
Transcription factor Regulation Reference
CREBBP Activation 12517954
EP300 Activation 12517954
HDAC1 Unknown 19198625
MTA1 Unknown 19198625
SPI1 Activation 16320347
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001503 Process Ossification ISS
GO:0002820 Process Negative regulation of adaptive immune response ISS
GO:0004052 Function Arachidonate 12(S)-lipoxygenase activity IBA 21873635
GO:0004052 Function Arachidonate 12(S)-lipoxygenase activity IDA 1944593
GO:0005506 Function Iron ion binding ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
152392 433 ENSG00000161905
Protein
UniProt ID P16050
Protein name Polyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A
Protein function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:17052953, PubMed:1944593, PubMed:24282679, PubMed:
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01477 PLAT 4 107 PLAT/LH2 domain Domain
PF00305 Lipoxygenase 183 650 Lipoxygenase Domain
Tissue specificity TISSUE SPECIFICITY: Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. {ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:9414270}.
Sequence
Sequence length 662
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Arachidonic acid metabolism
Linoleic acid metabolism
Metabolic pathways
Efferocytosis
Ferroptosis
Necroptosis
Serotonergic synapse
  Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of 12-eicosatetraenoic acid derivatives
Synthesis of 15-eicosatetraenoic acid derivatives
Interleukin-4 and Interleukin-13 signaling
Biosynthesis of DHA-derived SPMs
Biosynthesis of protectins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-6 SPMs
Biosynthesis of DPAn-3-derived protectins and resolvins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Esophagus neoplasm Esophageal Neoplasms, Malignant neoplasm of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 11406566
Hypertension Hypertensive disease rs13306026 22467300
Unknown
Disease term Disease name Evidence References Source
Atherosclerosis Atherosclerosis 16303615 ClinVar
Heart failure Heart Failure, Diastolic 29556499 ClinVar
Nasal polyposis Nasal polyposis GWAS
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 26826164
Abortion Spontaneous Associate 26826164
Acute Coronary Syndrome Associate 23535507
Acute Disease Associate 19095947
Adenocarcinoma of Lung Associate 39259123
Adenoma Inhibit 16357157
Adenoma Associate 17236225, 23778325
Adenomatous Polyposis Coli Inhibit 16357157
Allergic Fungal Sinusitis Associate 33218117
Alzheimer Disease Associate 15111312, 16151530