Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	246
Gene name Gene Name - the full gene name approved by the HGNC.	Arachidonate 15-lipoxygenase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ALOX15
Synonyms (NCBI Gene) Gene synonyms aliases	12-LOX, 15-LOX, 15-LOX-1, LOG15
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The e

Show/Hide all(195)

miRTarBase ID	miRNA	Experiments	Reference
MIRT437575	hsa-miR-203a-3p	Microarray, qRT-PCR	22815788
MIRT541602	hsa-miR-4432	PAR-CLIP	21572407
MIRT541601	hsa-miR-451b	PAR-CLIP	21572407
MIRT541599	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT541600	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT541598	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT541597	hsa-miR-6776-5p	PAR-CLIP	21572407
MIRT541596	hsa-miR-4696	PAR-CLIP	21572407
MIRT541595	hsa-miR-363-5p	PAR-CLIP	21572407
MIRT541594	hsa-miR-6745	PAR-CLIP	21572407
MIRT541593	hsa-miR-6756-5p	PAR-CLIP	21572407
MIRT541592	hsa-miR-6766-5p	PAR-CLIP	21572407
MIRT541591	hsa-miR-1293	PAR-CLIP	21572407
MIRT541590	hsa-miR-4483	PAR-CLIP	21572407
MIRT541589	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT541588	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT451512	hsa-miR-302f	PAR-CLIP	23592263
MIRT451511	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT451510	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT451509	hsa-miR-940	PAR-CLIP	23592263
MIRT451508	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT451507	hsa-miR-665	PAR-CLIP	23592263
MIRT451506	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT451505	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT451504	hsa-miR-1827	PAR-CLIP	23592263
MIRT451503	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT451502	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT451501	hsa-miR-1273e	PAR-CLIP	23592263
MIRT541602	hsa-miR-4432	PAR-CLIP	21572407
MIRT541601	hsa-miR-451b	PAR-CLIP	21572407
MIRT541599	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT541600	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT541598	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT541597	hsa-miR-6776-5p	PAR-CLIP	21572407
MIRT541596	hsa-miR-4696	PAR-CLIP	21572407
MIRT541595	hsa-miR-363-5p	PAR-CLIP	21572407
MIRT541594	hsa-miR-6745	PAR-CLIP	21572407
MIRT541593	hsa-miR-6756-5p	PAR-CLIP	21572407
MIRT541592	hsa-miR-6766-5p	PAR-CLIP	21572407
MIRT541591	hsa-miR-1293	PAR-CLIP	21572407
MIRT541590	hsa-miR-4483	PAR-CLIP	21572407
MIRT541589	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT541588	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT451512	hsa-miR-302f	PAR-CLIP	23592263
MIRT451511	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT451510	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT451509	hsa-miR-940	PAR-CLIP	23592263
MIRT451508	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT451507	hsa-miR-665	PAR-CLIP	23592263
MIRT451506	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT451505	hsa-miR-219b-3p	PAR-CLIP	23592263
MIRT451504	hsa-miR-1827	PAR-CLIP	23592263
MIRT451503	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT451502	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT451501	hsa-miR-1273e	PAR-CLIP	23592263
MIRT755579	hsa-miR-660-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunofluorescence	37425043
MIRT778866	hsa-miR-1225-3p	CLIP-seq
MIRT778867	hsa-miR-1233	CLIP-seq
MIRT778868	hsa-miR-203	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778870	hsa-miR-3065-5p	CLIP-seq
MIRT778871	hsa-miR-3120-5p	CLIP-seq
MIRT778872	hsa-miR-3135	CLIP-seq
MIRT778873	hsa-miR-3174	CLIP-seq
MIRT778874	hsa-miR-3180-5p	CLIP-seq
MIRT778875	hsa-miR-3609	CLIP-seq
MIRT778876	hsa-miR-3613-3p	CLIP-seq
MIRT778877	hsa-miR-3622b-5p	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778879	hsa-miR-3664-5p	CLIP-seq
MIRT778880	hsa-miR-3672	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778883	hsa-miR-3924	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778885	hsa-miR-3973	CLIP-seq
MIRT778886	hsa-miR-410	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778889	hsa-miR-4455	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778891	hsa-miR-4474-3p	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778893	hsa-miR-4517	CLIP-seq
MIRT778894	hsa-miR-4522	CLIP-seq
MIRT778895	hsa-miR-4635	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778898	hsa-miR-4793-3p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778900	hsa-miR-508-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778903	hsa-miR-520g	CLIP-seq
MIRT778904	hsa-miR-520h	CLIP-seq
MIRT778905	hsa-miR-548ah	CLIP-seq
MIRT778906	hsa-miR-554	CLIP-seq
MIRT778907	hsa-miR-579	CLIP-seq
MIRT778908	hsa-miR-609	CLIP-seq
MIRT778909	hsa-miR-661	CLIP-seq
MIRT778910	hsa-miR-766	CLIP-seq
MIRT778911	hsa-miR-921	CLIP-seq
MIRT1920243	hsa-miR-3168	CLIP-seq
MIRT1920244	hsa-miR-587	CLIP-seq
MIRT1920243	hsa-miR-3168	CLIP-seq
MIRT1920244	hsa-miR-587	CLIP-seq
MIRT1920243	hsa-miR-3168	CLIP-seq
MIRT1920244	hsa-miR-587	CLIP-seq
MIRT1929924	hsa-miR-183	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778873	hsa-miR-3174	CLIP-seq
MIRT778877	hsa-miR-3622b-5p	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT1929925	hsa-miR-4537	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778898	hsa-miR-4793-3p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778900	hsa-miR-508-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778907	hsa-miR-579	CLIP-seq
MIRT778910	hsa-miR-766	CLIP-seq
MIRT778911	hsa-miR-921	CLIP-seq
MIRT1929924	hsa-miR-183	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778889	hsa-miR-4455	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778898	hsa-miR-4793-3p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778900	hsa-miR-508-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778907	hsa-miR-579	CLIP-seq
MIRT778908	hsa-miR-609	CLIP-seq
MIRT778909	hsa-miR-661	CLIP-seq
MIRT778910	hsa-miR-766	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778907	hsa-miR-579	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778881	hsa-miR-3689a-3p	CLIP-seq
MIRT778882	hsa-miR-3689c	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778897	hsa-miR-4728-5p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq
MIRT778873	hsa-miR-3174	CLIP-seq
MIRT2473398	hsa-miR-4316	CLIP-seq
MIRT778911	hsa-miR-921	CLIP-seq
MIRT778869	hsa-miR-2114	CLIP-seq
MIRT778878	hsa-miR-3664-3p	CLIP-seq
MIRT778884	hsa-miR-3929	CLIP-seq
MIRT778887	hsa-miR-4419b	CLIP-seq
MIRT778888	hsa-miR-4433	CLIP-seq
MIRT778890	hsa-miR-4459	CLIP-seq
MIRT778892	hsa-miR-4478	CLIP-seq
MIRT778896	hsa-miR-4695-5p	CLIP-seq
MIRT778899	hsa-miR-485-5p	CLIP-seq
MIRT778901	hsa-miR-510	CLIP-seq
MIRT778902	hsa-miR-512-5p	CLIP-seq

Transcription factors

Show/Hide all(7)

Transcription factor	Regulation	Reference
CREBBP	Activation	12517954
EP300	Activation	12517954
HDAC1	Unknown	19198625
MTA1	Unknown	19198625
SPI1	Activation	16320347
STAT6	Activation	12517954
STAT6	Unknown	10657944

Show/Hide all(81)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001503	Process	Ossification	IEA
GO:0001503	Process	Ossification	ISS
GO:0002820	Process	Negative regulation of adaptive immune response	IEA
GO:0002820	Process	Negative regulation of adaptive immune response	ISS
GO:0004052	Function	Arachidonate 12(S)-lipoxygenase activity	IBA
GO:0004052	Function	Arachidonate 12(S)-lipoxygenase activity	IDA	1944593
GO:0004052	Function	Arachidonate 12(S)-lipoxygenase activity	IEA
GO:0005506	Function	Iron ion binding	IEA
GO:0005506	Function	Iron ion binding	ISS
GO:0005515	Function	Protein binding	IPI	21831839, 28514442, 33961781
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	17052953
GO:0005737	Component	Cytoplasm	IEA
GO:0005811	Component	Lipid droplet	IDA	19528634
GO:0005811	Component	Lipid droplet	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	17052953, 21831839
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006629	Process	Lipid metabolic process	IDA	23242647, 25293588
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	IEA
GO:0006646	Process	Phosphatidylethanolamine biosynthetic process	ISS
GO:0006954	Process	Inflammatory response	TAS	10200270
GO:0008289	Function	Lipid binding	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	17052953
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IDA	11278875
GO:0016020	Component	Membrane	IDA	21831839
GO:0016020	Component	Membrane	IEA
GO:0016165	Function	Linoleate 13S-lipoxygenase activity	IBA
GO:0016165	Function	Linoleate 13S-lipoxygenase activity	IDA	8334154
GO:0016165	Function	Linoleate 13S-lipoxygenase activity	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016702	Function	Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA
GO:0019369	Process	Arachidonate metabolic process	IBA
GO:0019369	Process	Arachidonate metabolic process	IDA	1944593, 8334154, 17052953, 24282679
GO:0019369	Process	Arachidonate metabolic process	IEA
GO:0019369	Process	Arachidonate metabolic process	NAS	3202857
GO:0019372	Process	Lipoxygenase pathway	IBA
GO:0019372	Process	Lipoxygenase pathway	IDA	1944593, 23242647
GO:0019372	Process	Lipoxygenase pathway	IEA
GO:0019372	Process	Lipoxygenase pathway	TAS
GO:0019395	Process	Fatty acid oxidation	ISS
GO:0030282	Process	Bone mineralization	IEA
GO:0030282	Process	Bone mineralization	ISS
GO:0030838	Process	Positive regulation of actin filament polymerization	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	ISS
GO:0034440	Process	Lipid oxidation	IBA
GO:0034440	Process	Lipid oxidation	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	ISS
GO:0035358	Process	Regulation of peroxisome proliferator activated receptor signaling pathway	IEA
GO:0035358	Process	Regulation of peroxisome proliferator activated receptor signaling pathway	ISS
GO:0035963	Process	Cellular response to interleukin-13	IMP	21831839
GO:0042060	Process	Wound healing	IEA
GO:0042060	Process	Wound healing	ISS
GO:0042759	Process	Long-chain fatty acid biosynthetic process	IEA
GO:0042759	Process	Long-chain fatty acid biosynthetic process	TAS
GO:0043277	Process	Apoptotic cell clearance	IEA
GO:0043277	Process	Apoptotic cell clearance	ISS
GO:0043651	Process	Linoleic acid metabolic process	IDA	8334154
GO:0043651	Process	Linoleic acid metabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	IBA
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	IDA	1944593, 8334154, 17052953, 24282679
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	IEA
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	NAS	3202857
GO:0050473	Function	Arachidonate 15-lipoxygenase activity	TAS
GO:0050727	Process	Regulation of inflammatory response	IDA	23242647
GO:0051122	Process	Hepoxilin biosynthetic process	ISS
GO:0051213	Function	Dioxygenase activity	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	21831839
GO:0071277	Process	Cellular response to calcium ion	IDA	17052953
GO:1901074	Process	Regulation of engulfment of apoptotic cell	IEA
GO:1901074	Process	Regulation of engulfment of apoptotic cell	ISS
GO:2001303	Process	Lipoxin A4 biosynthetic process	IEA
GO:2001303	Process	Lipoxin A4 biosynthetic process	ISS

MIM	HGNC	e!Ensembl
152392	433	ENSG00000161905

Protein

UniProt ID

P16050

Protein name

Polyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A

Protein function

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:17052953, PubMed:1944593, PubMed:24282679, PubMed:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01477	PLAT	4 → 107	PLAT/LH2 domain	Domain
PF00305	Lipoxygenase	183 → 650	Lipoxygenase	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. {ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:9414270}.

Sequence

MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI

Sequence length

662

Interactions

View interactions

	KEGG		Reactome
	Arachidonic acid metabolism Linoleic acid metabolism Metabolic pathways Efferocytosis Ferroptosis Necroptosis Serotonergic synapse		Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of protectins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of E-series 18(R)-resolvins Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived protectins and resolvins

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Asthma	Asthma, nasal polyps, and aspirin intolerance	N/A	N/A	ClinVar
Nasal polyposis	Nasal polyps	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (99)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Abortion Habitual	Associate	26826164
Abortion Spontaneous	Associate	26826164
Acute Coronary Syndrome	Associate	23535507
Acute Disease	Associate	19095947
Adenocarcinoma of Lung	Associate	39259123
Adenoma	Inhibit	16357157
Adenoma	Associate	17236225, 23778325
Adenomatous Polyposis Coli	Inhibit	16357157
Allergic Fungal Sinusitis	Associate	33218117
Alzheimer Disease	Associate	15111312, 16151530
Arthritis	Associate	17439326
Arthritis Rheumatoid	Associate	28316377
Asthma	Associate	15038835, 17439326, 19429775, 24465480, 30923181, 31095684, 32371071, 34106513, 38551536, 39270557
Atherosclerosis	Associate	11352986, 1729692, 17439326, 19429775, 19948975, 2010531, 28701173, 34905596, 7961680
Blood Platelet Disorders	Associate	24533104
Brain Ischemia	Stimulate	27552229
Breast Neoplasms	Associate	34059009, 37469520
Bronchitis Chronic	Associate	11003605
Carcinogenesis	Inhibit	16357157, 18030360, 24634093
Carcinogenesis	Associate	17167069, 18198215, 19429775, 20570882, 30941737
Carcinoma Hepatocellular	Associate	35934785
Carcinoma Non Small Cell Lung	Inhibit	26331820
Cardiomyopathies	Associate	30138423
Chronic Periodontitis	Associate	28492741
Colorectal Neoplasms	Associate	12189136, 16179498, 16288226, 17167069, 18198215, 18785202, 18799463, 19198625, 20026301, 20570882, 21881028, 27320813, 27546520, 9705287
Colorectal Neoplasms	Inhibit	15912043, 24634093
Coronary Artery Disease	Associate	17439326, 17959182, 29068244, 34905596
Dental Caries	Stimulate	25531160
Dental Caries	Associate	25531160
Dermatitis Atopic 3	Stimulate	8994519
Diabetes Mellitus	Associate	24955608
Diabetes Mellitus Type 2	Associate	35634436
Disease Progression	Associate	32371071
Drug Hypersensitivity	Associate	33218117, 36470944
Ectodermal Dysplasia Anhidrotic with Immunodeficiency Osteopetrosis and Lymphedema	Associate	23838566
Ectrodactyly Ectodermal Dysplasia And Cleft Lip Palate Syndrome 1	Associate	25531160
Eosinophilia	Associate	1662607
Eosinophilic Esophagitis	Associate	23503644, 37652141, 39343172
Esophagitis	Associate	29628359
Fabry Disease	Associate	29772700
Failed Back Surgery Syndrome	Associate	30138423
Glioblastoma	Associate	37991252
Gliosis	Associate	23838566
Graves Disease	Associate	16675443
Hashimoto Disease	Inhibit	39913970
Hearing Loss	Associate	34758154
Heart Diseases	Associate	23535507, 26826164, 30138423
Hodgkin Disease	Associate	23285160, 24465480
Hypereosinophilic Syndrome	Associate	33218117
Hypertrophy	Associate	29772700
Hypoxia	Inhibit	24634093
Hypoxia	Associate	27552229, 36316355
Hypoxia	Stimulate	30138423
Hypoxia Brain	Associate	20303950, 30138423
Immune System Diseases	Associate	23285160
Inflammation	Associate	1729692, 18799463, 23285160, 23838566, 24465480, 24955608, 26826164, 28316377, 30987861, 31704612, 32986378, 33218117, 34106513, 37603745, 37652141, 7961680 View all (1 more)
Inflammation	Inhibit	17439326, 19095947, 24696116
Insulin Resistance	Associate	24955608
Ischemia	Associate	23838566
Kidney Diseases	Associate	19095947
Leukemia Myeloid Acute	Associate	37271497
Leukemic Infiltration	Associate	23503644
Leukomalacia Periventricular	Associate	23838566
Lung Neoplasms	Associate	18785202, 8761486
Mesothelioma Malignant	Associate	30941737
Mouth Diseases	Associate	23838566
Muscular Dystrophy Duchenne	Inhibit	16598376
Myocardial Ischemia	Associate	27552229
Nasal Polyps	Associate	32371071, 33218117
Nasopharyngeal Carcinoma	Associate	32986378
Nasopharyngitis	Associate	32986378
Neoplasm Metastasis	Inhibit	24634093
Neoplasms	Associate	15912043, 17167069, 17218785, 21807091, 23285160, 23404351, 31314163, 35549670, 37469520, 38480935
Neoplasms	Inhibit	16874012, 18030360, 18198215, 18799463, 19198625, 21881028, 24634093
Neoplasms	Stimulate	31288808
Nephritis	Associate	19095947
Nerve Degeneration	Associate	23838566
Obesity	Associate	21094135, 22301860, 24955608
Osteoarthritis	Associate	28316377, 31704612
Pancreatic Neoplasms	Associate	18030360
Pdgfra Associated Chronic Eosinophilic Leukemia	Associate	33218117
Periodontal Diseases	Associate	28492741
Periodontitis	Associate	28492741
Pituitary Neoplasms	Stimulate	31288808
Placenta Diseases	Inhibit	20144201
Plasma Cell Granuloma Pulmonary	Associate	19429775
Prostatic Neoplasms	Associate	12189136, 17218785, 21225230, 23066085, 23285160, 24061634
Prostatitis	Associate	12189136, 20303950
Pulmonary Disease Chronic Obstructive	Associate	19429775
Rectal Neoplasms	Associate	23404351
Renal Insufficiency Chronic	Associate	33077691
Respiratory Tract Diseases	Associate	32371071
Seizures	Associate	30921410
Sinusitis	Associate	32371071
Squamous Cell Carcinoma of Head and Neck	Associate	35634436
Status Asthmaticus	Associate	15038835, 1905725, 24036245
Thrombosis	Associate	27552229
Waldenstrom Macroglobulinemia	Associate	33690107
Wounds and Injuries	Associate	28316377

ALOX15 (arachidonate 15-lipoxygenase)