Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	245711
Gene name Gene Name - the full gene name approved by the HGNC.	Speedy/RINGO cell cycle regulator family member A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SPDYA
Synonyms (NCBI Gene) Gene synonyms aliases	RINGO3, RINGOA, SPDY1, SPY1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p23.2

Show/Hide all(87)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018986	hsa-miR-335-5p	Microarray	18185580
MIRT2337546	hsa-miR-1245b-3p	CLIP-seq
MIRT2337547	hsa-miR-3145-5p	CLIP-seq
MIRT2337548	hsa-miR-508-5p	CLIP-seq
MIRT2460362	hsa-miR-299-5p	CLIP-seq
MIRT2460363	hsa-miR-3117-5p	CLIP-seq
MIRT2460364	hsa-miR-3121-3p	CLIP-seq
MIRT2460365	hsa-miR-3147	CLIP-seq
MIRT2460366	hsa-miR-3148	CLIP-seq
MIRT2460367	hsa-miR-3674	CLIP-seq
MIRT2460368	hsa-miR-3688-3p	CLIP-seq
MIRT2460369	hsa-miR-4259	CLIP-seq
MIRT2460370	hsa-miR-431	CLIP-seq
MIRT2460371	hsa-miR-4426	CLIP-seq
MIRT2460372	hsa-miR-4529-5p	CLIP-seq
MIRT2460373	hsa-miR-4635	CLIP-seq
MIRT2460374	hsa-miR-4640-5p	CLIP-seq
MIRT2460375	hsa-miR-4647	CLIP-seq
MIRT2460376	hsa-miR-4662b	CLIP-seq
MIRT2460377	hsa-miR-4698	CLIP-seq
MIRT2460378	hsa-miR-4699-5p	CLIP-seq
MIRT2460379	hsa-miR-4703-3p	CLIP-seq
MIRT2460380	hsa-miR-4709-3p	CLIP-seq
MIRT2460381	hsa-miR-4715-5p	CLIP-seq
MIRT2460382	hsa-miR-4726-5p	CLIP-seq
MIRT2460383	hsa-miR-489	CLIP-seq
MIRT2460384	hsa-miR-511	CLIP-seq
MIRT2460385	hsa-miR-514	CLIP-seq
MIRT2460386	hsa-miR-514b-3p	CLIP-seq
MIRT2460387	hsa-miR-569	CLIP-seq
MIRT2631069	hsa-miR-1256	CLIP-seq
MIRT2631070	hsa-miR-2115	CLIP-seq
MIRT2460363	hsa-miR-3117-5p	CLIP-seq
MIRT2460364	hsa-miR-3121-3p	CLIP-seq
MIRT2460366	hsa-miR-3148	CLIP-seq
MIRT2631071	hsa-miR-34b	CLIP-seq
MIRT2631072	hsa-miR-3647-3p	CLIP-seq
MIRT2460367	hsa-miR-3674	CLIP-seq
MIRT2460368	hsa-miR-3688-3p	CLIP-seq
MIRT2631073	hsa-miR-410	CLIP-seq
MIRT2460370	hsa-miR-431	CLIP-seq
MIRT2460371	hsa-miR-4426	CLIP-seq
MIRT2460373	hsa-miR-4635	CLIP-seq
MIRT2631074	hsa-miR-4642	CLIP-seq
MIRT2460375	hsa-miR-4647	CLIP-seq
MIRT2460376	hsa-miR-4662b	CLIP-seq
MIRT2460377	hsa-miR-4698	CLIP-seq
MIRT2460378	hsa-miR-4699-5p	CLIP-seq
MIRT2460379	hsa-miR-4703-3p	CLIP-seq
MIRT2460380	hsa-miR-4709-3p	CLIP-seq
MIRT2631075	hsa-miR-4775	CLIP-seq
MIRT2631076	hsa-miR-4789-5p	CLIP-seq
MIRT2460383	hsa-miR-489	CLIP-seq
MIRT2460384	hsa-miR-511	CLIP-seq
MIRT2460385	hsa-miR-514	CLIP-seq
MIRT2460386	hsa-miR-514b-3p	CLIP-seq
MIRT2631077	hsa-miR-516a-3p	CLIP-seq
MIRT2460387	hsa-miR-569	CLIP-seq
MIRT2631078	hsa-miR-587	CLIP-seq
MIRT2631079	hsa-miR-590-3p	CLIP-seq
MIRT2631069	hsa-miR-1256	CLIP-seq
MIRT2631070	hsa-miR-2115	CLIP-seq
MIRT2460363	hsa-miR-3117-5p	CLIP-seq
MIRT2460364	hsa-miR-3121-3p	CLIP-seq
MIRT2460366	hsa-miR-3148	CLIP-seq
MIRT2631071	hsa-miR-34b	CLIP-seq
MIRT2631072	hsa-miR-3647-3p	CLIP-seq
MIRT2460367	hsa-miR-3674	CLIP-seq
MIRT2460368	hsa-miR-3688-3p	CLIP-seq
MIRT2631073	hsa-miR-410	CLIP-seq
MIRT2460370	hsa-miR-431	CLIP-seq
MIRT2460371	hsa-miR-4426	CLIP-seq
MIRT2460373	hsa-miR-4635	CLIP-seq
MIRT2631074	hsa-miR-4642	CLIP-seq
MIRT2460375	hsa-miR-4647	CLIP-seq
MIRT2460376	hsa-miR-4662b	CLIP-seq
MIRT2460377	hsa-miR-4698	CLIP-seq
MIRT2460378	hsa-miR-4699-5p	CLIP-seq
MIRT2460379	hsa-miR-4703-3p	CLIP-seq
MIRT2460380	hsa-miR-4709-3p	CLIP-seq
MIRT2460383	hsa-miR-489	CLIP-seq
MIRT2460384	hsa-miR-511	CLIP-seq
MIRT2460385	hsa-miR-514	CLIP-seq
MIRT2460386	hsa-miR-514b-3p	CLIP-seq
MIRT2631077	hsa-miR-516a-3p	CLIP-seq
MIRT2460387	hsa-miR-569	CLIP-seq
MIRT2631078	hsa-miR-587	CLIP-seq

Show/Hide all(17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA	21873635
GO:0000082	Process	G1/S transition of mitotic cell cycle	IDA	11980914
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	11980914
GO:0005654	Component	Nucleoplasm	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0006974	Process	Cellular response to DNA damage stimulus	IDA	12839962
GO:0007140	Process	Male meiotic nuclear division	ISS
GO:0007275	Process	Multicellular organism development	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	11980914
GO:0019901	Function	Protein kinase binding	IBA	21873635
GO:0019901	Function	Protein kinase binding	IPI	11980914, 12839962, 28666995
GO:0030295	Function	Protein kinase activator activity	IDA	28666995
GO:0032147	Process	Activation of protein kinase activity	IEA
GO:0045737	Process	Positive regulation of cyclin-dependent protein serine/threonine kinase activity	IBA	21873635
GO:0045860	Process	Positive regulation of protein kinase activity	IDA	28666995

MIM	HGNC	e!Ensembl
614029	30613	ENSG00000163806

Protein

UniProt ID

Q5MJ70

Protein name

Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1)

Protein function

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obs

PDB

5UQ1 , 5UQ2 , 5UQ3 , 7E34

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11357	Spy1	69 → 199	Cell cycle regulatory protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expr

Sequence

MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPK
GPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTR
INFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRR
CCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATPVDCSLCGKKRRYVRL
GLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLK
KDKSMEWFTGSEE

Sequence length

313

Interactions

View interactions

	KEGG
	Oocyte meiosis Progesterone-mediated oocyte maturation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Noonan-like syndrome with loose anagen hair	NOONAN SYNDROME-LIKE DISORDER WITH LOOSE ANAGEN HAIR 2	rs267607048, rs730881020, rs886037952, rs886037954, rs886037955, rs1114167429, rs1553311527

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Brain Neoplasms	Associate	26017671
Carcinoma Hepatocellular	Associate	22457049
Glioblastoma	Associate	26017671

SPDYA (speedy/RINGO cell cycle regulator family member A)