Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	245711
Gene name	Speedy/RINGO cell cycle regulator family member A
Gene symbol	SPDYA
Synonyms (NCBI Gene)	RINGO3RINGOASPDY1SPY1
Chromosome	2
Chromosome location	2p23.2

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018986	hsa-miR-335-5p	Microarray	18185580
MIRT2337546	hsa-miR-1245b-3p	CLIP-seq
MIRT2337547	hsa-miR-3145-5p	CLIP-seq
MIRT2337548	hsa-miR-508-5p	CLIP-seq
MIRT2460362	hsa-miR-299-5p	CLIP-seq
MIRT2460363	hsa-miR-3117-5p	CLIP-seq
MIRT2460364	hsa-miR-3121-3p	CLIP-seq
MIRT2460365	hsa-miR-3147	CLIP-seq
MIRT2460366	hsa-miR-3148	CLIP-seq
MIRT2460367	hsa-miR-3674	CLIP-seq
MIRT2460368	hsa-miR-3688-3p	CLIP-seq
MIRT2460369	hsa-miR-4259	CLIP-seq
MIRT2460370	hsa-miR-431	CLIP-seq
MIRT2460371	hsa-miR-4426	CLIP-seq
MIRT2460372	hsa-miR-4529-5p	CLIP-seq
MIRT2460373	hsa-miR-4635	CLIP-seq
MIRT2460374	hsa-miR-4640-5p	CLIP-seq
MIRT2460375	hsa-miR-4647	CLIP-seq
MIRT2460376	hsa-miR-4662b	CLIP-seq
MIRT2460377	hsa-miR-4698	CLIP-seq
MIRT2460378	hsa-miR-4699-5p	CLIP-seq
MIRT2460379	hsa-miR-4703-3p	CLIP-seq
MIRT2460380	hsa-miR-4709-3p	CLIP-seq
MIRT2460381	hsa-miR-4715-5p	CLIP-seq
MIRT2460382	hsa-miR-4726-5p	CLIP-seq
MIRT2460383	hsa-miR-489	CLIP-seq
MIRT2460384	hsa-miR-511	CLIP-seq
MIRT2460385	hsa-miR-514	CLIP-seq
MIRT2460386	hsa-miR-514b-3p	CLIP-seq
MIRT2460387	hsa-miR-569	CLIP-seq
MIRT2631069	hsa-miR-1256	CLIP-seq
MIRT2631070	hsa-miR-2115	CLIP-seq
MIRT2460363	hsa-miR-3117-5p	CLIP-seq
MIRT2460364	hsa-miR-3121-3p	CLIP-seq
MIRT2460366	hsa-miR-3148	CLIP-seq
MIRT2631071	hsa-miR-34b	CLIP-seq
MIRT2631072	hsa-miR-3647-3p	CLIP-seq
MIRT2460367	hsa-miR-3674	CLIP-seq
MIRT2460368	hsa-miR-3688-3p	CLIP-seq
MIRT2631073	hsa-miR-410	CLIP-seq
MIRT2460370	hsa-miR-431	CLIP-seq
MIRT2460371	hsa-miR-4426	CLIP-seq
MIRT2460373	hsa-miR-4635	CLIP-seq
MIRT2631074	hsa-miR-4642	CLIP-seq
MIRT2460375	hsa-miR-4647	CLIP-seq
MIRT2460376	hsa-miR-4662b	CLIP-seq
MIRT2460377	hsa-miR-4698	CLIP-seq
MIRT2460378	hsa-miR-4699-5p	CLIP-seq
MIRT2460379	hsa-miR-4703-3p	CLIP-seq
MIRT2460380	hsa-miR-4709-3p	CLIP-seq
MIRT2631075	hsa-miR-4775	CLIP-seq
MIRT2631076	hsa-miR-4789-5p	CLIP-seq
MIRT2460383	hsa-miR-489	CLIP-seq
MIRT2460384	hsa-miR-511	CLIP-seq
MIRT2460385	hsa-miR-514	CLIP-seq
MIRT2460386	hsa-miR-514b-3p	CLIP-seq
MIRT2631077	hsa-miR-516a-3p	CLIP-seq
MIRT2460387	hsa-miR-569	CLIP-seq
MIRT2631078	hsa-miR-587	CLIP-seq
MIRT2631079	hsa-miR-590-3p	CLIP-seq
MIRT2631069	hsa-miR-1256	CLIP-seq
MIRT2631070	hsa-miR-2115	CLIP-seq
MIRT2460363	hsa-miR-3117-5p	CLIP-seq
MIRT2460364	hsa-miR-3121-3p	CLIP-seq
MIRT2460366	hsa-miR-3148	CLIP-seq
MIRT2631071	hsa-miR-34b	CLIP-seq
MIRT2631072	hsa-miR-3647-3p	CLIP-seq
MIRT2460367	hsa-miR-3674	CLIP-seq
MIRT2460368	hsa-miR-3688-3p	CLIP-seq
MIRT2631073	hsa-miR-410	CLIP-seq
MIRT2460370	hsa-miR-431	CLIP-seq
MIRT2460371	hsa-miR-4426	CLIP-seq
MIRT2460373	hsa-miR-4635	CLIP-seq
MIRT2631074	hsa-miR-4642	CLIP-seq
MIRT2460375	hsa-miR-4647	CLIP-seq
MIRT2460376	hsa-miR-4662b	CLIP-seq
MIRT2460377	hsa-miR-4698	CLIP-seq
MIRT2460378	hsa-miR-4699-5p	CLIP-seq
MIRT2460379	hsa-miR-4703-3p	CLIP-seq
MIRT2460380	hsa-miR-4709-3p	CLIP-seq
MIRT2460383	hsa-miR-489	CLIP-seq
MIRT2460384	hsa-miR-511	CLIP-seq
MIRT2460385	hsa-miR-514	CLIP-seq
MIRT2460386	hsa-miR-514b-3p	CLIP-seq
MIRT2631077	hsa-miR-516a-3p	CLIP-seq
MIRT2460387	hsa-miR-569	CLIP-seq
MIRT2631078	hsa-miR-587	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA
GO:0000082	Process	G1/S transition of mitotic cell cycle	IDA	11980914
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0001741	Component	XY body	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IDA	11980914
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0006974	Process	DNA damage response	IDA	12839962
GO:0006974	Process	DNA damage response	IEA
GO:0007140	Process	Male meiotic nuclear division	IEA
GO:0007140	Process	Male meiotic nuclear division	ISS
GO:0007283	Process	Spermatogenesis	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IBA
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	11980914
GO:0016233	Process	Telomere capping	IEA
GO:0019901	Function	Protein kinase binding	IBA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	11980914, 12839962, 28666995
GO:0030295	Function	Protein kinase activator activity	IDA	28666995
GO:0030295	Function	Protein kinase activator activity	IEA
GO:0045860	Process	Positive regulation of protein kinase activity	IDA	28666995
GO:0048477	Process	Oogenesis	IEA
GO:0070197	Process	Meiotic attachment of telomere to nuclear envelope	IEA
GO:0070200	Process	Establishment of protein localization to telomere	IEA

MIM	HGNC	e!Ensembl
614029	30613	ENSG00000163806

Q5MJ70

Protein name

Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy-1) (Spy1)

Protein function

Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2 (PubMed:12972555). Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing a conformation change of the CDK2 T-loop that obs

PDB

5UQ1 , 5UQ2 , 5UQ3 , 7E34

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11357	Spy1	69 → 199	Cell cycle regulatory protein	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expr

Sequence

MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPK
GPCLVIQRQDMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTR
INFFIALYLANTVEEDEEETKYEIFPWALGKNWRKLFPNFLKLRDQLWDRIDYRAIVSRR
CCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATPVDCSLCGKKRRYVRL
GLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLK
KDKSMEWFTGSEE

Sequence length

313

Interactions

View interactions

	KEGG
	Oocyte meiosis Progesterone-mediated oocyte maturation

SPDYA (speedy/RINGO cell cycle regulator family member A)