EML2 (EMAP like 2)

Gene

• Entrez ID: 24139
• Gene name: EMAP like 2
• Gene symbol: EML2
• Synonyms (NCBI Gene): ELP70, EMAP-2, EMAP2
• Chromosome: 19
• Chromosome location: 19q13.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT962089	hsa-miR-656	CLIP-seq
MIRT1985089	hsa-miR-1236	CLIP-seq
MIRT1985090	hsa-miR-345	CLIP-seq
MIRT1985091	hsa-miR-3622a-3p	CLIP-seq
MIRT1985092	hsa-miR-3622b-3p	CLIP-seq
MIRT1985093	hsa-miR-4292	CLIP-seq
MIRT1985094	hsa-miR-4308	CLIP-seq
MIRT1985095	hsa-miR-4522	CLIP-seq
MIRT1985096	hsa-miR-670	CLIP-seq
MIRT1985089	hsa-miR-1236	CLIP-seq
MIRT1985090	hsa-miR-345	CLIP-seq
MIRT1985091	hsa-miR-3622a-3p	CLIP-seq
MIRT1985092	hsa-miR-3622b-3p	CLIP-seq
MIRT1985093	hsa-miR-4292	CLIP-seq
MIRT1985094	hsa-miR-4308	CLIP-seq
MIRT1985095	hsa-miR-4522	CLIP-seq
MIRT1985096	hsa-miR-670	CLIP-seq
MIRT1985089	hsa-miR-1236	CLIP-seq
MIRT1985090	hsa-miR-345	CLIP-seq
MIRT1985091	hsa-miR-3622a-3p	CLIP-seq
MIRT1985092	hsa-miR-3622b-3p	CLIP-seq
MIRT1985093	hsa-miR-4292	CLIP-seq
MIRT1985094	hsa-miR-4308	CLIP-seq
MIRT1985095	hsa-miR-4522	CLIP-seq
MIRT1985096	hsa-miR-670	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0005515	Function	Protein binding	IPI	25416956, 25740311
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005875	Component	Microtubule associated complex	TAS	10521658
GO:0007601	Process	Visual perception	TAS	10521658
GO:0007605	Process	Sensory perception of sound	TAS	10521658
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IDA	11694528
GO:0008017	Function	Microtubule binding	IEA
GO:0010968	Process	Regulation of microtubule nucleation	IDA	11694528
GO:0015631	Function	Tubulin binding	IDA	24706829
GO:0031115	Process	Negative regulation of microtubule polymerization	IDA	11694528
GO:0072686	Component	Mitotic spindle	IBA
GO:0072686	Component	Mitotic spindle	IDA	11694528

Other IDs

• MIM: 617494
• HGNC: 18035
• e!Ensembl: ENSG00000125746

Protein

• UniProt ID: O95834
• Protein name: Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2)
• Protein function: Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.
• PDB: 4CGB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03451	HELP	19 → 93	HELP motif	Family
  PF00400	WD40	95 → 143	WD domain, G-beta repeat	Repeat
  PF00400	WD40	284 → 321	WD domain, G-beta repeat	Repeat
  PF00400	WD40	364 → 405	WD domain, G-beta repeat	Repeat
  PF00400	WD40	449 → 488	WD domain, G-beta repeat	Repeat
  PF00400	WD40	497 → 534	WD domain, G-beta repeat	Repeat
  PF00400	WD40	608 → 647	WD domain, G-beta repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10521658}.
• Sequence:

  MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWV
  YGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTI
  ATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVD
  ESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLS
  KRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGL
  CALRDGTLVSGGGRDRRVVLWGSDYSKLQEVEVPEDFGPVRTVAEGHGDTLYVGTTRNSI
  LQGSVHTGFSLLVQGHVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDP
  ARSAGFHPSGSVLAVGTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSH
  DNLVYVYTVDQGGRKVSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQ
  ITSADAVRNMEWATATCVLGFGVFGIWSEGADGTDINAVARSHDGKLLASADDFGKVHLF
  SYPCCQPRALSHKYGGHSSHVTNVAFLWDDSMALTTGGKDTSVLQWRVV

• Sequence length: 649

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	rs138590950	RCV005932191