ALOX5AP (arachidonate 5-lipoxygenase activating protein)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
241
Gene name Gene Name - the full gene name approved by the HGNC.
Arachidonate 5-lipoxygenase activating protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ALOX5AP
Synonyms (NCBI Gene) Gene synonyms aliases
FLAP
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis.
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
miRTarBase ID miRNA Experiments Reference
MIRT515812 hsa-miR-590-3p PAR-CLIP 23446348
MIRT515811 hsa-miR-634 PAR-CLIP 23446348
MIRT515810 hsa-miR-619-3p PAR-CLIP 23446348
MIRT515809 hsa-miR-7851-3p PAR-CLIP 23446348
MIRT515808 hsa-miR-338-3p PAR-CLIP 23446348
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
HIF1A Unknown 20448047
NFKB1 Unknown 20194722
RELA Unknown 20194722
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(28)
GO ID Ontology Definition Evidence Reference
GO:0002540 Process Leukotriene production involved in inflammatory response IEA
GO:0004364 Function Glutathione transferase activity IBA
GO:0004464 Function Leukotriene-C4 synthase activity IBA
GO:0004602 Function Glutathione peroxidase activity IBA
GO:0005515 Function Protein binding IPI 19233132, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603700 436 ENSG00000132965
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P20292
Protein name Arachidonate 5-lipoxygenase-activating protein (FLAP) (MK-886-binding protein)
Protein function Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the bi
PDB 2Q7M , 2Q7R , 6VGC , 6VGI
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01124 MAPEG 5 → 135 MAPEG family Family
Sequence
Sequence length 161
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Fc epsilon RI signaling pathway   Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Bipolar Disorder Bipolar I disorder N/A N/A GWAS
Show/Hide Text Mining Associations (50)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Coronary Syndrome Associate 25210744
Adenoma Associate 23404351
Alzheimer Disease Associate 33804025
Anemia Sickle Cell Associate 18945963
Aortic Aneurysm Abdominal Associate 21078989
Aortic Aneurysm Familial Abdominal 1 Associate 21078989
Asthma Associate 20067482, 22206291, 22537113, 23167751
Atherosclerosis Associate 24025248, 25815512, 36673783
Autoimmune Diseases Associate 36267464
Bipolar Disorder Associate 38303428