ALOX5 (arachidonate 5-lipoxygenase)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
240
Gene name Gene Name - the full gene name approved by the HGNC.
Arachidonate 5-lipoxygenase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ALOX5
Synonyms (NCBI Gene) Gene synonyms aliases
5-LO, 5-LOX, 5LPG, LOG5
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q11.21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachid
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
miRTarBase ID miRNA Experiments Reference
MIRT736469 hsa-miR-125a-3p RNA-seq, Immunofluorescence 33205517
MIRT736470 hsa-let-7e-3p RNA-seq, Immunofluorescence 33205517
MIRT736469 hsa-miR-125a-3p RNA-seq, Immunofluorescence 33205517
MIRT778919 hsa-miR-186 CLIP-seq
MIRT778920 hsa-miR-3688-3p CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(13)
Transcription factor Regulation Reference
EGR1 Activation 9062372
EGR1 Repression 15517885
EGR1 Unknown 10436859
HDAC2 Activation 21883892
HDAC3 Activation 21883892
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(59)
GO ID Ontology Definition Evidence Reference
GO:0001937 Process Negative regulation of endothelial cell proliferation ISS
GO:0002232 Process Leukocyte chemotaxis involved in inflammatory response IMP 17114001
GO:0002523 Process Leukocyte migration involved in inflammatory response ISS
GO:0002540 Process Leukotriene production involved in inflammatory response IEA
GO:0004051 Function Arachidonate 5-lipoxygenase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
152390 435 ENSG00000012779
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P09917
Protein name Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)
Protein function Catalyzes the oxygenation of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to 5-hydroperoxyeicosatetraenoate (5-HPETE) followed by the dehydration to 5,6- epoxyeicosatetraenoate (Leukotriene A4/LTA4), the first two steps in the biosynthesis o
PDB 3O8Y , 3V92 , 3V98 , 3V99 , 6N2W , 6NCF , 7TTJ , 7TTK , 7TTL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01477 PLAT 4 → 113 PLAT/LH2 domain Domain
PF00305 Lipoxygenase 216 → 662 Lipoxygenase Domain
Sequence
Sequence length 674
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Arachidonic acid metabolism
Metabolic pathways
Efferocytosis
Fc epsilon RI signaling pathway
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis 		  Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Synthesis of Lipoxins (LX)
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Interleukin-18 signaling
Biosynthesis of D-series resolvins
Biosynthesis of maresins
Biosynthesis of E-series 18(S)-resolvins
Biosynthesis of aspirin-triggered D-series resolvins
Biosynthesis of E-series 18(R)-resolvins
Biosynthesis of DPAn-3-derived protectins and resolvins
Biosynthesis of DPAn-3-derived maresins
Biosynthesis of DPAn-3-derived 13-series resolvins
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (10)
Causal
Disease term Disease name dbSNP ID References
Adenocarcinoma Adenocarcinoma, Adenocarcinoma, Basal Cell, Adenocarcinoma, Oxyphilic, Adenocarcinoma, Tubular rs121913530, rs886039394, rs121913474 30258081
Carcinoma Carcinoma, Cribriform, Carcinoma, Granular Cell rs121912654, rs555607708, rs786202962, rs1564055259 30258081
Colonic neoplasms Malignant tumor of colon, Colonic Neoplasms rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 14569062, 30258081, 18927292
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)		 20061081
Show/Hide Unknown Diseases (6)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma ClinVar
Atherosclerosis Atherosclerosis 16698924 ClinVar
Chromophobe carcinoma Chromophobe Renal Cell Carcinoma 30258081 ClinVar
Coronary heart disease Coronary heart disease 22319020 ClinVar
Show/Hide Text Mining Associations (138)
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Inhibit 10572106
Acquired Immunodeficiency Syndrome Associate 18180307
Adenocarcinoma of Lung Associate 37164914
Adenoma Associate 17236225, 20549218
Adenomatous Polyps Associate 20549218
Anemia Sickle Cell Associate 18945963
Aortic Aneurysm Abdominal Stimulate 21078989
Aortic Aneurysm Abdominal Associate 27927271, 31539405
Aortic Aneurysm Familial Abdominal 1 Associate 21078989
Aortic Valve Stenosis Associate 22616993