Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2395
Gene name	Frataxin
Gene symbol	FXN
Synonyms (NCBI Gene)	CyaYFAFARRFRDAX25
Chromosome	9
Chromosome location	9q21.11
Summary	This nuclear gene encodes a mitochondrial protein which belongs to the FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA from 8-33 repeats to >90 repeats r

Show/Hide all (18)

SNP ID	Visualize variation	Clinical significance	Consequence
rs56214919	T>G	Likely-pathogenic	Synonymous variant, missense variant, coding sequence variant
rs104894105	T>C,G	Pathogenic	Coding sequence variant, stop gained, missense variant
rs104894106	A>G,T	Pathogenic	Coding sequence variant, missense variant
rs104894107	G>C,T	Pathogenic	Coding sequence variant, missense variant
rs104894108	G>A,T	Pathogenic	Initiator codon variant, missense variant
rs140987490	A>G	Pathogenic	Splice acceptor variant
rs141935559	C>-,CC	Pathogenic	Frameshift variant, coding sequence variant
rs143232208	TC>-	Likely-pathogenic	Frameshift variant, coding sequence variant
rs145854903	C>T	Uncertain-significance, pathogenic	Missense variant, coding sequence variant
rs146818694	C>G	Pathogenic	Missense variant, coding sequence variant
rs367974156	T>C	Conflicting-interpretations-of-pathogenicity	Intron variant
rs372775073	T>A,C	Pathogenic	Stop gained, synonymous variant, coding sequence variant
rs886037630	ATGTCT>TACACCTTGAGGACA	Pathogenic	Coding sequence variant, inframe indel
rs1057519131	C>T	Conflicting-interpretations-of-pathogenicity	Synonymous variant, coding sequence variant
rs1554761915	G>C	Likely-pathogenic	Splice acceptor variant
rs1554762735	A>G	Likely-pathogenic	Splice acceptor variant
rs1564326640	->TT	Likely-pathogenic	Splice donor variant
rs1587832283	T>G	Likely-pathogenic	Stop gained, missense variant, coding sequence variant

625

Show/Hide all (625)

miRTarBase ID	miRNA	Experiments	Reference
MIRT007228	hsa-miR-559	Luciferase reporter assay	23382970
MIRT007229	hsa-miR-589-5p	Luciferase reporter assay	23382970
MIRT007230	hsa-miR-1270	Luciferase reporter assay	23382970
MIRT007231	hsa-miR-620	Luciferase reporter assay	23382970
MIRT007232	hsa-miR-522-3p	Luciferase reporter assay	23382970
MIRT007233	hsa-miR-299-3p	Luciferase reporter assay	23382970
MIRT007234	hsa-miR-506-3p	Luciferase reporter assay	23382970
MIRT007235	hsa-miR-124-3p	Luciferase reporter assay	23382970
MIRT007236	hsa-miR-624-3p	Luciferase reporter assay	23382970
MIRT048445	hsa-miR-100-5p	CLASH	23622248
MIRT036668	hsa-miR-935	CLASH	23622248
MIRT721558	hsa-miR-936	HITS-CLIP	19536157
MIRT721557	hsa-miR-199a-3p	HITS-CLIP	19536157
MIRT721556	hsa-miR-199b-3p	HITS-CLIP	19536157
MIRT721555	hsa-miR-3129-5p	HITS-CLIP	19536157
MIRT721554	hsa-miR-4738-3p	HITS-CLIP	19536157
MIRT721553	hsa-miR-342-5p	HITS-CLIP	19536157
MIRT721552	hsa-miR-4664-5p	HITS-CLIP	19536157
MIRT721551	hsa-miR-4651	HITS-CLIP	19536157
MIRT721550	hsa-miR-608	HITS-CLIP	19536157
MIRT721549	hsa-miR-6747-5p	HITS-CLIP	19536157
MIRT721548	hsa-miR-6742-5p	HITS-CLIP	19536157
MIRT721547	hsa-miR-222-5p	HITS-CLIP	19536157
MIRT721546	hsa-miR-6737-5p	HITS-CLIP	19536157
MIRT721545	hsa-miR-6812-5p	HITS-CLIP	19536157
MIRT721544	hsa-miR-6819-5p	HITS-CLIP	19536157
MIRT721543	hsa-miR-30a-3p	HITS-CLIP	19536157
MIRT721542	hsa-miR-30d-3p	HITS-CLIP	19536157
MIRT721541	hsa-miR-30e-3p	HITS-CLIP	19536157
MIRT678260	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678259	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT672893	hsa-miR-764	HITS-CLIP	23824327
MIRT678258	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678257	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT679832	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT672891	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT672889	hsa-miR-4635	HITS-CLIP	23824327
MIRT672890	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT672888	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT672887	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678254	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678253	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT672886	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT672884	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT672885	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678252	hsa-miR-640	HITS-CLIP	23824327
MIRT678251	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678260	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678259	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT672893	hsa-miR-764	HITS-CLIP	23824327
MIRT672892	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678258	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678257	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT672891	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678256	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT672889	hsa-miR-4635	HITS-CLIP	23824327
MIRT672890	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT672888	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT672887	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678255	hsa-miR-6131	HITS-CLIP	23824327
MIRT678254	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678253	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT672886	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT672884	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT672885	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678252	hsa-miR-640	HITS-CLIP	23824327
MIRT678251	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT672893	hsa-miR-764	HITS-CLIP	23824327
MIRT672892	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT672891	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT672889	hsa-miR-4635	HITS-CLIP	23824327
MIRT672890	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT672888	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT672887	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT672886	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT672884	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT672885	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT644353	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT635205	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT635204	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT635203	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT635202	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT635201	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT635200	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT635199	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT635198	hsa-miR-4284	HITS-CLIP	23824327
MIRT635205	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT635204	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT635203	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT635202	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT635201	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT635200	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT635199	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT635198	hsa-miR-4284	HITS-CLIP	23824327
MIRT563222	hsa-miR-7153-3p	PAR-CLIP	20371350
MIRT563215	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT563221	hsa-miR-6087	PAR-CLIP	20371350
MIRT563220	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT563219	hsa-miR-663a	PAR-CLIP	20371350
MIRT563217	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT563218	hsa-miR-193b-5p	PAR-CLIP	20371350
MIRT563216	hsa-miR-6866-5p	PAR-CLIP	20371350
MIRT563215	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT563214	hsa-miR-2681-5p	PAR-CLIP	20371350
MIRT107876	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT107879	hsa-miR-3662	PAR-CLIP	23592263
MIRT107878	hsa-miR-1252-3p	PAR-CLIP	23592263
MIRT454288	hsa-miR-6082	PAR-CLIP	23592263
MIRT454287	hsa-miR-8066	PAR-CLIP	23592263
MIRT107873	hsa-miR-369-3p	PAR-CLIP	23592263
MIRT454286	hsa-miR-5692b	PAR-CLIP	23592263
MIRT454285	hsa-miR-5692c	PAR-CLIP	23592263
MIRT107875	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT454284	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT454283	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT454282	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT454281	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT454280	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT454279	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT454278	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT454277	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT454276	hsa-miR-4458	PAR-CLIP	23592263
MIRT454275	hsa-miR-4500	PAR-CLIP	23592263
MIRT454274	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT454273	hsa-miR-202-3p	PAR-CLIP	23592263
MIRT107881	hsa-miR-4536-5p	PAR-CLIP	23592263
MIRT107874	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT107877	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT735358	hsa-miR-224-5p	Luciferase reporter assayWestern blottingRNA-seqqRT-PCR	32291635
MIRT721558	hsa-miR-936	HITS-CLIP	19536157
MIRT721557	hsa-miR-199a-3p	HITS-CLIP	19536157
MIRT721556	hsa-miR-199b-3p	HITS-CLIP	19536157
MIRT721555	hsa-miR-3129-5p	HITS-CLIP	19536157
MIRT721554	hsa-miR-4738-3p	HITS-CLIP	19536157
MIRT721553	hsa-miR-342-5p	HITS-CLIP	19536157
MIRT721552	hsa-miR-4664-5p	HITS-CLIP	19536157
MIRT721551	hsa-miR-4651	HITS-CLIP	19536157
MIRT721550	hsa-miR-608	HITS-CLIP	19536157
MIRT721549	hsa-miR-6747-5p	HITS-CLIP	19536157
MIRT721548	hsa-miR-6742-5p	HITS-CLIP	19536157
MIRT721547	hsa-miR-222-5p	HITS-CLIP	19536157
MIRT721546	hsa-miR-6737-5p	HITS-CLIP	19536157
MIRT721545	hsa-miR-6812-5p	HITS-CLIP	19536157
MIRT721544	hsa-miR-6819-5p	HITS-CLIP	19536157
MIRT721543	hsa-miR-30a-3p	HITS-CLIP	19536157
MIRT721542	hsa-miR-30d-3p	HITS-CLIP	19536157
MIRT721541	hsa-miR-30e-3p	HITS-CLIP	19536157
MIRT678260	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678259	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT672893	hsa-miR-764	HITS-CLIP	23824327
MIRT678258	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678257	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT679832	hsa-miR-519d-5p	HITS-CLIP	23824327
MIRT672891	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT672889	hsa-miR-4635	HITS-CLIP	23824327
MIRT672890	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT672888	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT672887	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678254	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678253	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT672886	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT672884	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT672885	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678252	hsa-miR-640	HITS-CLIP	23824327
MIRT678251	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678260	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678259	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT672893	hsa-miR-764	HITS-CLIP	23824327
MIRT672892	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678258	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678257	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT672891	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678256	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT672889	hsa-miR-4635	HITS-CLIP	23824327
MIRT672890	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT672888	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT672887	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678255	hsa-miR-6131	HITS-CLIP	23824327
MIRT678254	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678253	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT672886	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT672884	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT672885	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678252	hsa-miR-640	HITS-CLIP	23824327
MIRT678251	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT672893	hsa-miR-764	HITS-CLIP	23824327
MIRT672892	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT672891	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT672889	hsa-miR-4635	HITS-CLIP	23824327
MIRT672890	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT672888	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT672887	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT672886	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT672884	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT672885	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT644353	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT635205	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT635204	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT635203	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT635202	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT635201	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT635200	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT635199	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT635198	hsa-miR-4284	HITS-CLIP	23824327
MIRT635205	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT635204	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT635203	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT635202	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT635201	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT635200	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT635199	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT635198	hsa-miR-4284	HITS-CLIP	23824327
MIRT563222	hsa-miR-7153-3p	PAR-CLIP	20371350
MIRT563215	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT563221	hsa-miR-6087	PAR-CLIP	20371350
MIRT563220	hsa-miR-1908-5p	PAR-CLIP	20371350
MIRT563219	hsa-miR-663a	PAR-CLIP	20371350
MIRT563217	hsa-miR-6787-5p	PAR-CLIP	20371350
MIRT563218	hsa-miR-193b-5p	PAR-CLIP	20371350
MIRT563216	hsa-miR-6866-5p	PAR-CLIP	20371350
MIRT563215	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT563214	hsa-miR-2681-5p	PAR-CLIP	20371350
MIRT107876	hsa-miR-548c-3p	PAR-CLIP	23592263
MIRT107879	hsa-miR-3662	PAR-CLIP	23592263
MIRT107878	hsa-miR-1252-3p	PAR-CLIP	23592263
MIRT454288	hsa-miR-6082	PAR-CLIP	23592263
MIRT454287	hsa-miR-8066	PAR-CLIP	23592263
MIRT107873	hsa-miR-369-3p	PAR-CLIP	23592263
MIRT454286	hsa-miR-5692b	PAR-CLIP	23592263
MIRT454285	hsa-miR-5692c	PAR-CLIP	23592263
MIRT107875	hsa-miR-545-5p	PAR-CLIP	23592263
MIRT454284	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT454283	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT454282	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT454281	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT454280	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT454279	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT454278	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT454277	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT454276	hsa-miR-4458	PAR-CLIP	23592263
MIRT454275	hsa-miR-4500	PAR-CLIP	23592263
MIRT454274	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT454273	hsa-miR-202-3p	PAR-CLIP	23592263
MIRT107881	hsa-miR-4536-5p	PAR-CLIP	23592263
MIRT107874	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT107877	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT1007136	hsa-let-7a	CLIP-seq
MIRT1007137	hsa-let-7b	CLIP-seq
MIRT1007138	hsa-let-7c	CLIP-seq
MIRT1007139	hsa-let-7d	CLIP-seq
MIRT1007140	hsa-let-7e	CLIP-seq
MIRT1007141	hsa-let-7f	CLIP-seq
MIRT1007142	hsa-let-7g	CLIP-seq
MIRT1007143	hsa-let-7i	CLIP-seq
MIRT1007144	hsa-miR-106a	CLIP-seq
MIRT1007145	hsa-miR-106b	CLIP-seq
MIRT1007146	hsa-miR-1207-5p	CLIP-seq
MIRT1007147	hsa-miR-122	CLIP-seq
MIRT1007148	hsa-miR-1227	CLIP-seq
MIRT1007149	hsa-miR-124	CLIP-seq
MIRT1007150	hsa-miR-1253	CLIP-seq
MIRT1007151	hsa-miR-1255a	CLIP-seq
MIRT1007152	hsa-miR-1255b	CLIP-seq
MIRT1007153	hsa-miR-1272	CLIP-seq
MIRT1007154	hsa-miR-1273e	CLIP-seq
MIRT1007155	hsa-miR-1283	CLIP-seq
MIRT1007156	hsa-miR-1285	CLIP-seq
MIRT1007157	hsa-miR-1290	CLIP-seq
MIRT1007158	hsa-miR-1294	CLIP-seq
MIRT1007159	hsa-miR-129-5p	CLIP-seq
MIRT1007160	hsa-miR-1307	CLIP-seq
MIRT1007161	hsa-miR-1321	CLIP-seq
MIRT1007162	hsa-miR-142-5p	CLIP-seq
MIRT1007163	hsa-miR-17	CLIP-seq
MIRT1007164	hsa-miR-1908	CLIP-seq
MIRT1007165	hsa-miR-1909	CLIP-seq
MIRT1007166	hsa-miR-1972	CLIP-seq
MIRT1007167	hsa-miR-19a	CLIP-seq
MIRT1007168	hsa-miR-19b	CLIP-seq
MIRT1007169	hsa-miR-202	CLIP-seq
MIRT1007170	hsa-miR-205	CLIP-seq
MIRT1007171	hsa-miR-20a	CLIP-seq
MIRT1007172	hsa-miR-20b	CLIP-seq
MIRT1007173	hsa-miR-216a	CLIP-seq
MIRT1007174	hsa-miR-216b	CLIP-seq
MIRT1007175	hsa-miR-23a	CLIP-seq
MIRT1007176	hsa-miR-23b	CLIP-seq
MIRT1007177	hsa-miR-23c	CLIP-seq
MIRT1007178	hsa-miR-2964a-3p	CLIP-seq
MIRT1007179	hsa-miR-302f	CLIP-seq
MIRT1007180	hsa-miR-3065-5p	CLIP-seq
MIRT1007181	hsa-miR-3121-3p	CLIP-seq
MIRT1007182	hsa-miR-3122	CLIP-seq
MIRT1007183	hsa-miR-3123	CLIP-seq
MIRT1007184	hsa-miR-3126-5p	CLIP-seq
MIRT1007185	hsa-miR-3135b	CLIP-seq
MIRT1007186	hsa-miR-3146	CLIP-seq
MIRT1007187	hsa-miR-3149	CLIP-seq
MIRT739800	hsa-miR-3176	CLIP-seq
MIRT1007188	hsa-miR-3187-3p	CLIP-seq
MIRT1007189	hsa-miR-3187-5p	CLIP-seq
MIRT1007190	hsa-miR-340	CLIP-seq
MIRT1007191	hsa-miR-345	CLIP-seq
MIRT1007192	hsa-miR-3545-3p	CLIP-seq
MIRT1007193	hsa-miR-3609	CLIP-seq
MIRT1007194	hsa-miR-3613-3p	CLIP-seq
MIRT1007195	hsa-miR-3619-3p	CLIP-seq
MIRT1007196	hsa-miR-3652	CLIP-seq
MIRT1007197	hsa-miR-3654	CLIP-seq
MIRT1007198	hsa-miR-3675-3p	CLIP-seq
MIRT1007199	hsa-miR-3689a-3p	CLIP-seq
MIRT1007200	hsa-miR-3689c	CLIP-seq
MIRT1007201	hsa-miR-3692	CLIP-seq
MIRT1007202	hsa-miR-3714	CLIP-seq
MIRT1007203	hsa-miR-371-5p	CLIP-seq
MIRT1007204	hsa-miR-371b-5p	CLIP-seq
MIRT1007205	hsa-miR-374a	CLIP-seq
MIRT1007206	hsa-miR-374b	CLIP-seq
MIRT1007207	hsa-miR-3910	CLIP-seq
MIRT1007208	hsa-miR-3913-5p	CLIP-seq
MIRT1007209	hsa-miR-3919	CLIP-seq
MIRT739801	hsa-miR-3922-3p	CLIP-seq
MIRT1007210	hsa-miR-3929	CLIP-seq
MIRT1007211	hsa-miR-3934	CLIP-seq
MIRT1007212	hsa-miR-411	CLIP-seq
MIRT1007213	hsa-miR-4252	CLIP-seq
MIRT1007214	hsa-miR-4269	CLIP-seq
MIRT1007215	hsa-miR-4316	CLIP-seq
MIRT1007216	hsa-miR-4419a	CLIP-seq
MIRT1007217	hsa-miR-4419b	CLIP-seq
MIRT1007218	hsa-miR-4421	CLIP-seq
MIRT1007219	hsa-miR-4430	CLIP-seq
MIRT1007220	hsa-miR-4434	CLIP-seq
MIRT1007221	hsa-miR-4435	CLIP-seq
MIRT1007222	hsa-miR-4438	CLIP-seq
MIRT1007223	hsa-miR-4455	CLIP-seq
MIRT1007224	hsa-miR-4478	CLIP-seq
MIRT1007225	hsa-miR-4510	CLIP-seq
MIRT1007226	hsa-miR-4516	CLIP-seq
MIRT1007227	hsa-miR-4536	CLIP-seq
MIRT1007228	hsa-miR-4643	CLIP-seq
MIRT1007229	hsa-miR-4646-5p	CLIP-seq
MIRT1007230	hsa-miR-4649-3p	CLIP-seq
MIRT1007231	hsa-miR-4659a-5p	CLIP-seq
MIRT1007232	hsa-miR-4659b-5p	CLIP-seq
MIRT1007233	hsa-miR-4684-5p	CLIP-seq
MIRT1007234	hsa-miR-4696	CLIP-seq
MIRT1007235	hsa-miR-4700-3p	CLIP-seq
MIRT1007236	hsa-miR-4701-5p	CLIP-seq
MIRT1007237	hsa-miR-4708-3p	CLIP-seq
MIRT739802	hsa-miR-4716-5p	CLIP-seq
MIRT1007238	hsa-miR-4717-3p	CLIP-seq
MIRT1007239	hsa-miR-4728-5p	CLIP-seq
MIRT1007240	hsa-miR-4729	CLIP-seq
MIRT1007241	hsa-miR-4731-5p	CLIP-seq
MIRT1007242	hsa-miR-4735-5p	CLIP-seq
MIRT1007243	hsa-miR-4739	CLIP-seq
MIRT1007244	hsa-miR-4755-3p	CLIP-seq
MIRT1007245	hsa-miR-4756-5p	CLIP-seq
MIRT1007246	hsa-miR-4763-3p	CLIP-seq
MIRT1007247	hsa-miR-4768-3p	CLIP-seq
MIRT1007248	hsa-miR-4768-5p	CLIP-seq
MIRT1007249	hsa-miR-4775	CLIP-seq
MIRT1007250	hsa-miR-4776-3p	CLIP-seq
MIRT1007251	hsa-miR-4776-5p	CLIP-seq
MIRT1007252	hsa-miR-4781-3p	CLIP-seq
MIRT1007253	hsa-miR-4796-3p	CLIP-seq
MIRT1007254	hsa-miR-4802-3p	CLIP-seq
MIRT1007255	hsa-miR-485-5p	CLIP-seq
MIRT1007256	hsa-miR-490-5p	CLIP-seq
MIRT1007257	hsa-miR-506	CLIP-seq
MIRT1007258	hsa-miR-5095	CLIP-seq
MIRT1007259	hsa-miR-519a	CLIP-seq
MIRT1007260	hsa-miR-519b-3p	CLIP-seq
MIRT1007261	hsa-miR-519c-3p	CLIP-seq
MIRT1007262	hsa-miR-519d	CLIP-seq
MIRT1007263	hsa-miR-520g	CLIP-seq
MIRT1007264	hsa-miR-520h	CLIP-seq
MIRT1007265	hsa-miR-548ah	CLIP-seq
MIRT1007266	hsa-miR-548s	CLIP-seq
MIRT1007267	hsa-miR-568	CLIP-seq
MIRT1007268	hsa-miR-588	CLIP-seq
MIRT1007269	hsa-miR-590-3p	CLIP-seq
MIRT1007270	hsa-miR-612	CLIP-seq
MIRT1007271	hsa-miR-642b	CLIP-seq
MIRT1007272	hsa-miR-657	CLIP-seq
MIRT1007273	hsa-miR-661	CLIP-seq
MIRT1007274	hsa-miR-663	CLIP-seq
MIRT1007275	hsa-miR-665	CLIP-seq
MIRT1007276	hsa-miR-93	CLIP-seq
MIRT1007277	hsa-miR-98	CLIP-seq
MIRT1007278	hsa-miR-185	CLIP-seq
MIRT1007279	hsa-miR-4306	CLIP-seq
MIRT1007280	hsa-miR-4531	CLIP-seq
MIRT1007281	hsa-miR-4644	CLIP-seq
MIRT1007144	hsa-miR-106a	CLIP-seq
MIRT1007145	hsa-miR-106b	CLIP-seq
MIRT1998427	hsa-miR-1258	CLIP-seq
MIRT1007154	hsa-miR-1273e	CLIP-seq
MIRT1007159	hsa-miR-129-5p	CLIP-seq
MIRT1998428	hsa-miR-1303	CLIP-seq
MIRT1998429	hsa-miR-150	CLIP-seq
MIRT1998430	hsa-miR-153	CLIP-seq
MIRT1007163	hsa-miR-17	CLIP-seq
MIRT1998431	hsa-miR-184	CLIP-seq
MIRT1007171	hsa-miR-20a	CLIP-seq
MIRT1007172	hsa-miR-20b	CLIP-seq
MIRT1998432	hsa-miR-218	CLIP-seq
MIRT1998433	hsa-miR-223	CLIP-seq
MIRT1007175	hsa-miR-23a	CLIP-seq
MIRT1007176	hsa-miR-23b	CLIP-seq
MIRT1007177	hsa-miR-23c	CLIP-seq
MIRT1007178	hsa-miR-2964a-3p	CLIP-seq
MIRT1998434	hsa-miR-302a	CLIP-seq
MIRT1998435	hsa-miR-302b	CLIP-seq
MIRT1998436	hsa-miR-302c	CLIP-seq
MIRT1998437	hsa-miR-302d	CLIP-seq
MIRT1998438	hsa-miR-302e	CLIP-seq
MIRT1007179	hsa-miR-302f	CLIP-seq
MIRT1007183	hsa-miR-3123	CLIP-seq
MIRT1998439	hsa-miR-3152-5p	CLIP-seq
MIRT739800	hsa-miR-3176	CLIP-seq
MIRT1007188	hsa-miR-3187-3p	CLIP-seq
MIRT1007192	hsa-miR-3545-3p	CLIP-seq
MIRT1998440	hsa-miR-3655	CLIP-seq
MIRT1007203	hsa-miR-371-5p	CLIP-seq
MIRT1007204	hsa-miR-371b-5p	CLIP-seq
MIRT1998441	hsa-miR-372	CLIP-seq
MIRT1998442	hsa-miR-373	CLIP-seq
MIRT1007205	hsa-miR-374a	CLIP-seq
MIRT1007206	hsa-miR-374b	CLIP-seq
MIRT1007209	hsa-miR-3919	CLIP-seq
MIRT739801	hsa-miR-3922-3p	CLIP-seq
MIRT1007210	hsa-miR-3929	CLIP-seq
MIRT1007211	hsa-miR-3934	CLIP-seq
MIRT1998443	hsa-miR-3973	CLIP-seq
MIRT1007214	hsa-miR-4269	CLIP-seq
MIRT1007217	hsa-miR-4419b	CLIP-seq
MIRT1007221	hsa-miR-4435	CLIP-seq
MIRT1998444	hsa-miR-4446-5p	CLIP-seq
MIRT1007224	hsa-miR-4478	CLIP-seq
MIRT1998445	hsa-miR-448	CLIP-seq
MIRT1007230	hsa-miR-4649-3p	CLIP-seq
MIRT1998446	hsa-miR-4667-3p	CLIP-seq
MIRT1998447	hsa-miR-4697-3p	CLIP-seq
MIRT1007236	hsa-miR-4701-5p	CLIP-seq
MIRT1998448	hsa-miR-4703-3p	CLIP-seq
MIRT739802	hsa-miR-4716-5p	CLIP-seq
MIRT1007241	hsa-miR-4731-5p	CLIP-seq
MIRT1007242	hsa-miR-4735-5p	CLIP-seq
MIRT1007244	hsa-miR-4755-3p	CLIP-seq
MIRT1998449	hsa-miR-4755-5p	CLIP-seq
MIRT1007249	hsa-miR-4775	CLIP-seq
MIRT1998450	hsa-miR-4804-5p	CLIP-seq
MIRT1007255	hsa-miR-485-5p	CLIP-seq
MIRT1007258	hsa-miR-5095	CLIP-seq
MIRT1998451	hsa-miR-511	CLIP-seq
MIRT1998452	hsa-miR-512-3p	CLIP-seq
MIRT1007262	hsa-miR-519d	CLIP-seq
MIRT1998453	hsa-miR-520a-3p	CLIP-seq
MIRT1998454	hsa-miR-520b	CLIP-seq
MIRT1998455	hsa-miR-520c-3p	CLIP-seq
MIRT1998456	hsa-miR-520d-3p	CLIP-seq
MIRT1998457	hsa-miR-520e	CLIP-seq
MIRT1007263	hsa-miR-520g	CLIP-seq
MIRT1007264	hsa-miR-520h	CLIP-seq
MIRT1007266	hsa-miR-548s	CLIP-seq
MIRT1007268	hsa-miR-588	CLIP-seq
MIRT1007269	hsa-miR-590-3p	CLIP-seq
MIRT1998458	hsa-miR-642a	CLIP-seq
MIRT1007275	hsa-miR-665	CLIP-seq
MIRT1007276	hsa-miR-93	CLIP-seq
MIRT1007147	hsa-miR-122	CLIP-seq
MIRT2388267	hsa-miR-149	CLIP-seq
MIRT1007173	hsa-miR-216a	CLIP-seq
MIRT1007174	hsa-miR-216b	CLIP-seq
MIRT2388268	hsa-miR-3064-5p	CLIP-seq
MIRT1007185	hsa-miR-3135b	CLIP-seq
MIRT1007196	hsa-miR-3652	CLIP-seq
MIRT1007219	hsa-miR-4430	CLIP-seq
MIRT2388269	hsa-miR-4505	CLIP-seq
MIRT1007228	hsa-miR-4643	CLIP-seq
MIRT2388270	hsa-miR-4794	CLIP-seq
MIRT1007146	hsa-miR-1207-5p	CLIP-seq
MIRT1007159	hsa-miR-129-5p	CLIP-seq
MIRT2449962	hsa-miR-2392	CLIP-seq
MIRT2449963	hsa-miR-3120-5p	CLIP-seq
MIRT1007187	hsa-miR-3149	CLIP-seq
MIRT2449964	hsa-miR-338-5p	CLIP-seq
MIRT1007194	hsa-miR-3613-3p	CLIP-seq
MIRT2449965	hsa-miR-3664-5p	CLIP-seq
MIRT1007203	hsa-miR-371-5p	CLIP-seq
MIRT1007204	hsa-miR-371b-5p	CLIP-seq
MIRT1007212	hsa-miR-411	CLIP-seq
MIRT1007214	hsa-miR-4269	CLIP-seq
MIRT2449966	hsa-miR-4432	CLIP-seq
MIRT1007223	hsa-miR-4455	CLIP-seq
MIRT2449967	hsa-miR-4522	CLIP-seq
MIRT1007233	hsa-miR-4684-5p	CLIP-seq
MIRT2449968	hsa-miR-4691-3p	CLIP-seq
MIRT1007242	hsa-miR-4735-5p	CLIP-seq
MIRT1007246	hsa-miR-4763-3p	CLIP-seq
MIRT1007249	hsa-miR-4775	CLIP-seq
MIRT2449969	hsa-miR-483-5p	CLIP-seq
MIRT1007258	hsa-miR-5095	CLIP-seq
MIRT2449970	hsa-miR-548an	CLIP-seq
MIRT2449971	hsa-miR-552	CLIP-seq
MIRT1007269	hsa-miR-590-3p	CLIP-seq
MIRT1007159	hsa-miR-129-5p	CLIP-seq
MIRT1007187	hsa-miR-3149	CLIP-seq
MIRT1007212	hsa-miR-411	CLIP-seq
MIRT1007242	hsa-miR-4735-5p	CLIP-seq
MIRT1007249	hsa-miR-4775	CLIP-seq
MIRT2449969	hsa-miR-483-5p	CLIP-seq
MIRT1007269	hsa-miR-590-3p	CLIP-seq
MIRT1007146	hsa-miR-1207-5p	CLIP-seq
MIRT1007147	hsa-miR-122	CLIP-seq
MIRT2535958	hsa-miR-1262	CLIP-seq
MIRT1007155	hsa-miR-1283	CLIP-seq
MIRT1007156	hsa-miR-1285	CLIP-seq
MIRT1007159	hsa-miR-129-5p	CLIP-seq
MIRT1007160	hsa-miR-1307	CLIP-seq
MIRT2535959	hsa-miR-1976	CLIP-seq
MIRT1007173	hsa-miR-216a	CLIP-seq
MIRT1007174	hsa-miR-216b	CLIP-seq
MIRT2449963	hsa-miR-3120-5p	CLIP-seq
MIRT1007181	hsa-miR-3121-3p	CLIP-seq
MIRT1007182	hsa-miR-3122	CLIP-seq
MIRT1007185	hsa-miR-3135b	CLIP-seq
MIRT1007187	hsa-miR-3149	CLIP-seq
MIRT1007189	hsa-miR-3187-5p	CLIP-seq
MIRT1007193	hsa-miR-3609	CLIP-seq
MIRT1007194	hsa-miR-3613-3p	CLIP-seq
MIRT1007196	hsa-miR-3652	CLIP-seq
MIRT2449965	hsa-miR-3664-5p	CLIP-seq
MIRT1007198	hsa-miR-3675-3p	CLIP-seq
MIRT1007199	hsa-miR-3689a-3p	CLIP-seq
MIRT1007200	hsa-miR-3689c	CLIP-seq
MIRT1007203	hsa-miR-371-5p	CLIP-seq
MIRT1007204	hsa-miR-371b-5p	CLIP-seq
MIRT1007207	hsa-miR-3910	CLIP-seq
MIRT1007208	hsa-miR-3913-5p	CLIP-seq
MIRT1007212	hsa-miR-411	CLIP-seq
MIRT2535960	hsa-miR-4279	CLIP-seq
MIRT1007218	hsa-miR-4421	CLIP-seq
MIRT1007219	hsa-miR-4430	CLIP-seq
MIRT2449966	hsa-miR-4432	CLIP-seq
MIRT1007223	hsa-miR-4455	CLIP-seq
MIRT2535961	hsa-miR-451b	CLIP-seq
MIRT2449967	hsa-miR-4522	CLIP-seq
MIRT1007233	hsa-miR-4684-5p	CLIP-seq
MIRT2449968	hsa-miR-4691-3p	CLIP-seq
MIRT1007234	hsa-miR-4696	CLIP-seq
MIRT2535962	hsa-miR-4701-3p	CLIP-seq
MIRT2535963	hsa-miR-4722-3p	CLIP-seq
MIRT1007239	hsa-miR-4728-5p	CLIP-seq
MIRT1007242	hsa-miR-4735-5p	CLIP-seq
MIRT1007246	hsa-miR-4763-3p	CLIP-seq
MIRT2535964	hsa-miR-4769-3p	CLIP-seq
MIRT1007249	hsa-miR-4775	CLIP-seq
MIRT1007252	hsa-miR-4781-3p	CLIP-seq
MIRT2449969	hsa-miR-483-5p	CLIP-seq
MIRT2535965	hsa-miR-498	CLIP-seq
MIRT2535966	hsa-miR-508-5p	CLIP-seq
MIRT1007258	hsa-miR-5095	CLIP-seq
MIRT1007263	hsa-miR-520g	CLIP-seq
MIRT1007264	hsa-miR-520h	CLIP-seq
MIRT2535967	hsa-miR-542-3p	CLIP-seq
MIRT1007265	hsa-miR-548ah	CLIP-seq
MIRT2449970	hsa-miR-548an	CLIP-seq
MIRT2449971	hsa-miR-552	CLIP-seq
MIRT1007269	hsa-miR-590-3p	CLIP-seq
MIRT1007270	hsa-miR-612	CLIP-seq
MIRT1007273	hsa-miR-661	CLIP-seq
MIRT2535968	hsa-miR-766	CLIP-seq
MIRT1007146	hsa-miR-1207-5p	CLIP-seq
MIRT1007147	hsa-miR-122	CLIP-seq
MIRT1007155	hsa-miR-1283	CLIP-seq
MIRT1007156	hsa-miR-1285	CLIP-seq
MIRT1007159	hsa-miR-129-5p	CLIP-seq
MIRT1007160	hsa-miR-1307	CLIP-seq
MIRT2535959	hsa-miR-1976	CLIP-seq
MIRT1007173	hsa-miR-216a	CLIP-seq
MIRT1007174	hsa-miR-216b	CLIP-seq
MIRT2449963	hsa-miR-3120-5p	CLIP-seq
MIRT1007181	hsa-miR-3121-3p	CLIP-seq
MIRT1007185	hsa-miR-3135b	CLIP-seq
MIRT1007187	hsa-miR-3149	CLIP-seq
MIRT1007189	hsa-miR-3187-5p	CLIP-seq
MIRT1007193	hsa-miR-3609	CLIP-seq
MIRT1007194	hsa-miR-3613-3p	CLIP-seq
MIRT1007196	hsa-miR-3652	CLIP-seq
MIRT2449965	hsa-miR-3664-5p	CLIP-seq
MIRT1007198	hsa-miR-3675-3p	CLIP-seq
MIRT1007203	hsa-miR-371-5p	CLIP-seq
MIRT1007204	hsa-miR-371b-5p	CLIP-seq
MIRT1007207	hsa-miR-3910	CLIP-seq
MIRT1007212	hsa-miR-411	CLIP-seq
MIRT1007214	hsa-miR-4269	CLIP-seq
MIRT2535960	hsa-miR-4279	CLIP-seq
MIRT1007218	hsa-miR-4421	CLIP-seq
MIRT1007219	hsa-miR-4430	CLIP-seq
MIRT2449966	hsa-miR-4432	CLIP-seq
MIRT1007223	hsa-miR-4455	CLIP-seq
MIRT2535961	hsa-miR-451b	CLIP-seq
MIRT2449967	hsa-miR-4522	CLIP-seq
MIRT1007233	hsa-miR-4684-5p	CLIP-seq
MIRT1007234	hsa-miR-4696	CLIP-seq
MIRT2535963	hsa-miR-4722-3p	CLIP-seq
MIRT1007242	hsa-miR-4735-5p	CLIP-seq
MIRT1007246	hsa-miR-4763-3p	CLIP-seq
MIRT2535964	hsa-miR-4769-3p	CLIP-seq
MIRT1007249	hsa-miR-4775	CLIP-seq
MIRT2681238	hsa-miR-4786-5p	CLIP-seq
MIRT2449969	hsa-miR-483-5p	CLIP-seq
MIRT2535965	hsa-miR-498	CLIP-seq
MIRT1007258	hsa-miR-5095	CLIP-seq
MIRT1007263	hsa-miR-520g	CLIP-seq
MIRT1007264	hsa-miR-520h	CLIP-seq
MIRT1007265	hsa-miR-548ah	CLIP-seq
MIRT2449970	hsa-miR-548an	CLIP-seq
MIRT2449971	hsa-miR-552	CLIP-seq
MIRT1007269	hsa-miR-590-3p	CLIP-seq
MIRT1007270	hsa-miR-612	CLIP-seq
MIRT1007273	hsa-miR-661	CLIP-seq

Show/Hide all (1)

Transcription factor	Regulation	Reference
SRF	Unknown	20808827

Show/Hide all (69)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004322	Function	Ferroxidase activity	IDA	15641778
GO:0004322	Function	Ferroxidase activity	IEA
GO:0005515	Function	Protein binding	IPI	15123683, 15961414, 26702583, 31101807, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	17468497, 21298097
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	27519411
GO:0005759	Component	Mitochondrial matrix	IC	29491838
GO:0005759	Component	Mitochondrial matrix	ISS
GO:0005759	Component	Mitochondrial matrix	NAS	17285345
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005829	Component	Cytosol	IDA	17468497
GO:0005829	Component	Cytosol	IEA
GO:0006119	Process	Oxidative phosphorylation	IEA
GO:0006783	Process	Heme biosynthetic process	IDA	15123683
GO:0006783	Process	Heme biosynthetic process	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006826	Process	Iron ion transport	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	IEA
GO:0006879	Process	Intracellular iron ion homeostasis	IMP	18160053
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007628	Process	Adult walking behavior	IEA
GO:0008047	Function	Enzyme activator activity	IDA	15123683, 28634302, 38627381
GO:0008198	Function	Ferrous iron binding	IBA
GO:0008198	Function	Ferrous iron binding	IDA	12785837, 15123683, 17285345, 29576242
GO:0008199	Function	Ferric iron binding	IBA
GO:0008199	Function	Ferric iron binding	IDA	12785837, 18537827
GO:0008199	Function	Ferric iron binding	IEA
GO:0009060	Process	Aerobic respiration	IEA
GO:0009792	Process	Embryo development ending in birth or egg hatching	IEA
GO:0010039	Process	Response to iron ion	IMP	18424449
GO:0016226	Process	Iron-sulfur cluster assembly	IBA
GO:0016226	Process	Iron-sulfur cluster assembly	IDA	12785837
GO:0016226	Process	Iron-sulfur cluster assembly	IEA
GO:0016226	Process	Iron-sulfur cluster assembly	IEA
GO:0016226	Process	Iron-sulfur cluster assembly	NAS	29097656
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016540	Process	Protein autoprocessing	IDA	12785837
GO:0019230	Process	Proprioception	IEA
GO:0030003	Process	Intracellular monoatomic cation homeostasis	IEA
GO:0034551	Process	Mitochondrial respiratory chain complex III assembly	TAS
GO:0034986	Function	Iron chaperone activity	IBA
GO:0034986	Function	Iron chaperone activity	IDA	15123683
GO:0034986	Function	Iron chaperone activity	TAS
GO:0035265	Process	Organ growth	IEA
GO:0040008	Process	Regulation of growth	IEA
GO:0040015	Process	Negative regulation of multicellular organism growth	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	16608849
GO:0044571	Process	[2Fe-2S] cluster assembly	IDA	24971490, 29491838, 29576242, 38627381
GO:0044572	Process	[4Fe-4S] cluster assembly	IDA	29576242
GO:0044572	Process	[4Fe-4S] cluster assembly	IEA
GO:0044572	Process	[4Fe-4S] cluster assembly	ISS
GO:0046621	Process	Negative regulation of organ growth	IEA
GO:0046716	Process	Muscle cell cellular homeostasis	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051349	Process	Positive regulation of lyase activity	IDA	20053667
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IBA
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IDA	12785837
GO:0051604	Process	Protein maturation	IMP	15509595
GO:0070301	Process	Cellular response to hydrogen peroxide	IDA	15641778
GO:0090201	Process	Negative regulation of release of cytochrome c from mitochondria	IMP	16608849
GO:0098771	Process	Inorganic ion homeostasis	IEA
GO:0099128	Component	Mitochondrial [2Fe-2S] assembly complex	IDA	21298097, 29491838, 31101807
GO:0099128	Component	Mitochondrial [2Fe-2S] assembly complex	IEA
GO:1990229	Component	Iron-sulfur cluster assembly complex	NAS	29097656

MIM	HGNC	e!Ensembl
606829	3951	ENSG00000165060

Q16595

Protein name

Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN); Extramitochondria

Protein function

[Frataxin mature form]: Functions as an activator of persulfide transfer to the scaffoding protein ISCU as component of the core iron-sulfur cluster (ISC) assembly complex and participates to the [2Fe-2S] cluster assembly (PubMed:12785837, PubMe

PDB

1EKG , 1LY7 , 3S4M , 3S5D , 3S5E , 3S5F , 3T3J , 3T3K , 3T3L , 3T3T , 3T3X , 5KZ5 , 6NZU , 8PK8 , 8PK9 , 8RME

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01491	Frataxin_Cyay	90 → 198	Frataxin-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the heart, peripheral blood lymphocytes and dermal fibroblasts. {ECO:0000269|PubMed:17468497}.

Sequence

MWTLGRRAVAGLLASPSPAQAQTLTRVPRPAELAPLCGRRGLRTDIDATCTPRRASSNQR
GLNQIWNVKKQSVYLMNLRKSGTLGHPGSLDETTYERLAEETLDSLAEFFEDLADKPYTF
EDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIWLSSPSSGPKRYDWTGKNWVYSHDGV
SLHELLAAELTKALKTKLDLSSLAYSGKDA

Sequence length

210

Interactions

View interactions

	KEGG		Reactome
	Porphyrin metabolism		Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Friedreich ataxia	Pathogenic; Likely pathogenic	rs104894105, rs140987490, rs104894106, rs104894108, rs56214919, rs141935559	RCV000004186 RCV000004187 RCV000004188 RCV000004190 RCV000004191 RCV000004192
Friedreich ataxia 1	Likely pathogenic; Pathogenic	rs2133102338, rs193922938, rs104894106, rs104894108, rs143232208, rs2539217018, rs886037630, rs146818694	RCV001726502 RCV001726540 RCV004689408 RCV004017228 RCV003999024 RCV004527184 RCV000029175 RCV000664219

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cardiovascular phenotype	Conflicting classifications of pathogenicity	rs141858334	RCV000252988
Cervical cancer	Benign	rs59907886	RCV005894414
Charcot-Marie-Tooth-like disease	Conflicting classifications of pathogenicity	rs138034837	RCV001353170
Colon adenocarcinoma	Benign	rs59907886	RCV005894411
FXN-related disorder	Conflicting classifications of pathogenicity; Likely benign	rs138034837, rs769666460	RCV003928855 RCV003921965
Hepatocellular carcinoma	Benign	rs59907886	RCV005894412
Hypertrophic cardiomyopathy	Conflicting classifications of pathogenicity	rs145854903	RCV000852582
Malignant tumor of esophagus	Benign	rs59907886	RCV005894413
Ovarian serous cystadenocarcinoma	Benign	rs59907886	RCV005894416
Sarcoma	Benign	rs59907886	RCV005894415
Uterine carcinosarcoma	Benign	rs59907886	RCV005894417
Uterine corpus endometrial carcinoma	Benign	rs59907886	RCV005894418

Show/Hide Text Mining Associations (60)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Ankle Injuries	Associate	19485941
Ataxia	Associate	17110750, 19485941, 20001966, 23242090, 33348670, 34747814, 38396238
Carcinogenesis	Associate	31074541
Carcinoma Hepatocellular	Associate	29447225
Carcinoma Renal Cell	Associate	19679182
Cardiomyopathies	Associate	10900192, 11121484, 16608849, 19485941, 20001966, 31446150, 38396238
Cardiomyopathy Hypertrophic	Associate	31446150, 34923139
Charcot Marie Tooth Disease	Associate	34747814
Chromosomal Instability	Associate	32989015
Chromosome Fragility	Associate	26379101
Conversion Disorder	Associate	25333765
Dementia	Associate	40141365
Demyelinating Diseases	Associate	17499976, 19679182
Diabetes Mellitus	Associate	10900192, 16608849, 24375160, 38396238
DNA Virus Infections	Associate	33276460
Drug Hypersensitivity	Associate	22155640
Drug Related Side Effects and Adverse Reactions	Associate	19679182, 29794127
Dysarthria	Inhibit	22764244
Esophageal Neoplasms	Associate	33794814
Eye Abnormalities	Associate	24375160
Fanconi Anemia	Associate	32989015
Fatigue Syndrome Chronic	Associate	10428860
Fragile X Syndrome	Associate	24787137
Fragile X Tremor Ataxia Syndrome	Inhibit	21558427
Friedreich Ataxia	Associate	10230399, 10428860, 10766903, 10900192, 11907009, 11970939, 14977802, 14978261, 15507666, 15534367, 16608849, 16677095, 16787388, 16857735, 17110750 View all (125 more)
Friedreich Ataxia	Inhibit	10500204, 10908340, 11121484, 12915401, 12928720, 15201375, 15615730, 16989817, 18485778, 18759347, 18807169, 19158945, 20090835, 20889968, 21147271 View all (39 more)
Gait Ataxia	Inhibit	22764244
Genetic Diseases Inborn	Inhibit	25549872
Genetic Diseases Inborn	Associate	31584077
Glycogen Storage Disease Type II	Associate	36635061
Hand Arm Vibration Syndrome	Inhibit	22764244
Hereditary Sensory and Autonomic Neuropathy Type Ie	Inhibit	22764244
Heredodegenerative Disorders Nervous System	Associate	19843162, 21298097
Hypertension Pulmonary	Inhibit	34060487
Hypoxia	Associate	21368894
Hypoxia	Inhibit	29596470
Hypoxia Brain	Stimulate	21368894
Immunologic Deficiency Syndromes	Inhibit	25112975, 33432325
Immunologic Deficiency Syndromes	Associate	9443873
Inflammation	Associate	19679182, 35413853
Iron Overload	Associate	18424449
Metabolic Diseases	Associate	29329987
Mitochondrial complex I deficiency	Associate	11907009
Mitochondrial complex I deficiency	Inhibit	24705504
Mitochondrial Diseases	Associate	15615730, 16677095, 23146029, 31584077, 35413853, 38062036, 9443873
Mitochondrial Diseases	Inhibit	16608849, 21147271, 36107856
Myoclonic Cerebellar Dyssynergia	Associate	28789479
Myopathy with Lactic Acidosis Hereditary	Inhibit	31640150
Neoplasms	Associate	21368894, 23418481, 31074541, 31209948, 35335316
Nervous System Diseases	Associate	35335316
Neuralgia	Associate	25144566
Neurodegenerative Diseases	Associate	11121484, 12928720, 16787388, 17499976, 19679182, 22352884, 23909240, 25333765, 29192133, 30636112, 30975898, 31074541, 31209948, 31511419, 31848436, 33348670, 37606107 View all (2 more)
Oligodendroglioma	Associate	17499976
Optic Atrophy	Associate	38396238
Osteosarcoma	Associate	22752483
Paraparesis Spastic	Associate	34747814
Protein S Deficiency	Inhibit	21147271
Reflex Abnormal	Inhibit	22764244
Spastic Ataxia	Associate	32775015
Tendinopathy	Inhibit	22764244

FXN (frataxin)