MTCH2 (mitochondrial carrier 2)

Gene

• Entrez ID: 23788
• Gene name: Mitochondrial carrier 2
• Gene symbol: MTCH2
• Synonyms (NCBI Gene): HSPC032, MIMP, SLC25A50
• Chromosome: 11
• Chromosome location: 11p11.2
• Summary: This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029895	hsa-miR-26b-5p	Microarray	19088304
MIRT051550	hsa-let-7e-5p	CLASH	23622248
MIRT047945	hsa-miR-30c-5p	CLASH	23622248
MIRT042361	hsa-miR-484	CLASH	23622248
MIRT038156	hsa-miR-423-5p	CLASH	23622248
MIRT437877	hsa-miR-135b-5p	Luciferase reporter assay, Western blot	23623609
MIRT1162384	hsa-miR-106a	CLIP-seq
MIRT1162385	hsa-miR-106b	CLIP-seq
MIRT1162386	hsa-miR-1224-5p	CLIP-seq
MIRT1162387	hsa-miR-1256	CLIP-seq
MIRT1162388	hsa-miR-1304	CLIP-seq
MIRT1162389	hsa-miR-150	CLIP-seq
MIRT1162390	hsa-miR-17	CLIP-seq
MIRT1162391	hsa-miR-203	CLIP-seq
MIRT1162392	hsa-miR-20a	CLIP-seq
MIRT1162393	hsa-miR-20b	CLIP-seq
MIRT1162394	hsa-miR-24	CLIP-seq
MIRT1162395	hsa-miR-2467-5p	CLIP-seq
MIRT1162396	hsa-miR-2682	CLIP-seq
MIRT1162397	hsa-miR-3121-5p	CLIP-seq
MIRT1162398	hsa-miR-3148	CLIP-seq
MIRT1162399	hsa-miR-3185	CLIP-seq
MIRT1162400	hsa-miR-3192	CLIP-seq
MIRT1162401	hsa-miR-3199	CLIP-seq
MIRT1162402	hsa-miR-339-5p	CLIP-seq
MIRT1162403	hsa-miR-3613-3p	CLIP-seq
MIRT1162404	hsa-miR-3915	CLIP-seq
MIRT1162405	hsa-miR-3928	CLIP-seq
MIRT1162406	hsa-miR-3940-5p	CLIP-seq
MIRT1162407	hsa-miR-3974	CLIP-seq
MIRT1162408	hsa-miR-4257	CLIP-seq
MIRT1162409	hsa-miR-4314	CLIP-seq
MIRT1162410	hsa-miR-449c	CLIP-seq
MIRT1162411	hsa-miR-4507	CLIP-seq
MIRT1162412	hsa-miR-4528	CLIP-seq
MIRT1162413	hsa-miR-4642	CLIP-seq
MIRT1162414	hsa-miR-4646-5p	CLIP-seq
MIRT1162415	hsa-miR-4653-3p	CLIP-seq
MIRT1162416	hsa-miR-4689	CLIP-seq
MIRT1162417	hsa-miR-4712-3p	CLIP-seq
MIRT1162418	hsa-miR-4713-5p	CLIP-seq
MIRT1162419	hsa-miR-4768-5p	CLIP-seq
MIRT1162420	hsa-miR-4778-5p	CLIP-seq
MIRT1162421	hsa-miR-4802-3p	CLIP-seq
MIRT1162422	hsa-miR-499a-5p	CLIP-seq
MIRT1162423	hsa-miR-519d	CLIP-seq
MIRT1162424	hsa-miR-520d-5p	CLIP-seq
MIRT1162425	hsa-miR-524-5p	CLIP-seq
MIRT1162426	hsa-miR-532-3p	CLIP-seq
MIRT1162427	hsa-miR-543	CLIP-seq
MIRT1162428	hsa-miR-545	CLIP-seq
MIRT1162429	hsa-miR-548a-3p	CLIP-seq
MIRT1162430	hsa-miR-548ae	CLIP-seq
MIRT1162431	hsa-miR-548aj	CLIP-seq
MIRT1162432	hsa-miR-548am	CLIP-seq
MIRT1162433	hsa-miR-548e	CLIP-seq
MIRT1162434	hsa-miR-548f	CLIP-seq
MIRT1162435	hsa-miR-548m	CLIP-seq
MIRT1162436	hsa-miR-548t	CLIP-seq
MIRT1162437	hsa-miR-548x	CLIP-seq
MIRT1162438	hsa-miR-624	CLIP-seq
MIRT1162439	hsa-miR-93	CLIP-seq
MIRT1162440	hsa-miR-940	CLIP-seq
MIRT2046572	hsa-miR-1208	CLIP-seq
MIRT1162394	hsa-miR-24	CLIP-seq
MIRT1162395	hsa-miR-2467-5p	CLIP-seq
MIRT2046573	hsa-miR-3140-5p	CLIP-seq
MIRT1162400	hsa-miR-3192	CLIP-seq
MIRT1162401	hsa-miR-3199	CLIP-seq
MIRT1162402	hsa-miR-339-5p	CLIP-seq
MIRT2046574	hsa-miR-3622a-3p	CLIP-seq
MIRT2046575	hsa-miR-3622b-3p	CLIP-seq
MIRT1162408	hsa-miR-4257	CLIP-seq
MIRT1162409	hsa-miR-4314	CLIP-seq
MIRT1162414	hsa-miR-4646-5p	CLIP-seq
MIRT1162424	hsa-miR-520d-5p	CLIP-seq
MIRT1162425	hsa-miR-524-5p	CLIP-seq
MIRT2046576	hsa-miR-579	CLIP-seq
MIRT2046577	hsa-miR-606	CLIP-seq
MIRT2046578	hsa-miR-668	CLIP-seq
MIRT1162384	hsa-miR-106a	CLIP-seq
MIRT1162385	hsa-miR-106b	CLIP-seq
MIRT2046572	hsa-miR-1208	CLIP-seq
MIRT1162386	hsa-miR-1224-5p	CLIP-seq
MIRT2275684	hsa-miR-1271	CLIP-seq
MIRT1162388	hsa-miR-1304	CLIP-seq
MIRT1162389	hsa-miR-150	CLIP-seq
MIRT1162390	hsa-miR-17	CLIP-seq
MIRT2275685	hsa-miR-182	CLIP-seq
MIRT2275686	hsa-miR-186	CLIP-seq
MIRT1162392	hsa-miR-20a	CLIP-seq
MIRT1162393	hsa-miR-20b	CLIP-seq
MIRT2275687	hsa-miR-302a	CLIP-seq
MIRT2275688	hsa-miR-302b	CLIP-seq
MIRT2275689	hsa-miR-302c	CLIP-seq
MIRT2275690	hsa-miR-302d	CLIP-seq
MIRT2275691	hsa-miR-302e	CLIP-seq
MIRT1162397	hsa-miR-3121-5p	CLIP-seq
MIRT2275692	hsa-miR-3133	CLIP-seq
MIRT1162398	hsa-miR-3148	CLIP-seq
MIRT2275693	hsa-miR-3154	CLIP-seq
MIRT2275694	hsa-miR-3174	CLIP-seq
MIRT2275695	hsa-miR-3179	CLIP-seq
MIRT1162400	hsa-miR-3192	CLIP-seq
MIRT1162401	hsa-miR-3199	CLIP-seq
MIRT2275696	hsa-miR-372	CLIP-seq
MIRT2275697	hsa-miR-373	CLIP-seq
MIRT1162404	hsa-miR-3915	CLIP-seq
MIRT1162405	hsa-miR-3928	CLIP-seq
MIRT2275698	hsa-miR-410	CLIP-seq
MIRT2275699	hsa-miR-4268	CLIP-seq
MIRT1162409	hsa-miR-4314	CLIP-seq
MIRT2275700	hsa-miR-4424	CLIP-seq
MIRT2275701	hsa-miR-4503	CLIP-seq
MIRT2275702	hsa-miR-4511	CLIP-seq
MIRT1162414	hsa-miR-4646-5p	CLIP-seq
MIRT1162416	hsa-miR-4689	CLIP-seq
MIRT1162417	hsa-miR-4712-3p	CLIP-seq
MIRT1162418	hsa-miR-4713-5p	CLIP-seq
MIRT1162419	hsa-miR-4768-5p	CLIP-seq
MIRT1162420	hsa-miR-4778-5p	CLIP-seq
MIRT2275703	hsa-miR-519a	CLIP-seq
MIRT2275704	hsa-miR-519b-3p	CLIP-seq
MIRT2275705	hsa-miR-519c-3p	CLIP-seq
MIRT1162423	hsa-miR-519d	CLIP-seq
MIRT2275706	hsa-miR-520a-3p	CLIP-seq
MIRT2275707	hsa-miR-520b	CLIP-seq
MIRT2275708	hsa-miR-520c-3p	CLIP-seq
MIRT2275709	hsa-miR-520d-3p	CLIP-seq
MIRT2275710	hsa-miR-520e	CLIP-seq
MIRT2275711	hsa-miR-520f	CLIP-seq
MIRT1162426	hsa-miR-532-3p	CLIP-seq
MIRT1162427	hsa-miR-543	CLIP-seq
MIRT1162436	hsa-miR-548t	CLIP-seq
MIRT2275712	hsa-miR-550b	CLIP-seq
MIRT2275713	hsa-miR-556-5p	CLIP-seq
MIRT2046576	hsa-miR-579	CLIP-seq
MIRT2046578	hsa-miR-668	CLIP-seq
MIRT2275714	hsa-miR-760	CLIP-seq
MIRT2275715	hsa-miR-890	CLIP-seq
MIRT1162439	hsa-miR-93	CLIP-seq
MIRT2275716	hsa-miR-96	CLIP-seq
MIRT2574612	hsa-miR-1182	CLIP-seq
MIRT2574613	hsa-miR-1245	CLIP-seq
MIRT2574614	hsa-miR-1915	CLIP-seq
MIRT2574615	hsa-miR-2053	CLIP-seq
MIRT1162394	hsa-miR-24	CLIP-seq
MIRT1162395	hsa-miR-2467-5p	CLIP-seq
MIRT2574616	hsa-miR-2909	CLIP-seq
MIRT2574617	hsa-miR-3120-5p	CLIP-seq
MIRT2574618	hsa-miR-3150a-5p	CLIP-seq
MIRT2574619	hsa-miR-3150b-5p	CLIP-seq
MIRT1162402	hsa-miR-339-5p	CLIP-seq
MIRT2574620	hsa-miR-3545-3p	CLIP-seq
MIRT2574621	hsa-miR-3591-5p	CLIP-seq
MIRT2574622	hsa-miR-3606	CLIP-seq
MIRT2574623	hsa-miR-361-5p	CLIP-seq
MIRT2574624	hsa-miR-3616-5p	CLIP-seq
MIRT2574625	hsa-miR-3617	CLIP-seq
MIRT2574626	hsa-miR-3647-5p	CLIP-seq
MIRT2574627	hsa-miR-3673	CLIP-seq
MIRT2574628	hsa-miR-377	CLIP-seq
MIRT2574629	hsa-miR-3908	CLIP-seq
MIRT2574630	hsa-miR-3913-3p	CLIP-seq
MIRT2574631	hsa-miR-3942-5p	CLIP-seq
MIRT1162408	hsa-miR-4257	CLIP-seq
MIRT2275699	hsa-miR-4268	CLIP-seq
MIRT2574632	hsa-miR-432	CLIP-seq
MIRT2275701	hsa-miR-4503	CLIP-seq
MIRT2574633	hsa-miR-450b-5p	CLIP-seq
MIRT2574634	hsa-miR-4635	CLIP-seq
MIRT2574635	hsa-miR-4703-5p	CLIP-seq
MIRT1162417	hsa-miR-4712-3p	CLIP-seq
MIRT2574636	hsa-miR-4725-5p	CLIP-seq
MIRT2574637	hsa-miR-4728-5p	CLIP-seq
MIRT2574638	hsa-miR-4760-3p	CLIP-seq
MIRT2574639	hsa-miR-4766-3p	CLIP-seq
MIRT2574640	hsa-miR-4775	CLIP-seq
MIRT1162422	hsa-miR-499a-5p	CLIP-seq
MIRT2574641	hsa-miR-504	CLIP-seq
MIRT2574642	hsa-miR-516a-3p	CLIP-seq
MIRT1162424	hsa-miR-520d-5p	CLIP-seq
MIRT1162425	hsa-miR-524-5p	CLIP-seq
MIRT2574643	hsa-miR-526b	CLIP-seq
MIRT2574644	hsa-miR-548a-5p	CLIP-seq
MIRT2574645	hsa-miR-548ab	CLIP-seq
MIRT2574646	hsa-miR-548ak	CLIP-seq
MIRT2574647	hsa-miR-548b-5p	CLIP-seq
MIRT2574648	hsa-miR-548c-5p	CLIP-seq
MIRT2574649	hsa-miR-548d-5p	CLIP-seq
MIRT2574650	hsa-miR-548h	CLIP-seq
MIRT2574651	hsa-miR-548i	CLIP-seq
MIRT2574652	hsa-miR-548j	CLIP-seq
MIRT2574653	hsa-miR-548n	CLIP-seq
MIRT2574654	hsa-miR-548w	CLIP-seq
MIRT2574655	hsa-miR-548y	CLIP-seq
MIRT2574656	hsa-miR-556-3p	CLIP-seq
MIRT2275713	hsa-miR-556-5p	CLIP-seq
MIRT2574657	hsa-miR-559	CLIP-seq
MIRT2574658	hsa-miR-573	CLIP-seq
MIRT2574659	hsa-miR-578	CLIP-seq
MIRT2574660	hsa-miR-641	CLIP-seq
MIRT2574661	hsa-miR-656	CLIP-seq
MIRT2574662	hsa-miR-921	CLIP-seq
MIRT2574663	hsa-miR-944	CLIP-seq
MIRT2574612	hsa-miR-1182	CLIP-seq
MIRT2574613	hsa-miR-1245	CLIP-seq
MIRT2275686	hsa-miR-186	CLIP-seq
MIRT2574614	hsa-miR-1915	CLIP-seq
MIRT2574615	hsa-miR-2053	CLIP-seq
MIRT1162394	hsa-miR-24	CLIP-seq
MIRT1162395	hsa-miR-2467-5p	CLIP-seq
MIRT2574616	hsa-miR-2909	CLIP-seq
MIRT2574617	hsa-miR-3120-5p	CLIP-seq
MIRT2275692	hsa-miR-3133	CLIP-seq
MIRT2574618	hsa-miR-3150a-5p	CLIP-seq
MIRT2574619	hsa-miR-3150b-5p	CLIP-seq
MIRT2275693	hsa-miR-3154	CLIP-seq
MIRT2275695	hsa-miR-3179	CLIP-seq
MIRT1162402	hsa-miR-339-5p	CLIP-seq
MIRT2574620	hsa-miR-3545-3p	CLIP-seq
MIRT2574621	hsa-miR-3591-5p	CLIP-seq
MIRT2574622	hsa-miR-3606	CLIP-seq
MIRT2574624	hsa-miR-3616-5p	CLIP-seq
MIRT2574625	hsa-miR-3617	CLIP-seq
MIRT2574626	hsa-miR-3647-5p	CLIP-seq
MIRT2574627	hsa-miR-3673	CLIP-seq
MIRT2574628	hsa-miR-377	CLIP-seq
MIRT2574629	hsa-miR-3908	CLIP-seq
MIRT2574630	hsa-miR-3913-3p	CLIP-seq
MIRT2574631	hsa-miR-3942-5p	CLIP-seq
MIRT1162408	hsa-miR-4257	CLIP-seq
MIRT2275699	hsa-miR-4268	CLIP-seq
MIRT2574632	hsa-miR-432	CLIP-seq
MIRT2685452	hsa-miR-4470	CLIP-seq
MIRT2685453	hsa-miR-4494	CLIP-seq
MIRT2685454	hsa-miR-4499	CLIP-seq
MIRT2275701	hsa-miR-4503	CLIP-seq
MIRT2574633	hsa-miR-450b-5p	CLIP-seq
MIRT2574634	hsa-miR-4635	CLIP-seq
MIRT2574635	hsa-miR-4703-5p	CLIP-seq
MIRT1162417	hsa-miR-4712-3p	CLIP-seq
MIRT2574636	hsa-miR-4725-5p	CLIP-seq
MIRT2574637	hsa-miR-4728-5p	CLIP-seq
MIRT2574638	hsa-miR-4760-3p	CLIP-seq
MIRT2574639	hsa-miR-4766-3p	CLIP-seq
MIRT2574640	hsa-miR-4775	CLIP-seq
MIRT1162422	hsa-miR-499a-5p	CLIP-seq
MIRT2574641	hsa-miR-504	CLIP-seq
MIRT2574642	hsa-miR-516a-3p	CLIP-seq
MIRT1162424	hsa-miR-520d-5p	CLIP-seq
MIRT1162425	hsa-miR-524-5p	CLIP-seq
MIRT2574643	hsa-miR-526b	CLIP-seq
MIRT2574644	hsa-miR-548a-5p	CLIP-seq
MIRT2574645	hsa-miR-548ab	CLIP-seq
MIRT2574646	hsa-miR-548ak	CLIP-seq
MIRT2574647	hsa-miR-548b-5p	CLIP-seq
MIRT2574648	hsa-miR-548c-5p	CLIP-seq
MIRT2574649	hsa-miR-548d-5p	CLIP-seq
MIRT2574650	hsa-miR-548h	CLIP-seq
MIRT2574651	hsa-miR-548i	CLIP-seq
MIRT2574652	hsa-miR-548j	CLIP-seq
MIRT2574653	hsa-miR-548n	CLIP-seq
MIRT2574654	hsa-miR-548w	CLIP-seq
MIRT2574655	hsa-miR-548y	CLIP-seq
MIRT2574656	hsa-miR-556-3p	CLIP-seq
MIRT2275713	hsa-miR-556-5p	CLIP-seq
MIRT2574657	hsa-miR-559	CLIP-seq
MIRT2574658	hsa-miR-573	CLIP-seq
MIRT2574659	hsa-miR-578	CLIP-seq
MIRT2574660	hsa-miR-641	CLIP-seq
MIRT2275714	hsa-miR-760	CLIP-seq
MIRT2275715	hsa-miR-890	CLIP-seq
MIRT2574662	hsa-miR-921	CLIP-seq
MIRT2574663	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IDA	36264797
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0006089	Process	Lactate metabolic process	IEA
GO:0006839	Process	Mitochondrial transport	IEA
GO:0010635	Process	Regulation of mitochondrial fusion	IEA
GO:0010635	Process	Regulation of mitochondrial fusion	ISS
GO:0010917	Process	Negative regulation of mitochondrial membrane potential	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0032977	Function	Membrane insertase activity	IDA	36264797
GO:0035701	Process	Hematopoietic stem cell migration	IEA
GO:0042775	Process	Mitochondrial ATP synthesis coupled electron transport	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	ISS
GO:0045040	Process	Protein insertion into mitochondrial outer membrane	IDA	36264797
GO:0045820	Process	Negative regulation of glycolytic process	IEA
GO:0055088	Process	Lipid homeostasis	IEA
GO:0055088	Process	Lipid homeostasis	ISS
GO:0061484	Process	Hematopoietic stem cell homeostasis	IEA
GO:0070585	Process	Protein localization to mitochondrion	IEA
GO:0070585	Process	Protein localization to mitochondrion	IMP	23744079
GO:0071478	Process	Cellular response to radiation	IEA
GO:0090151	Process	Establishment of protein localization to mitochondrial membrane	IEA
GO:0090152	Process	Establishment of protein localization to mitochondrial membrane involved in mitochondrial fission	IEA
GO:0097284	Process	Hepatocyte apoptotic process	IEA
GO:1902108	Process	Regulation of mitochondrial membrane permeability involved in apoptotic process	IEA
GO:1902231	Process	Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA
GO:2000738	Process	Positive regulation of stem cell differentiation	IEA
GO:2000738	Process	Positive regulation of stem cell differentiation	ISS

Other IDs

• MIM: 613221
• HGNC: 17587
• e!Ensembl: ENSG00000109919

Protein

• UniProt ID: Q9Y6C9
• Protein name: Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein)
• Protein function: Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and mul
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00153	Mito_carr	118 → 205	Mitochondrial carrier protein	Family

• Sequence:

  MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPTIGRNIFGRQVCQLPGLFSYAQH
  IASIDGRRGLFTGLTPRLCSGVLGTVVHGKVLQHYQESDKGEELGPGNVQKEVSSSFDHV
  IKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIITIYREEGILGFFA
  GLVPRLLGDILSLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLV
  SNLMAVNNCGLAGGCPPYSPIYTSWIDCWCMLQKEGNMSRGNSLFFRKVPFGKTYCCDLK
  MLI

• Sequence length: 303