Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23787
Gene name	Mitochondrial carrier 1
Gene symbol	MTCH1
Synonyms (NCBI Gene)	CGI-64PIG60PSAPSLC25A49
Chromosome	6
Chromosome location	6p21.2
Summary	This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been

288

Show/Hide all (288)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022610	hsa-miR-124-3p	Microarray	18668037
MIRT052714	hsa-miR-1260b	CLASH	23622248
MIRT493074	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT493074	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT493072	hsa-miR-548n	PAR-CLIP	23592263
MIRT493073	hsa-miR-6768-5p	PAR-CLIP	23592263
MIRT493071	hsa-miR-4255	PAR-CLIP	23592263
MIRT493070	hsa-miR-3074-3p	PAR-CLIP	23592263
MIRT493069	hsa-miR-2115-3p	PAR-CLIP	23592263
MIRT493068	hsa-miR-539-5p	PAR-CLIP	23592263
MIRT493067	hsa-miR-4290	PAR-CLIP	23592263
MIRT493066	hsa-miR-361-5p	PAR-CLIP	23592263
MIRT493065	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT493074	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT493074	hsa-miR-142-3p	PAR-CLIP	23592263
MIRT493072	hsa-miR-548n	PAR-CLIP	23592263
MIRT493073	hsa-miR-6768-5p	PAR-CLIP	23592263
MIRT493071	hsa-miR-4255	PAR-CLIP	23592263
MIRT493070	hsa-miR-3074-3p	PAR-CLIP	23592263
MIRT493069	hsa-miR-2115-3p	PAR-CLIP	23592263
MIRT493068	hsa-miR-539-5p	PAR-CLIP	23592263
MIRT493067	hsa-miR-4290	PAR-CLIP	23592263
MIRT493066	hsa-miR-361-5p	PAR-CLIP	23592263
MIRT493065	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT1162330	hsa-miR-1245b-3p	CLIP-seq
MIRT1162331	hsa-miR-1289	CLIP-seq
MIRT1162332	hsa-miR-1322	CLIP-seq
MIRT1162333	hsa-miR-143	CLIP-seq
MIRT1162334	hsa-miR-1827	CLIP-seq
MIRT1162335	hsa-miR-1913	CLIP-seq
MIRT1162336	hsa-miR-2355-5p	CLIP-seq
MIRT1162337	hsa-miR-3117-3p	CLIP-seq
MIRT1162338	hsa-miR-3132	CLIP-seq
MIRT1162339	hsa-miR-3169	CLIP-seq
MIRT1162340	hsa-miR-3198	CLIP-seq
MIRT1162341	hsa-miR-323-5p	CLIP-seq
MIRT1162342	hsa-miR-324-3p	CLIP-seq
MIRT1162343	hsa-miR-326	CLIP-seq
MIRT1162344	hsa-miR-330-3p	CLIP-seq
MIRT1162345	hsa-miR-330-5p	CLIP-seq
MIRT1162346	hsa-miR-3614-3p	CLIP-seq
MIRT1162347	hsa-miR-3657	CLIP-seq
MIRT1162348	hsa-miR-3665	CLIP-seq
MIRT1162349	hsa-miR-3672	CLIP-seq
MIRT1162350	hsa-miR-3676	CLIP-seq
MIRT1162351	hsa-miR-3679-3p	CLIP-seq
MIRT1162352	hsa-miR-3934	CLIP-seq
MIRT1162353	hsa-miR-3940-5p	CLIP-seq
MIRT1162354	hsa-miR-4294	CLIP-seq
MIRT1162355	hsa-miR-4309	CLIP-seq
MIRT1162356	hsa-miR-431	CLIP-seq
MIRT1162357	hsa-miR-4323	CLIP-seq
MIRT1162358	hsa-miR-4435	CLIP-seq
MIRT1162359	hsa-miR-4507	CLIP-seq
MIRT1162360	hsa-miR-4514	CLIP-seq
MIRT1162361	hsa-miR-4692	CLIP-seq
MIRT1162362	hsa-miR-4722-5p	CLIP-seq
MIRT1162363	hsa-miR-4736	CLIP-seq
MIRT1162364	hsa-miR-4758-3p	CLIP-seq
MIRT1162365	hsa-miR-4759	CLIP-seq
MIRT1162366	hsa-miR-4761-5p	CLIP-seq
MIRT1162367	hsa-miR-4762-5p	CLIP-seq
MIRT1162368	hsa-miR-4768-3p	CLIP-seq
MIRT1162369	hsa-miR-4770	CLIP-seq
MIRT1162370	hsa-miR-4786-5p	CLIP-seq
MIRT1162371	hsa-miR-486-5p	CLIP-seq
MIRT1162372	hsa-miR-513b	CLIP-seq
MIRT1162373	hsa-miR-520d-5p	CLIP-seq
MIRT1162374	hsa-miR-524-5p	CLIP-seq
MIRT1162375	hsa-miR-539	CLIP-seq
MIRT1162376	hsa-miR-548a-3p	CLIP-seq
MIRT1162377	hsa-miR-548e	CLIP-seq
MIRT1162378	hsa-miR-548f	CLIP-seq
MIRT1162379	hsa-miR-580	CLIP-seq
MIRT1162380	hsa-miR-657	CLIP-seq
MIRT1162381	hsa-miR-764	CLIP-seq
MIRT1162382	hsa-miR-769-5p	CLIP-seq
MIRT1162383	hsa-miR-940	CLIP-seq
MIRT1162333	hsa-miR-143	CLIP-seq
MIRT2046540	hsa-miR-1587	CLIP-seq
MIRT1162334	hsa-miR-1827	CLIP-seq
MIRT1162338	hsa-miR-3132	CLIP-seq
MIRT2046541	hsa-miR-3135b	CLIP-seq
MIRT2046542	hsa-miR-3178	CLIP-seq
MIRT1162344	hsa-miR-330-3p	CLIP-seq
MIRT2046543	hsa-miR-3652	CLIP-seq
MIRT1162348	hsa-miR-3665	CLIP-seq
MIRT2046544	hsa-miR-3688-3p	CLIP-seq
MIRT2046545	hsa-miR-378	CLIP-seq
MIRT2046546	hsa-miR-378b	CLIP-seq
MIRT2046547	hsa-miR-378c	CLIP-seq
MIRT2046548	hsa-miR-378d	CLIP-seq
MIRT2046549	hsa-miR-378e	CLIP-seq
MIRT2046550	hsa-miR-378f	CLIP-seq
MIRT2046551	hsa-miR-378g	CLIP-seq
MIRT2046552	hsa-miR-378h	CLIP-seq
MIRT2046553	hsa-miR-378i	CLIP-seq
MIRT2046554	hsa-miR-422a	CLIP-seq
MIRT2046555	hsa-miR-4257	CLIP-seq
MIRT2046556	hsa-miR-4430	CLIP-seq
MIRT2046557	hsa-miR-4470	CLIP-seq
MIRT2046558	hsa-miR-4492	CLIP-seq
MIRT2046559	hsa-miR-4498	CLIP-seq
MIRT2046560	hsa-miR-4505	CLIP-seq
MIRT2046561	hsa-miR-4520a-3p	CLIP-seq
MIRT2046562	hsa-miR-4638-3p	CLIP-seq
MIRT2046563	hsa-miR-4643	CLIP-seq
MIRT2046564	hsa-miR-4656	CLIP-seq
MIRT2046565	hsa-miR-4675	CLIP-seq
MIRT2046566	hsa-miR-4717-3p	CLIP-seq
MIRT2046567	hsa-miR-4729	CLIP-seq
MIRT1162363	hsa-miR-4736	CLIP-seq
MIRT2046568	hsa-miR-4741	CLIP-seq
MIRT1162367	hsa-miR-4762-5p	CLIP-seq
MIRT1162369	hsa-miR-4770	CLIP-seq
MIRT2046569	hsa-miR-4786-3p	CLIP-seq
MIRT1162373	hsa-miR-520d-5p	CLIP-seq
MIRT1162374	hsa-miR-524-5p	CLIP-seq
MIRT2046570	hsa-miR-642b	CLIP-seq
MIRT2046571	hsa-miR-762	CLIP-seq
MIRT1162381	hsa-miR-764	CLIP-seq
MIRT1162383	hsa-miR-940	CLIP-seq
MIRT2275671	hsa-miR-1197	CLIP-seq
MIRT2275672	hsa-miR-1205	CLIP-seq
MIRT2275673	hsa-miR-1244	CLIP-seq
MIRT1162330	hsa-miR-1245b-3p	CLIP-seq
MIRT2275674	hsa-miR-1286	CLIP-seq
MIRT1162332	hsa-miR-1322	CLIP-seq
MIRT1162333	hsa-miR-143	CLIP-seq
MIRT2046540	hsa-miR-1587	CLIP-seq
MIRT1162334	hsa-miR-1827	CLIP-seq
MIRT1162336	hsa-miR-2355-5p	CLIP-seq
MIRT2275675	hsa-miR-2392	CLIP-seq
MIRT2275676	hsa-miR-3150b-3p	CLIP-seq
MIRT2275677	hsa-miR-3160-3p	CLIP-seq
MIRT2046542	hsa-miR-3178	CLIP-seq
MIRT1162343	hsa-miR-326	CLIP-seq
MIRT1162345	hsa-miR-330-5p	CLIP-seq
MIRT1162346	hsa-miR-3614-3p	CLIP-seq
MIRT1162348	hsa-miR-3665	CLIP-seq
MIRT1162351	hsa-miR-3679-3p	CLIP-seq
MIRT2046551	hsa-miR-378g	CLIP-seq
MIRT2275678	hsa-miR-4256	CLIP-seq
MIRT2046555	hsa-miR-4257	CLIP-seq
MIRT2275679	hsa-miR-4487	CLIP-seq
MIRT2046558	hsa-miR-4492	CLIP-seq
MIRT2046559	hsa-miR-4498	CLIP-seq
MIRT2046564	hsa-miR-4656	CLIP-seq
MIRT2275680	hsa-miR-4663	CLIP-seq
MIRT2046565	hsa-miR-4675	CLIP-seq
MIRT2275681	hsa-miR-4689	CLIP-seq
MIRT1162362	hsa-miR-4722-5p	CLIP-seq
MIRT2046567	hsa-miR-4729	CLIP-seq
MIRT1162363	hsa-miR-4736	CLIP-seq
MIRT2046568	hsa-miR-4741	CLIP-seq
MIRT1162367	hsa-miR-4762-5p	CLIP-seq
MIRT1162369	hsa-miR-4770	CLIP-seq
MIRT2275682	hsa-miR-4784	CLIP-seq
MIRT1162371	hsa-miR-486-5p	CLIP-seq
MIRT2275683	hsa-miR-558	CLIP-seq
MIRT2046570	hsa-miR-642b	CLIP-seq
MIRT2046571	hsa-miR-762	CLIP-seq
MIRT1162381	hsa-miR-764	CLIP-seq
MIRT1162383	hsa-miR-940	CLIP-seq
MIRT1162333	hsa-miR-143	CLIP-seq
MIRT2046540	hsa-miR-1587	CLIP-seq
MIRT2391131	hsa-miR-323b-3p	CLIP-seq
MIRT2046551	hsa-miR-378g	CLIP-seq
MIRT2046557	hsa-miR-4470	CLIP-seq
MIRT2046558	hsa-miR-4492	CLIP-seq
MIRT2046559	hsa-miR-4498	CLIP-seq
MIRT2046563	hsa-miR-4643	CLIP-seq
MIRT2046564	hsa-miR-4656	CLIP-seq
MIRT2046565	hsa-miR-4675	CLIP-seq
MIRT2046566	hsa-miR-4717-3p	CLIP-seq
MIRT2046567	hsa-miR-4729	CLIP-seq
MIRT2046568	hsa-miR-4741	CLIP-seq
MIRT1162367	hsa-miR-4762-5p	CLIP-seq
MIRT1162369	hsa-miR-4770	CLIP-seq
MIRT2046569	hsa-miR-4786-3p	CLIP-seq
MIRT1162370	hsa-miR-4786-5p	CLIP-seq
MIRT2046570	hsa-miR-642b	CLIP-seq
MIRT2046571	hsa-miR-762	CLIP-seq
MIRT1162382	hsa-miR-769-5p	CLIP-seq
MIRT1162331	hsa-miR-1289	CLIP-seq
MIRT2574598	hsa-miR-1291	CLIP-seq
MIRT2046540	hsa-miR-1587	CLIP-seq
MIRT2574599	hsa-miR-1972	CLIP-seq
MIRT1162336	hsa-miR-2355-5p	CLIP-seq
MIRT2574600	hsa-miR-296-5p	CLIP-seq
MIRT2574601	hsa-miR-3130-3p	CLIP-seq
MIRT2046541	hsa-miR-3135b	CLIP-seq
MIRT2574602	hsa-miR-3147	CLIP-seq
MIRT2574603	hsa-miR-3176	CLIP-seq
MIRT1162340	hsa-miR-3198	CLIP-seq
MIRT1162341	hsa-miR-323-5p	CLIP-seq
MIRT2574604	hsa-miR-323b-5p	CLIP-seq
MIRT1162343	hsa-miR-326	CLIP-seq
MIRT2574605	hsa-miR-328	CLIP-seq
MIRT1162345	hsa-miR-330-5p	CLIP-seq
MIRT1162346	hsa-miR-3614-3p	CLIP-seq
MIRT2046543	hsa-miR-3652	CLIP-seq
MIRT1162347	hsa-miR-3657	CLIP-seq
MIRT1162348	hsa-miR-3665	CLIP-seq
MIRT1162349	hsa-miR-3672	CLIP-seq
MIRT1162351	hsa-miR-3679-3p	CLIP-seq
MIRT2046544	hsa-miR-3688-3p	CLIP-seq
MIRT2046551	hsa-miR-378g	CLIP-seq
MIRT2574606	hsa-miR-3922-3p	CLIP-seq
MIRT1162352	hsa-miR-3934	CLIP-seq
MIRT2574607	hsa-miR-3940-3p	CLIP-seq
MIRT1162353	hsa-miR-3940-5p	CLIP-seq
MIRT1162354	hsa-miR-4294	CLIP-seq
MIRT1162355	hsa-miR-4309	CLIP-seq
MIRT1162356	hsa-miR-431	CLIP-seq
MIRT2574608	hsa-miR-4425	CLIP-seq
MIRT2046556	hsa-miR-4430	CLIP-seq
MIRT1162358	hsa-miR-4435	CLIP-seq
MIRT2046557	hsa-miR-4470	CLIP-seq
MIRT2046558	hsa-miR-4492	CLIP-seq
MIRT2046559	hsa-miR-4498	CLIP-seq
MIRT2046560	hsa-miR-4505	CLIP-seq
MIRT1162359	hsa-miR-4507	CLIP-seq
MIRT2046563	hsa-miR-4643	CLIP-seq
MIRT2574609	hsa-miR-4650-5p	CLIP-seq
MIRT2046564	hsa-miR-4656	CLIP-seq
MIRT2046565	hsa-miR-4675	CLIP-seq
MIRT2046566	hsa-miR-4717-3p	CLIP-seq
MIRT2046568	hsa-miR-4741	CLIP-seq
MIRT1162366	hsa-miR-4761-5p	CLIP-seq
MIRT2046569	hsa-miR-4786-3p	CLIP-seq
MIRT1162370	hsa-miR-4786-5p	CLIP-seq
MIRT2574610	hsa-miR-4793-3p	CLIP-seq
MIRT2574611	hsa-miR-490-3p	CLIP-seq
MIRT2046570	hsa-miR-642b	CLIP-seq
MIRT1162380	hsa-miR-657	CLIP-seq
MIRT2046571	hsa-miR-762	CLIP-seq
MIRT1162382	hsa-miR-769-5p	CLIP-seq
MIRT1162331	hsa-miR-1289	CLIP-seq
MIRT2574598	hsa-miR-1291	CLIP-seq
MIRT2046540	hsa-miR-1587	CLIP-seq
MIRT2574599	hsa-miR-1972	CLIP-seq
MIRT1162336	hsa-miR-2355-5p	CLIP-seq
MIRT2574600	hsa-miR-296-5p	CLIP-seq
MIRT2574601	hsa-miR-3130-3p	CLIP-seq
MIRT2046541	hsa-miR-3135b	CLIP-seq
MIRT2574602	hsa-miR-3147	CLIP-seq
MIRT2574603	hsa-miR-3176	CLIP-seq
MIRT1162340	hsa-miR-3198	CLIP-seq
MIRT1162341	hsa-miR-323-5p	CLIP-seq
MIRT2574604	hsa-miR-323b-5p	CLIP-seq
MIRT1162343	hsa-miR-326	CLIP-seq
MIRT2574605	hsa-miR-328	CLIP-seq
MIRT1162345	hsa-miR-330-5p	CLIP-seq
MIRT1162346	hsa-miR-3614-3p	CLIP-seq
MIRT2046543	hsa-miR-3652	CLIP-seq
MIRT1162347	hsa-miR-3657	CLIP-seq
MIRT1162348	hsa-miR-3665	CLIP-seq
MIRT1162351	hsa-miR-3679-3p	CLIP-seq
MIRT2046544	hsa-miR-3688-3p	CLIP-seq
MIRT2046551	hsa-miR-378g	CLIP-seq
MIRT2574606	hsa-miR-3922-3p	CLIP-seq
MIRT1162352	hsa-miR-3934	CLIP-seq
MIRT2574607	hsa-miR-3940-3p	CLIP-seq
MIRT1162353	hsa-miR-3940-5p	CLIP-seq
MIRT1162354	hsa-miR-4294	CLIP-seq
MIRT1162355	hsa-miR-4309	CLIP-seq
MIRT1162356	hsa-miR-431	CLIP-seq
MIRT2574608	hsa-miR-4425	CLIP-seq
MIRT2046556	hsa-miR-4430	CLIP-seq
MIRT2046557	hsa-miR-4470	CLIP-seq
MIRT2046558	hsa-miR-4492	CLIP-seq
MIRT2046559	hsa-miR-4498	CLIP-seq
MIRT2046560	hsa-miR-4505	CLIP-seq
MIRT1162359	hsa-miR-4507	CLIP-seq
MIRT2046563	hsa-miR-4643	CLIP-seq
MIRT2574609	hsa-miR-4650-5p	CLIP-seq
MIRT2046564	hsa-miR-4656	CLIP-seq
MIRT2046565	hsa-miR-4675	CLIP-seq
MIRT2046566	hsa-miR-4717-3p	CLIP-seq
MIRT2046568	hsa-miR-4741	CLIP-seq
MIRT1162366	hsa-miR-4761-5p	CLIP-seq
MIRT2046569	hsa-miR-4786-3p	CLIP-seq
MIRT2574610	hsa-miR-4793-3p	CLIP-seq
MIRT2574611	hsa-miR-490-3p	CLIP-seq
MIRT2046570	hsa-miR-642b	CLIP-seq
MIRT1162380	hsa-miR-657	CLIP-seq
MIRT2046571	hsa-miR-762	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10551805
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	IMP	12377771
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0009966	Process	Regulation of signal transduction	NAS	10551805
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0032977	Function	Membrane insertase activity	IDA	36264797
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IEP	12377771
GO:0045040	Process	Protein insertion into mitochondrial outer membrane	IDA	36264797
GO:0045161	Process	Neuronal ion channel clustering	NAS	10551805

MIM	HGNC	e!Ensembl
610449	17586	ENSG00000137409

Q9NZJ7

Protein name

Mitochondrial carrier homolog 1 (Presenilin-associated protein)

Protein function

Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane (PubMed:36264797). Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and mul

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00153	Mito_carr	191 → 282	Mitochondrial carrier protein	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with a predominant expression in brain. {ECO:0000269|PubMed:10551805}.

Sequence

MGASDPEVAPWARGGAAGMAGAGAGAGARGGAAAGVEARARDPPPAHRAHPRHPRPAAQP
SARRMDGGSGGLGSGDNAPTTEALFVALGAGVTALSHPLLYVKLLIQVGHEPMPPTLGTN
VLGRKVLYLPSFFTYAKYIVQVDGKIGLFRGLSPRLMSNALSTVTRGSMKKVFPPDEIEQ
VSNKDDMKTSLKKVVKETSYEMMMQCVSRMLAHPLHVISMRCMVQFVGREAKYSGVLSSI
GKIFKEEGLLGFFVGLIPHLLGDVVFLWGCNLLAHFINAYLVDDSVSDTPGGLGNDQNPG
SQFSQALAIRSYTKFVMGIAVSMLTYPFLLVGDLMAVNNCGLQAGLPPYSPVFKSWIHCW
KYLSVQGQLFRGSSLLFRRVSSGSCFALE

Sequence length

389

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	34195286	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	34195286	★★★★★ ★☆☆☆☆ Found in Text Mining only

MTCH1 (mitochondrial carrier 1)