Gene Gene information from NCBI Gene database.
Entrez ID 23786
Gene name BCL2 like 13
Gene symbol BCL2L13
Synonyms (NCBI Gene)
BCL-RAMBOBcl2-L-13MIL1
Chromosome 22
Chromosome location 22q11.21
Summary This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by Re
miRNA miRNA information provided by mirtarbase database.
628
miRTarBase ID miRNA Experiments Reference
MIRT024899 hsa-miR-215-5p Microarray 19074876
MIRT025555 hsa-miR-34a-5p Sequencing 20371350
MIRT025589 hsa-miR-10a-5p Sequencing 20371350
MIRT026746 hsa-miR-192-5p Microarray 19074876
MIRT046068 hsa-miR-125b-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
ZIC1 Activation 20713527
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0000423 Process Mitophagy IEA
GO:0005515 Function Protein binding IPI 16189514, 17360363, 25416956, 25910212, 26871637, 28514442, 32296183, 32814053, 33961781
GO:0005634 Component Nucleus IEA
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619822 17164 ENSG00000099968
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BXK5
Protein name Bcl-2-like protein 13 (Bcl2-L-13) (Bcl-rambo) (Protein Mil1)
Protein function May promote the activation of caspase-3 and apoptosis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00452 Bcl-2 104 200 Apoptosis regulator proteins, Bcl-2 family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.
Sequence
MASSSTVPLGFHYETKYVVLSYLGLLSQEKLQEQHLSSPQGVQLDIASQSLDQEILLKVK
TEIEEELKSLDKEISEAFTSTGFDRHTSPVFSPANPESSMEDCLAHLGEKVSQELKEPLH
KALQMLLSQPVTYQAFRECTLETTVHASGWNKILVPLVLLRQMLLELTRRGQEPLSALLQ
FGVTYLEDYSAEYIIQQGGW
GTVFSLESEEEEYPGITAEDSNDIYILPSDNSGQVSPPES
PTVTTSWQSESLPVSLSASQSWHTESLPVSLGPESWQQIAMDPEEVKSLDSNGAGEKSEN
NSSNSDIVHVEKEEVPEGMEEAAVASVVLPARELQEALPEAPAPLLPHITATSLLGTREP
DTEVITVEKSSPATSLFVELDEEEVKAATTEPTEVEEVVPALEPTETLLSEKEINAREES
LVEELSPASEKKPVPPSEGKSRLSPAGEMKPMPLSEGKSILLFGGAAAVAILAVAIGVAL
ALRKK
Sequence length 485
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Mitophagy - animal
Legionellosis
 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Ovarian serous cystadenocarcinoma Uncertain significance rs202002609 RCV005932599
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Glioblastoma Stimulate 24706805
Glioblastoma Associate 37660127
Hematologic Neoplasms Associate 24706805
Influenza Human Associate 35893690
Lymphoma Follicular Associate 37824846
Multiple Sclerosis Associate 36991503
Neoplasms Associate 27225591, 37660127
Pulmonary Disease Chronic Obstructive Associate 37442983