Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	23774
Gene name	Bromodomain containing 1
Gene symbol	BRD1
Synonyms (NCBI Gene)	BRLBRPF1BRPF2
Chromosome	22
Chromosome location	22q13.33
Summary	This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4,

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miRTarBase ID	miRNA	Experiments	Reference
MIRT021155	hsa-miR-186-5p	Sequencing	20371350
MIRT024192	hsa-miR-221-3p	Sequencing	20371350
MIRT046561	hsa-let-7g-5p	CLASH	23622248
MIRT041191	hsa-miR-497-5p	CLASH	23622248
MIRT040831	hsa-miR-18a-3p	CLASH	23622248
MIRT824152	hsa-miR-1273f	CLIP-seq
MIRT824153	hsa-miR-137	CLIP-seq
MIRT824154	hsa-miR-150	CLIP-seq
MIRT824155	hsa-miR-1972	CLIP-seq
MIRT824156	hsa-miR-2052	CLIP-seq
MIRT824157	hsa-miR-21	CLIP-seq
MIRT824158	hsa-miR-300	CLIP-seq
MIRT824159	hsa-miR-3163	CLIP-seq
MIRT824160	hsa-miR-329	CLIP-seq
MIRT824161	hsa-miR-338-5p	CLIP-seq
MIRT824162	hsa-miR-362-3p	CLIP-seq
MIRT824163	hsa-miR-3713	CLIP-seq
MIRT824164	hsa-miR-381	CLIP-seq
MIRT824165	hsa-miR-3941	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT824167	hsa-miR-4255	CLIP-seq
MIRT824168	hsa-miR-4452	CLIP-seq
MIRT824169	hsa-miR-4480	CLIP-seq
MIRT824170	hsa-miR-455-5p	CLIP-seq
MIRT824171	hsa-miR-4666-3p	CLIP-seq
MIRT824172	hsa-miR-4668-3p	CLIP-seq
MIRT824173	hsa-miR-4729	CLIP-seq
MIRT824174	hsa-miR-4789-5p	CLIP-seq
MIRT824175	hsa-miR-520g	CLIP-seq
MIRT824176	hsa-miR-520h	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT824178	hsa-miR-550a	CLIP-seq
MIRT824179	hsa-miR-561	CLIP-seq
MIRT824180	hsa-miR-568	CLIP-seq
MIRT824181	hsa-miR-586	CLIP-seq
MIRT824182	hsa-miR-590-5p	CLIP-seq
MIRT824183	hsa-miR-603	CLIP-seq
MIRT824184	hsa-miR-767-3p	CLIP-seq
MIRT824155	hsa-miR-1972	CLIP-seq
MIRT824158	hsa-miR-300	CLIP-seq
MIRT824160	hsa-miR-329	CLIP-seq
MIRT824162	hsa-miR-362-3p	CLIP-seq
MIRT824164	hsa-miR-381	CLIP-seq
MIRT824165	hsa-miR-3941	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT824171	hsa-miR-4666-3p	CLIP-seq
MIRT824173	hsa-miR-4729	CLIP-seq
MIRT824174	hsa-miR-4789-5p	CLIP-seq
MIRT824175	hsa-miR-520g	CLIP-seq
MIRT824176	hsa-miR-520h	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT824181	hsa-miR-586	CLIP-seq
MIRT824183	hsa-miR-603	CLIP-seq
MIRT2182303	hsa-miR-122	CLIP-seq
MIRT824154	hsa-miR-150	CLIP-seq
MIRT824157	hsa-miR-21	CLIP-seq
MIRT824159	hsa-miR-3163	CLIP-seq
MIRT2182304	hsa-miR-340	CLIP-seq
MIRT2182305	hsa-miR-3659	CLIP-seq
MIRT2182306	hsa-miR-3667-5p	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT2182307	hsa-miR-4289	CLIP-seq
MIRT824169	hsa-miR-4480	CLIP-seq
MIRT824172	hsa-miR-4668-3p	CLIP-seq
MIRT824175	hsa-miR-520g	CLIP-seq
MIRT824176	hsa-miR-520h	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT824182	hsa-miR-590-5p	CLIP-seq
MIRT824184	hsa-miR-767-3p	CLIP-seq
MIRT824152	hsa-miR-1273f	CLIP-seq
MIRT2486001	hsa-miR-3124-3p	CLIP-seq
MIRT2486002	hsa-miR-3692	CLIP-seq
MIRT2486003	hsa-miR-384	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT2486004	hsa-miR-4643	CLIP-seq
MIRT2486005	hsa-miR-466	CLIP-seq
MIRT2486006	hsa-miR-4672	CLIP-seq
MIRT2486007	hsa-miR-4698	CLIP-seq
MIRT2486008	hsa-miR-4713-5p	CLIP-seq
MIRT2486009	hsa-miR-4789-3p	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT2486010	hsa-miR-616	CLIP-seq
MIRT824152	hsa-miR-1273f	CLIP-seq
MIRT2676034	hsa-miR-1587	CLIP-seq
MIRT2486001	hsa-miR-3124-3p	CLIP-seq
MIRT2486002	hsa-miR-3692	CLIP-seq
MIRT2676035	hsa-miR-378g	CLIP-seq
MIRT824166	hsa-miR-3973	CLIP-seq
MIRT2676036	hsa-miR-4286	CLIP-seq
MIRT2676037	hsa-miR-4492	CLIP-seq
MIRT2676038	hsa-miR-4498	CLIP-seq
MIRT2676039	hsa-miR-4656	CLIP-seq
MIRT2486006	hsa-miR-4672	CLIP-seq
MIRT2676040	hsa-miR-4675	CLIP-seq
MIRT2486007	hsa-miR-4698	CLIP-seq
MIRT2486008	hsa-miR-4713-5p	CLIP-seq
MIRT2676041	hsa-miR-4741	CLIP-seq
MIRT2676042	hsa-miR-521	CLIP-seq
MIRT824177	hsa-miR-548k	CLIP-seq
MIRT2676043	hsa-miR-762	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	27142060, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	10602503, 21880731, 25593309
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	21753189
GO:0005634	Component	Nucleus	ISS
GO:0005634	Component	Nucleus	TAS	10602503
GO:0005694	Component	Chromosome	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0030425	Component	Dendrite	IEA
GO:0035902	Process	Response to immobilization stress	IEA
GO:0036408	Function	Histone H3K14 acetyltransferase activity	IDA	16387653
GO:0036409	Component	Histone H3-K14 acetyltransferase complex	IDA	21753189
GO:0036409	Component	Histone H3-K14 acetyltransferase complex	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0043249	Process	Erythrocyte maturation	IEA
GO:0043995	Function	Histone H4K5 acetyltransferase activity	IDA	16387653
GO:0043996	Function	Histone H4K8 acetyltransferase activity	IDA	16387653
GO:0043997	Function	Histone H4K12 acetyltransferase activity	IDA	16387653
GO:0045648	Process	Positive regulation of erythrocyte differentiation	IEA
GO:0045648	Process	Positive regulation of erythrocyte differentiation	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050793	Process	Regulation of developmental process	NAS	16387653
GO:0051602	Process	Response to electrical stimulus	IEA
GO:0070776	Component	MOZ/MORF histone acetyltransferase complex	IBA
GO:0070776	Component	MOZ/MORF histone acetyltransferase complex	IDA	16387653
GO:0070776	Component	MOZ/MORF histone acetyltransferase complex	IEA
GO:0070776	Component	MOZ/MORF histone acetyltransferase complex	ISS
GO:0140063	Function	Unmodified histone reader activity	IDA	21880731
GO:0140566	Function	Histone reader activity	IEA
GO:0140566	Function	Histone reader activity	ISS
GO:1903706	Process	Regulation of hemopoiesis	NAS	16387653

MIM	HGNC	e!Ensembl
604589	1102	ENSG00000100425

O95696

Protein name

Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2)

Protein function

Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by di

PDB

2KU3 , 2L43 , 2LQ6 , 3LYI , 3RCW , 4Z02 , 5AME , 5AMF , 5FG6 , 5GK9 , 5N49 , 5PNX , 5PNY , 5PNZ , 5PO0 , 5PO1 , 5PO2 , 5PO3 , 5PO4 , 5PO5 , 5PO6 , 5PO7 , 5PO8 , 5PO9 , 5POA , 5POB , 5POC , 5POD , 5POE , 5POF , 5POG , 5POH , 5POI , 5POJ , 5POK , 5POL , 5POM , 5PON , 5POO , 5POP , 5POQ , 5POR , 5POS , 5POT , 5POU , 5POV , 5POW , 5POX , 5POY , 5POZ , 5PP0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10513	EPL1	47 → 196	Enhancer of polycomb-like	Family
PF13831	PHD_2	228 → 262		Family
PF13832	zf-HC5HC2H_2	269 → 388		Domain
PF00439	Bromodomain	571 → 654	Bromodomain	Domain
PF00855	PWWP	927 → 1044	PWWP domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis. {ECO:0000269|PubMed:10602503}.

Sequence

MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEII
LEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEP
KVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPA
VSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLA
VHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPE
VGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGL
YMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTV
RSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPPQRLNRIANQVAIQRKKQFVERAHSYW
LLKRLSRNGAPLLRRLQSSLQSQRSSQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIE
LLRKREKLKREQVKVEQVAMELRLTPLTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYL
DHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGG
VVLRQARREVDSIGLEEASGMHLPERPAAAPRRPFSWEDVDRLLDPANRAHLGLEEQLRE
LLDMLDLTCAMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEEDGAALG
PEAGEEVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGL
GRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENGN
YAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHN
GVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETIDKLKM
MEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID

Sequence length

1058

Interactions

View interactions

	Reactome
			HATs acetylate histones Regulation of TP53 Activity through Acetylation

BRD1 (bromodomain containing 1)