Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23764
Gene name Gene Name - the full gene name approved by the HGNC.	MAF bZIP transcription factor F
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MAFF
Synonyms (NCBI Gene) Gene synonyms aliases	U-MAF, hMafF
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018523	hsa-miR-335-5p	Microarray	18185580
MIRT706868	hsa-miR-4781-3p	HITS-CLIP	21572407
MIRT706867	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT706866	hsa-miR-31-3p	HITS-CLIP	21572407
MIRT706865	hsa-miR-3135b	HITS-CLIP	21572407
MIRT706864	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT706863	hsa-miR-122-5p	HITS-CLIP	21572407
MIRT706862	hsa-miR-3652	HITS-CLIP	21572407
MIRT706861	hsa-miR-4430	HITS-CLIP	21572407
MIRT706860	hsa-miR-4466	HITS-CLIP	21572407
MIRT706859	hsa-miR-675-5p	HITS-CLIP	21572407
MIRT706858	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT706857	hsa-miR-6501-5p	HITS-CLIP	21572407
MIRT706856	hsa-miR-4423-5p	HITS-CLIP	21572407
MIRT706855	hsa-miR-744-3p	HITS-CLIP	21572407
MIRT706854	hsa-miR-6885-3p	HITS-CLIP	21572407
MIRT706853	hsa-miR-5698	HITS-CLIP	21572407
MIRT706868	hsa-miR-4781-3p	HITS-CLIP	21572407
MIRT706867	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT706866	hsa-miR-31-3p	HITS-CLIP	21572407
MIRT706865	hsa-miR-3135b	HITS-CLIP	21572407
MIRT706864	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT706863	hsa-miR-122-5p	HITS-CLIP	21572407
MIRT706862	hsa-miR-3652	HITS-CLIP	21572407
MIRT706861	hsa-miR-4430	HITS-CLIP	21572407
MIRT706860	hsa-miR-4466	HITS-CLIP	21572407
MIRT706859	hsa-miR-675-5p	HITS-CLIP	21572407
MIRT706858	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT706857	hsa-miR-6501-5p	HITS-CLIP	21572407
MIRT706856	hsa-miR-4423-5p	HITS-CLIP	21572407
MIRT706855	hsa-miR-744-3p	HITS-CLIP	21572407
MIRT706854	hsa-miR-6885-3p	HITS-CLIP	21572407
MIRT706853	hsa-miR-5698	HITS-CLIP	21572407
MIRT1125336	hsa-miR-122	CLIP-seq
MIRT1125337	hsa-miR-1273f	CLIP-seq
MIRT1125338	hsa-miR-1275	CLIP-seq
MIRT1125339	hsa-miR-1290	CLIP-seq
MIRT1125340	hsa-miR-129-5p	CLIP-seq
MIRT1125341	hsa-miR-197	CLIP-seq
MIRT1125342	hsa-miR-198	CLIP-seq
MIRT1125343	hsa-miR-3126-5p	CLIP-seq
MIRT1125344	hsa-miR-3147	CLIP-seq
MIRT1125345	hsa-miR-3149	CLIP-seq
MIRT1125346	hsa-miR-3170	CLIP-seq
MIRT1125347	hsa-miR-3199	CLIP-seq
MIRT1125348	hsa-miR-3663-5p	CLIP-seq
MIRT1125349	hsa-miR-3672	CLIP-seq
MIRT1125350	hsa-miR-3674	CLIP-seq
MIRT1125351	hsa-miR-3690	CLIP-seq
MIRT1125352	hsa-miR-371-5p	CLIP-seq
MIRT1125353	hsa-miR-371b-5p	CLIP-seq
MIRT1125354	hsa-miR-378	CLIP-seq
MIRT1125355	hsa-miR-378b	CLIP-seq
MIRT1125356	hsa-miR-378c	CLIP-seq
MIRT1125357	hsa-miR-378d	CLIP-seq
MIRT1125358	hsa-miR-378e	CLIP-seq
MIRT1125359	hsa-miR-378f	CLIP-seq
MIRT1125360	hsa-miR-378g	CLIP-seq
MIRT1125361	hsa-miR-378h	CLIP-seq
MIRT1125362	hsa-miR-378i	CLIP-seq
MIRT1125363	hsa-miR-422a	CLIP-seq
MIRT1125364	hsa-miR-4254	CLIP-seq
MIRT1125365	hsa-miR-4329	CLIP-seq
MIRT1125366	hsa-miR-4425	CLIP-seq
MIRT1125367	hsa-miR-4463	CLIP-seq
MIRT1125368	hsa-miR-4525	CLIP-seq
MIRT1125369	hsa-miR-4645-5p	CLIP-seq
MIRT1125370	hsa-miR-4665-5p	CLIP-seq
MIRT1125371	hsa-miR-4673	CLIP-seq
MIRT1125372	hsa-miR-4716-5p	CLIP-seq
MIRT1125373	hsa-miR-4723-5p	CLIP-seq
MIRT1125374	hsa-miR-4728-5p	CLIP-seq
MIRT1125375	hsa-miR-4732-5p	CLIP-seq
MIRT1125376	hsa-miR-4740-5p	CLIP-seq
MIRT1125377	hsa-miR-5096	CLIP-seq
MIRT1125378	hsa-miR-625	CLIP-seq
MIRT2035366	hsa-miR-1224-3p	CLIP-seq
MIRT2035367	hsa-miR-1260	CLIP-seq
MIRT2035368	hsa-miR-1260b	CLIP-seq
MIRT2035369	hsa-miR-1280	CLIP-seq
MIRT2035370	hsa-miR-150	CLIP-seq
MIRT1125336	hsa-miR-122	CLIP-seq
MIRT2265859	hsa-miR-1245	CLIP-seq
MIRT1125337	hsa-miR-1273f	CLIP-seq
MIRT1125340	hsa-miR-129-5p	CLIP-seq
MIRT2265860	hsa-miR-1321	CLIP-seq
MIRT2035370	hsa-miR-150	CLIP-seq
MIRT1125341	hsa-miR-197	CLIP-seq
MIRT2265861	hsa-miR-1976	CLIP-seq
MIRT2265862	hsa-miR-2110	CLIP-seq
MIRT2265863	hsa-miR-3150a-3p	CLIP-seq
MIRT2265864	hsa-miR-3160-3p	CLIP-seq
MIRT1125346	hsa-miR-3170	CLIP-seq
MIRT2265865	hsa-miR-3175	CLIP-seq
MIRT1125347	hsa-miR-3199	CLIP-seq
MIRT1125350	hsa-miR-3674	CLIP-seq
MIRT1125352	hsa-miR-371-5p	CLIP-seq
MIRT2265866	hsa-miR-4260	CLIP-seq
MIRT2265867	hsa-miR-4270	CLIP-seq
MIRT2265868	hsa-miR-4300	CLIP-seq
MIRT2265869	hsa-miR-4419a	CLIP-seq
MIRT2265870	hsa-miR-4438	CLIP-seq
MIRT2265871	hsa-miR-4441	CLIP-seq
MIRT2265872	hsa-miR-4510	CLIP-seq
MIRT1125369	hsa-miR-4645-5p	CLIP-seq
MIRT2265873	hsa-miR-4649-3p	CLIP-seq
MIRT1125371	hsa-miR-4673	CLIP-seq
MIRT2265874	hsa-miR-4695-3p	CLIP-seq
MIRT2265875	hsa-miR-4720-3p	CLIP-seq
MIRT2265876	hsa-miR-4722-3p	CLIP-seq
MIRT1125374	hsa-miR-4728-5p	CLIP-seq
MIRT1125375	hsa-miR-4732-5p	CLIP-seq
MIRT2265877	hsa-miR-4739	CLIP-seq
MIRT2265878	hsa-miR-4743	CLIP-seq
MIRT2265879	hsa-miR-4756-5p	CLIP-seq
MIRT2265880	hsa-miR-5095	CLIP-seq
MIRT1125377	hsa-miR-5096	CLIP-seq
MIRT2265881	hsa-miR-532-3p	CLIP-seq
MIRT2265882	hsa-miR-562	CLIP-seq
MIRT2265883	hsa-miR-675	CLIP-seq
MIRT2265884	hsa-miR-920	CLIP-seq
MIRT2265885	hsa-miR-939	CLIP-seq
MIRT2390450	hsa-miR-4287	CLIP-seq
MIRT2390451	hsa-miR-4469	CLIP-seq
MIRT2390452	hsa-miR-4685-3p	CLIP-seq
MIRT2390453	hsa-miR-4768-5p	CLIP-seq
MIRT2390454	hsa-miR-597	CLIP-seq
MIRT2390455	hsa-miR-942	CLIP-seq

Show/Hide all(27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	NAS	27052415, 33897412
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12490281
GO:0001701	Process	In utero embryonic development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	8932385, 23661758, 26496610, 28514442, 32911434, 33961781, 34591642
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	23661758
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005739	Component	Mitochondrion	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	NAS	23661758
GO:0007567	Process	Parturition	TAS	10527846
GO:0035914	Process	Skeletal muscle cell differentiation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	23332764
GO:0045604	Process	Regulation of epidermal cell differentiation	IBA
GO:0045604	Process	Regulation of epidermal cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12490281
GO:0090575	Component	RNA polymerase II transcription regulator complex	IPI	23661758
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
604877	6780	ENSG00000185022

Protein

UniProt ID

Q9ULX9

Protein name

Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F)

Protein function

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usua

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03131	bZIP_Maf	24 → 115	bZIP Maf transcription factor	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in the term myometrium and kidney.

Sequence

MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLK
NRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRLELDALRGKCEALQGFARS
VAAARGPATLVAPASVITIVKSTPGSGSGPAHGPDPAHGPASCS

Sequence length

164

Interactions

View interactions

	Reactome
			Factors involved in megakaryocyte development and platelet production

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Pelvic Organ Prolapse	Pelvic organ prolapse	N/A	N/A	GWAS

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	34151731
Carcinoma Hepatocellular	Associate	29757260
Carcinoma Hepatocellular	Inhibit	31969212
COVID 19	Associate	37283761
Glomerulonephritis IGA	Associate	28713898
Hepatitis B	Associate	33980595
Hypertension Pregnancy Induced	Associate	38006650
Hypertensive Nephropathy	Associate	28713898
Infections	Associate	33980595
Leukemia	Associate	28984203
Lung Diseases	Associate	29703138
Melanoma	Associate	23291271, 36423637
Melanoma Cutaneous Malignant	Associate	23291271
Neoplasms	Inhibit	31969212
Osteoarthritis	Associate	37283761
Squamous Cell Carcinoma of Head and Neck	Associate	33315534
Thyroid Cancer Papillary	Associate	25908172

MAFF (MAF bZIP transcription factor F)