Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	23764
Gene name	MAF bZIP transcription factor F
Gene symbol	MAFF
Synonyms (NCBI Gene)	U-MAFhMafF
Chromosome	22
Chromosome location	22q13.1
Summary	The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with o

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018523	hsa-miR-335-5p	Microarray	18185580
MIRT706868	hsa-miR-4781-3p	HITS-CLIP	21572407
MIRT706867	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT706866	hsa-miR-31-3p	HITS-CLIP	21572407
MIRT706865	hsa-miR-3135b	HITS-CLIP	21572407
MIRT706864	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT706863	hsa-miR-122-5p	HITS-CLIP	21572407
MIRT706862	hsa-miR-3652	HITS-CLIP	21572407
MIRT706861	hsa-miR-4430	HITS-CLIP	21572407
MIRT706860	hsa-miR-4466	HITS-CLIP	21572407
MIRT706859	hsa-miR-675-5p	HITS-CLIP	21572407
MIRT706858	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT706857	hsa-miR-6501-5p	HITS-CLIP	21572407
MIRT706856	hsa-miR-4423-5p	HITS-CLIP	21572407
MIRT706855	hsa-miR-744-3p	HITS-CLIP	21572407
MIRT706854	hsa-miR-6885-3p	HITS-CLIP	21572407
MIRT706853	hsa-miR-5698	HITS-CLIP	21572407
MIRT706868	hsa-miR-4781-3p	HITS-CLIP	21572407
MIRT706867	hsa-miR-6499-3p	HITS-CLIP	21572407
MIRT706866	hsa-miR-31-3p	HITS-CLIP	21572407
MIRT706865	hsa-miR-3135b	HITS-CLIP	21572407
MIRT706864	hsa-miR-504-3p	HITS-CLIP	21572407
MIRT706863	hsa-miR-122-5p	HITS-CLIP	21572407
MIRT706862	hsa-miR-3652	HITS-CLIP	21572407
MIRT706861	hsa-miR-4430	HITS-CLIP	21572407
MIRT706860	hsa-miR-4466	HITS-CLIP	21572407
MIRT706859	hsa-miR-675-5p	HITS-CLIP	21572407
MIRT706858	hsa-miR-143-5p	HITS-CLIP	21572407
MIRT706857	hsa-miR-6501-5p	HITS-CLIP	21572407
MIRT706856	hsa-miR-4423-5p	HITS-CLIP	21572407
MIRT706855	hsa-miR-744-3p	HITS-CLIP	21572407
MIRT706854	hsa-miR-6885-3p	HITS-CLIP	21572407
MIRT706853	hsa-miR-5698	HITS-CLIP	21572407
MIRT1125336	hsa-miR-122	CLIP-seq
MIRT1125337	hsa-miR-1273f	CLIP-seq
MIRT1125338	hsa-miR-1275	CLIP-seq
MIRT1125339	hsa-miR-1290	CLIP-seq
MIRT1125340	hsa-miR-129-5p	CLIP-seq
MIRT1125341	hsa-miR-197	CLIP-seq
MIRT1125342	hsa-miR-198	CLIP-seq
MIRT1125343	hsa-miR-3126-5p	CLIP-seq
MIRT1125344	hsa-miR-3147	CLIP-seq
MIRT1125345	hsa-miR-3149	CLIP-seq
MIRT1125346	hsa-miR-3170	CLIP-seq
MIRT1125347	hsa-miR-3199	CLIP-seq
MIRT1125348	hsa-miR-3663-5p	CLIP-seq
MIRT1125349	hsa-miR-3672	CLIP-seq
MIRT1125350	hsa-miR-3674	CLIP-seq
MIRT1125351	hsa-miR-3690	CLIP-seq
MIRT1125352	hsa-miR-371-5p	CLIP-seq
MIRT1125353	hsa-miR-371b-5p	CLIP-seq
MIRT1125354	hsa-miR-378	CLIP-seq
MIRT1125355	hsa-miR-378b	CLIP-seq
MIRT1125356	hsa-miR-378c	CLIP-seq
MIRT1125357	hsa-miR-378d	CLIP-seq
MIRT1125358	hsa-miR-378e	CLIP-seq
MIRT1125359	hsa-miR-378f	CLIP-seq
MIRT1125360	hsa-miR-378g	CLIP-seq
MIRT1125361	hsa-miR-378h	CLIP-seq
MIRT1125362	hsa-miR-378i	CLIP-seq
MIRT1125363	hsa-miR-422a	CLIP-seq
MIRT1125364	hsa-miR-4254	CLIP-seq
MIRT1125365	hsa-miR-4329	CLIP-seq
MIRT1125366	hsa-miR-4425	CLIP-seq
MIRT1125367	hsa-miR-4463	CLIP-seq
MIRT1125368	hsa-miR-4525	CLIP-seq
MIRT1125369	hsa-miR-4645-5p	CLIP-seq
MIRT1125370	hsa-miR-4665-5p	CLIP-seq
MIRT1125371	hsa-miR-4673	CLIP-seq
MIRT1125372	hsa-miR-4716-5p	CLIP-seq
MIRT1125373	hsa-miR-4723-5p	CLIP-seq
MIRT1125374	hsa-miR-4728-5p	CLIP-seq
MIRT1125375	hsa-miR-4732-5p	CLIP-seq
MIRT1125376	hsa-miR-4740-5p	CLIP-seq
MIRT1125377	hsa-miR-5096	CLIP-seq
MIRT1125378	hsa-miR-625	CLIP-seq
MIRT2035366	hsa-miR-1224-3p	CLIP-seq
MIRT2035367	hsa-miR-1260	CLIP-seq
MIRT2035368	hsa-miR-1260b	CLIP-seq
MIRT2035369	hsa-miR-1280	CLIP-seq
MIRT2035370	hsa-miR-150	CLIP-seq
MIRT1125336	hsa-miR-122	CLIP-seq
MIRT2265859	hsa-miR-1245	CLIP-seq
MIRT1125337	hsa-miR-1273f	CLIP-seq
MIRT1125340	hsa-miR-129-5p	CLIP-seq
MIRT2265860	hsa-miR-1321	CLIP-seq
MIRT2035370	hsa-miR-150	CLIP-seq
MIRT1125341	hsa-miR-197	CLIP-seq
MIRT2265861	hsa-miR-1976	CLIP-seq
MIRT2265862	hsa-miR-2110	CLIP-seq
MIRT2265863	hsa-miR-3150a-3p	CLIP-seq
MIRT2265864	hsa-miR-3160-3p	CLIP-seq
MIRT1125346	hsa-miR-3170	CLIP-seq
MIRT2265865	hsa-miR-3175	CLIP-seq
MIRT1125347	hsa-miR-3199	CLIP-seq
MIRT1125350	hsa-miR-3674	CLIP-seq
MIRT1125352	hsa-miR-371-5p	CLIP-seq
MIRT2265866	hsa-miR-4260	CLIP-seq
MIRT2265867	hsa-miR-4270	CLIP-seq
MIRT2265868	hsa-miR-4300	CLIP-seq
MIRT2265869	hsa-miR-4419a	CLIP-seq
MIRT2265870	hsa-miR-4438	CLIP-seq
MIRT2265871	hsa-miR-4441	CLIP-seq
MIRT2265872	hsa-miR-4510	CLIP-seq
MIRT1125369	hsa-miR-4645-5p	CLIP-seq
MIRT2265873	hsa-miR-4649-3p	CLIP-seq
MIRT1125371	hsa-miR-4673	CLIP-seq
MIRT2265874	hsa-miR-4695-3p	CLIP-seq
MIRT2265875	hsa-miR-4720-3p	CLIP-seq
MIRT2265876	hsa-miR-4722-3p	CLIP-seq
MIRT1125374	hsa-miR-4728-5p	CLIP-seq
MIRT1125375	hsa-miR-4732-5p	CLIP-seq
MIRT2265877	hsa-miR-4739	CLIP-seq
MIRT2265878	hsa-miR-4743	CLIP-seq
MIRT2265879	hsa-miR-4756-5p	CLIP-seq
MIRT2265880	hsa-miR-5095	CLIP-seq
MIRT1125377	hsa-miR-5096	CLIP-seq
MIRT2265881	hsa-miR-532-3p	CLIP-seq
MIRT2265882	hsa-miR-562	CLIP-seq
MIRT2265883	hsa-miR-675	CLIP-seq
MIRT2265884	hsa-miR-920	CLIP-seq
MIRT2265885	hsa-miR-939	CLIP-seq
MIRT2390450	hsa-miR-4287	CLIP-seq
MIRT2390451	hsa-miR-4469	CLIP-seq
MIRT2390452	hsa-miR-4685-3p	CLIP-seq
MIRT2390453	hsa-miR-4768-5p	CLIP-seq
MIRT2390454	hsa-miR-597	CLIP-seq
MIRT2390455	hsa-miR-942	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	NAS	27052415, 33897412
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	12490281
GO:0001701	Process	In utero embryonic development	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0005515	Function	Protein binding	IPI	8932385, 23661758, 26496610, 28514442, 32911434, 33961781, 34591642
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	23661758
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005739	Component	Mitochondrion	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	NAS	23661758
GO:0007567	Process	Parturition	TAS	10527846
GO:0035914	Process	Skeletal muscle cell differentiation	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	23332764
GO:0045604	Process	Regulation of epidermal cell differentiation	IBA
GO:0045604	Process	Regulation of epidermal cell differentiation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12490281
GO:0090575	Component	RNA polymerase II transcription regulator complex	IPI	23661758
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
604877	6780	ENSG00000185022

Q9ULX9

Protein name

Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F)

Protein function

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usua

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03131	bZIP_Maf	24 → 115	bZIP Maf transcription factor	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Expressed in the term myometrium and kidney.

Sequence

MSVDPLSSKALKIKRELSENTPHLSDEALMGLSVRELNRHLRGLSAEEVTRLKQRRRTLK
NRGYAASCRVKRVCQKEELQKQKSELEREVDKLARENAAMRLELDALRGKCEALQGFARS
VAAARGPATLVAPASVITIVKSTPGSGSGPAHGPDPAHGPASCS

Sequence length

164

Interactions

View interactions

	Reactome
			Factors involved in megakaryocyte development and platelet production

MAFF (MAF bZIP transcription factor F)