Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23705
Gene name Gene Name - the full gene name approved by the HGNC.
Cell adhesion molecule 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CADM1
Synonyms (NCBI Gene) Gene synonyms aliases
BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q23.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003888 hsa-miR-15a-5p Reporter assay, qRT-PCR 18362358
MIRT004382 hsa-miR-16-5p Reporter assay, qRT-PCR 18362358
MIRT004167 hsa-miR-192-5p Microarray 16822819
MIRT029576 hsa-miR-26b-5p Microarray 19088304
MIRT042379 hsa-miR-484 CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001819 Process Positive regulation of cytokine production IDA 15811952
GO:0001913 Process T cell mediated cytotoxicity IDA 15811952
GO:0002376 Process Immune system process IEA
GO:0005102 Function Signaling receptor binding IBA
GO:0005102 Function Signaling receptor binding IPI 15811952
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605686 5951 ENSG00000182985
Protein
UniProt ID Q9BY67
Protein name Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin-like protein 2) (NECL-2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC-1)
Protein function Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12050160, PubMed:22438059). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM
PDB 3BIN , 4H5S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 49 142 Immunoglobulin V-set domain Domain
PF08205 C2-set_2 148 230 CD80-like C2-set immunoglobulin domain Domain
PF13927 Ig_3 242 317 Domain
Sequence
MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVA
TISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEG
RYFCQLYTDPPQESYTTITVLV
PPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWF
KGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGN
LQTQRYLEVQ
YKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFI
NNLNKTDNGTYRCEASN
IVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITD
SRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADA
DTAIINAEGGQNNSEEKKEYFI
Sequence length 442
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell adhesion molecules   Adherens junctions interactions
Nectin/Necl trans heterodimerization
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Anorexia Anorexia nervosa N/A N/A GWAS
Autism Spectrum Disorder autism spectrum disorder N/A N/A GenCC
Breast Cancer Breast cancer specific mortality in breast cancer N/A N/A GWAS
Metabolic Syndrome Serum linoleic acid concentration in metabolic syndrome, Metabolic syndrome N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 12432281, 12942568, 24367507
Adenocarcinoma Bronchiolo Alveolar Associate 26231557
Adenocarcinoma of Lung Associate 12942568, 33205911
Adenocarcinoma of Lung Inhibit 16108829
Agnosia Associate 25065733
Alzheimer Disease Stimulate 39596356
Alzheimer Disease Associate 40430038
Anorexia Nervosa Associate 35470453
Arthritis Rheumatoid Associate 36851682
Atrial Fibrillation Associate 36604807