Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23678
Gene name Gene Name - the full gene name approved by the HGNC.
Serum/glucocorticoid regulated kinase family member 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SGK3
Synonyms (NCBI Gene) Gene synonyms aliases
CISK, SGK2, SGKL
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chl
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023535 hsa-miR-1-3p Microarray 18668037
MIRT027909 hsa-miR-96-5p Sequencing 20371350
MIRT002408 hsa-miR-21-5p Sequencing 20371350
MIRT031504 hsa-miR-16-5p Sequencing 20371350
MIRT653895 hsa-miR-4781-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001558 Process Regulation of cell growth TAS 20919962
GO:0004672 Function Protein kinase activity TAS 10548550, 10585774
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0005246 Function Calcium channel regulator activity TAS 16460280
GO:0005515 Function Protein binding IPI 16888620
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607591 10812 ENSG00000104205
Protein
UniProt ID Q96BR1
Protein name Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like)
Protein function Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels:
PDB 6EDX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00787 PX 38 120 PX domain Domain
PF00069 Pkinase 162 419 Protein kinase domain Domain
PF00433 Pkinase_C 440 487 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors. {ECO:000
Sequence
Sequence length 496
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  FoxO signaling pathway
PI3K-Akt signaling pathway
  Stimuli-sensing channels
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
26830138
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Hypophosphatemic Rickets hypophosphatemic rickets GenCC
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 21084382, 22576469, 31665227
Breast Neoplasms Stimulate 33783250
Carcinoma Hepatocellular Associate 27602769
Carcinoma Renal Cell Associate 31114998
Cell Transformation Neoplastic Associate 32385243
Colorectal Neoplasms Associate 33783250
Death Associate 37398883
Esophageal Squamous Cell Carcinoma Stimulate 37398883
Glioblastoma Associate 33783250
Glioma Associate 27560795, 31734653