Gene Gene information from NCBI Gene database.
Entrez ID 23678
Gene name Serum/glucocorticoid regulated kinase family member 3
Gene symbol SGK3
Synonyms (NCBI Gene)
CISKSGK2SGKL
Chromosome 8
Chromosome location 8q13.1
Summary This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chl
miRNA miRNA information provided by mirtarbase database.
365
miRTarBase ID miRNA Experiments Reference
MIRT023535 hsa-miR-1-3p Microarray 18668037
MIRT027909 hsa-miR-96-5p Sequencing 20371350
MIRT002408 hsa-miR-21-5p Sequencing 20371350
MIRT031504 hsa-miR-16-5p Sequencing 20371350
MIRT653895 hsa-miR-4781-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0001558 Process Regulation of cell growth IEA
GO:0001558 Process Regulation of cell growth TAS 20919962
GO:0004672 Function Protein kinase activity IEA
GO:0004672 Function Protein kinase activity TAS 10548550, 10585774
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607591 10812 ENSG00000104205
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96BR1
Protein name Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Cytokine-independent survival kinase) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid-regulated kinase-like)
Protein function Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels:
PDB 6EDX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00787 PX 38 120 PX domain Domain
PF00069 Pkinase 162 419 Protein kinase domain Domain
PF00433 Pkinase_C 440 487 Protein kinase C terminal domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors. {ECO:000
Sequence
Sequence length 496
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  FoxO signaling pathway
PI3K-Akt signaling pathway
  Stimuli-sensing channels
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Prostate cancer Uncertain significance rs193920898 RCV000149035
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 21084382, 22576469, 31665227
Breast Neoplasms Stimulate 33783250
Carcinoma Hepatocellular Associate 27602769
Carcinoma Renal Cell Associate 31114998
Cell Transformation Neoplastic Associate 32385243
Colorectal Neoplasms Associate 33783250
Death Associate 37398883
Esophageal Squamous Cell Carcinoma Stimulate 37398883
Glioblastoma Associate 33783250
Glioma Associate 27560795, 31734653