SH3BP4 (SH3 domain binding protein 4)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 23677 |
| Gene name | SH3 domain binding protein 4 |
| Gene symbol | SH3BP4 |
| Synonyms (NCBI Gene) |
BOG25TTP
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| Chromosome | 2 |
| Chromosome location | 2q37.2 |
| Summary | This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, speci |
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miRNA
miRNA information provided by mirtarbase database.
488
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9P0V3 | ||||||||||||||||||||
| Protein name | SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein) | ||||||||||||||||||||
| Protein function | May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting t | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level). {ECO:0000269|PubMed:10644451, ECO:0000269|PubMed:15616480}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 963 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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