TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2)

Gene

• Entrez ID: 23671
• Gene name: Transmembrane protein with EGF like and two follistatin like domains 2
• Gene symbol: TMEFF2
• Synonyms (NCBI Gene): CT120.2, HPP1, TENB2, TPEF, TR, TR-2
• Chromosome: 2
• Chromosome location: 2q32.3
• Summary: This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple s

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017377	hsa-miR-335-5p	Microarray	18185580
MIRT022402	hsa-miR-124-3p	Microarray	18668037
MIRT721792	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT721791	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT721790	hsa-miR-494-3p	HITS-CLIP	19536157
MIRT721789	hsa-miR-4252	HITS-CLIP	19536157
MIRT721788	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT721786	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT721787	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT497315	hsa-miR-4780	PAR-CLIP	22291592
MIRT497314	hsa-miR-6780b-3p	PAR-CLIP	22291592
MIRT497313	hsa-miR-623	PAR-CLIP	22291592
MIRT497312	hsa-miR-204-5p	PAR-CLIP	22291592
MIRT497311	hsa-miR-211-5p	PAR-CLIP	22291592
MIRT497310	hsa-miR-7641	PAR-CLIP	22291592
MIRT497309	hsa-miR-4755-5p	PAR-CLIP	22291592
MIRT497308	hsa-miR-5006-3p	PAR-CLIP	22291592
MIRT497307	hsa-miR-4446-5p	PAR-CLIP	22291592
MIRT721792	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT721791	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT721790	hsa-miR-494-3p	HITS-CLIP	19536157
MIRT721789	hsa-miR-4252	HITS-CLIP	19536157
MIRT721788	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT721786	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT721787	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT497315	hsa-miR-4780	PAR-CLIP	22291592
MIRT497314	hsa-miR-6780b-3p	PAR-CLIP	22291592
MIRT497313	hsa-miR-623	PAR-CLIP	22291592
MIRT497312	hsa-miR-204-5p	PAR-CLIP	22291592
MIRT497311	hsa-miR-211-5p	PAR-CLIP	22291592
MIRT497310	hsa-miR-7641	PAR-CLIP	22291592
MIRT497309	hsa-miR-4755-5p	PAR-CLIP	22291592
MIRT497308	hsa-miR-5006-3p	PAR-CLIP	22291592
MIRT497307	hsa-miR-4446-5p	PAR-CLIP	22291592
MIRT1429431	hsa-miR-105	CLIP-seq
MIRT1429432	hsa-miR-140-3p	CLIP-seq
MIRT1429433	hsa-miR-3671	CLIP-seq
MIRT1429434	hsa-miR-3935	CLIP-seq
MIRT1429435	hsa-miR-4719	CLIP-seq
MIRT1429436	hsa-miR-607	CLIP-seq
MIRT2128671	hsa-miR-494	CLIP-seq
MIRT1429433	hsa-miR-3671	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	26402097, 32296183, 32814053
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0006950	Process	Response to stress	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10903839, 10987305
GO:0030154	Process	Cell differentiation	IBA
GO:0030336	Process	Negative regulation of cell migration	IDA	24632071
GO:0044319	Process	Wound healing, spreading of cells	IDA	24632071
GO:0045720	Process	Negative regulation of integrin biosynthetic process	IMP	24632071
GO:0051497	Process	Negative regulation of stress fiber assembly	IDA	24632071

Other IDs

• MIM: 605734
• HGNC: 11867
• e!Ensembl: ENSG00000144339

Protein

• UniProt ID: Q9UIK5
• Protein name: Tomoregulin-2 (TR-2) (Hyperplastic polyposis protein 1) (Transmembrane protein with EGF-like and two follistatin-like domains)
• Protein function: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07648	Kazal_2	90 → 135	Kazal-type serine protease inhibitor domain	Domain
  PF07648	Kazal_2	181 → 227	Kazal-type serine protease inhibitor domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other
• Sequence:

  MVLWESPRQCSSWTLCEGFCWLLLLPVMLLIVARPVKLAAFPTSLSDCQTPTGWNCSGYD
  DRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNECYLRQAA
  CKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDEDAEDVWC
  VCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRCQDNTTTTTKSEDG
  HYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHC
  EKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQNTGH
  YSSDNTTRASTRLI

• Sequence length: 374