LSM5 (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)

Gene

• Entrez ID: 23658
• Gene name: LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
• Gene symbol: LSM5
• Synonyms (NCBI Gene): YER146W
• Chromosome: 7
• Chromosome location: 7p14.3
• Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051127	hsa-miR-16-5p	CLASH	23622248
MIRT1121872	hsa-miR-1225-5p	CLIP-seq
MIRT1121873	hsa-miR-1286	CLIP-seq
MIRT1121874	hsa-miR-1827	CLIP-seq
MIRT1121875	hsa-miR-3664-3p	CLIP-seq
MIRT1121876	hsa-miR-4316	CLIP-seq
MIRT1121877	hsa-miR-433	CLIP-seq
MIRT1121878	hsa-miR-4433	CLIP-seq
MIRT1121879	hsa-miR-4436a	CLIP-seq
MIRT1121880	hsa-miR-4459	CLIP-seq
MIRT1121881	hsa-miR-4506	CLIP-seq
MIRT1121882	hsa-miR-4643	CLIP-seq
MIRT1121883	hsa-miR-466	CLIP-seq
MIRT1121884	hsa-miR-4705	CLIP-seq
MIRT1121885	hsa-miR-4710	CLIP-seq
MIRT1121886	hsa-miR-4768-3p	CLIP-seq
MIRT1121887	hsa-miR-4779	CLIP-seq
MIRT1121888	hsa-miR-4789-3p	CLIP-seq
MIRT1121889	hsa-miR-520d-5p	CLIP-seq
MIRT1121890	hsa-miR-524-5p	CLIP-seq
MIRT1121891	hsa-miR-940	CLIP-seq
MIRT1121872	hsa-miR-1225-5p	CLIP-seq
MIRT1121892	hsa-miR-1255a	CLIP-seq
MIRT1121893	hsa-miR-1255b	CLIP-seq
MIRT1121894	hsa-miR-129-5p	CLIP-seq
MIRT1121895	hsa-miR-144	CLIP-seq
MIRT1121874	hsa-miR-1827	CLIP-seq
MIRT1121896	hsa-miR-200b	CLIP-seq
MIRT1121897	hsa-miR-200c	CLIP-seq
MIRT1121898	hsa-miR-3120-3p	CLIP-seq
MIRT1121899	hsa-miR-3165	CLIP-seq
MIRT1121900	hsa-miR-3180-5p	CLIP-seq
MIRT1121901	hsa-miR-323-3p	CLIP-seq
MIRT1121902	hsa-miR-330-3p	CLIP-seq
MIRT1121903	hsa-miR-34c-3p	CLIP-seq
MIRT1121904	hsa-miR-3613-3p	CLIP-seq
MIRT1121905	hsa-miR-3617	CLIP-seq
MIRT1121906	hsa-miR-3662	CLIP-seq
MIRT1121875	hsa-miR-3664-3p	CLIP-seq
MIRT1121907	hsa-miR-3688-5p	CLIP-seq
MIRT1121908	hsa-miR-374c	CLIP-seq
MIRT1121909	hsa-miR-3926	CLIP-seq
MIRT1121910	hsa-miR-4279	CLIP-seq
MIRT1121911	hsa-miR-429	CLIP-seq
MIRT1121876	hsa-miR-4316	CLIP-seq
MIRT1121877	hsa-miR-433	CLIP-seq
MIRT1121912	hsa-miR-4422	CLIP-seq
MIRT1121878	hsa-miR-4433	CLIP-seq
MIRT1121880	hsa-miR-4459	CLIP-seq
MIRT1121913	hsa-miR-4470	CLIP-seq
MIRT1121914	hsa-miR-448	CLIP-seq
MIRT1121881	hsa-miR-4506	CLIP-seq
MIRT1121882	hsa-miR-4643	CLIP-seq
MIRT1121915	hsa-miR-4645-3p	CLIP-seq
MIRT1121916	hsa-miR-4659a-3p	CLIP-seq
MIRT1121917	hsa-miR-4659b-3p	CLIP-seq
MIRT1121883	hsa-miR-466	CLIP-seq
MIRT1121918	hsa-miR-4693-3p	CLIP-seq
MIRT1121919	hsa-miR-4698	CLIP-seq
MIRT1121885	hsa-miR-4710	CLIP-seq
MIRT1121920	hsa-miR-4714-3p	CLIP-seq
MIRT1121921	hsa-miR-4729	CLIP-seq
MIRT1121886	hsa-miR-4768-3p	CLIP-seq
MIRT1121922	hsa-miR-4775	CLIP-seq
MIRT1121923	hsa-miR-4778-3p	CLIP-seq
MIRT1121887	hsa-miR-4779	CLIP-seq
MIRT1121888	hsa-miR-4789-3p	CLIP-seq
MIRT1121924	hsa-miR-499-3p	CLIP-seq
MIRT1121925	hsa-miR-499a-3p	CLIP-seq
MIRT1121926	hsa-miR-505	CLIP-seq
MIRT1121927	hsa-miR-510	CLIP-seq
MIRT1121928	hsa-miR-512-5p	CLIP-seq
MIRT1121889	hsa-miR-520d-5p	CLIP-seq
MIRT1121890	hsa-miR-524-5p	CLIP-seq
MIRT1121929	hsa-miR-539	CLIP-seq
MIRT1121930	hsa-miR-545	CLIP-seq
MIRT1121931	hsa-miR-548aa	CLIP-seq
MIRT1121932	hsa-miR-548ad	CLIP-seq
MIRT1121933	hsa-miR-548ag	CLIP-seq
MIRT1121934	hsa-miR-548ai	CLIP-seq
MIRT1121935	hsa-miR-548s	CLIP-seq
MIRT1121936	hsa-miR-556-3p	CLIP-seq
MIRT1121937	hsa-miR-605	CLIP-seq
MIRT1121938	hsa-miR-624	CLIP-seq
MIRT1121939	hsa-miR-633	CLIP-seq
MIRT1121940	hsa-miR-641	CLIP-seq
MIRT1121941	hsa-miR-655	CLIP-seq
MIRT1121942	hsa-miR-656	CLIP-seq
MIRT1121943	hsa-miR-665	CLIP-seq
MIRT1121944	hsa-miR-891b	CLIP-seq
MIRT1121873	hsa-miR-1286	CLIP-seq
MIRT1121874	hsa-miR-1827	CLIP-seq
MIRT2034473	hsa-miR-224	CLIP-seq
MIRT2034474	hsa-miR-3122	CLIP-seq
MIRT1121900	hsa-miR-3180-5p	CLIP-seq
MIRT2034475	hsa-miR-34b	CLIP-seq
MIRT2034476	hsa-miR-3665	CLIP-seq
MIRT2034477	hsa-miR-3689a-3p	CLIP-seq
MIRT2034478	hsa-miR-3689c	CLIP-seq
MIRT2034479	hsa-miR-3913-5p	CLIP-seq
MIRT2034480	hsa-miR-3929	CLIP-seq
MIRT1121876	hsa-miR-4316	CLIP-seq
MIRT1121877	hsa-miR-433	CLIP-seq
MIRT2034481	hsa-miR-4419b	CLIP-seq
MIRT1121878	hsa-miR-4433	CLIP-seq
MIRT1121879	hsa-miR-4436a	CLIP-seq
MIRT1121880	hsa-miR-4459	CLIP-seq
MIRT2034482	hsa-miR-4478	CLIP-seq
MIRT2034483	hsa-miR-4649-3p	CLIP-seq
MIRT1121916	hsa-miR-4659a-3p	CLIP-seq
MIRT1121917	hsa-miR-4659b-3p	CLIP-seq
MIRT1121884	hsa-miR-4705	CLIP-seq
MIRT1121885	hsa-miR-4710	CLIP-seq
MIRT2034484	hsa-miR-4728-5p	CLIP-seq
MIRT2034485	hsa-miR-4736	CLIP-seq
MIRT1121886	hsa-miR-4768-3p	CLIP-seq
MIRT1121923	hsa-miR-4778-3p	CLIP-seq
MIRT1121887	hsa-miR-4779	CLIP-seq
MIRT2034486	hsa-miR-485-5p	CLIP-seq
MIRT1121889	hsa-miR-520d-5p	CLIP-seq
MIRT1121890	hsa-miR-524-5p	CLIP-seq
MIRT1121933	hsa-miR-548ag	CLIP-seq
MIRT1121934	hsa-miR-548ai	CLIP-seq
MIRT1121943	hsa-miR-665	CLIP-seq
MIRT1121891	hsa-miR-940	CLIP-seq
MIRT2264944	hsa-miR-145	CLIP-seq
MIRT2264945	hsa-miR-1825	CLIP-seq
MIRT2264946	hsa-miR-199a-5p	CLIP-seq
MIRT2264947	hsa-miR-199b-5p	CLIP-seq
MIRT2264948	hsa-miR-204	CLIP-seq
MIRT2264949	hsa-miR-211	CLIP-seq
MIRT2264950	hsa-miR-3115	CLIP-seq
MIRT1121899	hsa-miR-3165	CLIP-seq
MIRT1121902	hsa-miR-330-3p	CLIP-seq
MIRT1121903	hsa-miR-34c-3p	CLIP-seq
MIRT1121904	hsa-miR-3613-3p	CLIP-seq
MIRT2264951	hsa-miR-3672	CLIP-seq
MIRT1121878	hsa-miR-4433	CLIP-seq
MIRT1121880	hsa-miR-4459	CLIP-seq
MIRT1121882	hsa-miR-4643	CLIP-seq
MIRT1121883	hsa-miR-466	CLIP-seq
MIRT2264952	hsa-miR-4681	CLIP-seq
MIRT2264953	hsa-miR-4755-5p	CLIP-seq
MIRT1121886	hsa-miR-4768-3p	CLIP-seq
MIRT1121888	hsa-miR-4789-3p	CLIP-seq
MIRT2264954	hsa-miR-515-5p	CLIP-seq
MIRT2264955	hsa-miR-623	CLIP-seq
MIRT1121892	hsa-miR-1255a	CLIP-seq
MIRT1121893	hsa-miR-1255b	CLIP-seq
MIRT2563938	hsa-miR-1273d	CLIP-seq
MIRT1121894	hsa-miR-129-5p	CLIP-seq
MIRT1121895	hsa-miR-144	CLIP-seq
MIRT1121874	hsa-miR-1827	CLIP-seq
MIRT2563939	hsa-miR-197	CLIP-seq
MIRT2034473	hsa-miR-224	CLIP-seq
MIRT1121898	hsa-miR-3120-3p	CLIP-seq
MIRT2034474	hsa-miR-3122	CLIP-seq
MIRT2563940	hsa-miR-3163	CLIP-seq
MIRT1121899	hsa-miR-3165	CLIP-seq
MIRT1121902	hsa-miR-330-3p	CLIP-seq
MIRT1121903	hsa-miR-34c-3p	CLIP-seq
MIRT1121904	hsa-miR-3613-3p	CLIP-seq
MIRT1121905	hsa-miR-3617	CLIP-seq
MIRT1121906	hsa-miR-3662	CLIP-seq
MIRT2034476	hsa-miR-3665	CLIP-seq
MIRT2034477	hsa-miR-3689a-3p	CLIP-seq
MIRT2034478	hsa-miR-3689c	CLIP-seq
MIRT2034479	hsa-miR-3913-5p	CLIP-seq
MIRT1121909	hsa-miR-3926	CLIP-seq
MIRT2034480	hsa-miR-3929	CLIP-seq
MIRT2563941	hsa-miR-421	CLIP-seq
MIRT1121910	hsa-miR-4279	CLIP-seq
MIRT2034481	hsa-miR-4419b	CLIP-seq
MIRT1121912	hsa-miR-4422	CLIP-seq
MIRT1121878	hsa-miR-4433	CLIP-seq
MIRT1121880	hsa-miR-4459	CLIP-seq
MIRT1121913	hsa-miR-4470	CLIP-seq
MIRT2034482	hsa-miR-4478	CLIP-seq
MIRT1121914	hsa-miR-448	CLIP-seq
MIRT2034483	hsa-miR-4649-3p	CLIP-seq
MIRT2563942	hsa-miR-4709-5p	CLIP-seq
MIRT1121920	hsa-miR-4714-3p	CLIP-seq
MIRT2034484	hsa-miR-4728-5p	CLIP-seq
MIRT1121921	hsa-miR-4729	CLIP-seq
MIRT2034485	hsa-miR-4736	CLIP-seq
MIRT1121886	hsa-miR-4768-3p	CLIP-seq
MIRT2034486	hsa-miR-485-5p	CLIP-seq
MIRT1121889	hsa-miR-520d-5p	CLIP-seq
MIRT1121890	hsa-miR-524-5p	CLIP-seq
MIRT1121929	hsa-miR-539	CLIP-seq
MIRT1121930	hsa-miR-545	CLIP-seq
MIRT1121931	hsa-miR-548aa	CLIP-seq
MIRT2563943	hsa-miR-548ac	CLIP-seq
MIRT2563944	hsa-miR-548ae	CLIP-seq
MIRT1121933	hsa-miR-548ag	CLIP-seq
MIRT1121934	hsa-miR-548ai	CLIP-seq
MIRT2563945	hsa-miR-548aj	CLIP-seq
MIRT2563946	hsa-miR-548am	CLIP-seq
MIRT2563947	hsa-miR-548c-3p	CLIP-seq
MIRT2563948	hsa-miR-548d-3p	CLIP-seq
MIRT1121935	hsa-miR-548s	CLIP-seq
MIRT2563949	hsa-miR-548x	CLIP-seq
MIRT2563950	hsa-miR-548z	CLIP-seq
MIRT1121936	hsa-miR-556-3p	CLIP-seq
MIRT2563951	hsa-miR-600	CLIP-seq
MIRT1121938	hsa-miR-624	CLIP-seq
MIRT1121940	hsa-miR-641	CLIP-seq
MIRT2563952	hsa-miR-642b	CLIP-seq
MIRT1121942	hsa-miR-656	CLIP-seq
MIRT1121891	hsa-miR-940	CLIP-seq
MIRT2563938	hsa-miR-1273d	CLIP-seq
MIRT1121894	hsa-miR-129-5p	CLIP-seq
MIRT1121874	hsa-miR-1827	CLIP-seq
MIRT1121898	hsa-miR-3120-3p	CLIP-seq
MIRT2034474	hsa-miR-3122	CLIP-seq
MIRT1121899	hsa-miR-3165	CLIP-seq
MIRT1121902	hsa-miR-330-3p	CLIP-seq
MIRT1121903	hsa-miR-34c-3p	CLIP-seq
MIRT1121905	hsa-miR-3617	CLIP-seq
MIRT2034476	hsa-miR-3665	CLIP-seq
MIRT2034477	hsa-miR-3689a-3p	CLIP-seq
MIRT2034478	hsa-miR-3689c	CLIP-seq
MIRT2034479	hsa-miR-3913-5p	CLIP-seq
MIRT1121909	hsa-miR-3926	CLIP-seq
MIRT2034480	hsa-miR-3929	CLIP-seq
MIRT1121910	hsa-miR-4279	CLIP-seq
MIRT2034481	hsa-miR-4419b	CLIP-seq
MIRT1121912	hsa-miR-4422	CLIP-seq
MIRT1121878	hsa-miR-4433	CLIP-seq
MIRT1121880	hsa-miR-4459	CLIP-seq
MIRT2034482	hsa-miR-4478	CLIP-seq
MIRT2034483	hsa-miR-4649-3p	CLIP-seq
MIRT1121920	hsa-miR-4714-3p	CLIP-seq
MIRT2034484	hsa-miR-4728-5p	CLIP-seq
MIRT2034485	hsa-miR-4736	CLIP-seq
MIRT1121886	hsa-miR-4768-3p	CLIP-seq
MIRT2034486	hsa-miR-485-5p	CLIP-seq
MIRT1121889	hsa-miR-520d-5p	CLIP-seq
MIRT1121890	hsa-miR-524-5p	CLIP-seq
MIRT1121929	hsa-miR-539	CLIP-seq
MIRT1121930	hsa-miR-545	CLIP-seq
MIRT1121931	hsa-miR-548aa	CLIP-seq
MIRT1121933	hsa-miR-548ag	CLIP-seq
MIRT1121934	hsa-miR-548ai	CLIP-seq
MIRT2563947	hsa-miR-548c-3p	CLIP-seq
MIRT1121935	hsa-miR-548s	CLIP-seq
MIRT2563951	hsa-miR-600	CLIP-seq
MIRT1121938	hsa-miR-624	CLIP-seq
MIRT1121940	hsa-miR-641	CLIP-seq
MIRT1121891	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	28781166
GO:0000398	Process	MRNA splicing, via spliceosome	NAS	30975767
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	10369684
GO:0005515	Function	Protein binding	IPI	15231747, 22365833, 25416956, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	26912367
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	30975767
GO:0005634	Component	Nucleus	TAS	10369684
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IEA
GO:0005681	Component	Spliceosomal complex	IPI	30975767
GO:0005688	Component	U6 snRNP	IBA
GO:0005737	Component	Cytoplasm	IDA	12515382
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	10369684
GO:0006402	Process	MRNA catabolic process	IDA	12515382
GO:0008380	Process	RNA splicing	IEA
GO:0009617	Process	Response to bacterium	IEA
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IBA
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IDA	26912367
GO:0046540	Component	U4/U6 x U5 tri-snRNP complex	IPI	30975767
GO:0046982	Function	Protein heterodimerization activity	IDA	12515382
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	28781166
GO:0120115	Component	Lsm2-8 complex	IDA	10523320
GO:1990726	Component	Lsm1-7-Pat1 complex	IBA
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 607285
• HGNC: 17162
• e!Ensembl: ENSG00000106355

Protein

• UniProt ID: Q9Y4Y9
• Protein name: U6 snRNA-associated Sm-like protein LSm5
• Protein function: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex
• PDB: 3JCR, 5O9Z, 6AH0, 6AHD, 6QW6, 6QX9, 7ABG, 8H6E, 8H6J, 8H6K, 8H6L, 8QO9, 8QXD, 8QZS, 8R08, 8R09, 8R0A, 8R0B, 8RM5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01423	LSM	16 → 84	LSM domain	Domain

• Sequence:

  MAANATTNPSQLLPLELVDKCIGSRIHIVMKSDKEIVGTLLGFDDFVNMVLEDVTEFEIT
  PEGRRITKLDQILLNGNNITMLVPGGEGPEV

• Sequence length: 91

Pathways

KEGG:

RNA degradation
Spliceosome

Reactome:

mRNA decay by 5' to 3' exoribonuclease
mRNA Splicing - Major Pathway