Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23657
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 7 member 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC7A11
Synonyms (NCBI Gene) Gene synonyms aliases
CCBR1, xCT
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q28.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamat
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003333 Process Amino acid transmembrane transport IBA
GO:0005515 Function Protein binding IPI 21397861, 32296183, 34880232
GO:0005886 Component Plasma membrane IDA 11417227, 15151999
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane IPI 34880232
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607933 11059 ENSG00000151012
Protein
UniProt ID Q9UPY5
Protein name Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
Protein function Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:11133847, PubMed:11417227, PubMed:14722095, PubMed:15
PDB 7CCS , 7EPZ , 7P9U , 7P9V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2 44 470 Amino acid permease Family
Tissue specificity TISSUE SPECIFICITY: Expressed in term placenta and primary term cytotrophoblast (PubMed:34120018). Expressed mainly in the brain, but also in pancreas (PubMed:11417227). {ECO:0000269|PubMed:11417227, ECO:0000269|PubMed:34120018}.
Sequence
Sequence length 501
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ferroptosis   Basigin interactions
Amino acid transport across the plasma membrane
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glioblastoma Glioblastoma N/A N/A GWAS
Neuroticism Neuroticism N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 34074015
Adenocarcinoma of Lung Associate 33422520, 35509981, 37552140, 37880315, 37916324
Adenocarcinoma of Lung Stimulate 37713821
Adrenocortical Carcinoma Associate 35500219, 39424480
Alcoholism Associate 34857913
Alzheimer Disease Associate 32199332, 34857913
Arthritis Rheumatoid Associate 37174663
Autoimmune Diseases Associate 34004141
Brain Neoplasms Associate 25228443
Breast Neoplasms Associate 21510944, 24686172, 25827424, 28630426, 29259101, 32630312, 34059009, 37712959, 38073087, 38116315, 40464376