Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23657
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 7 member 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC7A11
Synonyms (NCBI Gene) Gene synonyms aliases
CCBR1, xCT
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q28.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamat
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assay, qRT-PCR 19296470
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003333 Process Amino acid transmembrane transport IBA 21873635
GO:0005515 Function Protein binding IPI 21397861, 32296183
GO:0005791 Component Rough endoplasmic reticulum IEA
GO:0005856 Component Cytoskeleton IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607933 11059 ENSG00000151012
Protein
UniProt ID Q9UPY5
Protein name Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
Protein function Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:11133847, PubMed:11417227, PubMed:14722095, PubMed:15
PDB 7CCS , 7EPZ , 7P9U , 7P9V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2 44 470 Amino acid permease Family
Tissue specificity TISSUE SPECIFICITY: Expressed in term placenta and primary term cytotrophoblast (PubMed:34120018). Expressed mainly in the brain, but also in pancreas (PubMed:11417227). {ECO:0000269|PubMed:11417227, ECO:0000269|PubMed:34120018}.
Sequence
Sequence length 501
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ferroptosis   Basigin interactions
Amino acid transport across the plasma membrane
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Dermatitis Contact Dermatitis rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174 25724174
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 34074015
Adenocarcinoma of Lung Associate 33422520, 35509981, 37552140, 37880315, 37916324
Adenocarcinoma of Lung Stimulate 37713821
Adrenocortical Carcinoma Associate 35500219, 39424480
Alcoholism Associate 34857913
Alzheimer Disease Associate 32199332, 34857913
Arthritis Rheumatoid Associate 37174663
Autoimmune Diseases Associate 34004141
Brain Neoplasms Associate 25228443
Breast Neoplasms Associate 21510944, 24686172, 25827424, 28630426, 29259101, 32630312, 34059009, 37712959, 38073087, 38116315, 40464376