Gene Gene information from NCBI Gene database.
Entrez ID 23657
Gene name Solute carrier family 7 member 11
Gene symbol SLC7A11
Synonyms (NCBI Gene)
CCBR1xCT
Chromosome 4
Chromosome location 4q28.3
Summary This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamat
miRNA miRNA information provided by mirtarbase database.
1414
miRTarBase ID miRNA Experiments Reference
MIRT003108 hsa-miR-122-5p Luciferase reporter assayqRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assayqRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assayqRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assayqRT-PCR 19296470
MIRT003108 hsa-miR-122-5p Luciferase reporter assayqRT-PCR 19296470
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
57
GO ID Ontology Definition Evidence Reference
GO:0003333 Process Amino acid transmembrane transport IBA
GO:0005515 Function Protein binding IPI 21397861, 32296183, 34880232
GO:0005886 Component Plasma membrane IDA 11417227, 15151999
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane IPI 34880232
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607933 11059 ENSG00000151012
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UPY5
Protein name Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
Protein function Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane (PubMed:11133847, PubMed:11417227, PubMed:14722095, PubMed:15
PDB 7CCS , 7EPZ , 7P9U , 7P9V
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13520 AA_permease_2 44 470 Amino acid permease Family
Tissue specificity TISSUE SPECIFICITY: Expressed in term placenta and primary term cytotrophoblast (PubMed:34120018). Expressed mainly in the brain, but also in pancreas (PubMed:11417227). {ECO:0000269|PubMed:11417227, ECO:0000269|PubMed:34120018}.
Sequence
Sequence length 501
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Ferroptosis   Basigin interactions
Amino acid transport across the plasma membrane