Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23654
Gene name	Plexin B2
Gene symbol	PLXNB2
Synonyms (NCBI Gene)	MM1Nbla00445PLEXB2dJ402G11.3lncFAL
Chromosome	22
Chromosome location	22q13.33
Summary	Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023196	hsa-miR-124-3p	Microarray	18668037
MIRT024067	hsa-miR-1-3p	Proteomics	18668040
MIRT051886	hsa-let-7b-5p	CLASH	23622248
MIRT046780	hsa-miR-222-3p	CLASH	23622248
MIRT046780	hsa-miR-222-3p	CLASH	23622248
MIRT044983	hsa-miR-186-5p	CLASH	23622248
MIRT043447	hsa-miR-331-3p	CLASH	23622248
MIRT039807	hsa-miR-615-3p	CLASH	23622248
MIRT039807	hsa-miR-615-3p	CLASH	23622248
MIRT439944	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT439944	hsa-miR-493-3p	HITS-CLIP	24374217
MIRT736880	hsa-miR-138-5p	Luciferase reporter assayWestern blottingMicroarrayRNA-seqqRT-PCRFlow cytometry	32188026
MIRT1243829	hsa-miR-1180	CLIP-seq
MIRT1243830	hsa-miR-125a-5p	CLIP-seq
MIRT1243831	hsa-miR-125b	CLIP-seq
MIRT1243832	hsa-miR-126	CLIP-seq
MIRT1243833	hsa-miR-1266	CLIP-seq
MIRT1243834	hsa-miR-1270	CLIP-seq
MIRT1243835	hsa-miR-1294	CLIP-seq
MIRT1243836	hsa-miR-138	CLIP-seq
MIRT1243837	hsa-miR-139-5p	CLIP-seq
MIRT1243838	hsa-miR-1912	CLIP-seq
MIRT1243839	hsa-miR-2110	CLIP-seq
MIRT1243840	hsa-miR-221	CLIP-seq
MIRT1243841	hsa-miR-222	CLIP-seq
MIRT1243842	hsa-miR-3130-3p	CLIP-seq
MIRT1243843	hsa-miR-3150a-3p	CLIP-seq
MIRT1243844	hsa-miR-3175	CLIP-seq
MIRT1243845	hsa-miR-3178	CLIP-seq
MIRT1243846	hsa-miR-3180	CLIP-seq
MIRT1243847	hsa-miR-3180-3p	CLIP-seq
MIRT1243848	hsa-miR-3184	CLIP-seq
MIRT1243849	hsa-miR-3189-3p	CLIP-seq
MIRT1243850	hsa-miR-3196	CLIP-seq
MIRT1243851	hsa-miR-3664-3p	CLIP-seq
MIRT1243852	hsa-miR-371-3p	CLIP-seq
MIRT1243853	hsa-miR-3714	CLIP-seq
MIRT1243854	hsa-miR-3907	CLIP-seq
MIRT1243855	hsa-miR-3910	CLIP-seq
MIRT1243856	hsa-miR-423-5p	CLIP-seq
MIRT1243857	hsa-miR-4260	CLIP-seq
MIRT1243858	hsa-miR-4279	CLIP-seq
MIRT1243859	hsa-miR-4283	CLIP-seq
MIRT1243860	hsa-miR-4300	CLIP-seq
MIRT1243861	hsa-miR-4305	CLIP-seq
MIRT1243862	hsa-miR-4319	CLIP-seq
MIRT1243863	hsa-miR-4419a	CLIP-seq
MIRT1243864	hsa-miR-4466	CLIP-seq
MIRT1243865	hsa-miR-4476	CLIP-seq
MIRT1243866	hsa-miR-4486	CLIP-seq
MIRT1243867	hsa-miR-4487	CLIP-seq
MIRT1243868	hsa-miR-4489	CLIP-seq
MIRT1243869	hsa-miR-4492	CLIP-seq
MIRT1243870	hsa-miR-4498	CLIP-seq
MIRT1243871	hsa-miR-4505	CLIP-seq
MIRT1243872	hsa-miR-4510	CLIP-seq
MIRT1243873	hsa-miR-4518	CLIP-seq
MIRT1243874	hsa-miR-4683	CLIP-seq
MIRT1243875	hsa-miR-4710	CLIP-seq
MIRT1243876	hsa-miR-4731-5p	CLIP-seq
MIRT1243877	hsa-miR-4734	CLIP-seq
MIRT1243878	hsa-miR-4743	CLIP-seq
MIRT1243879	hsa-miR-4746-3p	CLIP-seq
MIRT1243880	hsa-miR-487b	CLIP-seq
MIRT1243881	hsa-miR-544b	CLIP-seq
MIRT1243882	hsa-miR-548q	CLIP-seq
MIRT1243883	hsa-miR-548v	CLIP-seq
MIRT1243884	hsa-miR-620	CLIP-seq
MIRT1243885	hsa-miR-675	CLIP-seq
MIRT1243886	hsa-miR-759	CLIP-seq
MIRT1243887	hsa-miR-762	CLIP-seq
MIRT1243888	hsa-miR-873	CLIP-seq
MIRT1243889	hsa-miR-920	CLIP-seq
MIRT1243890	hsa-miR-939	CLIP-seq
MIRT1243832	hsa-miR-126	CLIP-seq
MIRT2072066	hsa-miR-1265	CLIP-seq
MIRT1243835	hsa-miR-1294	CLIP-seq
MIRT1243836	hsa-miR-138	CLIP-seq
MIRT2072067	hsa-miR-192	CLIP-seq
MIRT1243839	hsa-miR-2110	CLIP-seq
MIRT2072068	hsa-miR-215	CLIP-seq
MIRT1243843	hsa-miR-3150a-3p	CLIP-seq
MIRT2072069	hsa-miR-3165	CLIP-seq
MIRT1243844	hsa-miR-3175	CLIP-seq
MIRT1243848	hsa-miR-3184	CLIP-seq
MIRT1243849	hsa-miR-3189-3p	CLIP-seq
MIRT2072070	hsa-miR-3614-5p	CLIP-seq
MIRT1243854	hsa-miR-3907	CLIP-seq
MIRT1243855	hsa-miR-3910	CLIP-seq
MIRT1243856	hsa-miR-423-5p	CLIP-seq
MIRT1243858	hsa-miR-4279	CLIP-seq
MIRT1243859	hsa-miR-4283	CLIP-seq
MIRT1243865	hsa-miR-4476	CLIP-seq
MIRT1243868	hsa-miR-4489	CLIP-seq
MIRT1243869	hsa-miR-4492	CLIP-seq
MIRT1243870	hsa-miR-4498	CLIP-seq
MIRT1243871	hsa-miR-4505	CLIP-seq
MIRT2072071	hsa-miR-4651	CLIP-seq
MIRT1243875	hsa-miR-4710	CLIP-seq
MIRT1243876	hsa-miR-4731-5p	CLIP-seq
MIRT1243880	hsa-miR-487b	CLIP-seq
MIRT1243882	hsa-miR-548q	CLIP-seq
MIRT2072072	hsa-miR-608	CLIP-seq
MIRT2072073	hsa-miR-654-3p	CLIP-seq
MIRT1243887	hsa-miR-762	CLIP-seq
MIRT1243888	hsa-miR-873	CLIP-seq
MIRT1243890	hsa-miR-939	CLIP-seq
MIRT1243830	hsa-miR-125a-5p	CLIP-seq
MIRT1243831	hsa-miR-125b	CLIP-seq
MIRT1243832	hsa-miR-126	CLIP-seq
MIRT1243833	hsa-miR-1266	CLIP-seq
MIRT1243835	hsa-miR-1294	CLIP-seq
MIRT2299122	hsa-miR-1305	CLIP-seq
MIRT1243838	hsa-miR-1912	CLIP-seq
MIRT2072067	hsa-miR-192	CLIP-seq
MIRT1243839	hsa-miR-2110	CLIP-seq
MIRT2072068	hsa-miR-215	CLIP-seq
MIRT1243843	hsa-miR-3150a-3p	CLIP-seq
MIRT1243844	hsa-miR-3175	CLIP-seq
MIRT1243848	hsa-miR-3184	CLIP-seq
MIRT1243849	hsa-miR-3189-3p	CLIP-seq
MIRT2299123	hsa-miR-34b	CLIP-seq
MIRT2299124	hsa-miR-3660	CLIP-seq
MIRT1243851	hsa-miR-3664-3p	CLIP-seq
MIRT2299125	hsa-miR-3671	CLIP-seq
MIRT1243852	hsa-miR-371-3p	CLIP-seq
MIRT1243853	hsa-miR-3714	CLIP-seq
MIRT1243855	hsa-miR-3910	CLIP-seq
MIRT1243856	hsa-miR-423-5p	CLIP-seq
MIRT1243858	hsa-miR-4279	CLIP-seq
MIRT1243859	hsa-miR-4283	CLIP-seq
MIRT1243862	hsa-miR-4319	CLIP-seq
MIRT2299126	hsa-miR-4436b-3p	CLIP-seq
MIRT1243865	hsa-miR-4476	CLIP-seq
MIRT1243868	hsa-miR-4489	CLIP-seq
MIRT1243873	hsa-miR-4518	CLIP-seq
MIRT2299127	hsa-miR-4526	CLIP-seq
MIRT2072071	hsa-miR-4651	CLIP-seq
MIRT1243875	hsa-miR-4710	CLIP-seq
MIRT2299128	hsa-miR-4761-3p	CLIP-seq
MIRT2299129	hsa-miR-4762-5p	CLIP-seq
MIRT2299130	hsa-miR-4777-3p	CLIP-seq
MIRT1243880	hsa-miR-487b	CLIP-seq
MIRT1243881	hsa-miR-544b	CLIP-seq
MIRT2299131	hsa-miR-607	CLIP-seq
MIRT2072072	hsa-miR-608	CLIP-seq
MIRT1243886	hsa-miR-759	CLIP-seq
MIRT1243888	hsa-miR-873	CLIP-seq
MIRT1243890	hsa-miR-939	CLIP-seq
MIRT2432194	hsa-miR-1293	CLIP-seq
MIRT2432195	hsa-miR-323-5p	CLIP-seq
MIRT2432196	hsa-miR-342-5p	CLIP-seq
MIRT2432197	hsa-miR-3936	CLIP-seq
MIRT2432198	hsa-miR-432	CLIP-seq
MIRT2432199	hsa-miR-4483	CLIP-seq
MIRT2432200	hsa-miR-4515	CLIP-seq
MIRT2072071	hsa-miR-4651	CLIP-seq
MIRT2432201	hsa-miR-4664-5p	CLIP-seq
MIRT2432202	hsa-miR-520d-5p	CLIP-seq
MIRT2432203	hsa-miR-524-5p	CLIP-seq
MIRT1243882	hsa-miR-548q	CLIP-seq
MIRT2072072	hsa-miR-608	CLIP-seq
MIRT1243832	hsa-miR-126	CLIP-seq
MIRT1243835	hsa-miR-1294	CLIP-seq
MIRT1243838	hsa-miR-1912	CLIP-seq
MIRT2072067	hsa-miR-192	CLIP-seq
MIRT1243839	hsa-miR-2110	CLIP-seq
MIRT2072068	hsa-miR-215	CLIP-seq
MIRT1243843	hsa-miR-3150a-3p	CLIP-seq
MIRT2439570	hsa-miR-3151	CLIP-seq
MIRT1243844	hsa-miR-3175	CLIP-seq
MIRT1243849	hsa-miR-3189-3p	CLIP-seq
MIRT2439571	hsa-miR-361-3p	CLIP-seq
MIRT1243852	hsa-miR-371-3p	CLIP-seq
MIRT1243855	hsa-miR-3910	CLIP-seq
MIRT1243865	hsa-miR-4476	CLIP-seq
MIRT2439572	hsa-miR-4530	CLIP-seq
MIRT1243875	hsa-miR-4710	CLIP-seq
MIRT1243880	hsa-miR-487b	CLIP-seq
MIRT1243886	hsa-miR-759	CLIP-seq
MIRT1243888	hsa-miR-873	CLIP-seq
MIRT1243890	hsa-miR-939	CLIP-seq
MIRT1243855	hsa-miR-3910	CLIP-seq
MIRT2595966	hsa-miR-1231	CLIP-seq
MIRT2072066	hsa-miR-1265	CLIP-seq
MIRT2595967	hsa-miR-1285	CLIP-seq
MIRT2595968	hsa-miR-1292	CLIP-seq
MIRT1243836	hsa-miR-138	CLIP-seq
MIRT2595969	hsa-miR-146b-3p	CLIP-seq
MIRT1243838	hsa-miR-1912	CLIP-seq
MIRT2595970	hsa-miR-1913	CLIP-seq
MIRT2595971	hsa-miR-1915	CLIP-seq
MIRT2072067	hsa-miR-192	CLIP-seq
MIRT2072068	hsa-miR-215	CLIP-seq
MIRT2595972	hsa-miR-22	CLIP-seq
MIRT2595973	hsa-miR-296-5p	CLIP-seq
MIRT2595974	hsa-miR-3117-3p	CLIP-seq
MIRT2595975	hsa-miR-3136-3p	CLIP-seq
MIRT2439570	hsa-miR-3151	CLIP-seq
MIRT2595976	hsa-miR-3157-3p	CLIP-seq
MIRT2595977	hsa-miR-3169	CLIP-seq
MIRT2595978	hsa-miR-3173-5p	CLIP-seq
MIRT2595979	hsa-miR-3187-5p	CLIP-seq
MIRT2595980	hsa-miR-3192	CLIP-seq
MIRT2595981	hsa-miR-324-3p	CLIP-seq
MIRT2595982	hsa-miR-3612	CLIP-seq
MIRT2439571	hsa-miR-361-3p	CLIP-seq
MIRT2072070	hsa-miR-3614-5p	CLIP-seq
MIRT2595983	hsa-miR-3622b-5p	CLIP-seq
MIRT1243852	hsa-miR-371-3p	CLIP-seq
MIRT2595984	hsa-miR-378g	CLIP-seq
MIRT2595985	hsa-miR-4253	CLIP-seq
MIRT2595986	hsa-miR-4292	CLIP-seq
MIRT2595987	hsa-miR-4313	CLIP-seq
MIRT2595988	hsa-miR-4314	CLIP-seq
MIRT2595989	hsa-miR-4330	CLIP-seq
MIRT2299126	hsa-miR-4436b-3p	CLIP-seq
MIRT2595990	hsa-miR-4443	CLIP-seq
MIRT1243864	hsa-miR-4466	CLIP-seq
MIRT2595991	hsa-miR-4471	CLIP-seq
MIRT1243866	hsa-miR-4486	CLIP-seq
MIRT2595992	hsa-miR-4488	CLIP-seq
MIRT2439572	hsa-miR-4530	CLIP-seq
MIRT2595993	hsa-miR-4646-5p	CLIP-seq
MIRT2595994	hsa-miR-4661-3p	CLIP-seq
MIRT2595995	hsa-miR-4697-5p	CLIP-seq
MIRT2595996	hsa-miR-4714-3p	CLIP-seq
MIRT2595997	hsa-miR-4759	CLIP-seq
MIRT2299128	hsa-miR-4761-3p	CLIP-seq
MIRT2595998	hsa-miR-4802-5p	CLIP-seq
MIRT1243882	hsa-miR-548q	CLIP-seq
MIRT2595999	hsa-miR-612	CLIP-seq
MIRT2596000	hsa-miR-637	CLIP-seq
MIRT2596001	hsa-miR-650	CLIP-seq
MIRT2072073	hsa-miR-654-3p	CLIP-seq
MIRT2596002	hsa-miR-658	CLIP-seq
MIRT1243885	hsa-miR-675	CLIP-seq
MIRT1243886	hsa-miR-759	CLIP-seq
MIRT2596003	hsa-miR-874	CLIP-seq
MIRT2595966	hsa-miR-1231	CLIP-seq
MIRT2072066	hsa-miR-1265	CLIP-seq
MIRT2595967	hsa-miR-1285	CLIP-seq
MIRT2595968	hsa-miR-1292	CLIP-seq
MIRT1243836	hsa-miR-138	CLIP-seq
MIRT2595969	hsa-miR-146b-3p	CLIP-seq
MIRT1243838	hsa-miR-1912	CLIP-seq
MIRT2595971	hsa-miR-1915	CLIP-seq
MIRT2072067	hsa-miR-192	CLIP-seq
MIRT2072068	hsa-miR-215	CLIP-seq
MIRT2595973	hsa-miR-296-5p	CLIP-seq
MIRT2595974	hsa-miR-3117-3p	CLIP-seq
MIRT2595975	hsa-miR-3136-3p	CLIP-seq
MIRT2439570	hsa-miR-3151	CLIP-seq
MIRT2595976	hsa-miR-3157-3p	CLIP-seq
MIRT2595977	hsa-miR-3169	CLIP-seq
MIRT2595978	hsa-miR-3173-5p	CLIP-seq
MIRT2595979	hsa-miR-3187-5p	CLIP-seq
MIRT2595980	hsa-miR-3192	CLIP-seq
MIRT2595982	hsa-miR-3612	CLIP-seq
MIRT2439571	hsa-miR-361-3p	CLIP-seq
MIRT2072070	hsa-miR-3614-5p	CLIP-seq
MIRT2595983	hsa-miR-3622b-5p	CLIP-seq
MIRT1243852	hsa-miR-371-3p	CLIP-seq
MIRT2595984	hsa-miR-378g	CLIP-seq
MIRT2595985	hsa-miR-4253	CLIP-seq
MIRT2595986	hsa-miR-4292	CLIP-seq
MIRT2595988	hsa-miR-4314	CLIP-seq
MIRT2595989	hsa-miR-4330	CLIP-seq
MIRT2299126	hsa-miR-4436b-3p	CLIP-seq
MIRT2595990	hsa-miR-4443	CLIP-seq
MIRT1243864	hsa-miR-4466	CLIP-seq
MIRT2595991	hsa-miR-4471	CLIP-seq
MIRT1243866	hsa-miR-4486	CLIP-seq
MIRT2595992	hsa-miR-4488	CLIP-seq
MIRT2439572	hsa-miR-4530	CLIP-seq
MIRT2595993	hsa-miR-4646-5p	CLIP-seq
MIRT2595994	hsa-miR-4661-3p	CLIP-seq
MIRT2595995	hsa-miR-4697-5p	CLIP-seq
MIRT2595996	hsa-miR-4714-3p	CLIP-seq
MIRT2595997	hsa-miR-4759	CLIP-seq
MIRT2299128	hsa-miR-4761-3p	CLIP-seq
MIRT2595998	hsa-miR-4802-5p	CLIP-seq
MIRT1243882	hsa-miR-548q	CLIP-seq
MIRT2595999	hsa-miR-612	CLIP-seq
MIRT2596000	hsa-miR-637	CLIP-seq
MIRT2596001	hsa-miR-650	CLIP-seq
MIRT2072073	hsa-miR-654-3p	CLIP-seq
MIRT1243885	hsa-miR-675	CLIP-seq
MIRT1243886	hsa-miR-759	CLIP-seq
MIRT2596003	hsa-miR-874	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001843	Process	Neural tube closure	IEA
GO:0001843	Process	Neural tube closure	ISS
GO:0001932	Process	Regulation of protein phosphorylation	ISS
GO:0002116	Component	Semaphorin receptor complex	IBA
GO:0002181	Process	Cytoplasmic translation	IDA	38718836
GO:0004888	Function	Transmembrane signaling receptor activity	IDA	29100074
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	15184888, 29040270
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12533544
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006898	Process	Receptor-mediated endocytosis	IDA	29100074
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IDA	16122393
GO:0007162	Process	Negative regulation of cell adhesion	IBA
GO:0007405	Process	Neuroblast proliferation	IEA
GO:0007405	Process	Neuroblast proliferation	ISS
GO:0007416	Process	Synapse assembly	IBA
GO:0007420	Process	Brain development	IEA
GO:0007420	Process	Brain development	ISS
GO:0008360	Process	Regulation of cell shape	IBA
GO:0008360	Process	Regulation of cell shape	IEA
GO:0008360	Process	Regulation of cell shape	ISS
GO:0009986	Component	Cell surface	HDA	19581412
GO:0010975	Process	Regulation of neuron projection development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	IDA	16122393
GO:0016020	Component	Membrane	IEA
GO:0017154	Function	Semaphorin receptor activity	IBA
GO:0017154	Function	Semaphorin receptor activity	IEA
GO:0017154	Function	Semaphorin receptor activity	ISS
GO:0030334	Process	Regulation of cell migration	IBA
GO:0031346	Process	Positive regulation of cell projection organization	IEA
GO:0032055	Process	Negative regulation of translation in response to stress	IDA	38718836
GO:0033554	Process	Cellular response to stress	IDA	38718836
GO:0036416	Process	TRNA stabilization	IDA	23843625
GO:0038023	Function	Signaling receptor activity	IDA	29100074
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0045727	Process	Positive regulation of translation	IMP	29100074
GO:0050772	Process	Positive regulation of axonogenesis	IBA
GO:0050772	Process	Positive regulation of axonogenesis	IEA
GO:0051246	Process	Regulation of protein metabolic process	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:1904861	Process	Excitatory synapse assembly	IEA
GO:1904861	Process	Excitatory synapse assembly	ISS
GO:2001222	Process	Regulation of neuron migration	IEA
GO:2001222	Process	Regulation of neuron migration	ISS

MIM	HGNC	e!Ensembl
604293	9104	ENSG00000196576

O15031

Protein name

Plexin-B2 (MM1)

Protein function

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By sim

PDB

4E71

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	36 → 447	Sema domain	Family
PF01437	PSI	468 → 519	Plexin repeat	Family
PF17960	TIG_plexin	525 → 613	TIG domain	Domain
PF01833	TIG	803 → 892	IPT/TIG domain	Domain
PF01833	TIG	895 → 979	IPT/TIG domain	Domain
PF01833	TIG	983 → 1091	IPT/TIG domain	Domain
PF08337	Plexin_cytopl	1271 → 1805	Plexin cytoplasmic RasGAP domain	Family

Sequence

MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAK
LQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGIC
ALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNG
IIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPA
RNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRD
SRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSK
SFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYL
TPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRD
SQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLT
VSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRR
GNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRA
HMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGT
FAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCA
WCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISV
AGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSV
EPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQML
LEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIA
EPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRA
LLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMK
TLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSL
ILPLVIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEM
EDQTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFS
NLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQY
VVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAV
QKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKIIDQVYR
GQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSK
VGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKEKERTKAITEI
YLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWK
TNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLL
YAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQK
YYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL

Sequence length

1838

Interactions

View interactions

	KEGG
	Axon guidance

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Amyotrophic Lateral Sclerosis	Associate	33523907	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Associate	32722525	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Stimulate	35335125	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Associate	33381571	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Stimulate	36749929	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	24158112, 25762646	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Associate	24158112, 25762646	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	33381571	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	30558617, 37272581	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemic Infiltration	Associate	30558617	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Associate	33381571	★★★★★ ★☆☆☆☆ Found in Text Mining only
Oral Ulcer	Associate	37369724	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis	Associate	36749929	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sjogren's Syndrome	Associate	36171070	★★★★★ ★☆☆☆☆ Found in Text Mining only

PLXNB2 (plexin B2)