Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23644
Gene name Gene Name - the full gene name approved by the HGNC.	Enhancer of mRNA decapping 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	EDC4
Synonyms (NCBI Gene) Gene synonyms aliases	GE1, Ge-1, HEDL5, HEDLS, RCD-8, RCD8
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q22.1

Show/Hide all(79)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031748	hsa-miR-16-5p	Proteomics	18668040
MIRT049266	hsa-miR-92a-3p	CLASH	23622248
MIRT046437	hsa-miR-15b-5p	CLASH	23622248
MIRT036488	hsa-miR-1226-3p	CLASH	23622248
MIRT952271	hsa-miR-1266	CLIP-seq
MIRT952272	hsa-miR-1305	CLIP-seq
MIRT952273	hsa-miR-3613-3p	CLIP-seq
MIRT952274	hsa-miR-3664-3p	CLIP-seq
MIRT952275	hsa-miR-4307	CLIP-seq
MIRT952276	hsa-miR-4436b-5p	CLIP-seq
MIRT952277	hsa-miR-4452	CLIP-seq
MIRT952278	hsa-miR-4518	CLIP-seq
MIRT952279	hsa-miR-4695-3p	CLIP-seq
MIRT952280	hsa-miR-513c	CLIP-seq
MIRT952281	hsa-miR-514b-5p	CLIP-seq
MIRT952282	hsa-miR-597	CLIP-seq
MIRT952283	hsa-miR-607	CLIP-seq
MIRT952284	hsa-miR-877	CLIP-seq
MIRT1981980	hsa-miR-1245b-5p	CLIP-seq
MIRT1981981	hsa-miR-148a	CLIP-seq
MIRT1981982	hsa-miR-148b	CLIP-seq
MIRT1981983	hsa-miR-152	CLIP-seq
MIRT1981984	hsa-miR-1913	CLIP-seq
MIRT1981985	hsa-miR-3120-5p	CLIP-seq
MIRT1981986	hsa-miR-3135	CLIP-seq
MIRT1981987	hsa-miR-3142	CLIP-seq
MIRT1981988	hsa-miR-3148	CLIP-seq
MIRT1981989	hsa-miR-3176	CLIP-seq
MIRT1981990	hsa-miR-3189-5p	CLIP-seq
MIRT1981991	hsa-miR-3194-5p	CLIP-seq
MIRT1981992	hsa-miR-324-3p	CLIP-seq
MIRT1981993	hsa-miR-346	CLIP-seq
MIRT1981994	hsa-miR-3647-3p	CLIP-seq
MIRT1981995	hsa-miR-3688-3p	CLIP-seq
MIRT1981996	hsa-miR-3922-3p	CLIP-seq
MIRT1981997	hsa-miR-4276	CLIP-seq
MIRT1981998	hsa-miR-4288	CLIP-seq
MIRT1981999	hsa-miR-4421	CLIP-seq
MIRT952276	hsa-miR-4436b-5p	CLIP-seq
MIRT1982000	hsa-miR-4725-5p	CLIP-seq
MIRT1982001	hsa-miR-4753-5p	CLIP-seq
MIRT1982002	hsa-miR-4758-3p	CLIP-seq
MIRT1982003	hsa-miR-4802-3p	CLIP-seq
MIRT1982004	hsa-miR-504	CLIP-seq
MIRT1982005	hsa-miR-632	CLIP-seq
MIRT952284	hsa-miR-877	CLIP-seq
MIRT952271	hsa-miR-1266	CLIP-seq
MIRT2216868	hsa-miR-3622b-5p	CLIP-seq
MIRT952274	hsa-miR-3664-3p	CLIP-seq
MIRT952278	hsa-miR-4518	CLIP-seq
MIRT2216869	hsa-miR-4645-5p	CLIP-seq
MIRT2216870	hsa-miR-4673	CLIP-seq
MIRT952279	hsa-miR-4695-3p	CLIP-seq
MIRT1981980	hsa-miR-1245b-5p	CLIP-seq
MIRT2520914	hsa-miR-125a-5p	CLIP-seq
MIRT2520915	hsa-miR-125b	CLIP-seq
MIRT2520916	hsa-miR-1273f	CLIP-seq
MIRT2520917	hsa-miR-140-3p	CLIP-seq
MIRT2520918	hsa-miR-1825	CLIP-seq
MIRT1981984	hsa-miR-1913	CLIP-seq
MIRT2520919	hsa-miR-2861	CLIP-seq
MIRT1981986	hsa-miR-3135	CLIP-seq
MIRT1981987	hsa-miR-3142	CLIP-seq
MIRT1981990	hsa-miR-3189-5p	CLIP-seq
MIRT1981991	hsa-miR-3194-5p	CLIP-seq
MIRT1981992	hsa-miR-324-3p	CLIP-seq
MIRT2520920	hsa-miR-4319	CLIP-seq
MIRT2520921	hsa-miR-4468	CLIP-seq
MIRT2520922	hsa-miR-4484	CLIP-seq
MIRT2520923	hsa-miR-4488	CLIP-seq
MIRT2520924	hsa-miR-4697-5p	CLIP-seq
MIRT1982000	hsa-miR-4725-5p	CLIP-seq
MIRT2520925	hsa-miR-4732-3p	CLIP-seq
MIRT1982001	hsa-miR-4753-5p	CLIP-seq
MIRT2520926	hsa-miR-4756-3p	CLIP-seq
MIRT1982002	hsa-miR-4758-3p	CLIP-seq
MIRT1982004	hsa-miR-504	CLIP-seq
MIRT2520927	hsa-miR-548an	CLIP-seq
MIRT2520928	hsa-miR-670	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IBA
GO:0000932	Component	P-body	IDA	20826699
GO:0000932	Component	P-body	IEA
GO:0005515	Function	Protein binding	IPI	15231747, 16364915, 19966221, 20543818, 20584987, 21903422, 22982864, 23064648, 24510189, 25036637, 26496610, 27918561, 28514442, 31422817, 33961781, 34819669, 35271311
GO:0005634	Component	Nucleus	IDA	7520377
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9067524
GO:0005829	Component	Cytosol	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0031087	Process	Deadenylation-independent decapping of nuclear-transcribed mRNA	IBA
GO:0031087	Process	Deadenylation-independent decapping of nuclear-transcribed mRNA	IEA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA

MIM	HGNC	e!Ensembl
606030	17157	ENSG00000038358

Protein

UniProt ID

Q6P2E9

Protein name

Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)

Protein function

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the ca

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16529	Ge1_WD40	114 → 441	WD40 region of Ge1, enhancer of mRNA-decapping protein	Domain

Sequence

MASCASIDIEDATQHLRDILKLDRPAGGPSAESPRPSSAYNGDLNGLLVPDPLCSGDSTS
ANKTGLRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVASSDSSISSKARGSNKVKI
QPVAKYDWEQKYYYGNLIAVSNSFLAYAIRAANNGSAMVRVISVSTSERTLLKGFTGSVA
DLAFAHLNSPQLACLDEAGNLFVWRLALVNGKIQEEILVHIRQPEGTPLNHFRRIIWCPF
IPEESEDCCEESSPTVALLHEDRAEVWDLDMLRSSHSTWPVDVSQIKQGFIVVKGHSTCL
SEGALSPDGTVLATASHDGYVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQ
DPDVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPSLKVCLDLSAEY
LILSDVQRKVLYVMELLQNQEEGHACFSSISEFLLTHPVLSFGIQVVSRCRLRHTEVLPA
EEENDSLGADGTHGAGAMESAAGVLIKLFCVHTKALQDVQIRFQPQLNPDVVAPLPTHTA
HEDFTFGESRPELGSEGLGSAAHGSQPDLRRIVELPAPADFLSLSSETKPKLMTPDAFMT
PSASLQQITASPSSSSSGSSSSSSSSSSSLTAVSAMSSTSAVDPSLTRPPEELTLSPKLQ
LDGSLTMSSSGSLQASPRGLLPGLLPAPADKLTPKGPGQVPTATSALSLELQEVEPLGLP
QASPSRTRSPDVISSASTALSQDIPEIASEALSRGFGSSAPEGLEPDSMASAASALHLLS
PRPRPGPELGPQLGLDGGPGDGDRHNTPSLLEAALTQEASTPDSQVWPTAPDITRETCST
LAESPRNGLQEKHKSLAFHRPPYHLLQQRDSQDASAEQSDHDDEVASLASASGGFGTKVP
APRLPAKDWKTKGSPRTSPKLKRKSKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRE
LAELRHSQEELLQRLCTQLEGLQSTVTGHVERALETRHEQEQRRLERALAEGQQRGGQLQ
EQLTQQLSQALSSAVAGRLERSIRDEIKKTVPPCVSRSLEPMAGQLSNSVATKLTAVEGS
MKENISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDS
FRLGTQEYLQQLESHMKSRKAREQEAREPVLAQLRGLVSTLQSATEQMAATVAGSVRAEV
QHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQAAVTSSIMQAMRSAAGTPVPSAHLD
CQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLS
LIQQLASDLGTRTDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQAEPHNS
LGKAARRLSLMLHGLVTPSLP

Sequence length

1401

Interactions

View interactions

	KEGG		Reactome
	RNA degradation		mRNA decay by 5' to 3' exoribonuclease

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Autoimmune Diseases	Associate	9067524
Breast Neoplasms	Associate	28027327, 29511213
Leukemia Myeloid Acute	Associate	30833276
Triple Negative Breast Neoplasms	Associate	38592437
Uterine Cervical Neoplasms	Associate	33054858

EDC4 (enhancer of mRNA decapping 4)