Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	23644
Gene name	Enhancer of mRNA decapping 4
Gene symbol	EDC4
Synonyms (NCBI Gene)	GE1Ge-1HEDL5HEDLSRCD-8RCD8
Chromosome	16
Chromosome location	16q22.1

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031748	hsa-miR-16-5p	Proteomics	18668040
MIRT049266	hsa-miR-92a-3p	CLASH	23622248
MIRT046437	hsa-miR-15b-5p	CLASH	23622248
MIRT036488	hsa-miR-1226-3p	CLASH	23622248
MIRT952271	hsa-miR-1266	CLIP-seq
MIRT952272	hsa-miR-1305	CLIP-seq
MIRT952273	hsa-miR-3613-3p	CLIP-seq
MIRT952274	hsa-miR-3664-3p	CLIP-seq
MIRT952275	hsa-miR-4307	CLIP-seq
MIRT952276	hsa-miR-4436b-5p	CLIP-seq
MIRT952277	hsa-miR-4452	CLIP-seq
MIRT952278	hsa-miR-4518	CLIP-seq
MIRT952279	hsa-miR-4695-3p	CLIP-seq
MIRT952280	hsa-miR-513c	CLIP-seq
MIRT952281	hsa-miR-514b-5p	CLIP-seq
MIRT952282	hsa-miR-597	CLIP-seq
MIRT952283	hsa-miR-607	CLIP-seq
MIRT952284	hsa-miR-877	CLIP-seq
MIRT1981980	hsa-miR-1245b-5p	CLIP-seq
MIRT1981981	hsa-miR-148a	CLIP-seq
MIRT1981982	hsa-miR-148b	CLIP-seq
MIRT1981983	hsa-miR-152	CLIP-seq
MIRT1981984	hsa-miR-1913	CLIP-seq
MIRT1981985	hsa-miR-3120-5p	CLIP-seq
MIRT1981986	hsa-miR-3135	CLIP-seq
MIRT1981987	hsa-miR-3142	CLIP-seq
MIRT1981988	hsa-miR-3148	CLIP-seq
MIRT1981989	hsa-miR-3176	CLIP-seq
MIRT1981990	hsa-miR-3189-5p	CLIP-seq
MIRT1981991	hsa-miR-3194-5p	CLIP-seq
MIRT1981992	hsa-miR-324-3p	CLIP-seq
MIRT1981993	hsa-miR-346	CLIP-seq
MIRT1981994	hsa-miR-3647-3p	CLIP-seq
MIRT1981995	hsa-miR-3688-3p	CLIP-seq
MIRT1981996	hsa-miR-3922-3p	CLIP-seq
MIRT1981997	hsa-miR-4276	CLIP-seq
MIRT1981998	hsa-miR-4288	CLIP-seq
MIRT1981999	hsa-miR-4421	CLIP-seq
MIRT952276	hsa-miR-4436b-5p	CLIP-seq
MIRT1982000	hsa-miR-4725-5p	CLIP-seq
MIRT1982001	hsa-miR-4753-5p	CLIP-seq
MIRT1982002	hsa-miR-4758-3p	CLIP-seq
MIRT1982003	hsa-miR-4802-3p	CLIP-seq
MIRT1982004	hsa-miR-504	CLIP-seq
MIRT1982005	hsa-miR-632	CLIP-seq
MIRT952284	hsa-miR-877	CLIP-seq
MIRT952271	hsa-miR-1266	CLIP-seq
MIRT2216868	hsa-miR-3622b-5p	CLIP-seq
MIRT952274	hsa-miR-3664-3p	CLIP-seq
MIRT952278	hsa-miR-4518	CLIP-seq
MIRT2216869	hsa-miR-4645-5p	CLIP-seq
MIRT2216870	hsa-miR-4673	CLIP-seq
MIRT952279	hsa-miR-4695-3p	CLIP-seq
MIRT1981980	hsa-miR-1245b-5p	CLIP-seq
MIRT2520914	hsa-miR-125a-5p	CLIP-seq
MIRT2520915	hsa-miR-125b	CLIP-seq
MIRT2520916	hsa-miR-1273f	CLIP-seq
MIRT2520917	hsa-miR-140-3p	CLIP-seq
MIRT2520918	hsa-miR-1825	CLIP-seq
MIRT1981984	hsa-miR-1913	CLIP-seq
MIRT2520919	hsa-miR-2861	CLIP-seq
MIRT1981986	hsa-miR-3135	CLIP-seq
MIRT1981987	hsa-miR-3142	CLIP-seq
MIRT1981990	hsa-miR-3189-5p	CLIP-seq
MIRT1981991	hsa-miR-3194-5p	CLIP-seq
MIRT1981992	hsa-miR-324-3p	CLIP-seq
MIRT2520920	hsa-miR-4319	CLIP-seq
MIRT2520921	hsa-miR-4468	CLIP-seq
MIRT2520922	hsa-miR-4484	CLIP-seq
MIRT2520923	hsa-miR-4488	CLIP-seq
MIRT2520924	hsa-miR-4697-5p	CLIP-seq
MIRT1982000	hsa-miR-4725-5p	CLIP-seq
MIRT2520925	hsa-miR-4732-3p	CLIP-seq
MIRT1982001	hsa-miR-4753-5p	CLIP-seq
MIRT2520926	hsa-miR-4756-3p	CLIP-seq
MIRT1982002	hsa-miR-4758-3p	CLIP-seq
MIRT1982004	hsa-miR-504	CLIP-seq
MIRT2520927	hsa-miR-548an	CLIP-seq
MIRT2520928	hsa-miR-670	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IBA
GO:0000932	Component	P-body	IDA	20826699
GO:0000932	Component	P-body	IEA
GO:0005515	Function	Protein binding	IPI	15231747, 16364915, 19966221, 20543818, 20584987, 21903422, 22982864, 23064648, 24510189, 25036637, 26496610, 27918561, 28514442, 31422817, 33961781, 34819669, 35271311
GO:0005634	Component	Nucleus	IDA	7520377
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	9067524
GO:0005829	Component	Cytosol	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0031087	Process	Deadenylation-independent decapping of nuclear-transcribed mRNA	IBA
GO:0031087	Process	Deadenylation-independent decapping of nuclear-transcribed mRNA	IEA
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA

MIM	HGNC	e!Ensembl
606030	17157	ENSG00000038358

Q6P2E9

Protein name

Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)

Protein function

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the ca

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16529	Ge1_WD40	114 → 441	WD40 region of Ge1, enhancer of mRNA-decapping protein	Domain

Sequence

MASCASIDIEDATQHLRDILKLDRPAGGPSAESPRPSSAYNGDLNGLLVPDPLCSGDSTS
ANKTGLRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVASSDSSISSKARGSNKVKI
QPVAKYDWEQKYYYGNLIAVSNSFLAYAIRAANNGSAMVRVISVSTSERTLLKGFTGSVA
DLAFAHLNSPQLACLDEAGNLFVWRLALVNGKIQEEILVHIRQPEGTPLNHFRRIIWCPF
IPEESEDCCEESSPTVALLHEDRAEVWDLDMLRSSHSTWPVDVSQIKQGFIVVKGHSTCL
SEGALSPDGTVLATASHDGYVKFWQIYIEGQDEPRCLHEWKPHDGRPLSCLLFCDNHKKQ
DPDVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPSLKVCLDLSAEY
LILSDVQRKVLYVMELLQNQEEGHACFSSISEFLLTHPVLSFGIQVVSRCRLRHTEVLPA
EEENDSLGADGTHGAGAMESAAGVLIKLFCVHTKALQDVQIRFQPQLNPDVVAPLPTHTA
HEDFTFGESRPELGSEGLGSAAHGSQPDLRRIVELPAPADFLSLSSETKPKLMTPDAFMT
PSASLQQITASPSSSSSGSSSSSSSSSSSLTAVSAMSSTSAVDPSLTRPPEELTLSPKLQ
LDGSLTMSSSGSLQASPRGLLPGLLPAPADKLTPKGPGQVPTATSALSLELQEVEPLGLP
QASPSRTRSPDVISSASTALSQDIPEIASEALSRGFGSSAPEGLEPDSMASAASALHLLS
PRPRPGPELGPQLGLDGGPGDGDRHNTPSLLEAALTQEASTPDSQVWPTAPDITRETCST
LAESPRNGLQEKHKSLAFHRPPYHLLQQRDSQDASAEQSDHDDEVASLASASGGFGTKVP
APRLPAKDWKTKGSPRTSPKLKRKSKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRE
LAELRHSQEELLQRLCTQLEGLQSTVTGHVERALETRHEQEQRRLERALAEGQQRGGQLQ
EQLTQQLSQALSSAVAGRLERSIRDEIKKTVPPCVSRSLEPMAGQLSNSVATKLTAVEGS
MKENISKLLKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDS
FRLGTQEYLQQLESHMKSRKAREQEAREPVLAQLRGLVSTLQSATEQMAATVAGSVRAEV
QHQLHVAVGSLQESILAQVQRIVKGEVSVALKEQQAAVTSSIMQAMRSAAGTPVPSAHLD
CQAQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLS
LIQQLASDLGTRTDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQAEPHNS
LGKAARRLSLMLHGLVTPSLP

Sequence length

1401

Interactions

View interactions

	KEGG		Reactome
	RNA degradation		mRNA decay by 5' to 3' exoribonuclease

EDC4 (enhancer of mRNA decapping 4)