Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23643
Gene name Gene Name - the full gene name approved by the HGNC.	Lymphocyte antigen 96
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LY96
Synonyms (NCBI Gene) Gene synonyms aliases	ESOP-1, MD-2, MD2, ly-96
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q21.11
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that thi

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
CREB5	Repression	21132541
STAT1	Activation	21572044

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001530	Function	Lipopolysaccharide binding	IEA
GO:0001875	Function	Lipopolysaccharide immune receptor activity	IBA
GO:0001875	Function	Lipopolysaccharide immune receptor activity	IDA	19252480
GO:0002221	Process	Pattern recognition receptor signaling pathway	IEA
GO:0002224	Process	Toll-like receptor signaling pathway	IDA	14607928
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	15728506, 17803912, 19060881, 19252480, 20547845, 22474354, 22532668, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IDA	11274165
GO:0005886	Component	Plasma membrane	NAS	33576548
GO:0005886	Component	Plasma membrane	TAS	10359581
GO:0006954	Process	Inflammatory response	IEA
GO:0006968	Process	Cellular defense response	TAS	10359581
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10359581
GO:0010008	Component	Endosome membrane	TAS
GO:0015026	Function	Coreceptor activity	TAS	10359581
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IEA
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IEA
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	IBA
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	IEA
GO:0032496	Process	Response to lipopolysaccharide	IDA	12594207
GO:0032496	Process	Response to lipopolysaccharide	IDA	14607928
GO:0032497	Process	Detection of lipopolysaccharide	IBA
GO:0032497	Process	Detection of lipopolysaccharide	IDA	19252480
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032760	Process	Positive regulation of tumor necrosis factor production	ISS
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IBA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IEA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	ISS
GO:0035662	Function	Toll-like receptor 4 binding	IEA
GO:0043235	Component	Receptor complex	IPI	19252480
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	NAS	33576548
GO:0046696	Component	Lipopolysaccharide receptor complex	IBA
GO:0046696	Component	Lipopolysaccharide receptor complex	IDA	11274165, 19252480
GO:0046696	Component	Lipopolysaccharide receptor complex	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA

MIM	HGNC	e!Ensembl
605243	17156	ENSG00000154589

Protein

UniProt ID

Q9Y6Y9

Protein name

Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2)

Protein function

Binds bacterial lipopolysaccharide (LPS) (PubMed:17569869, PubMed:17803912). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and G

PDB

2E56 , 2E59 , 2Z65 , 3FXI , 3ULA , 4G8A , 8WO1 , 8WTA

Family and domains

Sequence

MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGL
LHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFS
FKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN

Sequence length

160

Interactions

View interactions

	KEGG		Reactome
	NF-kappa B signaling pathway Toll-like receptor signaling pathway Alcoholic liver disease Salmonella infection Pertussis Toxoplasmosis Lipid and atherosclerosis		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

LY96 (lymphocyte antigen 96)