Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23643
Gene name	Lymphocyte antigen 96
Gene symbol	LY96
Synonyms (NCBI Gene)	ESOP-1MD-2MD2ly-96
Chromosome	8
Chromosome location	8q21.11
Summary	This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that thi

Show/Hide all (2)

Transcription factor	Regulation	Reference
CREB5	Repression	21132541
STAT1	Activation	21572044

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001530	Function	Lipopolysaccharide binding	IEA
GO:0001875	Function	Lipopolysaccharide immune receptor activity	IBA
GO:0001875	Function	Lipopolysaccharide immune receptor activity	IDA	19252480
GO:0002221	Process	Pattern recognition receptor signaling pathway	IEA
GO:0002224	Process	Toll-like receptor signaling pathway	IDA	14607928
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	15728506, 17803912, 19060881, 19252480, 20547845, 22474354, 22532668, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005886	Component	Plasma membrane	IDA	11274165
GO:0005886	Component	Plasma membrane	NAS	33576548
GO:0005886	Component	Plasma membrane	TAS	10359581
GO:0006954	Process	Inflammatory response	IEA
GO:0006968	Process	Cellular defense response	TAS	10359581
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10359581
GO:0010008	Component	Endosome membrane	TAS
GO:0015026	Function	Coreceptor activity	TAS	10359581
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IEA
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IEA
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	IBA
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	IEA
GO:0032496	Process	Response to lipopolysaccharide	IDA	12594207
GO:0032496	Process	Response to lipopolysaccharide	IDA	14607928
GO:0032497	Process	Detection of lipopolysaccharide	IBA
GO:0032497	Process	Detection of lipopolysaccharide	IDA	19252480
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IEA
GO:0032760	Process	Positive regulation of tumor necrosis factor production	ISS
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IBA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IEA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	ISS
GO:0035662	Function	Toll-like receptor 4 binding	IEA
GO:0043235	Component	Receptor complex	IPI	19252480
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	NAS	33576548
GO:0046696	Component	Lipopolysaccharide receptor complex	IBA
GO:0046696	Component	Lipopolysaccharide receptor complex	IDA	11274165, 19252480
GO:0046696	Component	Lipopolysaccharide receptor complex	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IBA
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA

MIM	HGNC	e!Ensembl
605243	17156	ENSG00000154589

Q9Y6Y9

Protein name

Lymphocyte antigen 96 (Ly-96) (ESOP-1) (Protein MD-2)

Protein function

Binds bacterial lipopolysaccharide (LPS) (PubMed:17569869, PubMed:17803912). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and G

PDB

2E56 , 2E59 , 2Z65 , 3FXI , 3ULA , 4G8A , 8WO1 , 8WTA

Family and domains

Sequence

MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGL
LHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFS
FKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN

Sequence length

160

Interactions

View interactions

	KEGG		Reactome
	NF-kappa B signaling pathway Toll-like receptor signaling pathway Alcoholic liver disease Salmonella infection Pertussis Toxoplasmosis Lipid and atherosclerosis		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ARTHRITIS, RHEUMATOID	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLESTASIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (36)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Psoriatic	Associate	39509434	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Associate	34177888, 35789606, 35844557, 37667923, 39509434	★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Associate	22192168	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Associate	26385043	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brain Injuries Traumatic	Associate	28222567	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	2765362	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Associate	27118139	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	36932108	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Periodontitis	Associate	15664906	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Associate	24971461	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	20699280, 22180778, 32210720	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Death	Associate	36429083, 36932108	★★★★★ ★☆☆☆☆ Found in Text Mining only
Drug Hypersensitivity	Associate	24648737	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometriosis	Associate	36339397	★★★★★ ★☆☆☆☆ Found in Text Mining only
Enterocolitis Necrotizing	Associate	25816011	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Associate	19423540	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heredodegenerative Disorders Nervous System	Associate	38614225	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Associate	29351188, 32099002	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infections	Associate	17643099	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	11923281, 19710105, 20959532, 24971461, 26385043, 26581717, 32210720, 38256136, 40252899	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Stimulate	19710105, 23437263	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intervertebral disc disease	Associate	35767190	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lipoma of the Conjunctiva	Associate	34349764	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Associate	22180778	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Associate	38218802	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	22180778, 32210720	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	17643099, 20699280, 22180778, 2765362, 32210720, 38256136	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroinflammatory Diseases	Associate	36032146	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	27118139	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Associate	38614225	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Associate	26581717, 38218802	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precancerous Conditions	Associate	34334530	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	20438785	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Associate	32099002	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Carcinoma Anaplastic	Associate	37990304	★★★★★ ★☆☆☆☆ Found in Text Mining only
Wilms Tumor	Associate	34334530	★★★★★ ★☆☆☆☆ Found in Text Mining only

LY96 (lymphocyte antigen 96)