BACE1 (beta-secretase 1)

Gene

• Entrez ID: 23621
• Gene name: Beta-secretase 1
• Gene symbol: BACE1
• Synonyms (NCBI Gene): ASP2, BACE, HSPC104
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. Thi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000800	hsa-miR-107	Western blot, Northern blot	18234899
MIRT001825	hsa-miR-124-3p	Luciferase reporter assay	18434550
MIRT001802	hsa-miR-15a-5p	Luciferase reporter assay	18434550
MIRT001793	hsa-miR-19b-3p	Luciferase reporter assay	18434550
MIRT001766	hsa-miR-29a-3p	Luciferase reporter assay, Western blot	18434550
MIRT000930	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	18434550
MIRT001736	hsa-miR-9-5p	Luciferase reporter assay	18434550
MIRT000930	hsa-miR-29b-3p	Luciferase reporter assay, Western blot	18434550
MIRT000800	hsa-miR-107	Western blot, Northern blot	18234899
MIRT000800	hsa-miR-107	Western blot, Northern blot	18234899
MIRT000800	hsa-miR-107	Western blot, Northern blot	18234899
MIRT000800	hsa-miR-107	Luciferase reporter assay	18234899
MIRT000103	hsa-miR-298	Luciferase reporter assay	18642050
MIRT001766	hsa-miR-29a-3p	Luciferase reporter assay	18434550
MIRT000930	hsa-miR-29b-3p	Luciferase reporter assay	18434550
MIRT000080	hsa-miR-328-3p	Luciferase reporter assay	18716028
MIRT020416	hsa-miR-29c-3p	Reporter assay;Western blot;qRT-PCR	21565331
MIRT001736	hsa-miR-9-5p	Reporter assay;Other	18434550
MIRT000800	hsa-miR-107	Western blot;Microarray	20489155
MIRT000800	hsa-miR-107	Reporter assay	18234899
MIRT001766	hsa-miR-29a-3p	Reporter assay;Other	18434550
MIRT030156	hsa-miR-26b-5p	Microarray	19088304
MIRT001793	hsa-miR-19b-3p	Reporter assay;Other	18434550
MIRT001802	hsa-miR-15a-5p	Reporter assay;Other	18434550
MIRT050944	hsa-miR-17-5p	CLASH	23622248
MIRT438049	hsa-miR-339-5p	Luciferase reporter assay, qRT-PCR, Western blot	24352696
MIRT438049	hsa-miR-339-5p	Luciferase reporter assay, qRT-PCR, Western blot	24352696
MIRT438049	hsa-miR-339-5p	Luciferase reporter assay, qRT-PCR, Western blot	24352696
MIRT438049	hsa-miR-339-5p	Luciferase reporter assay, qRT-PCR, Western blot	24352696
MIRT438049	hsa-miR-339-5p	Luciferase reporter assay, qRT-PCR, Western blot	24352696
MIRT438049	hsa-miR-339-5p	Luciferase reporter assay, qRT-PCR, Western blot	24352696
MIRT438049	hsa-miR-339-5p	Luciferase reporter assay, qRT-PCR, Western blot	24352696
MIRT438049	hsa-miR-339-5p	Luciferase reporter assay, qRT-PCR, Western blot	24352696
MIRT714365	hsa-miR-1267	HITS-CLIP	19536157
MIRT714364	hsa-miR-7159-5p	HITS-CLIP	19536157
MIRT714363	hsa-miR-505-3p	HITS-CLIP	19536157
MIRT714362	hsa-miR-421	HITS-CLIP	19536157
MIRT714361	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT714365	hsa-miR-1267	HITS-CLIP	19536157
MIRT714364	hsa-miR-7159-5p	HITS-CLIP	19536157
MIRT714363	hsa-miR-505-3p	HITS-CLIP	19536157
MIRT714362	hsa-miR-421	HITS-CLIP	19536157
MIRT714361	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT732050	hsa-miR-16-5p	ELISA, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	26440600
MIRT732050	hsa-miR-16-5p	ELISA, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	26440600
MIRT732050	hsa-miR-16-5p	ELISA, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	26440600
MIRT732050	hsa-miR-16-5p	ELISA, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	26440600
MIRT000930	hsa-miR-29b-3p	ELISA	26818210
MIRT020416	hsa-miR-29c-3p	Luciferase reporter assay, qRT-PCR, Western blot	25973041
MIRT732984	hsa-miR-31-5p	Immunohistochemistry (IHC), qRT-PCR	32069773
MIRT000800	hsa-miR-107	Luciferase reporter assay, Western blotting, qRT-PCR	32674073
MIRT714365	hsa-miR-1267	HITS-CLIP	19536157
MIRT714364	hsa-miR-7159-5p	HITS-CLIP	19536157
MIRT714363	hsa-miR-505-3p	HITS-CLIP	19536157
MIRT714362	hsa-miR-421	HITS-CLIP	19536157
MIRT714361	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT714365	hsa-miR-1267	HITS-CLIP	19536157
MIRT714364	hsa-miR-7159-5p	HITS-CLIP	19536157
MIRT714363	hsa-miR-505-3p	HITS-CLIP	19536157
MIRT714362	hsa-miR-421	HITS-CLIP	19536157
MIRT714361	hsa-miR-653-5p	HITS-CLIP	19536157
MIRT814134	hsa-miR-1252	CLIP-seq
MIRT814135	hsa-miR-1912	CLIP-seq
MIRT814136	hsa-miR-28-5p	CLIP-seq
MIRT814137	hsa-miR-3139	CLIP-seq
MIRT814138	hsa-miR-3153	CLIP-seq
MIRT814139	hsa-miR-345	CLIP-seq
MIRT814140	hsa-miR-374a	CLIP-seq
MIRT814141	hsa-miR-374b	CLIP-seq
MIRT814142	hsa-miR-3925-5p	CLIP-seq
MIRT814143	hsa-miR-4260	CLIP-seq
MIRT814144	hsa-miR-4266	CLIP-seq
MIRT814145	hsa-miR-4271	CLIP-seq
MIRT814146	hsa-miR-4476	CLIP-seq
MIRT814147	hsa-miR-4533	CLIP-seq
MIRT814148	hsa-miR-4685-5p	CLIP-seq
MIRT814149	hsa-miR-4704-3p	CLIP-seq
MIRT814150	hsa-miR-4706	CLIP-seq
MIRT814151	hsa-miR-4709-3p	CLIP-seq
MIRT814152	hsa-miR-4725-3p	CLIP-seq
MIRT814153	hsa-miR-4728-5p	CLIP-seq
MIRT814154	hsa-miR-4731-3p	CLIP-seq
MIRT814155	hsa-miR-4749-5p	CLIP-seq
MIRT814156	hsa-miR-4773	CLIP-seq
MIRT814157	hsa-miR-4775	CLIP-seq
MIRT814158	hsa-miR-4781-5p	CLIP-seq
MIRT814159	hsa-miR-4801	CLIP-seq
MIRT814160	hsa-miR-486-3p	CLIP-seq
MIRT814161	hsa-miR-508-5p	CLIP-seq
MIRT814162	hsa-miR-548a-3p	CLIP-seq
MIRT814163	hsa-miR-548ae	CLIP-seq
MIRT814164	hsa-miR-548aj	CLIP-seq
MIRT814165	hsa-miR-548am	CLIP-seq
MIRT814166	hsa-miR-548e	CLIP-seq
MIRT814167	hsa-miR-548f	CLIP-seq
MIRT814168	hsa-miR-548x	CLIP-seq
MIRT814169	hsa-miR-577	CLIP-seq
MIRT814170	hsa-miR-589	CLIP-seq
MIRT814171	hsa-miR-590-3p	CLIP-seq
MIRT814172	hsa-miR-708	CLIP-seq
MIRT814173	hsa-miR-1207-3p	CLIP-seq
MIRT814174	hsa-miR-1244	CLIP-seq
MIRT814134	hsa-miR-1252	CLIP-seq
MIRT814175	hsa-miR-1295	CLIP-seq
MIRT814176	hsa-miR-15a	CLIP-seq
MIRT814177	hsa-miR-15b	CLIP-seq
MIRT814178	hsa-miR-16	CLIP-seq
MIRT814179	hsa-miR-195	CLIP-seq
MIRT814180	hsa-miR-29a	CLIP-seq
MIRT814181	hsa-miR-29b	CLIP-seq
MIRT814182	hsa-miR-29c	CLIP-seq
MIRT814183	hsa-miR-3064-5p	CLIP-seq
MIRT814184	hsa-miR-3065-3p	CLIP-seq
MIRT814185	hsa-miR-3120-3p	CLIP-seq
MIRT814186	hsa-miR-3127-5p	CLIP-seq
MIRT814187	hsa-miR-3145-3p	CLIP-seq
MIRT814188	hsa-miR-3157-5p	CLIP-seq
MIRT814189	hsa-miR-330-3p	CLIP-seq
MIRT814190	hsa-miR-3591-3p	CLIP-seq
MIRT814191	hsa-miR-3607-3p	CLIP-seq
MIRT814192	hsa-miR-3653	CLIP-seq
MIRT814193	hsa-miR-3658	CLIP-seq
MIRT814194	hsa-miR-3689a-5p	CLIP-seq
MIRT814195	hsa-miR-3689b	CLIP-seq
MIRT814196	hsa-miR-3689e	CLIP-seq
MIRT814197	hsa-miR-3689f	CLIP-seq
MIRT814198	hsa-miR-3918	CLIP-seq
MIRT814199	hsa-miR-424	CLIP-seq
MIRT814200	hsa-miR-4287	CLIP-seq
MIRT814201	hsa-miR-4290	CLIP-seq
MIRT814202	hsa-miR-4446-3p	CLIP-seq
MIRT814203	hsa-miR-4446-5p	CLIP-seq
MIRT814204	hsa-miR-4469	CLIP-seq
MIRT814146	hsa-miR-4476	CLIP-seq
MIRT814205	hsa-miR-4477a	CLIP-seq
MIRT814147	hsa-miR-4533	CLIP-seq
MIRT814206	hsa-miR-4649-3p	CLIP-seq
MIRT814207	hsa-miR-4656	CLIP-seq
MIRT814208	hsa-miR-4667-3p	CLIP-seq
MIRT814209	hsa-miR-4670-3p	CLIP-seq
MIRT814210	hsa-miR-4685-3p	CLIP-seq
MIRT814211	hsa-miR-4691-3p	CLIP-seq
MIRT814212	hsa-miR-4717-5p	CLIP-seq
MIRT814213	hsa-miR-4755-5p	CLIP-seq
MIRT814214	hsa-miR-497	CLIP-seq
MIRT814215	hsa-miR-498	CLIP-seq
MIRT814216	hsa-miR-519a	CLIP-seq
MIRT814217	hsa-miR-519b-3p	CLIP-seq
MIRT814218	hsa-miR-519c-3p	CLIP-seq
MIRT814219	hsa-miR-642a	CLIP-seq
MIRT814220	hsa-miR-643	CLIP-seq
MIRT814221	hsa-miR-653	CLIP-seq
MIRT814222	hsa-miR-873	CLIP-seq
MIRT814223	hsa-miR-922	CLIP-seq
MIRT1545671	hsa-miR-1200	CLIP-seq
MIRT1545672	hsa-miR-3150a-3p	CLIP-seq
MIRT1545673	hsa-miR-3175	CLIP-seq
MIRT1545674	hsa-miR-3176	CLIP-seq
MIRT1545675	hsa-miR-3194-3p	CLIP-seq
MIRT1545676	hsa-miR-3907	CLIP-seq
MIRT1545677	hsa-miR-3922-3p	CLIP-seq
MIRT1545678	hsa-miR-4324	CLIP-seq
MIRT1545679	hsa-miR-4701-5p	CLIP-seq
MIRT1545680	hsa-miR-4711-3p	CLIP-seq
MIRT814153	hsa-miR-4728-5p	CLIP-seq
MIRT1545681	hsa-miR-491-5p	CLIP-seq
MIRT1545682	hsa-miR-544b	CLIP-seq
MIRT1545683	hsa-miR-552	CLIP-seq
MIRT1545684	hsa-miR-588	CLIP-seq
MIRT1545685	hsa-miR-764	CLIP-seq
MIRT1545686	hsa-miR-939	CLIP-seq
MIRT1940726	hsa-miR-2682	CLIP-seq
MIRT1940727	hsa-miR-3714	CLIP-seq
MIRT1940728	hsa-miR-449c	CLIP-seq
MIRT1940729	hsa-miR-3132	CLIP-seq
MIRT1940730	hsa-miR-3156-3p	CLIP-seq
MIRT1545675	hsa-miR-3194-3p	CLIP-seq
MIRT1940731	hsa-miR-4301	CLIP-seq
MIRT814203	hsa-miR-4446-5p	CLIP-seq
MIRT1940732	hsa-miR-4727-5p	CLIP-seq
MIRT1545671	hsa-miR-1200	CLIP-seq
MIRT2179726	hsa-miR-128	CLIP-seq
MIRT2179727	hsa-miR-1293	CLIP-seq
MIRT2179728	hsa-miR-140-3p	CLIP-seq
MIRT2179729	hsa-miR-2114	CLIP-seq
MIRT2179730	hsa-miR-27a	CLIP-seq
MIRT2179731	hsa-miR-27b	CLIP-seq
MIRT1545672	hsa-miR-3150a-3p	CLIP-seq
MIRT814138	hsa-miR-3153	CLIP-seq
MIRT1545673	hsa-miR-3175	CLIP-seq
MIRT1545674	hsa-miR-3176	CLIP-seq
MIRT2179732	hsa-miR-3189-3p	CLIP-seq
MIRT1545675	hsa-miR-3194-3p	CLIP-seq
MIRT2179733	hsa-miR-3649	CLIP-seq
MIRT1545676	hsa-miR-3907	CLIP-seq
MIRT1545677	hsa-miR-3922-3p	CLIP-seq
MIRT2179734	hsa-miR-4274	CLIP-seq
MIRT2179735	hsa-miR-4308	CLIP-seq
MIRT1545678	hsa-miR-4324	CLIP-seq
MIRT2179736	hsa-miR-4483	CLIP-seq
MIRT2179737	hsa-miR-4519	CLIP-seq
MIRT2179738	hsa-miR-4642	CLIP-seq
MIRT814148	hsa-miR-4685-5p	CLIP-seq
MIRT1545679	hsa-miR-4701-5p	CLIP-seq
MIRT814153	hsa-miR-4728-5p	CLIP-seq
MIRT2179739	hsa-miR-4778-5p	CLIP-seq
MIRT2179740	hsa-miR-4795-3p	CLIP-seq
MIRT2179741	hsa-miR-4803	CLIP-seq
MIRT1545681	hsa-miR-491-5p	CLIP-seq
MIRT2179742	hsa-miR-499-3p	CLIP-seq
MIRT2179743	hsa-miR-499a-3p	CLIP-seq
MIRT814161	hsa-miR-508-5p	CLIP-seq
MIRT2179744	hsa-miR-5096	CLIP-seq
MIRT2179745	hsa-miR-513a-5p	CLIP-seq
MIRT1545682	hsa-miR-544b	CLIP-seq
MIRT1545683	hsa-miR-552	CLIP-seq
MIRT1545684	hsa-miR-588	CLIP-seq
MIRT2179746	hsa-miR-671-5p	CLIP-seq
MIRT1545685	hsa-miR-764	CLIP-seq
MIRT1545686	hsa-miR-939	CLIP-seq
MIRT2444589	hsa-miR-1246	CLIP-seq
MIRT2444590	hsa-miR-1263	CLIP-seq
MIRT2444591	hsa-miR-127-5p	CLIP-seq
MIRT2179726	hsa-miR-128	CLIP-seq
MIRT2444592	hsa-miR-1287	CLIP-seq
MIRT2444593	hsa-miR-1290	CLIP-seq
MIRT2444594	hsa-miR-1321	CLIP-seq
MIRT2444595	hsa-miR-141	CLIP-seq
MIRT2444596	hsa-miR-1972	CLIP-seq
MIRT2444597	hsa-miR-19a	CLIP-seq
MIRT2444598	hsa-miR-19b	CLIP-seq
MIRT2444599	hsa-miR-200a	CLIP-seq
MIRT2179730	hsa-miR-27a	CLIP-seq
MIRT2179731	hsa-miR-27b	CLIP-seq
MIRT2444600	hsa-miR-3134	CLIP-seq
MIRT2444601	hsa-miR-3135b	CLIP-seq
MIRT2444602	hsa-miR-3146	CLIP-seq
MIRT2444603	hsa-miR-3150b-3p	CLIP-seq
MIRT2444604	hsa-miR-3152-5p	CLIP-seq
MIRT814138	hsa-miR-3153	CLIP-seq
MIRT2444605	hsa-miR-3162-5p	CLIP-seq
MIRT2444606	hsa-miR-3167	CLIP-seq
MIRT2444607	hsa-miR-342-5p	CLIP-seq
MIRT2444608	hsa-miR-3611	CLIP-seq
MIRT2444609	hsa-miR-3614-5p	CLIP-seq
MIRT2444610	hsa-miR-3620	CLIP-seq
MIRT2444611	hsa-miR-3663-5p	CLIP-seq
MIRT2444612	hsa-miR-3674	CLIP-seq
MIRT2444613	hsa-miR-4289	CLIP-seq
MIRT2444614	hsa-miR-4320	CLIP-seq
MIRT2444615	hsa-miR-450b-3p	CLIP-seq
MIRT2444616	hsa-miR-451b	CLIP-seq
MIRT2444617	hsa-miR-4651	CLIP-seq
MIRT2444618	hsa-miR-4664-5p	CLIP-seq
MIRT2444619	hsa-miR-4689	CLIP-seq
MIRT2444620	hsa-miR-4710	CLIP-seq
MIRT2444621	hsa-miR-4726-3p	CLIP-seq
MIRT2444622	hsa-miR-4739	CLIP-seq
MIRT2444623	hsa-miR-4753-3p	CLIP-seq
MIRT2444624	hsa-miR-4756-5p	CLIP-seq
MIRT2444625	hsa-miR-4768-5p	CLIP-seq
MIRT814157	hsa-miR-4775	CLIP-seq
MIRT2444626	hsa-miR-4784	CLIP-seq
MIRT2179745	hsa-miR-513a-5p	CLIP-seq
MIRT814171	hsa-miR-590-3p	CLIP-seq
MIRT2444627	hsa-miR-608	CLIP-seq
MIRT2444628	hsa-miR-635	CLIP-seq
MIRT2444629	hsa-miR-654-3p	CLIP-seq
MIRT2444630	hsa-miR-769-3p	CLIP-seq
MIRT2444631	hsa-miR-876-5p	CLIP-seq
MIRT2483119	hsa-miR-1225-5p	CLIP-seq
MIRT2444589	hsa-miR-1246	CLIP-seq
MIRT2444590	hsa-miR-1263	CLIP-seq
MIRT2483120	hsa-miR-1270	CLIP-seq
MIRT2444591	hsa-miR-127-5p	CLIP-seq
MIRT2444592	hsa-miR-1287	CLIP-seq
MIRT2444593	hsa-miR-1290	CLIP-seq
MIRT2444594	hsa-miR-1321	CLIP-seq
MIRT2483121	hsa-miR-133a	CLIP-seq
MIRT2483122	hsa-miR-133b	CLIP-seq
MIRT2483123	hsa-miR-1343	CLIP-seq
MIRT2444595	hsa-miR-141	CLIP-seq
MIRT2444597	hsa-miR-19a	CLIP-seq
MIRT2444598	hsa-miR-19b	CLIP-seq
MIRT2444599	hsa-miR-200a	CLIP-seq
MIRT2483124	hsa-miR-223	CLIP-seq
MIRT1940726	hsa-miR-2682	CLIP-seq
MIRT814136	hsa-miR-28-5p	CLIP-seq
MIRT2483125	hsa-miR-299-5p	CLIP-seq
MIRT2444600	hsa-miR-3134	CLIP-seq
MIRT2444601	hsa-miR-3135b	CLIP-seq
MIRT2483126	hsa-miR-3138	CLIP-seq
MIRT814137	hsa-miR-3139	CLIP-seq
MIRT2444602	hsa-miR-3146	CLIP-seq
MIRT2444603	hsa-miR-3150b-3p	CLIP-seq
MIRT2444604	hsa-miR-3152-5p	CLIP-seq
MIRT2444605	hsa-miR-3162-5p	CLIP-seq
MIRT2483127	hsa-miR-3165	CLIP-seq
MIRT2444606	hsa-miR-3167	CLIP-seq
MIRT2483128	hsa-miR-3173-3p	CLIP-seq
MIRT2179732	hsa-miR-3189-3p	CLIP-seq
MIRT2444607	hsa-miR-342-5p	CLIP-seq
MIRT2444609	hsa-miR-3614-5p	CLIP-seq
MIRT2179733	hsa-miR-3649	CLIP-seq
MIRT2444612	hsa-miR-3674	CLIP-seq
MIRT2483129	hsa-miR-3689d	CLIP-seq
MIRT1940727	hsa-miR-3714	CLIP-seq
MIRT2483130	hsa-miR-378	CLIP-seq
MIRT2483131	hsa-miR-378b	CLIP-seq
MIRT2483132	hsa-miR-378c	CLIP-seq
MIRT2483133	hsa-miR-378d	CLIP-seq
MIRT2483134	hsa-miR-378e	CLIP-seq
MIRT2483135	hsa-miR-378f	CLIP-seq
MIRT2483136	hsa-miR-378h	CLIP-seq
MIRT2483137	hsa-miR-378i	CLIP-seq
MIRT2483138	hsa-miR-3940-5p	CLIP-seq
MIRT2483139	hsa-miR-409-3p	CLIP-seq
MIRT2483140	hsa-miR-422a	CLIP-seq
MIRT814144	hsa-miR-4266	CLIP-seq
MIRT2483141	hsa-miR-4278	CLIP-seq
MIRT2483142	hsa-miR-4281	CLIP-seq
MIRT2483143	hsa-miR-4286	CLIP-seq
MIRT1940731	hsa-miR-4301	CLIP-seq
MIRT2444614	hsa-miR-4320	CLIP-seq
MIRT2483144	hsa-miR-4328	CLIP-seq
MIRT2483145	hsa-miR-4422	CLIP-seq
MIRT2483146	hsa-miR-4428	CLIP-seq
MIRT2483147	hsa-miR-4434	CLIP-seq
MIRT2483148	hsa-miR-4477b	CLIP-seq
MIRT2483149	hsa-miR-4487	CLIP-seq
MIRT2483150	hsa-miR-4493	CLIP-seq
MIRT1940728	hsa-miR-449c	CLIP-seq
MIRT2483151	hsa-miR-4507	CLIP-seq
MIRT2444615	hsa-miR-450b-3p	CLIP-seq
MIRT2483152	hsa-miR-4516	CLIP-seq
MIRT2444616	hsa-miR-451b	CLIP-seq
MIRT2483153	hsa-miR-4531	CLIP-seq
MIRT2179738	hsa-miR-4642	CLIP-seq
MIRT2444617	hsa-miR-4651	CLIP-seq
MIRT2444618	hsa-miR-4664-5p	CLIP-seq
MIRT814148	hsa-miR-4685-5p	CLIP-seq
MIRT2444619	hsa-miR-4689	CLIP-seq
MIRT814150	hsa-miR-4706	CLIP-seq
MIRT2444620	hsa-miR-4710	CLIP-seq
MIRT2483154	hsa-miR-4716-3p	CLIP-seq
MIRT2483155	hsa-miR-4724-5p	CLIP-seq
MIRT2444621	hsa-miR-4726-3p	CLIP-seq
MIRT814153	hsa-miR-4728-5p	CLIP-seq
MIRT2483156	hsa-miR-4738-3p	CLIP-seq
MIRT2444622	hsa-miR-4739	CLIP-seq
MIRT814155	hsa-miR-4749-5p	CLIP-seq
MIRT2444623	hsa-miR-4753-3p	CLIP-seq
MIRT2444624	hsa-miR-4756-5p	CLIP-seq
MIRT2444625	hsa-miR-4768-5p	CLIP-seq
MIRT814157	hsa-miR-4775	CLIP-seq
MIRT814158	hsa-miR-4781-5p	CLIP-seq
MIRT2444626	hsa-miR-4784	CLIP-seq
MIRT2483157	hsa-miR-4790-3p	CLIP-seq
MIRT2483158	hsa-miR-548b-3p	CLIP-seq
MIRT814171	hsa-miR-590-3p	CLIP-seq
MIRT2444627	hsa-miR-608	CLIP-seq
MIRT2483159	hsa-miR-617	CLIP-seq
MIRT2483160	hsa-miR-620	CLIP-seq
MIRT2444628	hsa-miR-635	CLIP-seq
MIRT814220	hsa-miR-643	CLIP-seq
MIRT2444629	hsa-miR-654-3p	CLIP-seq
MIRT2483161	hsa-miR-661	CLIP-seq
MIRT2483162	hsa-miR-662	CLIP-seq
MIRT814172	hsa-miR-708	CLIP-seq
MIRT2444630	hsa-miR-769-3p	CLIP-seq
MIRT2444631	hsa-miR-876-5p	CLIP-seq
MIRT2444623	hsa-miR-4753-3p	CLIP-seq
MIRT814173	hsa-miR-1207-3p	CLIP-seq
MIRT2483119	hsa-miR-1225-5p	CLIP-seq
MIRT2444589	hsa-miR-1246	CLIP-seq
MIRT2444590	hsa-miR-1263	CLIP-seq
MIRT2483120	hsa-miR-1270	CLIP-seq
MIRT2444591	hsa-miR-127-5p	CLIP-seq
MIRT2179726	hsa-miR-128	CLIP-seq
MIRT2444592	hsa-miR-1287	CLIP-seq
MIRT2444593	hsa-miR-1290	CLIP-seq
MIRT2444594	hsa-miR-1321	CLIP-seq
MIRT2483121	hsa-miR-133a	CLIP-seq
MIRT2483122	hsa-miR-133b	CLIP-seq
MIRT2483123	hsa-miR-1343	CLIP-seq
MIRT2675833	hsa-miR-135a	CLIP-seq
MIRT2675834	hsa-miR-135b	CLIP-seq
MIRT2444595	hsa-miR-141	CLIP-seq
MIRT2444597	hsa-miR-19a	CLIP-seq
MIRT2444598	hsa-miR-19b	CLIP-seq
MIRT2444599	hsa-miR-200a	CLIP-seq
MIRT2483124	hsa-miR-223	CLIP-seq
MIRT1940726	hsa-miR-2682	CLIP-seq
MIRT2179730	hsa-miR-27a	CLIP-seq
MIRT2179731	hsa-miR-27b	CLIP-seq
MIRT814136	hsa-miR-28-5p	CLIP-seq
MIRT2483125	hsa-miR-299-5p	CLIP-seq
MIRT814183	hsa-miR-3064-5p	CLIP-seq
MIRT2444600	hsa-miR-3134	CLIP-seq
MIRT2444601	hsa-miR-3135b	CLIP-seq
MIRT814137	hsa-miR-3139	CLIP-seq
MIRT2444602	hsa-miR-3146	CLIP-seq
MIRT2444603	hsa-miR-3150b-3p	CLIP-seq
MIRT2444604	hsa-miR-3152-5p	CLIP-seq
MIRT814138	hsa-miR-3153	CLIP-seq
MIRT2444605	hsa-miR-3162-5p	CLIP-seq
MIRT2444606	hsa-miR-3167	CLIP-seq
MIRT2483128	hsa-miR-3173-3p	CLIP-seq
MIRT2675835	hsa-miR-3182	CLIP-seq
MIRT2444607	hsa-miR-342-5p	CLIP-seq
MIRT814190	hsa-miR-3591-3p	CLIP-seq
MIRT2444609	hsa-miR-3614-5p	CLIP-seq
MIRT2179733	hsa-miR-3649	CLIP-seq
MIRT2444612	hsa-miR-3674	CLIP-seq
MIRT2483129	hsa-miR-3689d	CLIP-seq
MIRT1940727	hsa-miR-3714	CLIP-seq
MIRT2483130	hsa-miR-378	CLIP-seq
MIRT2483131	hsa-miR-378b	CLIP-seq
MIRT2483132	hsa-miR-378c	CLIP-seq
MIRT2483133	hsa-miR-378d	CLIP-seq
MIRT2483134	hsa-miR-378e	CLIP-seq
MIRT2483135	hsa-miR-378f	CLIP-seq
MIRT2483136	hsa-miR-378h	CLIP-seq
MIRT2483137	hsa-miR-378i	CLIP-seq
MIRT2483138	hsa-miR-3940-5p	CLIP-seq
MIRT2483139	hsa-miR-409-3p	CLIP-seq
MIRT2483140	hsa-miR-422a	CLIP-seq
MIRT2675836	hsa-miR-4265	CLIP-seq
MIRT814144	hsa-miR-4266	CLIP-seq
MIRT2483142	hsa-miR-4281	CLIP-seq
MIRT2483143	hsa-miR-4286	CLIP-seq
MIRT814200	hsa-miR-4287	CLIP-seq
MIRT814201	hsa-miR-4290	CLIP-seq
MIRT2675837	hsa-miR-4296	CLIP-seq
MIRT1940731	hsa-miR-4301	CLIP-seq
MIRT2444614	hsa-miR-4320	CLIP-seq
MIRT2675838	hsa-miR-4322	CLIP-seq
MIRT2483144	hsa-miR-4328	CLIP-seq
MIRT2675839	hsa-miR-4417	CLIP-seq
MIRT2483146	hsa-miR-4428	CLIP-seq
MIRT2483147	hsa-miR-4434	CLIP-seq
MIRT814203	hsa-miR-4446-5p	CLIP-seq
MIRT2675840	hsa-miR-4464	CLIP-seq
MIRT2483148	hsa-miR-4477b	CLIP-seq
MIRT2483149	hsa-miR-4487	CLIP-seq
MIRT2483150	hsa-miR-4493	CLIP-seq
MIRT1940728	hsa-miR-449c	CLIP-seq
MIRT2483151	hsa-miR-4507	CLIP-seq
MIRT2444615	hsa-miR-450b-3p	CLIP-seq
MIRT2483152	hsa-miR-4516	CLIP-seq
MIRT2444616	hsa-miR-451b	CLIP-seq
MIRT2483153	hsa-miR-4531	CLIP-seq
MIRT814206	hsa-miR-4649-3p	CLIP-seq
MIRT2444617	hsa-miR-4651	CLIP-seq
MIRT2675841	hsa-miR-4652-3p	CLIP-seq
MIRT2444618	hsa-miR-4664-5p	CLIP-seq
MIRT814208	hsa-miR-4667-3p	CLIP-seq
MIRT814210	hsa-miR-4685-3p	CLIP-seq
MIRT814148	hsa-miR-4685-5p	CLIP-seq
MIRT2444619	hsa-miR-4689	CLIP-seq
MIRT2675842	hsa-miR-4691-5p	CLIP-seq
MIRT2444620	hsa-miR-4710	CLIP-seq
MIRT2675843	hsa-miR-4716-5p	CLIP-seq
MIRT2483155	hsa-miR-4724-5p	CLIP-seq
MIRT2444621	hsa-miR-4726-3p	CLIP-seq
MIRT2483156	hsa-miR-4738-3p	CLIP-seq
MIRT2444622	hsa-miR-4739	CLIP-seq
MIRT2675844	hsa-miR-4748	CLIP-seq
MIRT2444623	hsa-miR-4753-3p	CLIP-seq
MIRT814213	hsa-miR-4755-5p	CLIP-seq
MIRT2444624	hsa-miR-4756-5p	CLIP-seq
MIRT2444625	hsa-miR-4768-5p	CLIP-seq
MIRT814157	hsa-miR-4775	CLIP-seq
MIRT2179739	hsa-miR-4778-5p	CLIP-seq
MIRT2444626	hsa-miR-4784	CLIP-seq
MIRT2179740	hsa-miR-4795-3p	CLIP-seq
MIRT2675845	hsa-miR-4797-3p	CLIP-seq
MIRT2179741	hsa-miR-4803	CLIP-seq
MIRT2179742	hsa-miR-499-3p	CLIP-seq
MIRT2179743	hsa-miR-499a-3p	CLIP-seq
MIRT814161	hsa-miR-508-5p	CLIP-seq
MIRT2179745	hsa-miR-513a-5p	CLIP-seq
MIRT2483158	hsa-miR-548b-3p	CLIP-seq
MIRT2675846	hsa-miR-556-3p	CLIP-seq
MIRT2675847	hsa-miR-578	CLIP-seq
MIRT814171	hsa-miR-590-3p	CLIP-seq
MIRT2444627	hsa-miR-608	CLIP-seq
MIRT2483159	hsa-miR-617	CLIP-seq
MIRT2483160	hsa-miR-620	CLIP-seq
MIRT2675848	hsa-miR-630	CLIP-seq
MIRT2444628	hsa-miR-635	CLIP-seq
MIRT814219	hsa-miR-642a	CLIP-seq
MIRT814220	hsa-miR-643	CLIP-seq
MIRT2444629	hsa-miR-654-3p	CLIP-seq
MIRT2675849	hsa-miR-656	CLIP-seq
MIRT2483161	hsa-miR-661	CLIP-seq
MIRT2483162	hsa-miR-662	CLIP-seq
MIRT814172	hsa-miR-708	CLIP-seq
MIRT2444630	hsa-miR-769-3p	CLIP-seq
MIRT814222	hsa-miR-873	CLIP-seq
MIRT2444631	hsa-miR-876-5p	CLIP-seq
MIRT2675850	hsa-miR-942	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
GATA1	Unknown	12815710
NFKB1	Repression	17385716
RELA	Repression	17385716
SP1	Activation	21712774;22275252
SP1	Unknown	15681800;15857888
TFAP2A	Unknown	15059977

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IPI	16407538
GO:0004175	Function	Endopeptidase activity	IDA	10677483
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004190	Function	Aspartic-type endopeptidase activity	IDA	10531052
GO:0004190	Function	Aspartic-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	10677483, 12901838, 15286784, 15466887, 15886016, 16407538, 16965550, 17573534, 19011241, 20354142, 22709416, 22801501, 23701002, 24612608, 25957769, 26053850, 26840340, 27179792, 29507146, 30538620, 32814053
GO:0005764	Component	Lysosome	IDA	16033761, 23109336, 27084579, 27302062
GO:0005764	Component	Lysosome	IEA
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IDA	10531052
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	15886016, 23109336, 24305806, 27084579, 27302062
GO:0005769	Component	Early endosome	IEA
GO:0005770	Component	Late endosome	IDA	16033761, 23109336, 24612608, 27084579, 27302062
GO:0005770	Component	Late endosome	IEA
GO:0005771	Component	Multivesicular body	IDA	24612608
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005794	Component	Golgi apparatus	IDA	10531052, 11466313, 12586838
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IBA
GO:0005802	Component	Trans-Golgi network	IDA	11466313, 15886016, 23109336
GO:0005802	Component	Trans-Golgi network	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	12586838, 24612608
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	10887202
GO:0006508	Process	Proteolysis	IDA	10531052, 10677483
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0006509	Process	Membrane protein ectodomain proteolysis	IBA
GO:0006509	Process	Membrane protein ectodomain proteolysis	IDA	18353773
GO:0006509	Process	Membrane protein ectodomain proteolysis	IEA
GO:0006509	Process	Membrane protein ectodomain proteolysis	TAS	12354787
GO:0008021	Component	Synaptic vesicle	IEA
GO:0008233	Function	Peptidase activity	IDA	8562317
GO:0008233	Function	Peptidase activity	IEA
GO:0008798	Function	Beta-aspartyl-peptidase activity	TAS
GO:0009986	Component	Cell surface	IDA	15886016, 23109336
GO:0009986	Component	Cell surface	IEA
GO:0009986	Component	Cell surface	ISS
GO:0010008	Component	Endosome membrane	TAS
GO:0010288	Process	Response to lead ion	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10531052
GO:0016485	Process	Protein processing	IDA	10531052
GO:0016787	Function	Hydrolase activity	IEA
GO:0019899	Function	Enzyme binding	IPI	12586838
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0034205	Process	Amyloid-beta formation	IDA	24352696
GO:0042987	Process	Amyloid precursor protein catabolic process	IEA
GO:0042987	Process	Amyloid precursor protein catabolic process	ISS	20704561
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043525	Process	Positive regulation of neuron apoptotic process	IGI	29371969
GO:0045121	Component	Membrane raft	IEA
GO:0050435	Process	Amyloid-beta metabolic process	IBA
GO:0050435	Process	Amyloid-beta metabolic process	IDA	10677483, 15080893
GO:0050435	Process	Amyloid-beta metabolic process	IEA
GO:0050435	Process	Amyloid-beta metabolic process	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0050966	Process	Detection of mechanical stimulus involved in sensory perception of pain	IEA
GO:0055037	Component	Recycling endosome	IDA	15886016, 27084579, 27302062
GO:0055037	Component	Recycling endosome	IEA
GO:0060134	Process	Prepulse inhibition	IEA
GO:0070931	Component	Golgi-associated vesicle lumen	TAS
GO:0071280	Process	Cellular response to copper ion	IEA
GO:0071287	Process	Cellular response to manganese ion	IEA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098793	Component	Presynapse	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:0120283	Function	Protein serine/threonine kinase binding	IPI	24305806
GO:0140448	Process	Signaling receptor ligand precursor processing	IEA
GO:1904646	Process	Cellular response to amyloid-beta	IEA
GO:1990000	Process	Amyloid fibril formation	TAS

Other IDs

• MIM: 604252
• HGNC: 933
• e!Ensembl: ENSG00000186318

Protein

• UniProt ID: P56817
• Protein name: Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
• Protein function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved s
• PDB: 1FKN, 1M4H, 1PY1, 1SGZ, 1TQF, 1UJJ, 1UJK, 1W50, 1W51, 1XN2, 1XN3, 1XS7, 1YM2, 1YM4, 2B8L, 2B8V, 2F3E, 2F3F, 2FDP, 2G94, 2HIZ, 2HM1, 2IQG, 2IRZ, 2IS0, 2NTR, 2OAH, 2OF0, 2OHK, 2OHL, 2OHM, 2OHN, 2OHP, 2OHQ, 2OHR, 2OHS, 2OHT, 2OHU, 2P4J, 2P83, 2P8H, 2PH6, 2PH8, 2Q11, 2Q15, 2QK5, 2QMD, 2QMF, 2QMG, 2QP8, 2QU2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00026	Asp	74 → 418	Eukaryotic aspartyl protease	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata. {ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:11083922}.
• Sequence:

  MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
  VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
  YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
  GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
  DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
  VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
  ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
  HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
  RCLRCLRQQHDDFADDISLLK

• Sequence length: 501

Pathways

KEGG:

Alzheimer disease

Reactome:

Amyloid fiber formation