Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23613
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger MYND-type containing 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZMYND8
Synonyms (NCBI Gene) Gene synonyms aliases
PRKCBP1, PRO2893, RACK7
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.12
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Fi
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT050675 hsa-miR-18a-5p CLASH 23622248
MIRT049407 hsa-miR-92a-3p CLASH 23622248
MIRT039404 hsa-miR-421 CLASH 23622248
MIRT037778 hsa-miR-548d-5p CLASH 23622248
MIRT615847 hsa-miR-3140-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003714 Function Transcription corepressor activity IMP 27477906
GO:0003714 Function Transcription corepressor activity ISS
GO:0005515 Function Protein binding IPI 15095401, 16147992, 28966017
GO:0005634 Component Nucleus IDA 27477906, 28966017
GO:0005634 Component Nucleus ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615713 9397 ENSG00000101040
Protein
UniProt ID Q9ULU4
Protein name MYND-type zinc finger-containing chromatin reader ZMYND8 (Cutaneous T-cell lymphoma-associated antigen se14-3) (CTCL-associated antigen se14-3) (Protein kinase C-binding protein 1) (Rack7) (Transcription coregulator ZMYND8) (Zinc finger MYND domain-contai
Protein function Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4
PDB 4COS , 5B73 , 5MQ4 , 5Y1Z , 7CWH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00439 Bromodomain 157 240 Bromodomain Domain
PF00855 PWWP 275 351 PWWP domain Domain
PF12064 DUF3544 413 620 Protein kinase C-binding protein 1 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in neurons (at protein level) (PubMed:36064715). Absent in astrocytes (at protein level) (PubMed:36064715). Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta (PubMed:11003709, Pu
Sequence
MDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSE
LRHGPFYYMKQPLTTDPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSE
PEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKMKQPGTDAFQKPVPLE
QHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKV

VIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKD
GQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVE
NIRRKFGVF
NYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGT
GRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTK
TGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQS
TPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDS
EYISDDEQKSKNEPEDTEDK
EGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADP
GAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGED
HSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTS
TSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQ
QQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTITLVTSTQSSPLVTSSG
SMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEI
RRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVD
ETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTE
TLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSTLDLSGSRETPSSILLGSNQG
SDHSRSNKSSWSSSDEKRGSTRSDHNTSTSTKSLLPKESRLDTFWD
Sequence length 1186
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Migraine Migraine Disorders rs794727411 27182965
Unknown
Disease term Disease name Evidence References Source
Autism Spectrum Disorder autism spectrum disorder GenCC
Neurodevelopmental Disorders neurodevelopmental disorder GenCC
Neuroticism Neuroticism GWAS
Bipolar Disorder Bipolar Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 28055972, 30952871, 33593912
Carcinoma Renal Cell Stimulate 33593912
Colorectal Neoplasms Associate 32224527
Disease Associate 36153585
Endometriosis Associate 36153585
Glioblastoma Associate 32832624
Glioma Associate 36692427, 36826993
Leukemia Associate 34358447
Leukemia Myeloid Acute Associate 23667654, 34358447, 34478652
Neoplasms Associate 29393731, 30952871, 32224527, 32832624, 33593912, 36153585